Selected Publications

Academic Article

Year Title Altmetric
2020 The Mammary Gland as an Integral Component of the Common Mucosal Immune System 2020
2018 Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients 2018
2017 Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy 2017
2017 Two cells, one antibody: The discovery of the cellular origins and transport of secretory iga 2017
2017 An update on the treatment of IgA nephropathy 2017
2017 Current findings in the pathogenesis of IgA nephropathy 2017
2017 Dysregulation of Systemic and Mucosal Humoral Responses to Microbial and Food Antigens as a Factor Contributing to Microbial Translocation and Chronic Inflammation in HIV-1 Infection 2017
2016 IgA nephropathy - research-generated questions 2016
2016 IgA nephropathy enigma 2016
2016 Diminished CD103 (αEβ7) Expression on Resident T Cells from the Female Genital Tract of HIV-Positive Women. 2016
2016 Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytes 2016
2016 The origin and activities of IgA1-containing immune complexes in IGA nephropathy 2016
2016 Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge 2016
2015 IgA nephropathy. Facts, uncertainties, and potential causal therapy approaches 2015
2014 Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection 2014
2014 Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease 2014
2014 Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women 2014
2014 Origin of galactose-deficient immunoglobulin G in gingival crevicular fluid in periodontitis 2014
2013 The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells 2013
2013 IgA nephropathy: Molecular mechanisms of the disease 2013
2012 Comparative evaluation of HIV-1 neutralization in external secretions and sera of HIV-1-infected women 2012
2012 In vitro-generated immune complexes containing galactose-deficient IgA1 stimulate proliferation of mesangial cells 2012
2012 Role of the mucosal immune system and commensal bacteria in allergy 2012
2012 Glycosylation of IgA1 and pathogenesis of IgA nephropathy 2012
2012 Naturally occurring structural isomers in serum IgA1 O -glycosylation 2012
2011 Menstrual blood as a potential source of endometrial derived CD3+ T cells 2011
2011 Current view of the pathogenesis of IgA nephropathy and possibilities for causal therapy 2011
2011 IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells 2011
2011 Strategic dominance of the mucosal immune system in the defense and tolerance 2011
2011 The pathophysiology of IgA nephropathy 2011
2011 Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines 2011
2011 Aberrant glycosylation of iga1 and anti-glycan antibodies in iga nephropathy: Role of mucosal immune system 2011
2011 Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women 2011
2011 Systemic and mucosal differences in hiv burden, immune, and therapeutic responses 2011
2011 Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions 2011
2010 Clustered O-glycans of IgA1: Defining macro- and microheterogeneity by use of electron capture/transfer dissociation 2010
2010 Enhancing oral vaccine potency by targeting intestinal M cells 2010
2010 Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: A comparative binding study. 2010
2010 Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition 2010
2010 Mucosal HIV vaccines: A holy grail or a dud? 2010
2010 Tolerance and protection against infection in the genital tract 2010
2010 Antibody-mediated protection and the mucosal immune system of the genital tract: Relevance to vaccine design 2010
2010 Expression of homing receptors on IgA1 and IgA2 plasmablasts in blood reflects differential distribution of IgA1 and IgA2 in various body fluids 2010
2010 Tissue distribution and biological activities of immune complexes are determined by their size and composition 2010
2010 Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection 2010
2009 P19-46. Co-delivery of mucosal chemokine plasmids in a systemically delivered DNA vaccine elicits systemic and mucosal immune responses in mice and macaques 2009
2009 Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfaces 2009
2009 Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity 2009
2009 Mucosal antibody responses to HIV 2009
2009 Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection 2009
2008 Oral immunization: An update 2008
2008 Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy 2008
2008 Treatment of IgA nephropathy 2008
2008 Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses 2008
2008 IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1 2008
2008 Peyer's patches as the inductive site for IgA responses 2008
2008 Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of iga nephropathy 2008
2008 IgA Glycosylation and IgA Immune Complexes in the Pathogenesis of IgA Nephropathy 2008
2007 Mucosal immune system of genital tract 2007
2007 Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura 2007
2007 Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: Implications for IgA nephropathy 2007
2007 Neutralizing antibodies in mucosal secretions: IgG or IgA? 2007
2007 Perspectives on mucosal vaccines: Is mucosal tolerance a barrier? 2007
2007 Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire 2007
2007 Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in mice 2007
2007 Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels 2007
2007 IgA nephropathy and henoch-schoenlein purpura nephritis: Aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells 2007
