Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils.  Neuroscience.  437:64-75. 2020
2020 Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples.  Autophagy.  2020
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytes..  npj Parkinson's Disease.  5:29. 2019
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytes.  npj Parkinson's Disease.  5. 2019
2019 Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.  Biophysical Journal.  117:631-645. 2019
2019 Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum.  Neuroscience.  409:169-179. 2019
2019 Analysis of α-synuclein pathology in PINK1 knockout rat brains.  Frontiers in Neuroscience.  13. 2019
2018 Reactive species balance via GTP cyclohydrolase i regulates glioblastoma growth and tumor initiating cell maintenance.  Neuro-Oncology.  20:1055-1067. 2018
2018 New Developments in Genetic rat models of Parkinson's Disease.  Movement Disorders.  33:717-729. 2018
2017 Parkin and PINK1 functions in oxidative stress and neurodegeneration.  Brain Research Bulletin.  133:51-59. 2017
2017 Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.  Neurobiology of Disease.  98:122-136. 2017
2015 The role of ventral striatal cAMP signaling in stress-induced behaviors.  Nature Neuroscience.  18:1094-1100. 2015
2014 Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.  Neurobiology of Disease.  70:190-203. 2014
2014 Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.  Neurobiology of Disease.  62:113-123. 2014
2013 Parkin-Dependent Degradation of the F-Box Protein Fbw7β Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1.  Molecular and Cellular Biology.  33:3627-3643. 2013
2013 Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1-/- mice.  Journal of Neuroinflammation.  10. 2013
2013 Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.  PLoS ONE.  8. 2013
2012 A mutation in CLOCK leads to altered dopamine receptor function.  Journal of Neurochemistry.  123:124-134. 2012
2012 Number and Brightness Analysis of LRRK2 Oligomerization in Live Cells.  Biophysical Journal.  102:L41-L43. 2012
2012 Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis.  PLoS ONE.  7:e38144-e38144. 2012
2011 Lipopolysaccharide and tumor necrosis factor regulate parkin expression via Nuclear factor-kappa B.  PLoS ONE.  6. 2011
2011 Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the clockδ19 mouse model of mania.  Neuropsychopharmacology.  36:1478-1488. 2011
2011 Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.  Journal of Biological Chemistry.  286:16504-16515. 2011
2010 Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35.  Biological Psychiatry.  68:1163-1171. 2010
2010 Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention.  Neurobiology of Disease.  37:510-518. 2010
2010 Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.  Cell Death and Differentiation.  17:158-169. 2010
2009 Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.  Nature Cell Biology.  11:1370-1375. 2009
2009 Parkin-mediated ubiquitination regulates phospholipase C-γ1.  Journal of Cellular and Molecular Medicine.  13:3061-3068. 2009
2009 Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP.  PLoS ONE.  4. 2009
2009 Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains.  Molecular Neurodegeneration.  4:12-12. 2009
2008 Parkin deficiency increases vulnerability to inflammation-related nigral degeneration 2008
2006 Parkin Protects against Mitochondrial Toxins and β-Amyloid Accumulation in Skeletal Muscle Cells.  Journal of Biological Chemistry.  281:12809-12816. 2006
2005 Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1.  Neuron.  45:489-496. 2005
2004 Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice.  Journal of Biological Chemistry.  279:18614-18622. 2004
2003 Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons.  Journal of Biological Chemistry.  278:43628-43635. 2003
2002 alpha-Synuclein is phosphorylated in synucleinopathy lesions..  Nature Cell Biology.  4:160-164. 2002
2001 -Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins 2001
2000 Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?.  Nature Cell Biology.  2:E115-E119. 2000
1997 Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL 1997
1992 The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X-ray structures.  Protein Science.  1:736-751. 1992
1992 NMR studies of structure and dynamics of isotope enriched proteins.  Biopolymers.  32:381-390. 1992

Principal Investigator On

  • Determining PINK1 and PRKN Enzyme Activities in Vivo  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2021 - 2022
  • Efficacy of Parkin Gene Delivery Towards Mitigation of A-Syn PFF-Induced Degeneration  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2021 - 2022
  • Immune Cell Dysfunction in PINK1 PD Animal Models  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2019 - 2021
  • Role of Alpha Synuclein in PINK1-linked Parkinson's Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2020
  • MOU - LRRK2 Consortium Memorandum of Understanding  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2015 - 2020
  • Characterization of the in Vivo Effects of aSyn PFFs on Mouse Brain Mitochondria  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2018 - 2019
  • Advancing PINK1 KO Rat Animal Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2017 - 2019
  • Analysis of Parkin Activity in W403A Parkin Knockin Mice  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2016 - 2018
  • Mechanisms of Age-Dependent Nigral Neuron Loss in PINK1 Knockout Rats  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2018
  • Advancing PINK1 KO Rat Animal Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2016 - 2017
  • Mechanisms of Protection Against Age-Dependent Nigral Neuron Loss in DJ-1 KO Rats  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2017
  • Mechanisms of LRRK2 Membrane Association  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2015 - 2016

    • Investigator On

    Education And Training

  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, Yale University 1998

    • Full Name

  • Matthew Goldberg