• Dr. Michele Kong obtained her medical degree from the University of Calgary, Canada. She completed her pediatric critical care training at UAB. She is currently a translational physician scientist with a clinical practice in a tertiary 24-bed Pediatric Intensive Care Unit at Children's of Alabama. Her research is focused on understanding the role of protease dysregulation in the pathogenesis of Respiratory Syncytial Virus (RSV) lung disease and acute lung injury in children. With the COVID-19 pandemic, her research work has extended to elucidating the epidemiology, pathophysiology and immune response to Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) in hospitalized children. In addition, Dr. Kong is the founder and developer of the Sensory Pathway (with the focus of removing barriers to diagnosis and improving delivery of care, particularly for children with sensory, social and communication challenges) and continues to provide oversight to the implementation of the pathway at Children's of Alabama. Twitter Handle: @Michele_KongMD
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescentsiScience.  40. 2021
    2021 Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory SyndromeJAMA Neurology.  78:536-547. 2021
    2021 Characteristics and Outcomes of US Children and Adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) Compared with Severe Acute COVID-19 2021
    2021 What COVID-19 means for non-neurotypical children and their familiesPediatric Research.  89:396-397. 2021
    2021 Hiding in plain sightPediatric Research2021
    2020 The 5-Es: a model for providing care for non-neurotypical patientsPediatric Research.  88:686-687. 2020
    2020 Considerations for Young Children and Those with Special Needs as COVID-19 ContinuesJAMA Pediatrics.  174:1012. 2020
    2020 Extubation Take Two 2020
    2020 Multisystem Inflammatory Syndrome in U.S. Children and AdolescentsNew England Journal of Medicine.  383:334-346. 2020
    2020 Azithromycin Treatment vs Placebo in Children with Respiratory Syncytial Virus-Induced Respiratory Failure: A Phase 2 Randomized Clinical TrialJAMA Network Open.  3. 2020
    2019 Sensory processing: shifting our mindset to improve care deliveryPediatric Research.  86:544-545. 2019
    2019 Utilization of a Novel Pathway in a Tertiary Pediatric Hospital to Meet the Sensory Needs of Acutely Ill Pediatric PatientsFrontiers in Pediatrics.  7. 2019
    2019 The authors replyPediatric Critical Care Medicine.  20:795-796. 2019
    2019 Antibiotic prescription in young children with respiratory syncytial virus-associated respiratory failure and associated outcomesPediatric Critical Care Medicine.  20:101-109. 2019
    2019 Contemporary trainee knowledge of autism: How prepared are our future providers?Frontiers in Pediatrics.  7. 2019
    2018 Viral sepsis in childrenFrontiers in Pediatrics.  6. 2018
    2017 A community-based sensory training program leads to improved experience at a local zoo for children with sensory challengesFrontiers in Pediatrics.  5. 2017
    2017 A call to the senses: The community approachFrontiers in Pediatrics.  5. 2017
    2017 Goodbyes are not foreverJAMA Pediatrics.  171:109. 2017
    2016 Love at First SightJAMA Pediatrics.  170:1120-1120. 2016
    2016 Viral infection in the development and progression of pediatric acute respiratory distress syndromeFrontiers in Pediatrics.  4. 2016
    2016 Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomesAmerican Journal of Respiratory Cell and Molecular Biology.  54:359-369. 2016
    2015 Chromobacterium Violaceum sepsis: Rethinking conventional therapy to improve outcomeThe American Journal of Case Reports.  16:740-744. 2015
    2015 Balance is in the MomentFrontiers in Pediatrics.  3. 2015
    2015 Addendum: Kong, M.Y.; Whitley, R.J.; Peng, N.; Oster, R.; Schoeb, T.R.; Sullender, W.; Ambalavanan, N.; Clancy, J.P.; Gaggar, A.; Blalock J.E. Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo. Viruses 2015, 30, 7, 4230–4253.Viruses.  7:5609. 2015
    2015 Matrix metalloproteinase-9 mediates RSV infection in vitro and in vivoViruses.  7:4230-4253. 2015
    2015 Diagnosis and History Taking in Children with Autism Spectrum Disorder: Dealing with the ChallengesFrontiers in Pediatrics.  3. 2015
    2014 Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virusEuropean Respiratory Journal.  43:1086-1096. 2014
    2013 Respiratory syncytial virus infection disrupts monolayer integrity and function in cystic fibrosis airway cellsViruses.  5:2260-2271. 2013
    2011 Early elevation of matrix Metalloproteinase-8 and -9 in pediatric ARDS is associated with an increased risk of prolonged mechanical ventilationPLoS ONE.  6. 2011
    2007 Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients 2007
    2007 Is hyperglycemia really harmful? A critical appraisal of "Persistent hyperglycemia in critically ill children" by Faustino and Apkon (J Pediatr 2005; 146:30-34)Pediatric Critical Care Medicine.  8:482-485. 2007

    Research Overview

  • -Development of sensory integration program aimed at removing barriers to assessment, diagnosis, management, and overall care delivery for patients with developmental and cognitive delay, who often have social, communication and sensory vulnerabilities.

