Selected Publications

Academic Article

Year Title Altmetric
2019 Relative stabilities of wild-type and mutant glial fibrillary acidic protein in patients with Alexander disease 2019
2019 AP-1 and the injury response of the GFAP gene 2019
2016 Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease 2016
2015 Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease 2015
2015 A new mutation in GFAP widens the spectrum of Alexander disease 2015
2014 Changes in the morphology and proliferation of astrocytes induced by two modalities of chemically functionalized single-walled carbon nanotubes are differentially mediated by glial fibrillary acidic protein 2014
2014 Role of GFAP in CNS injuries 2014
2013 Transgenic analysis of GFAP promoter elements 2013
2012 Splice site, frameshift, and chimeric GFAP mutations in Alexander disease 2012
2012 Alexander disease 2012
2012 Archetypal and new families with Alexander disease and novel mutations in GFAP 2012
2010 Alteration Of glial-neuronal metabolic interactions in a mouse model of Alexander disease 2010
2010 Drug screening to identify suppressors of GFAP expression 2010
2009 An infantile case of Alexander disease unusual for its MRI features and a GFAP allele carrying both the p.Arg79His mutation and the p.Glu223Gln coding variant 2009
2008 Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brain 2008
2008 GFAP promoter elements required for region-specific and astrocyte-specific expression 2008
2008 Adult-onset Alexander disease with progressive ataxia and palatal tremor 2008
2006 Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice 2006
2006 Astrocyte heterogeneity revealed by expression of a GFAP-LacZ transgene 2006
2006 Increased glia-specific transgene expression with glial fibrillary acidic protein promoters containing multiple enhancer elements 2006
2006 Propensity for paternal inheritance of de novo mutations in Alexander disease 2006
2006 The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of αB-crystallin and HSP27 2006
2005 Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP 2005
2005 Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease 2005
2005 Unusual variants of Alexander's disease 2005
2004 Expression specificity of GFAP transgenes 2004
2004 Expression specificity of GFAP transgenes. 2004
2004 Dominantly-inherited adult-onset leukodystrophy with palatal tremor caused by a mutation in the glial fibrillary acidic protein gene 2004
2004 Expression of glial fibrillary acidic protein in primary cultures of human Müller cells 2004
2003 Alexander's disease: Clinical, pathologic, and genetic features 2003
2003 GFAP: Functional implications gleaned from studies of genetically engineered mice 2003
2003 Alexander disease: GFAP mutations unify young and old 2003
2002 GFAP mutations in Alexander disease 2002
2002 ICP monitoring following bilateral carotid occlusion in GFAP-null mice 2002
2001 hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo 2001
2001 A novel mutation in glial fibrillary acidic protein gene in a patient with Alexander disease 2001
2001 Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease 2001
2001 Alexander disease: New insights from genetics 2001
2001 Update on white matter genetic disorders (multiple letters) [2] 2001
2000 High susceptibility to cerebral ischemia in GFAP-null mice 2000
2000 Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter 2000
1999 Nonlethal detection of transgene expression in the CNS of founder mice 1999
1999 Biosynthetic capacity of C6 cells engineered with a glial fibrillary acidic protein-tyrosine hydroxylase transgene 1999
1985 The role of enzyme sequestration in the regulation of the adenylate cyclase of Dictyostelium discoideum 1985
1984 Transmembrane signaling in Dictyostelium discoideum: A possible mechanism 1984
1983 Forskolin does not activate cyclic AMP synthesis in Dictyostelium discoideum in vivo or in vitro 1983


Year Title Altmetric
2017 The significance of deiminated GFAP in neurodegenerative diseases with special emphasis on alexander disease.  391-412. 2017
2014 Alexander disease and astrotherapeutics.  89-105. 2014
2014 Alexander's Disease.  106-109. 2014
2014 Ongoing studies of deimination in neurodegenerative diseases using the F95 antibody.  257-280. 2014
2009 Alexander disease: A genetic disorder of astrocytes.  591-648. 2009
2003 Models of Alexander Disease.  1115-1124. 2003

Education And Training

  • Doctor of Philosophy in Biochemistry, University of California System : Berkeley 1970
  • Full Name

  • Michael Brenner