2007 IgA nephropathy: A clinical overview 2007
2007 IgA nephropathy: Characterization of IgG antibodies specific for galactose-deficient IgA1 2007
2007 IgA nephropathy: Current views of immune complex formation 2007
2007 Identification and Characterization of CMP-NeuAc:GalNAc-IgA1 α2,6-Sialyltransferase in IgA1-producing Cells 2007
2007 Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins 2007
2007 Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins 2007
2007 Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites (DOI:10.1016/j.jri.2006.05.006) 2007
2006 IgA-containing immune complexes in the urine of IgA nephropathy patients 2006
2006 HIV infection: first battle decides the war 2006
2006 Immunoglobulin A and renal diseases 2006
2006 Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites 2006
2006 Influenza virus infection of the murine uterus: A new model for antiviral immunity in the female reproductive tract 2006
2006 Influenza virus infection of the murine uterus: a new model for antiviral immunity in the female reproductive tract. 2006
2006 University of Alabama at Birmingham 2006
2005 European Union and EDCTP strategy in the global context: Recommendations for preventive HIV/AIDS vaccines research 2005
2005 Urinary IgA in IgA nephropathy patients - A new finding which support diagnosis of IgA nephropathy 2005
2005 Heterogeneity of IgG glycosylation in adult periodontal disease 2005
2005 Human male genital tract secretions: Both mucosal and systemic immune compartments contribute to the humoral immunity 2005
2005 Interaction of mucosal microbiota with the innate immune system 2005
2005 Mucosal immunoglobulins 2005
2005 Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation Fourier transform-ion cyclotron resonance mass spectrometry 2005
2005 Immunologic uniqueness of the genital tract: Challenge for vaccine development 2005
2005 Immune response versus mucosal tolerance to mucosally administered antigens 2005
2005 Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals 2005
2005 Immune responses to human papillomavirus in genital tract of women with cervical cancer 2005
2005 IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells 2005
2004 Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA Loads 2004
2004 Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals 2004
2004 Role for antibodies in heterosubtypic immunity: The link between innate and adaptive immunity 2004
2004 Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein 2004
2004 Oral tolerance in humans: Failure to suppress an existing immune response by oral antigen administration 2004
2002 Detection of mucosal antibodies in HIV type 1-infected individuals 2002
2002 [IgA nephropathy. Significance of immunoglobulin A glycosylation in pathogenesis and clinical presentation]. 2002
2002 Cloning and expression of the turtle (Trachemys scripta) immunoglobulin joining (J)-chain cDNA 2002
2002 Cloning of the chicken immunoglobulin joining (J)-chain gene and characterization of its promoter region 2002
2002 Hydrostatic pressure induces the fusion-active state of enveloped viruses 2002
2002 Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure 2002
2002 Humoral immune responses to microbial infections in the genital tract 2002
2002 IgA nephropathy pathogenetic importance of immunoglobulin a glycosylation and clinical presentation 2002
2002 Interactions of human mesangial cells with IgA and IgA-containing immune complexes 2002
2002 Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells 2002
2001 Homeostasis of the mucosal immune system: Human milk and lactation 2001
2001 Progress in molecular and genetic studies of IgA nephropathy 2001
2001 Urethral cytokine and immune responses in Chlamydia trachomatis-infected males 2001
2001 Induction of specific immune responses in the genital tract of women after oral or rectal immunization and rectal boosting with Salmonella typhi Ty 21a vaccine 2001
2001 Mechanism of heterosubtypic immunity to influenza A virus infection 2001
2001 Biodegradable block copolymers for delivery of proteins and water-insoluble drugs 2001
2001 A Phase I safety and immunogenicity trial of UBI® microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects 2001
2001 In Vitro exposure to highly cytopathic HIV-1 X4 strains increases expression of mucosa-associated integrins on CD4+ T Cells 2001
2001 Heterosubtypic immunity to influenza A virus infection requires B cells but not CD8+ cytotoxic T lymphocytes 2001
2001 Mechanisms of immune tolerance to food antigens in humans 2001
2000 Heterogeneity of O-glycosylation in the hinge region of human IgA1 2000
2000 Strategies of immunization against mucosal infections 2000
2000 Cytokine profiles in seronegative volunteers immunized with a recombinant canarypox and gp120 prime-boost HIV-1 vaccine 2000
2000 Expression of the recombinant human immunoglobulin J chain in Escherichia coli 2000
2000 Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in mice 2000
2000 False positivity of enzyme-linked immunosorbent assay for measurement of secretory IgA antibodies directed at HIV type 1 antigens 2000
2000 Production, distribution, and structure of human IgA molecules 2000
2000 A method for quantification of absolute amounts of nucleic acids by (RT)-PCR and a new mathematical model for data analysis. 2000
2000 Cloning and expression of the chicken immunoglobulin joining (J)-chain cDNA 2000
2000 IgA1 glycosylation and the pathogenesis of IgA nephropathy 2000
