Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 AP-1 and the injury response of the GFAP geneJournal of Neuroscience Research.  97:149-161. 2019
2016 Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander DiseaseJournal of Proteome Research.  15:2265-2282. 2016
2015 Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander diseaseGlia.  63:2285-2297. 2015
2015 A new mutation in GFAP widens the spectrum of Alexander diseaseEuropean Journal of Human Genetics.  23:1-2. 2015
2014 Changes in the morphology and proliferation of astrocytes induced by two modalities of chemically functionalized single-walled carbon nanotubes are differentially mediated by glial fibrillary acidic proteinNano Letters.  14:3720-3727. 2014
2014 Role of GFAP in CNS injuriesNeuroscience Letters.  565:7-13. 2014
2013 Transgenic analysis of GFAP promoter elementsGlia.  61:1488-1499. 2013
2012 Splice site, frameshift, and chimeric GFAP mutations in Alexander diseaseHuman Mutation.  33:1141-1148. 2012
2012 Alexander diseaseJournal of Neuroscience.  32:5017-5023. 2012
2012 Archetypal and new families with Alexander disease and novel mutations in GFAPArchives of Neurology -Chigago-.  69:208-214. 2012
2010 Alteration Of glial-neuronal metabolic interactions in a mouse model of Alexander diseaseGlia.  58:1228-1234. 2010
2010 Drug screening to identify suppressors of GFAP expressionHuman Molecular Genetics.  19:3169-3178. 2010
2009 An infantile case of Alexander disease unusual for its MRI features and a GFAP allele carrying both the p.Arg79His mutation and the p.Glu223Gln coding variantJournal of Neurology.  256:679-682. 2009
2008 Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brainJournal of Gene Medicine.  10:583-592. 2008
2008 GFAP promoter elements required for region-specific and astrocyte-specific expressionGlia.  56:481-493. 2008
2008 Adult-onset Alexander disease with progressive ataxia and palatal tremorMovement Disorders.  23:118-122. 2008
2006 Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null miceJournal of Clinical Neuroscience.  13:934-938. 2006
2006 Astrocyte heterogeneity revealed by expression of a GFAP-LacZ transgeneGlia.  53:677-687. 2006
2006 Increased glia-specific transgene expression with glial fibrillary acidic protein promoters containing multiple enhancer elementsJournal of Neuroscience Research.  83:744-753. 2006
2006 Propensity for paternal inheritance of de novo mutations in Alexander diseaseHuman Genetics.  119:137-144. 2006
2006 The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of αB-crystallin and HSP27American Journal of Human Genetics.  79:197-213. 2006
2005 Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAPJournal of Cell Science.  118:2057-2065. 2005
2005 Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander diseaseAnnals of Neurology.  57:310-326. 2005
2005 Unusual variants of Alexander's diseaseAnnals of Neurology.  57:327-338. 2005
2004 Expression specificity of GFAP transgenesNeurochemical Research.  29:2075-2093. 2004
2004 Expression specificity of GFAP transgenes.Neurochemical Research.  29:2075-2093. 2004
2004 Dominantly-inherited adult-onset leukodystrophy with palatal tremor caused by a mutation in the glial fibrillary acidic protein geneMovement Disorders.  19:1244-1248. 2004
2004 Expression of glial fibrillary acidic protein in primary cultures of human Müller cellsExperimental Eye Research.  79:423-429. 2004
2003 Alexander's disease: Clinical, pathologic, and genetic featuresJournal of Child Neurology.  18:625-632. 2003
2003 GFAP: Functional implications gleaned from studies of genetically engineered miceGlia.  43:87-90. 2003
2003 Alexander disease: GFAP mutations unify young and oldLancet Neurology.  2:75. 2003
2002 GFAP mutations in Alexander diseaseInternational Journal of Developmental Neuroscience.  20:259-268. 2002
2002 ICP monitoring following bilateral carotid occlusion in GFAP-null miceActa Neurochirurgica -Supplementum then Supplement- Wien-.  81:269-270. 2002
2001 hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivoDevelopmental Genetics.  31:85-94. 2001
2001 A novel mutation in glial fibrillary acidic protein gene in a patient with Alexander diseaseNeuroscience Letters.  312:71-74. 2001
2001 Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander diseaseNature Genetics.  27:117-120. 2001
2001 Alexander disease: New insights from geneticsJournal of Neuropathology and Experimental Neurology.  60:563-573. 2001
2001 Update on white matter genetic disorders (multiple letters) [2]Pediatric Neurology.  25:347-348. 2001
2000 High susceptibility to cerebral ischemia in GFAP-null miceJournal of Cerebral Blood Flow and Metabolism.  20:1040-1044. 2000
2000 Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoterCancer Gene Therapy.  7:1120-1126. 2000
1999 Nonlethal detection of transgene expression in the CNS of founder miceBioTechniques.  26:302-307. 1999
1999 Biosynthetic capacity of C6 cells engineered with a glial fibrillary acidic protein-tyrosine hydroxylase transgeneMedical Science Research.  27:423-425. 1999
1985 The role of enzyme sequestration in the regulation of the adenylate cyclase of Dictyostelium discoideumJournal of Biological Chemistry.  260:3613-3616. 1985
1984 Transmembrane signaling in Dictyostelium discoideum: A possible mechanismFederation proceedings.  43. 1984
1983 Forskolin does not activate cyclic AMP synthesis in Dictyostelium discoideum in vivo or in vitroJournal of cyclic nucleotide and protein phosphorylation research.  9:297-303. 1983

Chapter

Year Title Altmetric
2017 The significance of deiminated GFAP in neurodegenerative diseases with special emphasis on alexander disease.  391-412. 2017
2014 Alexander disease and astrotherapeutics.  89-105. 2014
2014 Alexander's Disease.  106-109. 2014
2014 Ongoing studies of deimination in neurodegenerative diseases using the F95 antibody.  257-280. 2014
2009 Alexander disease: A genetic disorder of astrocytes.  591-648. 2009
2003 Models of Alexander Disease.  1115-1124. 2003

Education And Training

  • Doctor of Philosophy in Biochemistry, University of California System : Berkeley 1970
  • Full Name

  • Michael Brenner