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Joseph Messina Ph.D.
Professor
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E-mail
messinaj@uab.edu
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Co-investigator Network
Joseph Messina Ph.D.
Professor
Positions
Senior Scientist (C)
,
Comprehensive Cardiovascular Center
,
School of Medicine
Senior Scientist (C)
,
Comprehensive Diabetes Center
,
School of Medicine
Senior Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
Senior Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Senior Scientist (C)
,
Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED)
,
School of Dentistry
Senior Scientist (C)
,
Nutrition Obesity Res Center (NORC)
,
Nutrition Sciences Research
Professor (S)
,
Cell, Developmental and Integrative Biology (CDIB)
,
Academic Joint Departments
Professor (P)
,
Molecular & Cellular Pathology
,
Joint Pathology
Senior Scientist (C)
,
Center for Exercise Medicine
,
Cell, Developmental and Integrative Biology (CDIB)
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2022
Regulation of glucose responsive protein (GRP) gene expression by insulin
.
Cell Stress and Chaperones
. 27:27-35.
2022
2017
Polytrauma-induced hepatic stress response and the development of liver insulin resistance
.
BBA: Molecular Basis of Disease
. 1863:2672-2679.
2017
2017
Insulin attenuates TNFα-induced hemopexin mRNA: An anti-inflammatory action of insulin in rat H4IIE hepatoma cells
.
Biochemistry and Biophysics Reports
. 9:211-216.
2017
2016
Prenylation differentially inhibits insulin-dependent immediate early gene mRNA expression
.
Biochemical and Biophysical Research Communications
. 474:594-598.
2016
2016
Skeletal muscle atrogene expression and insulin resistance in a rat model of polytrauma
.
Physiological Reports
. 4.
2016
2015
A rat model of concurrent combined injuries (polytrauma)
.
International Journal of Clinical and Experimental Medicine
. 8:20097-20110.
2015
2014
Aging and energetics' 'Top 40' future research opportunities 2010-2013
.
F1000Research
. 3.
2014
2014
Regulation of hepatic insulin receptor activity following injury
.
American Journal of Physiology: Gastrointestinal and Liver Physiology
. 306.
2014
2013
Acute psychological stress results in the rapid development of insulin resistance
.
Journal of Endocrinology
. 217:175-184.
2013
2013
Hepatic growth hormone resistance after acute injury
.
Endocrinology
. 154:1577-1588.
2013
2012
Injury-induced insulin resistance in adipose tissue
.
Biochemical and Biophysical Research Communications
. 421:442-448.
2012
2012
Role of tissue macrophages in the development of critical illness diabetes
.
Shock
. 37:70-76.
2012
2011
Role of inhibitory κB kinase and c-Jun NH
2
-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes
.
American Journal of Physiology: Gastrointestinal and Liver Physiology
. 301.
2011
2011
Role of reactive oxygen species in injury-induced insulin resistance
.
Molecular Endocrinology
. 25:492-502.
2011
2010
Adenovirus infection results in alterations of insulin signaling and glucose homeostasis
.
American Journal of Physiology: Endocrinology and Metabolism
. 298.
2010
2010
Anti-Inflammatory Action of Insulin via Induction of Gadd45-β Transcription by the mTOR Signaling Pathway.
.
Hepatic Medicine : Evidence and Research
. 2001:79-85.
2010
2010
Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: Role in glucose-induced insulin resistance
.
American Journal of Physiology: Endocrinology and Metabolism
. 298.
2010
2009
Age and tissue specific differences in the development of acute insulin resistance following injury
.
Journal of Endocrinology
. 203:365-374.
2009
2009
Acute insulin resistance following injury
.
Trends in Endocrinology and Metabolism
. 20:429-435.
2009
2009
Chapter 6 Crosstalk Between Growth Hormone and Insulin Signaling
.
Vitamins and Hormones: Advances in Research and Applications
. 80:125-153.
2009
2009
Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury
.
Endocrinology
. 150:24-32.
2009
2008
Acute, muscle-type specific insulin resistance following injury
.
Molecular Medicine
. 14:715-723.
2008
2008
Trauma and hemorrhage-induced acute hepatic insulin resistance: Dominant role of tumor necrosis factor-α
.
Endocrinology
. 149:2369-2382.
2008
2007
Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action
.
Journal of Biological Chemistry
. 282:25649-25658.
2007
2007
Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cells
.
Molecular and Cellular Endocrinology
. 274:53-59.
2007
2007
Insulin regulation of growth hormone receptor gene expression: Involvement of both the PI-3 kinase and MEK/ERK signaling pathways
.
Endocrine
. 32:219-226.
2007
2006
Insulin reverses growth hormone-induced homologous desensitization
.
Journal of Biological Chemistry
. 281:21594-21606.
2006
2006
Insulin enhances growth hormone induction of the MEK/ERK signaling pathway
.
Journal of Biological Chemistry
. 281:982-992.
2006
2005
Blockade of rapid versus prolonged extracellularly regulated kinase 1/2 activation has differential effects on insulin-induced gene expression
.
Endocrinology
. 146:2716-2725.
2005
2005
Gene 33 inhibits apoptosis of breast cancer cells and increases poly(ADP-ribose) polymerase expression
.
Breast Cancer Research and Treatment
. 91:207-215.
2005
2005
Modulation of Elk-dependent-transcription by gene33
.
Journal of Cellular Biochemistry
. 94:1190-1198.
2005
2005
Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1
.
Journal of Endocrinology
. 184:481-492.
2005
2005
Genetic variability in the immune-inflammatory response after major burn injury
.
Shock
. 23:123-128.
2005
2004
Mechanism of cardiac depression after trauma-hemorrhage: Increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function
.