2000 Induction of mucosal immune responses in the human genital tract 2000
2000 Invited Lecture 3:Production, distribution, and structure of human IgA molecules 2000
2000 Role of nuclear factor-κB in the expression by tumor necrosis factor-α of the human polymeric immunoglobulin receptor (pIgR) gene 2000
1999 Induction of immune responses to SIV antigens by mucosally administered vaccines 1999
1999 Mucosal immunity and tolerance: Relevance to vaccine development 1999
1999 Limited local and systemic antibody responses to Neisseria gonorrhoeae during uncomplicated genital infections 1999
1999 An IgA-binding peptide derived from a streptococcal surface protein 1999
1999 Mucosal immune system of the human genital tract 1999
1999 Differential homing commitments of antigen-specific T cells after oral or parenteral immunization in humans 1999
1999 Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8+ cytotoxic T lymphocyte responses induced in mucosa-associated tissues 1999
1999 Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies 1999
1999 Intestinal IgA: Novel views on its function in the defence of the largest mucosal surface 1999
1999 Mucosal immunity in the genital tract: Prospects for vaccines against sexually transmitted diseases. A review 1999
1999 Progress in the pathogenesis of IgA nephropathy. 1999
1998 Differences in immune responses induced by oral and rectal immunizations with Salmonella typhi Ty21a: Evidence for compartmentalization within the common mucosal immune system in humans 1998
1998 Evaluation of immunoglobulin A1 (IgA1) protease and IgA1 protease- inhibitory activity in human female genital infection with Neisseria gonorrhoeae 1998
1998 Nomenclature of immunoglobulin A and other proteins of the mucosal immune system 1998
1998 Nomenclature of immunoglobulin A and other proteins of the mucosal immune system 1998
1998 Human and nonhuman primate lymphocytes engrafted into SCID mice reside in unique mesenteric lymphoid structures 1998
1998 Vitamin A is required for regulation of polymeric immunoglobulin receptor (plgR) expression by interleukin-4 and interferon-γ in a human intestinal epithelial cell line 1998
1998 Passive and active protection against disorders of the gut. 1998
1998 Mucosal immunity in the female reproductive tract: Correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulation 1998
1998 Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes 1998
1998 HIV-1/simian immunodeficiency virus infection of human and nonhuman primate lymphocytes results in the migration of CD2+ T cells into the intestine of engrafted SCID mice 1998
1998 Immunological and virological analyses of persons infected by human immunodeficiency virus type 1 while participating in trials of recombinant gp120 subunit vaccines 1998
1998 In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgA 1998
1998 Immune responses to human immunodeficiency virus (HIV) type 1 induced by canarypox expressing HIV-1(MN) gp120, HIV-1(SF2) recombinant gp120, or both vaccines in seronegative adults 1998
1998 Modulation of immunologic responses to HIV-1(MN) recombinant gp160 vaccine by dose and schedule of administration 1998
1998 Passive and active protection against disorders of the gut 1998
1997 Rectal immunization for induction of specific antibody in the genital tract of women 1997
1997 Current options for vaccine delivery systems by mucosal routes 1997
1997 Structural differences among serum IgA proteins of chimpanzee, rhesus monkey and rat origin 1997
1997 Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG 1997
1997 Human peritoneal B-1 cells and the influence of continuous ambulatory peritoneal dialysis on peritoneal and peripheral blood mononuclear cell (PBMC) composition and immunoglobulin levels 1997
1997 IgA antibody as a non-inflammatory regulator of immunity 1997
1997 Immunoglobulin J chain. An early differentiation marker of human B cells 1997
1997 Mucosal immunoglobulins and their contribution to defence mechanisms: An overview 1997
1997 Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans. 1997
1996 Impaired mucosal iga responses in tcr6-/- mice 1996
1996 In vitro HIV infection increases mucosal-associated adhesion molecules on CD4+ T CELLS 1996
1996 Mucosally activated circulating human T-cells express the gut homing receptor α4β7 1996
1996 Multiple mechanisms of oral tolerance to food antigens in humans 1996
1996 Evaluation of monoclonal antibodies with specificity for human IgA, IgA subclasses and allotypes and secretory component. Results of an IUIS/WHO collaborative study 1996
1996 Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit 1996
1996 gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses. 1996
1996 γ/δ T cell-deficient mice have impaired mucosal immunoglobulin a responses 1996
1996 The joining (J) chain is present in invertebrates that do not express immunoglobulins 1996
1996 Comparative analysis of oral delivery systems for live rotavirus vaccines 1996
1996 Immunoglobulin-containing plasma cells recruited to cervical neoplasia 1996
1996 Induction of tolerance in humans: Effectiveness of oral and nasal immunization routes 1996
1996 Polyethylene glycol precipitates of serum contain a large proportion of uncomplexed immunoglobulins and C3 1996
1996 Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation 1996
1995 Compartmentalization within the common mucosal immune system 1995
1995 A polarized human endometrial cell line that binds and transports polymeric IgA 1995
