Selected Publications

Academic Article

Year Title Altmetric
2022 Regulation of glucose responsive protein (GRP) gene expression by insulinCell Stress and Chaperones.  27:27-35. 2022
2017 Polytrauma-induced hepatic stress response and the development of liver insulin resistanceBBA: Molecular Basis of Disease.  1863:2672-2679. 2017
2017 Insulin attenuates TNFα-induced hemopexin mRNA: An anti-inflammatory action of insulin in rat H4IIE hepatoma cellsBiochemistry and Biophysics Reports.  9:211-216. 2017
2016 Prenylation differentially inhibits insulin-dependent immediate early gene mRNA expressionBiochemical and Biophysical Research Communications.  474:594-598. 2016
2016 Skeletal muscle atrogene expression and insulin resistance in a rat model of polytraumaPhysiological Reports.  4. 2016
2015 A rat model of concurrent combined injuries (polytrauma)International Journal of Clinical and Experimental Medicine.  8:20097-20110. 2015
2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013F1000Research.  3. 2014
2014 Regulation of hepatic insulin receptor activity following injuryAmerican Journal of Physiology: Gastrointestinal and Liver Physiology.  306. 2014
2013 Acute psychological stress results in the rapid development of insulin resistanceJournal of Endocrinology.  217:175-184. 2013
2013 Hepatic growth hormone resistance after acute injuryEndocrinology.  154:1577-1588. 2013
2012 Injury-induced insulin resistance in adipose tissueBiochemical and Biophysical Research Communications.  421:442-448. 2012
2012 Role of tissue macrophages in the development of critical illness diabetesShock.  37:70-76. 2012
2011 Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetesAmerican Journal of Physiology: Gastrointestinal and Liver Physiology.  301. 2011
2011 Role of reactive oxygen species in injury-induced insulin resistanceMolecular Endocrinology.  25:492-502. 2011
2010 Adenovirus infection results in alterations of insulin signaling and glucose homeostasisAmerican Journal of Physiology: Endocrinology and Metabolism.  298. 2010
2010 Anti-Inflammatory Action of Insulin via Induction of Gadd45-β Transcription by the mTOR Signaling Pathway.Hepatic Medicine : Evidence and Research.  2001:79-85. 2010
2010 Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: Role in glucose-induced insulin resistanceAmerican Journal of Physiology: Endocrinology and Metabolism.  298. 2010
2009 Age and tissue specific differences in the development of acute insulin resistance following injuryJournal of Endocrinology.  203:365-374. 2009
2009 Acute insulin resistance following injuryTrends in Endocrinology and Metabolism.  20:429-435. 2009
2009 Chapter 6 Crosstalk Between Growth Hormone and Insulin SignalingVitamins and Hormones: Advances in Research and Applications.  80:125-153. 2009
2009 Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injuryEndocrinology.  150:24-32. 2009
2008 Acute, muscle-type specific insulin resistance following injuryMolecular Medicine.  14:715-723. 2008
2008 Trauma and hemorrhage-induced acute hepatic insulin resistance: Dominant role of tumor necrosis factor-αEndocrinology.  149:2369-2382. 2008
2007 Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and actionJournal of Biological Chemistry.  282:25649-25658. 2007
2007 Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cellsMolecular and Cellular Endocrinology.  274:53-59. 2007
2007 Insulin regulation of growth hormone receptor gene expression: Involvement of both the PI-3 kinase and MEK/ERK signaling pathwaysEndocrine.  32:219-226. 2007
2006 Insulin reverses growth hormone-induced homologous desensitizationJournal of Biological Chemistry.  281:21594-21606. 2006
2006 Insulin enhances growth hormone induction of the MEK/ERK signaling pathwayJournal of Biological Chemistry.  281:982-992. 2006
2005 Blockade of rapid versus prolonged extracellularly regulated kinase 1/2 activation has differential effects on insulin-induced gene expressionEndocrinology.  146:2716-2725. 2005
2005 Gene 33 inhibits apoptosis of breast cancer cells and increases poly(ADP-ribose) polymerase expressionBreast Cancer Research and Treatment.  91:207-215. 2005
2005 Modulation of Elk-dependent-transcription by gene33Journal of Cellular Biochemistry.  94:1190-1198. 2005
2005 Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1Journal of Endocrinology.  184:481-492. 2005
2005 Genetic variability in the immune-inflammatory response after major burn injuryShock.  23:123-128. 2005
2004 Mechanism of cardiac depression after trauma-hemorrhage: Increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac functionAmerican Journal of Physiology: Heart and Circulatory Physiology.  287. 2004
