Positions

Overview

  • Dr. McDonald is the Director of Integrative 'Omics and an Assistant Professor of Medicine in the UAB Division of Pulmonary, Allergy, and Critical Care Medicine. She is a genetic epidemiologist with interests in the analysis of complex traits and diseases including COPD, cachexia, sarcopenia, osteoarthritis and smoking behaviors such as menthol. Her lab is involved with some of the most cutting-edge studies including the Million Veterans Program (MVP) and the Trans-Omics for Precision Medicine (TOPMed) Initiative.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study 2019
    2019 It's more than low BMI: Prevalence of cachexia and associated mortality in COPD 2019
    2019 Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease 2019
    2018 Whole-genome sequencing in severe chronic obstructive pulmonary disease 2018
    2018 Genetic variants predicting aerobic capacity response to training are also associated with skeletal muscle oxidative capacity in moderate-to-severe COPD 2018
    2018 Pectoralis muscle area and mortality in smokers without airflow obstruction 2018
    2018 Common and rare variants genetic association analysis of cigarettes per day among ever-smokers in chronic obstructive pulmonary disease cases and controls 2018
    2018 Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression 2018
    2018 Lung, fat and bone: Increased adiponectin associates with the combination of smoking-related lung disease and osteoporosis 2018
    2017 Chest computed tomography-derived low fat-free mass index and mortality in COPD 2017
    2017 Handgrip strength in chronic obstructive pulmonary disease associations with acute exacerbations and body composition 2017
    2017 Multiomics approach to asthma: Navigating the network 2017
    2017 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1 2017
    2017 Sex-based genetic association study identifies celsr1 as a possible chronic obstructive pulmonary disease risk locus among women 2017
    2017 Obesity Is Associated With Increased Morbidity in Moderate to Severe COPD 2017
    2017 Susceptibility to childhood pneumonia: A genome-wide analysis 2017
    2016 Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: A cohort study 2016
    2016 A genome-wide analysis of the response to inhaled β 2-agonists in chronic obstructive pulmonary disease 2016
    2016 Sarcopenic Obesity, Functional Outcomes, and Systemic Inflammation in Patients With Chronic Obstructive Pulmonary Disease 2016
    2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry 2015
    2015 Continuous fat-free mass decline in COPD: Fact or fiction? 2015
    2015 IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease 2015
    2015 Reduced bone density and vertebral fractures in smokers. Men and COPD patients at increased risk 2015
    2014 Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene 2014
    2014 Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease 2014
    2014 DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease 2014
    2014 The clinical and genetic features of COPD-asthma overlap syndrome 2014
    2014 A comparative analysis of family-based and population-based association tests using whole genome sequence data 2014
    2014 Beyond GWAS in COPD: Probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks 2014
    2014 Chest CT Measures of Muscle and Adipose Tissue in COPD: Gender-based Differences in Content and in Relationships with Blood Biomarkers 2014
    2014 Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease 2014
    2014 Genome-wide association identifies regulatory loci associated with distinct local histogram emphysema patterns 2014
    2014 Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease: A cross-sectional study 2014
    2014 Risk loci for chronic obstructive pulmonary disease: A genome-wide association study and meta-analysis 2014
    2012 The chicken frizzle feather is due to an α-Keratin (KRT75) mutation that causes a defective rachis 2012
    2012 Genetic association of cyclic AMP signaling genes with bipolar disorder. 2012
    2011 Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1 2011
    2011 Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections 2011
    2009 Novel autosomal recessive non-syndromic hearing impairment locus (DFNB71) maps to chromosome 8p22-21.3 2009
    2008 Mapping of a new autosomal recessive non-syndromic hearing impairment locus (DFNB45) to chromosome 1q43-q44 [4] 2008
    2008 Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families 2008
    2005 Reduced endothelial secretion and plasma levels of transforming growth factor-β1 in patients with hereditary hemorrhagic telangiectasia type 1 2005
    2001 Potential Role of Modifier Genes Influencing Transforming Growth Factor-β1 Levels in the Development of Vascular Defects in Endoglin Heterozygous Mice with Hereditary Hemorrhagic Telangiectasia 2001

    Research Overview

  • Dr. McDonald’s research is focused on Network Medicine Approaches to Cachexia in COPD. Her research program is currently funded by the National Institutes of Health (K99/R00) and the Parker B. Francis Foundation. Dr. McDonald is an active member of the American Thoracic Society, the American Society of Human Genetics and the Society on Sarcopenia, Cachexia and Wasting Disorders.

    • Principal Investigator On

    Teaching Overview

  • Dr. McDonald is passionate about teaching and training. The use of genomics to help us understand human disease is a fascinating topic. She is currently accepting applications from students and post-docs.

    • Teaching Activities

    Education And Training

  • Baylor College of Medicine, Other
  • Brigham and Women's Hospital Channing Division of Network Medicine, Postdoctoral Research

    • Full Name

  • Merry-Lynn McDonald