Selected Publications

Academic Article

Year Title Altmetric
2022 IVUS Guidance on Optimal Stent Deployment: New Insights and PerspectivesJACC: Cardiovascular Interventions.  15:217-219. 2022
2021 The role of far-field intravascular ultrasound in transcatheter aortic valve replacement 2021
2021 A New Method to Optimize Stent Deployment by High-Definition Intravascular UltrasoundJournal of Invasive Cardiology.  33:E532-E539. 2021
2021 Prolyl endopeptidase contributes to early neutrophilic inflammation in acute myocardial transplant rejectionJCI insight.  6. 2021
2021 A new intravascular ultrasound-guided stenting strategy compared with angiography on stent expansion and procedural outcomes in patients with positive lesion remodelingCatheterization and Cardiovascular Interventions.  97:237-244. 2021
2020 A Novel Fluoroscopic-guided Technique With Micropuncture Needle for the Common Femoral Artery AccessCardiovascular Revascularization Medicine.  21:668-674. 2020
2019 Effects of Crushed Ticagrelor Versus Eptifibatide Bolus Plus Clopidogrel in Troponin-Negative Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: A Randomized Clinical Trial 2019
2019 Ischemic Evaluation in Patients Presenting with Hypertensive Emergency / Urgency and Acute Systolic Heart Failure: Is Coronary Angiography Required for all?Cardiovascular Revascularization Medicine.  20:492-495. 2019
2019 Intravascular ultrasound of normal left main arteries: Insights for stent optimization and standardizationCatheterization and Cardiovascular Interventions.  93:239-240. 2019
2019 Percutaneous closure of right coronary to superior vena cava fistulaFuture Cardiology.  15:161-167. 2019
2018 Impact of ticagrelor and aspirin versus clopidogrel and aspirin in symptomatic patients with peripheral arterial disease: Thrombus burden assessed by optical coherence tomographyCardiovascular Revascularization Medicine.  19:778-784. 2018
2018 Evaluation of lesion flow coefficient for the detection of coronary artery disease in patient groups from two academic medical centersCardiovascular Revascularization Medicine.  19:348-354. 2018
2018 Thrombolytic therapy in the current era: Myocardial infarction and beyondCurrent Pharmaceutical Design.  24:414-426. 2018
2017 Large-field intravascular ultrasound for annular sizing and predicting paravalvular regurgitation during TAVR: Comparisons with multidetector computed tomography and transoesophageal echocardiographyEHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging.  18:1404-1413. 2017
2017 The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac RejectionScientific Reports.  7. 2017
2017 Clinical outcomes of tricuspid valve repair accompanying left-sided heart disease.World Journal of Cardiology.  9:787-793. 2017
2017 Role of Proximal Optimization Technique Guided by Intravascular Ultrasound on Stent Expansion, Stent Symmetry Index, and Side-Branch Hemodynamics in Patients with Coronary Bifurcation LesionsCirculation: Cardiovascular Interventions.  10. 2017
2017 Descending septal branch of right coronary artery: Rare, but important in hypertrophic cardiomyopathyCardiovascular Revascularization Medicine.  18:23-25. 2017
2017 Ticagrelor and Eptifibatide Bolus Versus Ticagrelor and Eptifibatide Bolus With 2-Hour Infusion in High-Risk Acute Coronary Syndromes Patients Undergoing Early Percutaneous Coronary Intervention 2017
2017 Comprehensive review on cardio-oncology: Role of multimodality imagingJournal of Nuclear Cardiology.  24:906-935. 2017
2017 Jailing polymer jacketed guide-wires during bifurcation coronary interventions is associated with procedural myocardial infarction.World Journal of Cardiology.  9:442-447. 2017
2017 Management of radial artery perforation during transradial catheterization using a polytetrafluoroethylene-covered coronary stentCardiovascular Revascularization Medicine.  18:133-135. 2017
2017 No Wire Fracture Is Great News, But Is Polymer Shearing the Real Danger?JACC: Cardiovascular Interventions.  10:203-204. 2017
2016 Catheter-directed treatment for acute pulmonary embolism: Systematic review and single-arm meta-analysesInternational Journal of Cardiology.  225:128-139. 2016
2016 Optical coherence tomography compared with intravascular ultrasound and with angiography to guide coronary stent implantation (ILUMIEN III: OPTIMIZE PCI): a randomised controlled trial 2016