    -Understanding the pathogenesis of Respiratory Syncytial Virus-induced respiratory failure, and best clinical practice for management of severe Pediatric Acute Respiratory Distress Syndrome.

    - Understanding the epidemiology, pathophysiology and immune response to Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) in hospitalized children.
  • Principal Investigator On

  • A Phase 3 Randomized Controlled Trial of AZM for RSV-Induced Respiratory Failure in Children in the ICU  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Age of Blood in Children in Pediatric Intensive Care Units (ABC-PICU)  awarded by Washington University
  • Ancillary to ABC PICU to Study MOD in Critically Ill Children  awarded by University of California, Los Angeles
  • Genetic Epidemiology and Immune Response to Life- Threatening Influenza Infection in Children and Yound Adults (PICFlu)  awarded by CHILDREN'S HOSPITAL (BOSTON)
  • Genetic Epidemiology of Life-Threatening Influenza in Children  awarded by CHILDREN'S HOSPITAL (BOSTON)
  • Genetic and Environmental Influences on Recovery of Severe Pediatric Brain Injury. (ADAPT Genomics)  awarded by CHILDREN'S HOSPITAL MEDICAL CENTER (CINCINNATI)
  • Genetic and Environmental Influences on Recovery of Severe Pediatric Brain Injury. (ADAPT Genomics) - CR for Coordinator Effort  awarded by CHILDREN'S HOSPITAL MEDICAL CENTER (CINCINNATI)
  • Identification of Prognostic Protein and Bioactive Lipid Biomarkers in Critically Ill Children with Influenza Infection  awarded by CHILDREN'S HOSPITAL (BOSTON)
  • Immunobiology of Influenza Virus-Related Critical Illness in Young Hosts (PICFLU2)  awarded by BOSTON CHILDREN'S HOSPITAL
  • Impact of RBC-derived DAMPs on Innate Immunity in Pediatric Sepsis (RBC-DAMPs)  awarded by Washington University
  • Influenza Vaccine Effectiveness for Preventing Laboratory-Confirmed Severe Influenza Associated Illness in US Children (PICFLU-VE)  awarded by BOSTON CHILDREN'S HOSPITAL
  • Massive Transfusion Epidemiology and Outcomes in Children (MATIC) Study  awarded by Washington University
  • Matrix Metalloproteinase Driven Lung Inflammation in RSV Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Matrix Metalloproteinase-9 in Pediatric RSV-Induced Respiratory Failure  awarded by CHILDREN’S CENTER FOR RESEARCH AND INNOVATION
  • Multiple Therapies for Pediatric TBI: Comparative Effectiveness Approach (ADAPT)  awarded by CHILDREN'S NATIONAL MEDICAL CENTER - NEW
  • PROSpect - Prone and Oscillation Pediatric Clinical Trial  awarded by University of Pennsylvania
  • Pediatric Critical Care Scientist Development Program: "RSV-Induced Respiratory Failure: Role of MMP-9 in Lung Injury Through Generation of PGP"  awarded by University of Utah
  • Private Grant  awarded by MedImmune
  • Private Grant  awarded by Gilead Sciences ^
  • RSV-Mediated Regulation of Neutrophilic Inflammation in CF Lung Disease  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE
  • Sepsis-Induced Red Cell Dysfunction (SIRD}  awarded by Washington University
  • Understanding COVID-19 Among Critically Ill Children in the Pediatric Acute Lung Injury and Sepsis Investigator's (PALISI) Network  awarded by BOSTON CHILDREN'S HOSPITAL
  • Education And Training

  • Leadership Birmingham, Other
  • University of Alabama at Birmingham, Other
  • University of Alabama at Birmingham, Other
  • University of Mississippi Medical Center, Internship
  • University of Mississippi Medical Center, Residency
  • UAB Hospital, Postdoctoral Fellowship
  • Doctor of Medicine, 2001
  • Full Name

  • Michele Kong