American Journal of Physiology: Heart and Circulatory Physiology
. 287.
2004
2004
Regulation of Gene33 expression by insulin requires MEK-ERK activation
.
Biochimica et Biophysica Acta: Gene Regulatory Mechanisms
. 1679:248-255.
2004
2004
Mechanisms of hemorrhage-induced hepatic insulin resistance: Role of tumor necrosis factor-α
.
Endocrinology
. 145:5168-5176.
2004
2003
Insulin-Regulated Expression of Egr-1 and Krox20: Dependence on ERK1/2 and Interaction with p38 and PI3-Kinase Pathways
.
Endocrinology
. 144:5402-5410.
2003
2003
Identification of hemopexin as a GH-regulated gene
.
Molecular and Cellular Endocrinology
. 204:101-110.
2003
2003
Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cells
.
Molecular and Cellular Endocrinology
. 204:111-116.
2003
2002
Insulin signal transduction pathways and insulin-induced gene expression
.
Journal of Biological Chemistry
. 277:48565-48573.
2002
2002
Growth hormone-induced differential desensitization of STAT5, ERK, and Akt phosphorylation
.
Journal of Biological Chemistry
. 277:28384-28393.
2002
1999
Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway
.
Journal of Biological Chemistry
. 274:13434-13442.
1999
1998
Nitric oxide-dependent induction of glutathione synthesis through increased expression of γ-glutamylcysteine synthetase
.
Archives of Biochemistry and Biophysics
. 358:74-82.
1998
1998
Translocation of PKC delta by insulin in a rat hepatoma cell line
.
Endocrine
. 8:161-167.
1998
1997
Insulin induction of pip 92, CL-6, and novel mRNAs in rat hepatoma cells
.
Endocrine
. 7:199-207.
1997
1997
Pioglitazone: In vitro effects on rat hepatoma cells and in vivo liver hypertrophy in kka
y
mice
.
Pharmacology
. 54:169-178.
1997
1995
One of three CCArGG box/serum response elements of the β-actin gene is an insulin-responsive element
.
Endocrinology
. 136:306-315.
1995
1994
Evidence for diverse roles of protein kinase-C in the inhibition of gene expression by insulin: the tyrosine aminotransferase, albumin, and phosphoenolpyruvate carboxykinase genes.
.
Endocrinology
. 135:2327-2334.
1994
1994
Identification of β-actin sequences necessary for induction by phorbol esters and calcium ionophores
.
Oncogene
. 9:1713-1722.
1994
1994
Synergistic induction of gene 33 expression by retinoic acid and insulin.
.
Endocrinology
. 134:2237-2244.
1994
1994
Regulation of γ‐actin gene expression by insulin
.
Journal of Cellular Physiology
. 160:287-294.
1994
1993
Role of cytosolic calcium in regulation of cytoskeletal gene expression by insulin.
.
American Journal of Physiology
. 264:E519-E525.
1993
1992
Vanadate and insulin stimulate gene 33 expression
.
Biochemical and Biophysical Research Communications
. 189:931-937.
1992
1992
Rapid regulation of albumin transcription by insulin and phorbol esters in rat hepatoma cells
.
BBA: Molecular Cell Research
. 1137:225-230.
1992
1992
Induction of cytoskeletal gene expression by insulin.
.
Molecular Endocrinology
. 6:112-119.
1992
1992
Protein synthesis and insulin regulation of p33 and PEPCK gene expression
.
Molecular and Cellular Endocrinology
. 84:39-46.
1992
1992
Regulation of β-actin gene transcription by insulin and phorbol esters
.
Experimental Cell Research
. 200:532-535.
1992
1992
Role of protein kinase C in insulin's regulation of c-fos transcription
.
Journal of Biological Chemistry
. 267:9223-9228.
1992
1992
Short- and long-term effects of insulin on tyrosine aminotransferase gene expression
.
Archives of Biochemistry and Biophysics
. 298:56-62.
1992
1991
Inhibition and stimulation of c-myc gene transcription by insulin in rat hepatoma cells: Insulin alters the intragenic pausing of c-myc transcription
.
Journal of Biological Chemistry
. 266:17995-18001.
1991
1990
Interaction of insulin and phorbol esters on the regulation of DNA synthesis in rat hepatome cells
.
Biochemical and Biophysical Research Communications
. 172:759-766.
1990
1990
Decreased induction of an hepatic mRNA by phorbol esters after insulin desensitization
.
Molecular and Cellular Endocrinology
. 72:121-129.
1990
1990
Insulin's regulation of c-fos gene transcription in hepatoma cells
.
Journal of Biological Chemistry
. 265:11700-11705.
1990
1989
Insulin and dexamethasone regulation of a rat hepatoma messenger ribonucleic acid: Insulin has a transcriptional and a posttranscriptional effect
.
Endocrinology
. 124:754-761.
1989
1988
Transcriptional regulation of a rat hepatoma gene by insulin and protein kinase-c
.
Endocrinology
. 123:366-372.
1988
1987
Positive interaction between insulin and phorbol esters on the regulation of a specific messenger ribonucleic acid in rat hepatoma cells
.
Endocrinology
. 121:1227-1232.
1987
1985
Effects of insulin alone on the accumulation of a specific mRNA in rat hepatoma cells
.
Journal of Biological Chemistry
. 260:16418-16423.
1985
Research
Principal Investigator On
Hepatic Insulin Resistance Following Hemorrhage
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Investigator On
Training Program in Cardiovascular Pathophysiology
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
UAB Obesity Training Program
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Background
Education And Training
Doctor of Philosophy in Physiology,
University of Michigan System : Ann Arbor
1982
Contact
Full Name
Joseph
Messina