2016 Bioresorbable vascular scaffolds in coronary bifurcation lesions: The next frontiers?Catheterization and Cardiovascular Interventions.  88:870-871. 2016
2016 Safety of hydrophilic guidewires used for side-branch protection during stenting and proximal optimization technique in coronary bifurcation lesionsCardiovascular Revascularization Medicine.  17:456-462. 2016
2016 Comparison of failure rates of crossing side branch with pressure vs. coronary guidewire: A meta-analysisEuropean Journal of Clinical Investigation.  46:448-459. 2016
2016 Impact of Transcatheter Aortic Valve Replacement on Surgical Volumes and Outcomes in a Tertiary Academic Cardiac Surgical PracticeJournal of The American College of Surgeons.  222:645-655. 2016
2016 SCAI Expert consensus statement: Evaluation, management, and special considerations of cardio-oncology patients in the cardiac catheterization laboratory (endorsed by the cardiological society of India, and sociedad Latino Americana de Cardiologbox drawings light down and lefta intervencionista)Catheterization and Cardiovascular Interventions.  87:E202-E223. 2016
2016 SCAI expert consensus statement: Evaluation, management, and special considerations of cardio-oncology patients in the cardiac catheterization laboratory (Endorsed by the Cardiological Society of India, and Sociedad Latino Americana de Cardiologbox drawings light down and lefta Intervencionista)Catheterization and Cardiovascular Interventions.  87:895-899. 2016
2016 Vascular toxicities of cancer therapies: The old and the new - An evolving avenueCirculation.  133:1272-1289. 2016
2016 U.S. trends in inpatient utilization of fractional flow reserve and percutaneous coronary interventionJournal of the American College of Cardiology.  67:732-733. 2016
2016 Diagnostic cutoff for pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve: A Patient-Level AnalysisCatheterization and Cardiovascular Interventions.  87:273-282. 2016
2015 The Role of Vascular Imaging in Guiding Routine Percutaneous Coronary Interventions: A Meta-Analysis of Bare Metal Stent and Drug-Eluting Stent Trials 2015
2015 Letter by Reddy and Leesar regarding article "assisted beating of the ischemic heart: How to manage the Pulseless st-segment-elevation myocardial infarction patient"Circulation.  131:e533. 2015
2015 Coronary bifurcation lesions: Present status and future perspectivesInternational Journal of Cardiology.  187:48-57. 2015
2015 Glycoprotein IIb/IIIa inhibitors improve mortality after aspiration thrombectomy in patients with ST-segment elevation myocardial infarctionInternational Journal of Cardiology.  187:206-207. 2015
2015 A risk-scoring model to predict one-year major adverse cardiac events after percutaneous coronary interventionJournal of Tehran University Heart Center.  10:167-175. 2015
2015 Lesion flow coefficient: A combined anatomical and functional parameter for detection of coronary artery disease - A clinical studyJournal of Invasive Cardiology.  27:54-64. 2015
2015 Transcatheter aortic valve replacement program in the post-Food and Drug Administration approval era early outcomes at an academic medical centerInnovations:Technology and Techniques in Cardiothoracic and Vascular Surgery.  10:48-51. 2015
2014 Optical coherence tomography to guide below-the-knee endovascular interventionsInternational Journal of Cardiology.  176:1336-1338. 2014
2014 12-month primary patency rates of contemporary endovascular device therapy for femoro-popliteal occlusive disease in 6,024 patients: Beyond balloon angioplastyCatheterization and Cardiovascular Interventions.  84:555-564. 2014
2014 Cardioprotective effect of high-dose intragraft adenosine infusion on microvascular function and prevention of no-reflow during saphenous vein grafts interventionCatheterization and Cardiovascular Interventions.  83:1045-1054. 2014
2014 Functional diagnosis of coronary stenoses using pressure drop coefficient: A pilot study in humansCatheterization and Cardiovascular Interventions.  83:377-385. 2014
2014 Diagnostic performance of pressure drop coefficient in relation to fractional flow reserve and coronary flow reserveJournal of Invasive Cardiology.  26:188-195. 2014
2014 Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model 2014
2014 Hyperemia-free delineation of epicardial and microvascular impairments using a basal indexAnnals of Biomedical Engineering.  42:1681-1690. 2014
