Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Relative stabilities of wild-type and mutant glial fibrillary acidic protein in patients with Alexander diseaseJournal of Biological Chemistry.  294:15604-15612. 2019
2019 AP-1 and the injury response of the GFAP geneJournal of Neuroscience Research.  97:149-161. 2019
2016 Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander DiseaseJournal of Proteome Research.  15:2265-2282. 2016
2015 Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander diseaseGlia.  63:2285-2297. 2015
2015 A new mutation in GFAP widens the spectrum of Alexander diseaseEuropean Journal of Human Genetics.  23:1-2. 2015
2014 Changes in the morphology and proliferation of astrocytes induced by two modalities of chemically functionalized single-walled carbon nanotubes are differentially mediated by glial fibrillary acidic protein 2014
2014 Role of GFAP in CNS injuriesNeuroscience Letters.  565:7-13. 2014
2013 Transgenic analysis of GFAP promoter elementsGlia.  61:1488-1499. 2013
2012 Splice site, frameshift, and chimeric GFAP mutations in Alexander diseaseHuman Mutation.  33:1141-1148. 2012
2012 Alexander disease 2012
2012 Archetypal and new families with Alexander disease and novel mutations in GFAPArchives of Neurology.  69:208-214. 2012
2010 Alteration Of glial-neuronal metabolic interactions in a mouse model of Alexander diseaseGlia.  58:1228-1234. 2010
2010 Drug screening to identify suppressors of GFAP expressionHuman Molecular Genetics.  19:3169-3178. 2010
2009 An infantile case of Alexander disease unusual for its MRI features and a GFAP allele carrying both the p.Arg79His mutation and the p.Glu223Gln coding variantJournal of Neurology.  256:679-682. 2009
2008 Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brainJournal of Gene Medicine.  10:583-592. 2008
2008 GFAP promoter elements required for region-specific and astrocyte-specific expressionGlia.  56:481-493. 2008
2008 Adult-onset Alexander disease with progressive ataxia and palatal tremorMovement Disorders.  23:118-122. 2008
2006 Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null miceJournal of Clinical Neuroscience.  13:934-938. 2006
2006 Astrocyte heterogeneity revealed by expression of a GFAP-LacZ transgeneGlia.  53:677-687. 2006
2006 Increased glia-specific transgene expression with glial fibrillary acidic protein promoters containing multiple enhancer elementsJournal of Neuroscience Research.  83:744-753. 2006
2006 Propensity for paternal inheritance of de novo mutations in Alexander diseaseHuman Genetics.  119:137-144. 2006
2006 The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of αB-crystallin and HSP27American Journal of Human Genetics.  79:197-213. 2006
2005 Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAPJournal of Cell Science.  118:2057-2065. 2005
2005 Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander diseaseAnnals of Neurology.  57:310-326. 2005
2005 Unusual variants of Alexander's diseaseAnnals of Neurology.  57:327-338. 2005
2004 Expression specificity of GFAP transgenesNeurochemical Research.  29:2075-2093. 2004
2004 Expression specificity of GFAP transgenes.Neurochemical Research.  29:2075-2093. 2004
2004 Dominantly-inherited adult-onset leukodystrophy with palatal tremor caused by a mutation in the glial fibrillary acidic protein geneMovement Disorders.  19:1244-1248. 2004
2004 Expression of glial fibrillary acidic protein in primary cultures of human Müller cellsExperimental Eye Research.  79:423-429. 2004
2003 Alexander's disease: Clinical, pathologic, and genetic featuresJournal of Child Neurology.  18:625-632. 2003
2003 GFAP: Functional implications gleaned from studies of genetically engineered miceGlia.  43:87-90. 2003
2003 Alexander disease: GFAP mutations unify young and oldLancet Neurology.  2:75. 2003
2002 GFAP mutations in Alexander diseaseInternational Journal of Developmental Neuroscience.  20:259-268. 2002
2002 ICP monitoring following bilateral carotid occlusion in GFAP-null mice 2002
2001 hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo 2001
2001 A novel mutation in glial fibrillary acidic protein gene in a patient with Alexander diseaseNeuroscience Letters.  312:71-74. 2001
2001 Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander diseaseNature Genetics.  27:117-120. 2001
2001 Alexander disease: New insights from geneticsJournal of Neuropathology and Experimental Neurology.  60:563-573. 2001
2001 Update on white matter genetic disorders (multiple letters) [2]Pediatric Neurology.  25:347-348. 2001
2000 High susceptibility to cerebral ischemia in GFAP-null miceJournal of Cerebral Blood Flow and Metabolism.  20:1040-1044. 2000
2000 Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoterCancer Gene Therapy.  7:1120-1126. 2000
1999 Biosynthetic capacity of C6 cells engineered with a glial fibrillary acidic protein-tyrosine hydroxylase transgeneMedical Science Research.  27:423-425. 1999
1999 Nonlethal detection of transgene expression in the CNS of founder mice 1999
1985 The role of enzyme sequestration in the regulation of the adenylate cyclase of Dictyostelium discoideumJournal of Biological Chemistry.  260:3613-3616. 1985
1984 Transmembrane signaling in Dictyostelium discoideum: A possible mechanismThe FASEB Journal.  43. 1984
1983 Forskolin does not activate cyclic AMP synthesis in Dictyostelium discoideum in vivo or in vitroJournal of cyclic nucleotide and protein phosphorylation research.  9:297-303. 1983

Chapter

Year Title Altmetric
2017 The significance of deiminated GFAP in neurodegenerative diseases with special emphasis on alexander disease.  391-412. 2017
2014 Alexander disease and astrotherapeutics.  89-105. 2014
2014 Alexander's Disease.  106-109. 2014
2014 Ongoing studies of deimination in neurodegenerative diseases using the F95 antibody.  257-280. 2014
2009 Alexander disease: A genetic disorder of astrocytes.  591-648. 2009
2003 Models of Alexander Disease.  1115-1124. 2003

Education And Training

  • Doctor of Philosophy in Biochemistry, University of California System : Berkeley 1970
  • Full Name

  • Michael Brenner