1995 Alterations in the IgA carbohydrate chains influence the cellular distribution of IgA1. 1995
1995 Antisperm antibodies in infertile women: Subclass distribution of immunoglobulin (Ig) A antibodies and removal of IgA sperm-bound antibodies with a specific IgA1 protease 1995
1995 Characterization of IgA1, IgA2 and secretory IgA carbohydrate chains using plant lectins 1995
1995 Clonal antibody dominance after influenza vaccination in IgA nephropathy patients and controls 1995
1995 Decreased IgA-producing cells in the gut of SIV-infected rhesus monkeys 1995
1995 Human immune responses to influenza virus vaccines administered by systemic or mucosal routes 1995
1995 Ig-Secreting and interferon-γ-producing cells in mice mucosally immunized with influenza virus 1995
1995 IgA nephropathy: A disease of incomplete IgA 1 glycosylation? 1995
1995 IgA production and transport in the murine liver after mucosal immunization 1995
1995 Intestinal Immune Function Is Unaffected By Parenteral Nutrition In Man 1995
1995 Intraperitoneal administration of tetanus toxoid elicits a specific responses of antibody-secreting cells in the peritoneal cavity 1995
1995 Normal Uterine Cervix: Characterization of Isolated Lymphocyte Phenotypes and Immunoglobulin Secretion 1995
1995 Oral immunization studies with streptococcus mutans and influenza vaccines in rhesus macaque monkeys 1995
1995 Oral tolerance in humans: T cell but not B cell tolerance to a soluble protein antigen 1995
1995 Phylogeny of the immunoglobulin joining (J) chain 1995
1995 T lymphocytes infiltrating advanced grades of cervical neoplasia. CD8‐positive cells are recruited to invasion 1995
1994 Antispermatozoal antibodies in human colostrum and milk 1994
1994 Mucosal immunity in the female genital tract: Relevance to vaccination efforts against the human immunodeficiency virus 1994
1994 Reassessment of the impact of mucosal immunity in infection with the human immunodeficiency virus (HIV) and design of relevant vaccines 1994
1994 HIV Infection in Vaccinated Volunteers 1994
1994 Molecular characterization of protein Sir, a streptococcal cell surface protein that binds both immunoglobulin A and immunoglobulin G 1994
1994 Oral tolerance in humans: T cell but not B cell tolerance after antigen feeding 1994
1994 Antisperm Antibodies (ASAs) in Infertile Males: Subclass Distribution of IgA Antibodies and the Effect of an IgA1 Protease on Sperm‐Bound Antibodies 1994
1994 Biodegradable microspheres for the delivery of oral vaccines 1994
1994 Carbohydrate heterogeneity of human myeloma proteins of the IgA1 and IgA2 subclasses 1994
1994 Conference on advances in AIDS vaccine development - 1993 summary: Cytotoxic T-cell immunity workshop 1994
1994 Conference on advances in AIDS vaccine development - 1993 summary: Mucosal immunity workshop 1994
1994 Effects of total parenteral nutrition on intestinal morphology and function in humans 1994
1994 Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit a secretory IgA response 1994
1994 Lectin Receptors on IgA Isotypes 1994
1994 Mucosal immunity and strategies for novel microbial vaccines 1994
1994 Secretory immunity in the female reproductive tract 1994
1994 Suppression of the immune response by nasal immunization 1994
1993 Surface expression of secretory component and HLA class II DR antigen on glandular epithelial cells from human endometrium and two endometrial adenocarcinoma cell lines 1993
1993 Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues. 1993
1993 Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. 1993
1993 Early Expression of Human J Chain and μ Chain Gene in the Fetal Liver 1993
1993 Immune response of the female rat genital tract after oral and local immunization with keyhole limpet hemocyanin conjugated to the cholera toxin B subunit 1993
1993 Interactions of cell-surface galactosyltransferase with immunoglobulins 1993
1993 Interactions of galactosyltransferase with serum and secretory immunoglobulins and their component chains 1993
1993 Murine model for evaluation of protective immunity to influenza virus 1993
1993 Oral immunization with influenza virus in biodegradable microspheres 1993
1993 Saliva as a Manifestation of the Common Mucosal Immune System 1993
1993 Serum IgG and IgM levels to bacterial antigens in necrotizing ulcerative gingivitis. 1993
1993 Shared idiotypes in mesangial deposits in IgA nephropathy are not disease-specific 1993
1992 Liposomes and conjugate vaccines for antigen delivery and induction of mucosal immune responses 1992
1992 Prospects for human mucosal vaccines 1992
1992 Transforming growth factor-β inhibits the production of IgG, IgM, and IgA in human lymphocyte cultures 1992
1992 Antisperm antibodies: Current knowledge and new horizons 1992
1992 Binding of serum immunoglobulins to collagens in IgA nephropathy and HIV infection 1992
1992 Cytokine-Induced Immunoglobulin Production in Primary IgA Nephropathy 1992
1992 Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: A comparison between intravenously and genitally inoculated Rhesus macaques 1992
1992 IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathy 1992
1992 Isotype of anti-SIV responses in infected rhesus macaques and in animals immunized by mucosal routes 1992
1992 Molecular heterogeneity of human IgA antibodies during an immune response 1992
1992 Properties of IgA‐Binding Receptors on Murine T Cells: Relative Importance of FcαR, β‐Galactosyltransferase and Anti‐Secretory Component Reactive Proteins (ASCP) 1992
1992 The mucosal immune system: from fundamental concepts to vaccine development 1992