2014 Stenting for renal-artery stenosis [3]New England Journal of Medicine.  370:1853. 2014
2014 Use of optical coherence tomography during superficial femoral artery interventionsJournal of Invasive Cardiology.  26:220-223. 2014
2013 Drug-eluting stents for ostial coronary stenoses: Perspectives on the horizonCatheterization and Cardiovascular Interventions.  82:735-736. 2013
2013 Safety and efficacy of device closure for patent foramen ovale for secondary prevention of neurological events: Comprehensive systematic review and meta-analysis of randomized controlled trialsCardiovascular Revascularization Medicine.  14:349-355. 2013
2013 Impact of kissing balloon inflation on the main vessel stent volume, area, and symmetry after side-branch dilation in patients with coronary bifurcation lesions: A serial volumetric intravascular ultrasound studyJACC: Cardiovascular Interventions.  6:923-931. 2013
2012 Back to the future: How biology and technology could change the role of ptfe grafts in vascular access managementSeminars in Dialysis.  25:495-504. 2012
2012 Left main coronary stenosis and acute myocardial infarction: Stent or surgery? An evolving perspectiveCatheterization and Cardiovascular Interventions.  79:988-989. 2012
2012 Effect of heart rate on hemodynamic endpoints under concomitant microvascular disease in a porcine model 2012
2012 Fractional flow reserve: A new paradigm for diagnosis and management of coronary artery diseaseInterventional Cardiology.  4:61-71. 2012
2012 Effect of changes in contractility on pressure drop coefficient and fractional flow reserve in a porcine modelJournal of Invasive Cardiology.  24:6-12. 2012
2011 The impact of fractional flow reserve measurement on clinical outcomes after transradial coronary stentingEurointervention.  7:917-923. 2011
2011 Clinical presentation and outcomes of drug-eluting stent-associated coronary aneurysmsEurointervention.  7:487-496. 2011
2011 Drug-eluting stents for saphenous vein graft lesionsJACC: Cardiovascular Interventions.  4:590. 2011
2011 Biventricular pacing leading to coronary stent fractureTexas Heart Institute Journal.  38:208-209. 2011
2011 Letter by Hakeem et al regarding article, "drug-eluting or bare metal stents for the treatment of saphenous vein graft disease: A bayesian meta-analysis"Circulation: Cardiovascular Interventions.  4. 2011
2011 Safety and efficacy of drug eluting stents compared with bare metal stents for saphenous vein graft interventions: A comprehensive meta-analysis of randomized trials and observational studies comprising 7,994 patientsCatheterization and Cardiovascular Interventions.  77:343-355. 2011
2011 Influence of heart rate on fractional flow reserve, pressure drop coefficient, and lesion flow coefficient for epicardial coronary stenosis in a porcine model 2011
2011 Takotsubo cardiomyopathy and microvascular dysfunction: Another diagnostic criteria or predisposing factor?Catheterization and Cardiovascular Interventions.  77:132-133. 2011
2010 Physiological assessment of renal artery stenosis: Comparisons of resting with hyperemic renal pressure measurementsCatheterization and Cardiovascular Interventions.  76:726-732. 2010
2010 Prediction of hemodialysis graft patency by intragraft pressure measurements: Prognostic or reflective?Catheterization and Cardiovascular Interventions.  76:212-213. 2010
2010 Angiographic Versus Functional Severity of Coronary Artery Stenoses in the FAME Study. Fractional Flow Reserve Versus Angiography in Multivessel EvaluationJournal of the American College of Cardiology.  55:2816-2821. 2010
2010 Sirolimus-eluting stent fractures leading to restenosis in cardiac allograft vasculopathyCardiovascular Revascularization Medicine.  11:120-123. 2010
2010 Intravascular ultrasound optimization of drug-eluting stents: Still not enough dataCatheterization and Cardiovascular Interventions.  75:584-585. 2010
2010 Hemodynamic and intravascular ultrasound assessment of myocardial bridging: Fractional flow reserve paradox with dobutamine versus adenosineCatheterization and Cardiovascular Interventions.  75:229-236. 2010
2009 Defining a new standard for IVUS optimized drug-eluting stent implantation - The PRAVIO study: Do we know the right technique for stent optimization?Catheterization and Cardiovascular Interventions.  74:357-358. 2009
