Positions

Overview

  • Dr. Mrug is a Professor of Medicine in the Division of Nephrology at the University of Alabama at Birmingham (UAB) where he trains the next generation of physicians and scientists. Dr. Mrug is recognized as one of “Top Doctors” by Castle Connolly Medical Ltd. He co-founded and co-directs the UAB Polycystic Kidney Disease (PKD) Clinic and oversees clinical PKD research activities at UAB (since 2009). This includes the CRISP study, an NIH-funded collaborative effort between Emory University, University of Kansas, Mayo Clinic, UAB and University of Pittsburgh that has led to many seminal discoveries. He also coordinated the REPRISE clinical trial for UAB; outcomes of this study played a crucial role in the recent FDA approval of tolvaptan as the first treatment for autosomal dominant PKD (ADPKD). Dr. Mrug’s clinical research interests are centered on the development of statistical models for prediction of the decline in the kidney function in patients with ADPKD over time and better identification of those patients that may benefit most from therapeutic interventions. Dr. Mrug’s basic research (funded since 2005) is focused on the identification of molecular pathways that modulate progression of renal cystic diseases, especially those related to inflammation. He also directs the Therapeutics Development and Screening Core, one of four cores within the UAB Hepatorenal Fibrocystic Disease Core Center (HRFD CC). The UAB HRFD CC is one of four NIH-funded P30 centers focused on PKD, with the other three PKD Core Centers being located at University of Kansas, Mayo Clinic and University of Maryland. The mission of these centers is the development of innovative technologies to advance PKD research and providing access to these resources to other scientists to help them promote PKD research in institutions where such resources are not available. The activities of the UAB HRFD CC are centered on Autosomal Recessive PKD (ARPKD) and other recessive fibrocystic disorders affecting the kidney and liver. Dr. Mrug also serves as the Scientific Advisory Committee Chair for the PKD Foundation’s Board of Trustees.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Role of chemokines, innate and adaptive immunity. 2020
    2019 Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease 2019
    2019 Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease 2019
    2019 Growth pattern of kidney cyst number and volume in autosomal dominant polycystic kidney disease 2019
    2019 Long-term trajectory of kidney function in autosomal-dominant polycystic kidney disease 2019
    2019 Single-cell RNA sequencing identifies candidate renal resident macrophage gene expression signatures across species 2019
    2019 Heterozygous Pkhd1C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidney 2019
    2019 Truncating PKHD1 and PKD2 mutations alter energy metabolism 2019
    2019 Resident macrophages reprogram toward a developmental state after acute kidney injury 2019
    2019 Mks6 mutations reveal tissue-and cell type-specific roles for the cilia transition zone 2019
    2019 Sodium and potassium excretion predict increased depression in urban adolescents 2019
    2019 Tissue-resident macrophages promote renal cystic disease 2019
    2019 Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney disease 2019
    2018 Relationship between caffeine intake and autosomal dominant polycystic kidney disease progression: A retrospective analysis using the CRISP cohort 2018
    2018 A practical guide for treatment of rapidly progressive ADPKD with tolvaptan 2018
    2018 Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8 2018
    2018 Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease 2018
    2017 Image texture features predict renal function decline in patients with autosomal dominant polycystic kidney disease 2017
    2017 Performance of the CKD-EPI Equation to Estimate GFR in a Longitudinal Study of Autosomal Dominant Polycystic Kidney Disease 2017
    2017 Recovery of methotrexate-induced anuric acute kidney injury after glucarpidase therapy. 2017
    2017 Uric Acid Excretion Predicts Increased Blood Pressure Among American Adolescents of African Descent 2017
    2016 International Multi-Specialty Delphi Survey: Identification of Diagnostic Criteria for Hepatic and Renal Cyst Infection 2016
    2016 Automated segmentation of liver and liver cysts from bounded abdominal MR images in patients with autosomal dominant polycystic kidney disease 2016
    2016 Uric acid excretion predicts increased aggression in urban adolescents 2016
    2016 Automated segmentation of kidneys from mr images in patients with autosomal dominant polycystic kidney disease 2016
    2016 Predicted mutation strength of nontruncating PKD1 mutations AIDS genotype-phenotype correlations in autosomal dominant polycystic kidney disease 2016