1992 The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigens 1992
1991 Anti-adhesive molecules in human milk 1991
1991 Immunological properties and differentiation potential of human colostral lymphocytes of B cell lineage 1991
1991 Role of IL-6 in human antigen-specific and polyclonal IgA responses 1991
1991 Cellular origins of human polymeric and monomeric IgA: enumeration of single cells secreting polymeric IgA1 and IgA2 in peripheral blood, bone marrow, spleen, gingiva and synovial tissue 1991
1991 Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis 1991
1991 IgA nephropathy in blacks: Studies of IgA2 allotypes and clinical course 1991
1991 Immunoglobulin isotype distribution of locally produced autoantibodies to collagen type I in adult periodontitis: Relationship to periodontal treatment 1991
1991 Local iga and igm rheumatoid factor production in autoimmune MRL/ipr mice 1991
1991 Peyer's patch B cells with memory cell characteristics undergo terminal differentiation within 24 hours in response to interleukin-6 1991
1991 Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells 1991
1991 Regulation of mucosal responses by cd4+ t lymphocytes: Effects of anti-l3t4 treatment on the gastrointestinal immune system 1991
1991 Selective transport of IgA: Cellular and molecular aspects 1991
1991 Targeting and controlled release of antigens for the effective induction of secretory antibody responses 1991
1991 Transforming growth factor-β enhances secretory component and major histocompatibility complex class I antigen expression on rat IEC-6 intestinal epithelial cells 1991
1990 Antibody-secreting peripheral blood lymphocytes induced by immunization with a conjugate consisting of Streptococcus pneumoniae type 12F polysaccharide and diphtheria toxoid 1990
1990 In defense of mucosal surfaces. Development of novel vaccines for IgA responses protective at the portals of entry of microbial pathogens. 1990
1990 Degradation of IgA proteins by Pseudomonas aeruginosa elastase 1990
1990 Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responses 1990
1990 Immunoglobulin A (IgA) Polymerization Sites in Human Immunocytes: Immunoelectron Microscopic Study 1990
1990 J chain disease: A novel form of plasma cell dyscrasia 1990
1990 Liposomes containing anti-idiotypic antibodies: An oral vaccine to induce protective secretory immune response specific for pathogens of mucosal surfaces 1990
1990 Secretory immune system of the female reproductive tract. II. Local immune system in normal and infected fallopian tube 1990
1990 Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli type 1 fimbrial lectin 1990
1990 Serum antibody response in adult volunteers elicited by injection of Streptococcus pneumoniae type 12F polysaccharide alone or conjugated to diphtheria toxoid 1990
1990 Site of Catabolism of Autologous and Heterologous IgA in Non‐Human Primates 1990
1990 Synergistic effect of IL-4 and IFN-γ on the expression of polymeric Ig receptor (secretory component) and IgA binding by human epithelial cells 1990
1989 Local production of IgA- and IgM-rheumatoid factors in adult periodontal disease 1989
1989 Regulation of IgA synthesis and immune response by T cells and interleukins 1989
1989 Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue 1989
1989 Bacteroides-specific IgG and IgA subclass antibody-secreting cells isolated from chronically inflamed gingival tissues 1989
1989 Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue. 1989
1989 Distribution of immunoglobulin isotypes including IgA subclasses in adult, juvenile, and rapidly progressive periodontitis 1989
1989 IgA subclasses of human colostral antibodies specific for microbial and food antigens 1989
1989 IgA-induced eosinophil degranulation 1989
1989 Immune responses to influenza virus in orally and systemically immunized mice. 1989
1989 Non-specific mesangial staining with antibodies against cytomegalovirus in immunoglobulin-A nephropathy 1989
1989 Oral immunization: past and present. 1989
1989 Systemic immunization for the induction of IgA responses. 1989
1989 The role of the liver in catabolism of mouse and human iga 1989
1988 A novel two colour ELISPOT assay. I. Simultaneous detection of distinct types of antibody-secreting cells 1988
1988 Immunobiology of IgA. 1988
1988 Agglutination of E. coli by secretory IgA--a result of interaction between bacterial mannose-specific adhesins and immunoglobulin carbohydrate? 1988
1988 Autoimmunity to collagen in adult periodontal disease 1988
1988 Binding of IgA to erythrocytes from patients with IgA nephropathy 1988
1988 Defense mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteases 1988
1988 Editorial 1988
1988 HNK‐1+ (Leu‐7) cells and natural killer cell activity in inflamed human gingival tissue 1988
1988 IgA nephropathy, the most common glomerulonephritis worldwide. A neglected disease in the United States? 1988
1988 IgA-mediated clearance and tissue deposition of dinitrophenylated human serum albumin at various DNP:HSA ratios 1988
1988 Immunobiology of IgA 1988
1988 Induction of the mucosal immune response. 1988
1988 Interaction of lymphoid cells with epithelial cells: selectivity of the expression of IgA in mucosal plasma cells and of the transport of polymeric IgA. 1988
1988 Intestinal IgA system 1988
1988 Receptor-mediated binding and uptake of immunoglobulin a by human liver 1988
1988 Role of hepatocytes in the uptake of IgA and IgA-containing immune complexes in mice 1988
