Positions

Overview

  • Martin Young received his Bachelors, Masters, PhD degrees in Biochemistry from the University of Oxford. Following postdoctoral training at Boston University and the University of Texas-Houston, Dr. Young held faculty appointments at the University of Texas-Houston and Baylor College of Medicine, before joining the University of Alabama at Birmingham (UAB). Dr. Young is currently a Professor of Medicine, Vice-Director for Research in the Division of Cardiovascular Disease, and Section Chief for Basic and Translational Research in the Division of Cardiovascular Disease. He is also the Jeanne V. Marks Endowed Chair of Cardiovascular Disease. Dr. Young has published over 160 peer-reviewed manuscripts in top tier journals, such as Circulation Research and Journal of Biological Chemistry, and has been commissioned by numerous journals (including Nature Reviews Endocrinology) for the completion of invited reviews.

    Research in Dr. Young’s laboratory is focused on understanding how environmental factors, such as time-of-day and nutrition, influence cardiovascular health and disease. Regarding time-of-day, the laboratory is actively seeking to understand how an intrinsic time-keeping mechanism, known as the circadian clock, affects the function of the heart. More specifically, a broad objective of the laboratory has been to test the hypothesis that the circadian clock synchronizes responsiveness of the heart to diurnal fluctuations in the environment. Impairment of this molecular mechanism would therefore result in an inability of the heart to respond appropriately to the onset of normal stimuli/stresses, thereby leading to contractile dysfunction and cardiac disease.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Circadian Regulation of Cardiac Physiology: Rhythms That Keep the Heart Beating.Annual Review of Physiology2019
    2018 An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clockFree Radical Biology and Medicine.  119:75-84. 2018
    2018 Temporal partitioning of adaptive responses of the murine heart to fastingLife Sciences.  197:30-39. 2018
    2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heartJournal of Molecular and Cellular Cardiology.  110:80-95. 2017
    2017 VEGF-B: Friend or foe to the heart in times of nutrient excess?AJP - Heart and Circulatory Physiology.  313:H244-H247. 2017
    2016 Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant miceBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids.  1861:1579-1595. 2016
    2016 Biotinylation: A novel posttranslational modification linking cell autonomous circadian clocks with metabolismAJP - Heart and Circulatory Physiology.  310:H1520-H1532. 2016
    2015 Influence of the cardiomyocyte circadian clock on cardiac physiology and pathophysiologyJournal of Biological Rhythms.  30:183-205. 2015
    2014 Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heartJournal of Biological Rhythms.  29:257-276. 2014
    2014 Circadian regulation of metabolismJournal of Endocrinology.  222. 2014

    Investigator On

  • Circadian Regulation of Vascular Aging  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2022
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2022
  • UAB Nutrition Obesity Research Center - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 1 = Circadian Control of Sodium Excretion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Basic and Translational Science in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Cardioprotective Effects of Autophagy Are Dependent on Mitochondrial Biogenesis during Ischemia/Reperfusion  awarded by American Heart Association 2019 - 2020
  • Anti-Obesity Effect Of No-Releasing Nanomatrix  awarded by National Institute on Aging/NIH/DHHS 2018 - 2020
  • Regulation of Skeletal Muscle Mitochondrial Quality Control Parameters and Systemic Metabolism  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2020
  • Macrophage Circadian Clock Disruption and Inflammation in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2020
  • Saturated Fatty Acid-Induced Autophagy in Vascular Endothelium  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2020
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center - Novel Mechanisms of Salt-Sensitivity and Diurnal Blood Pressure Rhythm - Project 3  awarded by American Heart Association 2015 - 2020
  • Disruption of the Clock O-GlcNAc Axis in Diabetic Cardiomyopathy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2019
  • Alcohol-Induced Mitochondrial Dysfunction and the Hepatocyte Clock  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS 2016 - 2019
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center  awarded by American Heart Association 2015 - 2019
  • Improving Mitochondrial Function to Protect Against Myocardial Ischemia/Reperfusion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2018
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2018
  • UAB Nutrition Obesity Research Center - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2018
  • Circadian Dysfunction and GSK3 in Neurodegenerative Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2018
  • Energetics, Disparities, & Lifespan: A Unified Hypothesis  awarded by National Institute on Aging/NIH/DHHS 2012 - 2017
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017
  • UAB Nutrition Obesity Research Center (NORC) - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017
  • Protein O-GlcNAcylation and the Regulation of Cardiac Function  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2010 - 2016
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2015
  • Hepatocyte Clock and Alcoholic Fatty Liver Injury  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS 2011 - 2014
  • Genomic Classification of the Heart Transplant Endomyocardial Biopsy  awarded by University of California, Los Angeles 2012 - 2013
  • Education And Training

  • Doctor of Philosophy in Biochemistry, University of Oxford 1999
  • Master of Life Sciences in Biochemistry, University of Oxford 1995
  • Full Name

  • Martin Young