    2015 Genetic and informatic analyses implicate Kif12 as a candidate gene within the Mpkd2 locus that modulates renal cystic disease severity in the Cys1cpk mouse 2015
    2015 A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease 2015
    2015 Autosomal-dominant polycystic kidney disease (ADPKD): Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference 2015
    2015 Imaging classification of autosomal dominant polycystic kidney disease: A simple model for selecting patients for clinical trials 2015
    2014 Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patients 2014
    2014 Novel methodology to evaluate renal cysts in polycystic kidney disease 2014
    2013 Innovations in studying in vivo cell behavior and pharmacology in complex tissues - Microvascular endothelial cells in the spotlight 2013
    2013 Beware the low HDAC11: Males at risk for ischemic kidney injury 2013
    2013 Novel approach to estimate kidney and cyst volumes using mid-slice magnetic resonance images in polycystic kidney disease 2013
    2013 Segmentation of individual renal cysts from mr images in patients with autosomal dominant polycystic kidney disease 2013
    2013 Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption 2013
    2013 Urinary Proteomic Biomarkers for Diagnosis and Risk Stratification of Autosomal Dominant Polycystic Kidney Disease: A Multicentric Study 2013
    2013 Renal macrophages in autosomal recessive polycystic kidney disease 2013
    2012 Impact of ultrasound-guided kidney biopsy simulation on trainee confidence and biopsy outcomes 2012
    2012 Microarray analysis of normal and abnormal chick ventricular myocardial development 2012
    2012 Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement 2012
    2011 Potentially modifiable factors affecting the progression of autosomal dominant polycystic kidney disease 2011
    2010 Comprehensive human urine standards for comparability and standardization in clinical proteome analysis 2010
    2010 Renal CD14 expression correlates with the progression of cystic kidney disease 2010
    2010 Simulation of real-time ultrasound-guided renal biopsy 2010
    2009 Validation of endogenous internal real-time PCR controls in renal tissues 2009
    2009 C3 polymorphisms and outcomes of renal allografts 2009
    2008 Overexpression of innate immune response genes in a model of recessive polycystic kidney disease 2008
    2008 Response to 'Overexpression of complement-component genes in Han:SPRD rats a model of polycystic kidney disease' 2008
    2006 Blood-borne stem cells differentiate into vascular and cardiac lineages during normal development 2006
    2005 Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse 2005
    2004 Angiotensin II Receptor Type 1 Expression in Erythroid Progenitors: Implications for the Pathogenesis of Postrenal Transplant Erythrocytosis 2004
    2002 Hemothorax and retroperitoneal hematoma after anticoagulation with enoxaparin 2002
    2002 Refinement of the autosomal recessive polycystic kidney disease (PKHD1) interval and exclusion of an EF hand-containing gene as a PKHD1 candidate gene 2002
    2002 Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. 2002
    2002 Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease 2002
    2002 Not one but two inflammatory bowel disease susceptibility loci map to chromosome 16 2002
    2002 PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats 2002
    2001 An integrated genetic and physical map of the 650-kb region containing the congenital polycystic kidney (cpk) locus on mouse chromosome 12 2001
    2001 Non-anemic homozygous β thalassemia in an african-american family: Association of high fetal hemoglobin levels with β thalassemia alleles 2001
    2000 Mapping of mouse α1(XIII) collagen to chromosome 10 and its exclusion as a kd candidate gene 2000
    2000 Genomic structure of the gene for the human p1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease 2000
    1999 Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene 1999
    1997 Angiotensin II stimulates proliferation of normal early erythroid progenitors 1997
    1997 'Complicated' autosomal dominant familial spastic paraplegia is genetically distinct from 'pure' forms 1997
    1997 The gene for autosomal dominant craniometaphyseal dysplasia maps to chromosome 5p and is distinct from the growth hormone-receptor gene 1997
    1996 Identification of highly polymorphic microsatellites in the rhesus macaque Macaca mulatta by cross-species amplification 1996
    1993 Polymorphisms in the pseudoautosomal regions of X and Y in DNA diagnosis 1993

    Chapter

    Year Title Altmetric
    2018 The role of inflammation and fibrosis in cystic kidney disease.  111-129. 2018

    Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Medicine, 1995
  • University of South Alabama, Internship 2000
  • University of South Alabama, Residency 2002
  • UAB Hospital, Postdoctoral Fellowship 2004

    • Full Name

  • Michal Mrug