1988 Secretory immune system of the female reproductive tract: I. immunoglobulin and secretory component-containing cells 1988
1988 Systemic immunization with pneumococcal polysaccharide vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodies 1988
1988 The sites of catabolism of murine monomeric IgA 1988
1988 precursor B cells transformed by Epstein-Barr virus undergo sterile plasma-cell differentiation: J-chain expression without immunoglobulin 1988
1987 Induction and molecular properties of secretory and serum IgA antibodies specific for environmental antigens 1987
1987 Enteric immunization reveals a T cell network for IgA responses and suggests that humans possess a common mucosal immune system 1987
1987 Induction and molecular properties of secretory and serum IgA antibodies specific for environmental antigens. 1987
1987 IgA antibody-producing cells in peripheral blood after antigen ingestion: Evidence for a common mucosal immune system in humans 1987
1987 The common mucosal immune system and current strategies for induction of immune responses in external secretions 1987
1987 Analysis of paraprotein transport into the saliva by using anti-idiotype antibodies 1987
1987 Antibodies directed at Fab of IgA in the sera of normal individuals and IgA nephropathy patients. 1987
1987 Binding, uptake and processing of various molecular forms of IgA by human hepatoma cell line (HepG2). 1987
1987 Detection of food antigen-specific IgA immune complexes in human sera. 1987
1987 Glycoconjugate receptors for bacteria attaching to mucosal sites: examples for Escherichia coli and Streptococcus pneumoniae. 1987
1987 Heterogeneity of binding of monoclonal IgA to staphylococcal protein A is related to the IgA polymerization state 1987
1987 IgA on the surface of erythrocytes from IgA nephropathy patients. 1987
1987 IgA subclass responses to lipopolysaccharide in humans. 1987
1987 IgA-associated renal diseases: immunochemical studies of IgA1 proteins, circulating immune complexes, and cellular interactions. 1987
1987 Immunoglobulin A (IgA): Molecular and Cellular Interactions Involved in IgA Biosynthesis and Immune Response 1987
1987 Immunoglobulin A (IgA): Molecular and cellular interactions involved in IgA biosynthesis and immune response. 1987
1987 Immunohistochemical study of the ontogeny of the secretory immune system. 1987
1987 Immunological studies of IgA nephropathy: familial and racial aspects. 1987
1987 Influence of IgA on carbohydrate-mediated clearance of antigen. 1987
1987 Inhibition of natural killer (NK) activity by human colostral and serum IgA. 1987
1987 Molecular form and subclass distribution of IgA antibodies after immunization with live and inactivated influenza A vaccines. 1987
1987 Normal human sera contain antibodies directed at Fab of IgA 1987
1987 Novel oral vaccines: the effectiveness of cloned gene products on inducing secretory immune responses. 1987
1987 Oral immunization with bacterial antigen induces IgA-secreting cells in peripheral blood in humans. 1987
1987 Secretory component binding: immunofluorescence and ultrastructural studies. 1987
1987 Striking Elevation of Serum IgA, IgA-Containing Immune Complexes, and IgA Rheumatoid Factor in Clinically Silent Dermatitis Herpetiformis 1987
1986 Potential for immunological intervention against dental caries. 1986
1986 Isotype-specific immunoregulation; characterization and function of Fc receptors on T-T hybridomas which produce murine IgA-binding factor 1986
1986 Assay of human IgA subclass antibodies in serum and secretions by means of monoclonal antibodies 1986
1986 Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodies 1986
1986 Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathies 1986
1986 IgA subclasses. 1986
1986 IgA-associated renal diseases: Antibodies to environmental antigens in sera and deposition of immunoglobulins and antigens in glomeruli 1986
1986 Inhibition of natural killer cell activity by IgA 1986
1986 The human IgA system: A reassessment 1986
1986 The stoichiometry of J chain in human secretory dimeric IgA 1986
1985 Secondary structure of the immunoglobulin J chain. (circular dichroism/hydrophobicity profile/tertiary structure/antiparallel β-barrel) 1985
1985 Subclass distribution and molecular form of immunoglobulin A hemagglutinin antibodies in sera and nasal secretions after experimental secondary infection with influenza A virus in humans 1985
1985 Secondary structure of the immunoglobulin J chain. 1985
1985 Urinary IgA in IgA nephropathy and Henoch-Schoenlein purpura 1985
1985 J-chain expression in human cells producing IgG subclasses 1985
1985 Analysis of the hepatobiliary transport of polymeric IgA with monoclonal anti-allotypic antibodies 1985
1985 Carbohydrate-mediated clearance of secretory IgA from the circulation 1985
1985 Electronmicroscopic and cytofluorographic analysis of Fcα receptor bearing T-T hybridomas 1985
1985 Enumeration of antibody-secreting cells in mice immunized with Streptococcus mutans 1985
1985 IgA rheumatoid factor synthesis by dissociated synovial cells. Characterization and relationship to IgM rheumatoid factor synthesis 1985
1985 Immunoglobulin A subclass distribution of naturally occurring salivary antibodies to microbial antigens 1985
1985 Major site(s) of mIgA catabolism in BALB/c mice 1985
1985 Molecular forms of tear IgA and distribution of IgA subclasses in human lacrimal glands 1985
1985 Natural killer cells in human colostrum 1985
1985 Ontogeny of J chain expression in pig lymphocytes 1985