2009 Prediction of Hypertension Improvement After Stenting of Renal Artery Stenosis. Comparative Accuracy of Translesional Pressure Gradients, Intravascular Ultrasound, and AngiographyJournal of the American College of Cardiology.  53:2363-2371. 2009
2009 Baseline Fractional Flow Reserve and Stent Diameter Predict Event Rates After Stenting. A Further Step, But Still Much to LearnJACC: Cardiovascular Interventions.  2:364-365. 2009
2008 Myocardial protection with a beta blocker and glycoprotein IIb/IIIa inhibitor during PCI: Attractive concept, but limited evidence of benefitCatheterization and Cardiovascular Interventions.  72:498-499. 2008
2008 Acute myocardial infarction in a 19 year-old female owing to hypercoagulable state of pregnancy and the puerperiumJournal of Invasive Cardiology.  20. 2008
2008 Fractional flow reserve: FFR B4 U stentCatheterization and Cardiovascular Interventions.  72:257-258. 2008
2008 Platelet glycoprotein IIb/IIIa receptor inhibitors: Is their future as bright as their past?Catheterization and Cardiovascular Interventions.  71:907-908. 2008
2008 A revisit: Repeat stent placement versus angioplasty alone for renal in-stent restenosisCatheterization and Cardiovascular Interventions.  71:706-707. 2008
2007 Hemodynamic and intravascular ultrasound assessment of an ambiguous left main coronary artery stenosisCatheterization and Cardiovascular Interventions.  70:721-730. 2007
2007 Iatrogenic fistula between the left anterior descending coronary artery and anterior interventricular vein following stentingJournal of Invasive Cardiology.  19. 2007
2007 Recombinant Nematode Anticoagulant Protein c2 in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome. The ANTHEM-TIMI-32 TrialJournal of the American College of Cardiology.  49:2398-2407. 2007
2007 Renal hemodynamics: Theory and practical tipsCatheterization and Cardiovascular Interventions.  69:894-901. 2007
2007 Pretreatment With Intracoronary Enalaprilat Protects Human Myocardium During Percutaneous Coronary AngioplastyJournal of the American College of Cardiology.  49:1607-1610. 2007
2007 Peroxisome proliferator-activated receptor γ agonists for the Prevention of Adverse events following percutaneous coronary Revascularization-results of the PPAR StudyAmerican Heart Journal.  154:137-143. 2007
2006 Congenital ostial left main coronary artery stenosis associated with a bicuspid aortic valve in a young womanJournal of Invasive Cardiology.  18. 2006
2005 Intravascular ultrasound for the assessment of an ambiguous left main coronary stenosis [1] (multiple letters)Journal of the American College of Cardiology.  46:2145-2146. 2005
2005 Thirty-month outcome after fractional flow reserve-guided versus conventional multivessel percutaneous coronary interventionAmerican Journal of Cardiology.  96:877-884. 2005
2005 Delayed preconditioning-mimetic actions of nitroglycerin in patients undergoing exercise tolerance testsCirculation.  111:2565-2571. 2005
2005 Thrombolysis and counterpulsation to improve survival in myocardial infarction complicated by hypotension and suspected cardiogenic shock or heart failure: Results of the TACTICS trialJournal of Thrombosis and Thrombolysis.  19:33-39. 2005
2004 Correlations between fractional flow reserve and intravascular ultrasound in patients with an ambiguous left main coronary artery stenosisCirculation.  110:2831-2836. 2004
2004 Novel implication of combined stent crushing and intravascular ultrasound for dislodged stentsJournal of Invasive Cardiology.  16:445-446. 2004
2004 Physiological and intravascular ultrasound assessment of an ambiguous left main coronary artery stenosisCatheterization and Cardiovascular Interventions.  62:349-357. 2004
2004 Use of Aminophylline in the Treatment of Severe Symptomatic Bradycardia Resistant to AtropineCardiology in Review.  12:65-68. 2004
2004 Quadfurcation of the Left Main Coronary Artery: Double Ramus Medianus Coronary SystemAngiology.  55:109-110. 2004
2003 Nonelectrocardiographic evidence that both ischemic preconditioning and adenosine preconditioning exist in humansJournal of the American College of Cardiology.  42:437-445. 2003
2003 Conflicting functional assessment of stenoses in patients with previous myocardial infarctionCatheterization and Cardiovascular Interventions.  59:489-495. 2003
