Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats.  Neurobiology of Disease.  150. 2021
2020 Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils.  Neuroscience.  437:64-75. 2020
2020 Formalin Versus Bouin Solution for Testis Biopsies: Which Is the Better Fixative? 2020
2020 Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples.  Autophagy.  2020
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytes..  npj Parkinson's Disease.  5:29. 2019
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytes.  npj Parkinson's Disease.  5. 2019
2019 Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.  Biophysical Journal.  117:631-645. 2019
2019 Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum.  Neuroscience.  409:169-179. 2019
2019 Analysis of α-synuclein pathology in PINK1 knockout rat brains.  Frontiers in Neuroscience.  13. 2019
2018 Reactive species balance via GTP cyclohydrolase i regulates glioblastoma growth and tumor initiating cell maintenance.  Neuro-Oncology.  20:1055-1067. 2018
2018 New Developments in Genetic rat models of Parkinson's Disease.  Movement Disorders.  33:717-729. 2018
2017 Parkin and PINK1 functions in oxidative stress and neurodegeneration.  Brain Research Bulletin.  133:51-59. 2017
2017 Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.  Neurobiology of Disease.  98:122-136. 2017
2015 The role of ventral striatal cAMP signaling in stress-induced behaviors.  Nature Neuroscience.  18:1094-1100. 2015
2014 Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.  Neurobiology of Disease.  70:190-203. 2014
2014 Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.  Neurobiology of Disease.  62:113-123. 2014
2013 Parkin-Dependent Degradation of the F-Box Protein Fbw7β Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1.  Molecular and Cellular Biology.  33:3627-3643. 2013
2013 Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1-/- mice.  Journal of Neuroinflammation.  10. 2013
2013 Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.  PLoS ONE.  8. 2013
2012 A mutation in CLOCK leads to altered dopamine receptor function.  Journal of Neurochemistry.  123:124-134. 2012
2012 Number and Brightness Analysis of LRRK2 Oligomerization in Live Cells.  Biophysical Journal.  102:L41-L43. 2012
2012 Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis.  PLoS ONE.  7:e38144-e38144. 2012
2011 Lipopolysaccharide and tumor necrosis factor regulate parkin expression via Nuclear factor-kappa B.  PLoS ONE.  6. 2011
2011 Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the clockδ19 mouse model of mania.  Neuropsychopharmacology.  36:1478-1488. 2011
2011 Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.  Journal of Biological Chemistry.  286:16504-16515. 2011
2010 Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35.  Biological Psychiatry.  68:1163-1171. 2010
2010 Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention.  Neurobiology of Disease.  37:510-518. 2010
2010 Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.  Cell Death and Differentiation.  17:158-169. 2010
2009 Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.  Nature Cell Biology.  11:1370-1375. 2009
2009 Parkin-mediated ubiquitination regulates phospholipase C-γ1.  Journal of Cellular and Molecular Medicine.  13:3061-3068. 2009
2009 Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP.  PLoS ONE.  4. 2009
2009 Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains.  Molecular Neurodegeneration.  4:12-12. 2009
2008 Parkin deficiency increases vulnerability to inflammation-related nigral degeneration 2008
2006 Parkin Protects against Mitochondrial Toxins and β-Amyloid Accumulation in Skeletal Muscle Cells.  Journal of Biological Chemistry.  281:12809-12816. 2006
2005 Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1.  Neuron.  45:489-496. 2005
2004 Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice.  Journal of Biological Chemistry.  279:18614-18622. 2004
2003 Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons.  Journal of Biological Chemistry.  278:43628-43635. 2003
2002 alpha-Synuclein is phosphorylated in synucleinopathy lesions..  Nature Cell Biology.  4:160-164. 2002
2001 -Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins 2001
2000 Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?.  Nature Cell Biology.  2:E115-E119. 2000
1997 Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL 1997
1992 The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X-ray structures.  Protein Science.  1:736-751. 1992
1992 NMR studies of structure and dynamics of isotope enriched proteins.  Biopolymers.  32:381-390. 1992

Principal Investigator On

  • Determining PINK1 and PRKN Enzyme Activities in Vivo  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2021 - 2022
  • Efficacy of Parkin Gene Delivery Towards Mitigation of A-Syn PFF-Induced Degeneration  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2021 - 2022
  • Immune Cell Dysfunction in PINK1 PD Animal Models  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2019 - 2021
  • Role of Alpha Synuclein in PINK1-linked Parkinson's Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2020
  • MOU - LRRK2 Consortium Memorandum of Understanding  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2015 - 2020
  • Characterization of the in Vivo Effects of aSyn PFFs on Mouse Brain Mitochondria  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2018 - 2019
  • Advancing PINK1 KO Rat Animal Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2017 - 2019
  • Analysis of Parkin Activity in W403A Parkin Knockin Mice  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2016 - 2018
  • Mechanisms of Age-Dependent Nigral Neuron Loss in PINK1 Knockout Rats  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2018
  • Advancing PINK1 KO Rat Animal Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2016 - 2017
  • Mechanisms of Protection Against Age-Dependent Nigral Neuron Loss in DJ-1 KO Rats  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2017
  • Mechanisms of LRRK2 Membrane Association  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2015 - 2016

    • Investigator On

    Education And Training

  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, Yale University 1998

    • Full Name

  • Matthew Goldberg