1985 Prevention of Streptococcus mutans colonization by salivary IgA antibodies 1985
1985 Subclass distribution of human serum and salivary IgA antibodies to lipopolysaccharides 1985
1985 Urinary Immunoglobulins in Healthy Individuals and Children with Acute Pyelonephritis 1985
1985 [3] Immunoglobulin A (IgA) 1985
1984 Cellular origins of human polymeric and monomeric IgA: Intracellular and secreted forms of IgA 1984
1984 Racial difference in the prevalence of IgA-associated nephropathies. 1984
1984 Distribution of IgA1-, IgA2-, and J chain-containing cells in human tissues 1984
1984 Characterization of a monoclonal antibody to human J chain 1984
1984 Effect of IgA on natural killer cells 1984
1984 Elimination of intestinally absorbed antigen into the bile by IgA 1984
1984 Human colostral cells. II. Response to mitogens 1984
1984 Immunohistochemical distribution of immunoglobulins, lactoferrin, and lysozyme in human minor salivary glands 1984
1984 J chain expression in human cells producing IgG subclasses 1984
1984 Receptors for secretory and serum IgA in human liver 1984
1984 Selective hepatobiliary transport of human polymeric IgA in mice 1984
1984 Serum IgA antibodies to environmental antigens in patients with IgA nephropathy 1984
1984 Workshop Report: The Periodontium as a Watershed Between Mucosal and Systemic Immunology 1984
1983 IgA-mediated elimination of antigens by the hepatobiliary route 1983
1983 Immunoglobulin A-mediated hepatobiliary transport constitutes an natural pathway for disposing of bacterial antigens 1983
1983 Ultrastructural studies of human lymphoid cells: µ and J chain expression as a function of B cell differentiation 1983
1983 Localization of IgA and IgM in human colostral elements using immunoelectron microscopy 1983
1983 Immunoinhibitory elements in human colostrum 1983
1983 Biosynthesis of J-chain in human lymphoid cells producing immunoglobulins of various isotypes 1983
1982 Human milk peroxidase is derived from milk leukocytes 1982
1982 Interaction of specific and innate factors of immunity: IgA enhances the antimicrobial effect of the lactoperoxidase system against Streptococcus mutans 1982
1982 Hepatobiliary transport of IgA immune complexes: Molecular and cellular aspects 1982
1982 Preferential transport of IgA and IgA-immune complexes to bile compared with other external secretions 1982
1982 Properties of immunoglobulin A in serum of individuals with liver diseases and in hepatic bile 1982
1982 Tissue origins of human polymeric and monomeric IgA 1982
1981 Oral-parenteral immunization leads to the appearance of IgG auto-anti-idiotypic cells in mucosal tissues 1981
1981 Antibodies to mouse mammary tumor virus‐related antigen in sera of patients with breast carcinoma 1981
1981 Hemolytic plaque formation by cellular and noncellular elements of human colostrum 1981
1981 Immunoblastic lymphoma: An immunologic study 1981
1981 Immunodeficiency disease and dental caries in man 1981
1981 Inhibition of the pokeweed mitogen-induced response of normal peripheral blood lymphocytes by humoral components of colostrum 1981
1981 Interference of secretory immunoglobulin A with sorption of oral bacteria to hydroxyapatite 1981
1981 Nanosecond Fluorescence Spectroscopy of Human Immunoglobulin A 1981
1981 Role of serum IgA. Hepatobiliary transport of circulating antigen 1981
1981 Shared Idiotypes Among Anti‐Albumin Antibodies of Different Species 1981
1980 Molecular-cellular interactions in the secretory IgA response. 1980
1980 Production of predominantly polymeric IgA by human peripheral blood lymphocytes stimulated in vitro with mitogens 1980
1980 IgA1 proteases from Haemophilus influenzae, Streptococcus pneumoniae, Neisseria meningitidis, and Streptococcus sanguis: Comparative immunochemical studies 1980
1980 Presence of J chain in human lymphoid cells 1980
1979 Human colostral cells. I. Separation and characterization 1979
1979 Pathogenic species of the genus Haemophilus and Streptococcus pneumoniae produce immunoglobulin A1 protease 1979
1979 Secretory component: Interactions with intracellular and surface imunoglobulins of human lymphoid cells 1979
1979 Presence of plasma cells binding autologous antibody during an immune response 1979
1978 Concept of the local and common mucosal immune response. 1978
1978 Effective immunity to dental caries: selective induction of secretory immunity by oral administration of Streptococcus mutans in rodents. 1978
1978 Induction of secretory antibodies in humans following ingestion of Streptococcus mutans. 1978
1978 Molecular-cellular interactions in the secretory IgA system. 1978
1978 Report of the summation committee: recommended areas for future research. 1978
1978 Secretory immunity and immunodeficiency. 1978
1978 Secretory component on epithelial cells is a surface receptor for polymeric immunoglobulins* 1978
1978 Secretory immunity and infection 1978
1978 Selective induction of an immune response in human external secretions by ingestion of bacterial antigen. 1978
1977 Monoclonal IgG3 kappa and IgG1 λ proteins with different iodiotypic determinants present in a single patient 1977
1977 Parallel synthesis of immunoglobulins and J chain in pokeweed mitogen-stimulated normal cells and in lymphoblastoid cell lines* 1977
1977 Properties of IgA myeloma proteins isolated from sera of patients with the hyperviscosity syndrome 1977
1976 Introduction to the structural and cellular aspects of the secretory IgA system 1976