2003 Use of fractional flow reserve versus stress perfusion scintigraphy after unstable angina: Effect on duration of hospitalization, cost, procedural characteristics, and clinical outcomeJournal of the American College of Cardiology.  41:1115-1121. 2003
2001 Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplastyCirculation.  103:2935-2941. 2001
2000 Cardioesophageal reflexes: An invasive human studyDigestive Diseases and Sciences.  45:2451-2454. 2000
1999 Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction - Results of a multicenter, randomized, placebo-controlled trial: The acute myocardial infarction STudy of ADenosine (AMISTAD) trialJournal of the American College of Cardiology.  34:1711-1720. 1999
1999 Bradykinin-induced preconditioning in patients undergoing coronary angioplastyJournal of the American College of Cardiology.  34:639-650. 1999
1998 Adenosine-induced preconditioning of human myocardium? [2] (multiple letters)Circulation.  98:824-825. 1998
1998 Adenosine pretreatment of human myocardium and ischemic preconditioning [2] (multiple letters)Circulation.  97:2279. 1998
1997 Ischemic preconditioning during coronary angioplasty [1]Journal of the American College of Cardiology.  29:469-470. 1997
1997 Preconditioning of human myocardium with adenosine during coronary angioplastyCirculation.  95:2500-2507. 1997
1996 Cost and therapeutic modification of intracoronary ultrasound-assisted coronary angioplastyAmerican Journal of Cardiology.  77:1278-1282. 1996
1996 Exogenous fibronectin to prevent neointimal hyperplasia after balloon angioplastyJournal of Invasive Cardiology.  8:107-112. 1996
1995 Coronary angioplasty compared with bypass graftingNew England Journal of Medicine.  332:888-890. 1995
1995 Coronary angioplasty compared with bypass grafting.New England Journal of Medicine.  332:889. 1995
1995 A Prospective Randomized Trial of 0.010″ Versus 0.014″ Balloon PTCA Systems and Interventional Fellow Versus Attending Physician as Primary Operator in Elective PTCA: Economic, Technical, and Clinical End Points 1995
1994 Economic Aspects of Using Alternative Diagnostic Techniques in Addition to Angiography During Percutaneous Coronary Artery Revascularization 1994
1994 Noncardiogenic pulmonary edema complicating massive verapamil overdoseChest.  105:606-607. 1994


Year Title Altmetric
2018 Stent thrombosis: Early, late, and very late.  217-224. 2018
2014 Urgent Endovascular Renal Intervention.  366-375. 2014

Investigator On

  • Cerebral Hemodynamics And Neurocognition In Severe Acrtic Valve Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • International Study of Comparative Health Effectiveness with Medical and Invasive Approaches  awarded by New York University
  • International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA)  awarded by NEW YORK UNIVERSITY SCHOOL OF MEDICINE
  • Left Ventricular Torsional Hysteresis: A Global Parameter for Diastolic Function  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Private Grant  awarded by Baxter Healthcare Corporation
  • Private Grant  awarded by Gilead Sciences ^
  • Private Grant  awarded by ABBOTT VASCULAR, INC.
  • Private Grant  awarded by ABIOMED, INC.
  • Private Grant  awarded by ASTRAZENECA PHARMACEUTICALS LP
  • Private Grant  awarded by ABBOTT VASCULAR, INC.
  • Private Grant  awarded by MAQUET CARDIOVASCULAR, LLC
  • Private Grant  awarded by St. Jude Medical
  • Private Grant  awarded by DIRECT FLOW MEDICAL
  • Private Grant  awarded by St. Jude Medical
  • Private Grant  awarded by Edwards Lifesciences Corp.
  • Private Grant  awarded by Edwards Lifesciences Corp.
  • Private Grant  awarded by CARDIOVASCULAR SYSTEM INC.
  • Private Grant  awarded by BOSTON SCIENTIFIC CORPORATION
  • Private Grant  awarded by CARDIOVASCULAR SYSTEM INC.
  • Private Grant  awarded by ABBOTT VASCULAR, INC.
  • Private Grant  awarded by St. Jude Medical
  • Private Grant  awarded by ABIOMED, INC.
  • Private Grant  awarded by CARDIOVASCULAR SYSTEM INC.
  • Education And Training

  • Tehran University of Medical Sciences, Internship
  • Toronto General Hospital, Residency
  • Waterbury Hospital, Residency
  • Detroit Medical Center (DMC) Sinai - Grace, Postdoctoral Fellowship
  • UC Health - University Hospital, Postdoctoral Fellowship
  • University of Louisville Hospital, Postdoctoral Fellowship
  • Doctor of Medicine, Mashhad University of Medical Sciences 1981
  • Full Name

  • Massoud Leesar