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Matthew Goldberg
Associate Professor
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mattgoldberg@uab.edu
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Matthew Goldberg
Associate Professor
Positions
Associate Professor (P)
,
Neurology
,
School of Medicine
2014 -
Scientist (C)
,
Neurodegeneration and Experimental Therapeutics (CNET)
,
Neurology
2014 -
Associate Scientist (C)
,
Comprehensive Neuroscience Center
,
General Clinical Research Center
2014 -
Investigator (C)
,
Evelyn F. McKnight Brain Institute
,
Neurology
2014 -
Associate Professor (S)
,
Neurobiology
,
Academic Joint Departments
2015 -
Scientist (C)
,
Civitan International Research Center
,
Academic Joint Departments
2017 -
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2020
Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils
.
Neuroscience
. 437:64-75.
2020
2020
Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples
.
Autophagy
.
2020
2019
PINK1 phosphorylates ubiquitin predominantly in astrocytes.
.
npj Parkinson's Disease
. 5:29.
2019
2019
PINK1 phosphorylates ubiquitin predominantly in astrocytes
.
npj Parkinson's Disease
. 5.
2019
2019
Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision
.
Biophysical Journal
. 117:631-645.
2019
2019
Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum
.
Neuroscience
. 409:169-179.
2019
2019
Analysis of α-synuclein pathology in PINK1 knockout rat brains
.
Frontiers in Neuroscience
. 13.
2019
2018
Reactive species balance via GTP cyclohydrolase i regulates glioblastoma growth and tumor initiating cell maintenance
.
Neuro-Oncology
. 20:1055-1067.
2018
2018
New Developments in Genetic rat models of Parkinson's Disease
.
Movement Disorders
. 33:717-729.
2018
2017
Parkin and PINK1 functions in oxidative stress and neurodegeneration
.
Brain Research Bulletin
. 133:51-59.
2017
2017
Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity
.
Neurobiology of Disease
. 98:122-136.
2017
2015
The role of ventral striatal cAMP signaling in stress-induced behaviors
.
Nature Neuroscience
. 18:1094-1100.
2015
2014
Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease
.
Neurobiology of Disease
. 70:190-203.
2014
2014
Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease
.
Neurobiology of Disease
. 62:113-123.
2014
2013
Parkin-Dependent Degradation of the F-Box Protein Fbw7β Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1
.
Molecular and Cellular Biology
. 33:3627-3643.
2013
2013
Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1
-/-
mice
.
Journal of Neuroinflammation
. 10.
2013
2013
Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase
.
PLoS ONE
. 8.
2013
2012
A mutation in CLOCK leads to altered dopamine receptor function
.
Journal of Neurochemistry
. 123:124-134.
2012
2012
Number and Brightness Analysis of LRRK2 Oligomerization in Live Cells
.
Biophysical Journal
. 102:L41-L43.
2012
2012
Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis
.
PLoS ONE
. 7:e38144-e38144.
2012
2011
Lipopolysaccharide and tumor necrosis factor regulate parkin expression via Nuclear factor-kappa B
.
PLoS ONE
. 6.
2011
2011
Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the clockδ19 mouse model of mania
.
Neuropsychopharmacology
. 36:1478-1488.
2011
2011
Alternative mitochondrial electron transfer as a novel strategy for neuroprotection
.
Journal of Biological Chemistry
. 286:16504-16515.
2011
2010
Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35
.
Biological Psychiatry
. 68:1163-1171.
2010
2010
Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
.
Neurobiology of Disease
. 37:510-518.
2010
2010
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6
.
Cell Death and Differentiation
. 17:158-169.
2010
2009
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease
.
Nature Cell Biology
. 11:1370-1375.
2009
2009
Parkin-mediated ubiquitination regulates phospholipase C-γ1
.
Journal of Cellular and Molecular Medicine
. 13:3061-3068.
2009
2009
Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP
.
PLoS ONE
. 4.
2009
2009
Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
.
Molecular Neurodegeneration
. 4:12-12.
2009
2008
Parkin deficiency increases vulnerability to inflammation-related nigral degeneration
2008
2006
Parkin Protects against Mitochondrial Toxins and β-Amyloid Accumulation in Skeletal Muscle Cells
.
Journal of Biological Chemistry
. 281:12809-12816.
2006
2005
Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1
.
Neuron
. 45:489-496.
2005
2004
Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice
.
Journal of Biological Chemistry
. 279:18614-18622.
2004
2003
Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons
.
Journal of Biological Chemistry
. 278:43628-43635.
2003
2002
alpha-Synuclein is phosphorylated in synucleinopathy lesions.
.
Nature Cell Biology
. 4:160-164.
2002
2001
-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins
2001
2000
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?
.
Nature Cell Biology
. 2:E115-E119.
2000
1997
Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL
1997
1992
The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X-ray structures
.
Protein Science
. 1:736-751.
1992
1992
NMR studies of structure and dynamics of isotope enriched proteins
.
Biopolymers
. 32:381-390.
1992
Research
Principal Investigator On
Determining PINK1 and PRKN Enzyme Activities in Vivo
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2021 - 2022
Efficacy of Parkin Gene Delivery Towards Mitigation of A-Syn PFF-Induced Degeneration
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2021 - 2022
Immune Cell Dysfunction in PINK1 PD Animal Models
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2019 - 2021
Role of Alpha Synuclein in PINK1-linked Parkinson's Disease
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
2018 - 2020
MOU - LRRK2 Consortium Memorandum of Understanding
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2015 - 2020
Characterization of the in Vivo Effects of aSyn PFFs on Mouse Brain Mitochondria
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2018 - 2019
Advancing PINK1 KO Rat Animal Models of PD
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2017 - 2019
Analysis of Parkin Activity in W403A Parkin Knockin Mice
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2016 - 2018
Mechanisms of Age-Dependent Nigral Neuron Loss in PINK1 Knockout Rats
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
2014 - 2018
Advancing PINK1 KO Rat Animal Models of PD
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2016 - 2017
Mechanisms of Protection Against Age-Dependent Nigral Neuron Loss in DJ-1 KO Rats
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
2014 - 2017
Mechanisms of LRRK2 Membrane Association
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2015 - 2016
Investigator On
Enhancing Autophagy and Mitochondrial Biogenesis to Mitigate Cardiac Reperfusion Injury
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2020 - 2025
UAB Research and Education Program in Neuroscience
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
2017 - 2022
The Edmond J. Safra Fellowship in Movement Disorders 2019 Program
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2019 - 2022
Lysosomal Enhancement Strategies in Dopaminergic Neurodegeneration
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
2017 - 2021
O-GlcNAc Regulation of Protein Clearance in the Context of AD and DLB
awarded by
National Institute on Aging/NIH/DHHS
2019 - 2021
University of Alabama at Birmingham_The Edumond J. Safra Fellowship in Movement Disorders 2017
awarded by
Fox (Michael J.) Foundation for Parkinson's Research
2017 - 2020
Background
Education And Training
Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology,
Yale University
1998
Contact
Full Name
Matthew
Goldberg