1976 Naturally occurring secretory immunoglobulin A antibodies to Streptococcus mutans in human colostrum and saliva 1976
1976 Salivary proteins and the development of dental plaque 1976
1976 Caries immunization through ingestion of Streptococcus mutans. 1976
1976 Affinity chromatography of glycopeptides using Concanavalin A 1976
1976 Affinity chromatography of glycopeptides using Concanavalin A 1976
1976 Antibodies to human native and denatured collagens in synovial fluids of patients with rheumatoid arthritis 1976
1976 Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis 1976
1976 Characterization of antibodies to the native human collagens and to their component α chains in the sera and the joint fluids of patients with rheumatoid arthritis 1976
1976 Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity 1976
1976 The differences in carbohydrate composition between the subclasses of IgA immunoglobulins 1976
1975 Identification and properties of J chain isolated from catfish macroglobulin 1975
1975 Presence of antibodies specific to cartilage type collagen in rheumatoid synovial tissue 1975
1975 Carbohydrate composition of IgA glycopeptides 1975
1975 J chain: Occurrence and characteristics in bony fishes 1975
1975 Studies on human dental plaque: 2. Immunochemical characteristics 1975
1975 The Nature of the Polymeric Serum IgA in Man 1975
1974 Site of attachment of J chain to human immunoglobulin M 1974
1974 Studies on human secretory immunoglobulin A. VI. Cyanogen bromide cleavage 1974
1974 The J chain of polymeric immunoglobulins. 1974
1974 Association of S-IgA subunits. 1974
1974 Site of J chain attachment to human polymeric IgA 1974
1974 The carbohydrate composition of glycopeptides isolated from IgA2 immunoglobulin. 1974
1974 The interactions of human complement with interfacially aggregated preparations of human secretory IgA 1974
1974 The origin of monomeric and polymeric forms of IgA in man. 1974
1973 Recombination of the polypeptide chains of a Waldenstrom's IgM that binds IgG 1973
1973 Molecular weight of a human J chain 1973
1972 Studies on human secretory immunoglobulin A. IV. Carbohydrate composition. 1972
1972 Studies on human secretory immunoglobulin A. II. Subunit structure. 1972
1972 The carbohydrate composition of J chain from human serum and secretory IgA 1972
1972 Immune Response to Clostridial Collagenase in Gingiva and other Tissues of the Rabbit 1972
1972 Structure of antibodies 1972
1972 Studies on human secretory immunoglobulin A-III. J chain 1972
1972 Studies on human secretory immunoglobulin a V. Trypsin hydrolysis at elevated temperatures 1972
1972 The carbohydrate composition of human myeloma IgA 1972
1971 Species distribution of J chain. 1971
1971 Method of serum IgA isolation. 1971
1971 Immunoglobulin M and secretory immunoglobulin A: Presence of a common polypeptide chain different from light chains 1971
1971 Immunohistochemical localization of amylase, lysozyme and immunoglobulins in the human parotid gland 1971
1970 Proportion of human colostral immunoglobulin-A molecules containing the secretory determinant. 1970
1969 Immunofluorescent localization of lysozyme in human leukocytes. 1969
1969 Rivanol-ethanol fractionation of parotid fluid and colostrum 1969
1969 A simple quantitative method for α-amylase determinations 1969
1967 Role of lysozyme and character of antibodies in experimental viral infection. 1967
1967 Detection of lysozyme production in individual cells by the plaque technique 1967
1966 Primary antibody response studied by using inhibitors of nucleic acid synthesis 1966
1966 Variances in the levels of serum lysozyme in X-irradiated mice 1966


Year Title Altmetric
2015 Mucosal immunology: Fourth edition.  Ed. 1-2.  2015
2015 Preface to the First Edition.  Ed. 1-2.  2015
2015 Preface to the Fourth Edition.  Ed. 1-2.  2015
2015 Preface to the Second Edition.  Ed. 1-2.  2015
2015 Preface to the Third Edition.  Ed. 1-2.  2015
2005 Historical aspects of mucosal immunology 2005
2005 Mucosal Immunology, Two-Volume set 2005
2005 Preface to the first edition 2005
2005 Preface to the second edition 2005
2005 Preface to the third edition 2005
2005 Mucosal Immunology, Two-Volume set 2005


Year Title Altmetric
2016 Heterogeneity of aberrant O-glycosylation of IgA1 in IgA nephropathy.  53-68. 2016
2015 Historical Aspects of Mucosal Immunology.  xxxi-lvii. 2015
2015 IgA Nephropathy and Related Diseases.  2023-2038. 2015
2015 Immunity to Sexually Transmitted Infections.  2183-2214. 2015
2015 Mucosal Immunity in the Human Female Reproductive Tract.  2097-2124. 2015
2015 Mucosal Immunoglobulins.  287-324. 2015
2015 Mucosal Vaccines: An Overview.  1039-1046. 2015
2015 Overview: The Mucosal Immune System. The Mucosal Immune System.  3-8. 2015
2015 Urogenital Tract and Mammary Gland: Overview.  2019-2022. 2015
2009 IgA immune-complex.  177-191. 2009
2007 IgA-associated diseases.  321-344. 2007
2005 Collection and processing of human mucosal secretions.  1829-1839. 2005
2005 IgA nephropathy and related diseases.  1579-1600. 2005
2005 Immunology and immunopathology of the genitourinary tract: An overview.  1575-1577. 2005
2005 Mucosal immunity in the human female reproductive tract.  1631-1646. 2005
2005 Mucosal immunoglobulins.  153-181. 2005
2005 Mucosal immunology of sexually transmitted diseases.  1693-1720. 2005
2005 Mucosal vaccines: An overview.  855-874. 2005

Education And Training

  • Doctor of Philosophy Level Degree in Cell Physiology, 1999
  • Doctor of Medicine, Charles University in Prague 1964
  • Full Name

  • Jiri Mestecky