2004 Regulation of Gene33 expression by insulin requires MEK-ERK activationBiochimica et Biophysica Acta: Gene Regulatory Mechanisms.  1679:248-255. 2004
2004 Mechanisms of hemorrhage-induced hepatic insulin resistance: Role of tumor necrosis factor-αEndocrinology.  145:5168-5176. 2004
2003 Insulin-Regulated Expression of Egr-1 and Krox20: Dependence on ERK1/2 and Interaction with p38 and PI3-Kinase PathwaysEndocrinology.  144:5402-5410. 2003
2003 Identification of hemopexin as a GH-regulated geneMolecular and Cellular Endocrinology.  204:101-110. 2003
2003 Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cellsMolecular and Cellular Endocrinology.  204:111-116. 2003
2002 Insulin signal transduction pathways and insulin-induced gene expressionJournal of Biological Chemistry.  277:48565-48573. 2002
2002 Growth hormone-induced differential desensitization of STAT5, ERK, and Akt phosphorylationJournal of Biological Chemistry.  277:28384-28393. 2002
1999 Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathwayJournal of Biological Chemistry.  274:13434-13442. 1999
1998 Nitric oxide-dependent induction of glutathione synthesis through increased expression of γ-glutamylcysteine synthetaseArchives of Biochemistry and Biophysics.  358:74-82. 1998
1998 Translocation of PKC delta by insulin in a rat hepatoma cell lineEndocrine.  8:161-167. 1998
1997 Insulin induction of pip 92, CL-6, and novel mRNAs in rat hepatoma cellsEndocrine.  7:199-207. 1997
1997 Pioglitazone: In vitro effects on rat hepatoma cells and in vivo liver hypertrophy in kkay micePharmacology.  54:169-178. 1997
1995 One of three CCArGG box/serum response elements of the β-actin gene is an insulin-responsive elementEndocrinology.  136:306-315. 1995
1994 Evidence for diverse roles of protein kinase-C in the inhibition of gene expression by insulin: the tyrosine aminotransferase, albumin, and phosphoenolpyruvate carboxykinase genes.Endocrinology.  135:2327-2334. 1994
1994 Identification of β-actin sequences necessary for induction by phorbol esters and calcium ionophoresOncogene.  9:1713-1722. 1994
1994 Synergistic induction of gene 33 expression by retinoic acid and insulin.Endocrinology.  134:2237-2244. 1994
1994 Regulation of γ‐actin gene expression by insulinJournal of Cellular Physiology.  160:287-294. 1994
1993 Role of cytosolic calcium in regulation of cytoskeletal gene expression by insulin.American Journal of Physiology.  264:E519-E525. 1993
1992 Vanadate and insulin stimulate gene 33 expressionBiochemical and Biophysical Research Communications.  189:931-937. 1992
1992 Rapid regulation of albumin transcription by insulin and phorbol esters in rat hepatoma cellsBBA: Molecular Cell Research.  1137:225-230. 1992
1992 Induction of cytoskeletal gene expression by insulin.Molecular Endocrinology.  6:112-119. 1992
1992 Protein synthesis and insulin regulation of p33 and PEPCK gene expressionMolecular and Cellular Endocrinology.  84:39-46. 1992
1992 Regulation of β-actin gene transcription by insulin and phorbol estersExperimental Cell Research.  200:532-535. 1992
1992 Role of protein kinase C in insulin's regulation of c-fos transcriptionJournal of Biological Chemistry.  267:9223-9228. 1992
1992 Short- and long-term effects of insulin on tyrosine aminotransferase gene expressionArchives of Biochemistry and Biophysics.  298:56-62. 1992
1991 Inhibition and stimulation of c-myc gene transcription by insulin in rat hepatoma cells: Insulin alters the intragenic pausing of c-myc transcriptionJournal of Biological Chemistry.  266:17995-18001. 1991
1990 Interaction of insulin and phorbol esters on the regulation of DNA synthesis in rat hepatome cellsBiochemical and Biophysical Research Communications.  172:759-766. 1990
1990 Decreased induction of an hepatic mRNA by phorbol esters after insulin desensitizationMolecular and Cellular Endocrinology.  72:121-129. 1990
1990 Insulin's regulation of c-fos gene transcription in hepatoma cellsJournal of Biological Chemistry.  265:11700-11705. 1990
1989 Insulin and dexamethasone regulation of a rat hepatoma messenger ribonucleic acid: Insulin has a transcriptional and a posttranscriptional effectEndocrinology.  124:754-761. 1989
1988 Transcriptional regulation of a rat hepatoma gene by insulin and protein kinase-cEndocrinology.  123:366-372. 1988
1987 Positive interaction between insulin and phorbol esters on the regulation of a specific messenger ribonucleic acid in rat hepatoma cellsEndocrinology.  121:1227-1232. 1987
1985 Effects of insulin alone on the accumulation of a specific mRNA in rat hepatoma cellsJournal of Biological Chemistry.  260:16418-16423. 1985

Education And Training

  • Doctor of Philosophy in Physiology, University of Michigan System : Ann Arbor 1982
  • Full Name

  • Joseph Messina