| Year |
Title |
Altmetric |
| 2019
|
Kinetics mechanism and regulation of native human hepatic thymidine phosphorylase
2019
|
|
| 2018
|
Enzymes of pyrimidine salvage pathways in intraerythrocytic Plasmodium falciparum
2018
|
|
| 2018
|
Distinct substrate specificity and physicochemical characterization of native human hepatic thymidine phosphorylase.
PLoS ONE.
13.
2018
|
|
| 2017
|
Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets
2017
|
|
| 2015
|
Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine
2015
|
|
| 2014
|
Isolation and substrate specificity of an adenine nucleoside phosphorylase from adult Schistosoma mansoni.
Molecular and Biochemical Parasitology.
194:44-47.
2014
|
|
| 2014
|
Nucleoside kinases in adult Schistosoma mansoni: Phosphorylation of pyrimidine nucleosides.
Molecular and Biochemical Parasitology.
194:53-55.
2014
|
|
| 2013
|
Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription.
Journal of Molecular Biology.
425:812-829.
2013
|
|
| 2012
|
Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: Remission and lack of host toxicity.
Cancer Chemotherapy and Pharmacology.
69:1449-1455.
2012
|
|
| 2010
|
Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate
2010
|
|
| 2010
|
Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: Biological activities and selective toxicities.
Biochemical Pharmacology.
80:955-963.
2010
|
|
| 2010
|
Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.
Bioorganic and Medicinal Chemistry.
18:3403-3412.
2010
|
|
| 2008
|
7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities.
Biochemical Pharmacology.
76:958-966.
2008
|
|
| 2008
|
Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase.
Journal of Medicinal Chemistry.
51:3934-3945.
2008
|
|
| 2008
|
Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity.
Cancer Chemotherapy and Pharmacology.
62:85-96.
2008
|
|
| 2008
|
Uridine protects cortical neurons from glucose deprivation-induced death: Possible role of uridine phosphorylase.
Journal of Neurotrauma.
25:695-707.
2008
|
|
| 2007
|
Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.
Biochemical Pharmacology.
73:1558-1572.
2007
|
|
| 2007
|
Adenosine metabolism in Toxoplasma gondii: Potential targets for chemotherapy.
Current Pharmaceutical Design.
13:581-597.
2007
|
|
| 2007
|
Editorial: Potential targets for the rational design of antiparasitic drugs.
Current Pharmaceutical Design.
13:553-554.
2007
|
|
| 2007
|
Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase.
Acta Crystallographica Section D: Biological Crystallography.
63:126-134.
2007
|
|
| 2006
|
Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor.
Cancer Chemotherapy and Pharmacology.
58:692-698.
2006
|
|
| 2006
|
Uridine prevents the glucose deprivation-induced death of immunostimulated astrocytes via the action of uridine phosphorylase..
Neuroscience Research.
56:111-118.
2006
|
|
| 2006
|
Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 Å resolution.
Acta Crystallographica Section D: Biological Crystallography.
62:140-145.
2006
|
|
| 2005
|
6-Benzylthioinosine analogues: Promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 (es).
Biochemical Pharmacology.
71:69-73.
2005
|
|
| 2005
|
Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta Crystallographica Section D: Biological Crystallography.
61:863-872.
2005
|
|
| 2005
|
5-(Phenylthio)acyclouridine: A powerful enhancer of oral uridine bioavailability: Relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens.
Cancer Chemotherapy and Pharmacology.
55:541-551.
2005
|
|
| 2005
|
6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities.
Biochemical Pharmacology.
69:1409-1419.
2005
|
|
| 2004
|
Synthesis, Biological Activity and Molecular Modeling of 6-Benzylthioinosine Analogues as Subversive Substrates of Toxoplasma gondii Adenosine Kinase.
Journal of Medicinal Chemistry.
47:1987-1996.
2004
|
|
| 2003
|
Uptake of nitrobenzylthioinosine and purine β-L-nucleosides by intracellular Toxoplasma gondii.
Antimicrobial Agents and Chemotherapy.
47:3247-3251.
2003
|
|
| 2003
|
Potential chemotherapeutic targets in the purine metabolism of parasites.
Pharmacology and Therapeutics.
99:283-309.
2003
|
|
| 2002
|
Trends in the design of nucleoside analogues as anti-HIV drugs.
Current Pharmaceutical Design.
8:581-593.
2002
|
|
| 2001
|
Synthesis of carbocyclic orotidine analogs as potential orotidinedecarboxylase inhibitors
2001
|
|
| 2001
|
Antiviral activity and intracellular metabolism of bis(tButyISATE) phosphotriester of β-L-2′,3′dideoxyadenosine, a potent inhibitor of HIV and HBV replication.
Antiviral Chemistry and Chemotherapy.
12:99-108.
2001
|
|
| 2001
|
Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: Implications for uridine rescue regimens in chemotherapy.
Cancer Chemotherapy and Pharmacology.
48:389-397.
2001
|
|
| 2001
|
Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: Implications for chemotherapy.
Cancer Chemotherapy and Pharmacology.
48:145-150.
2001
|
|
| 2000
|
5-Phenylthioacyclouridine: A potent and specific inhibitor of uridine phosphorylase.
Biochemical Pharmacology.
60:851-856.
2000
|
|
| 2000
|
Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10.
Biochemical Pharmacology.
60:687-692.
2000
|
|
| 2000
|
Modulation of 5-fluorouracil host toxicity by 5- (benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine.
Biochemical Pharmacology.
60:427-431.
2000
|
|
| 2000
|
Intracellular metabolism of β-L-2',3'-dideoxyadenosine: Relevance to its limited antiviral activity.
Antimicrobial Agents and Chemotherapy.
44:853-858.
2000
|
|
| 2000
|
Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2', 3', 5'-tri-O-acetyluridine, a prodrug of uridine: Relevance to uridine rescue in chemotherapy.
Cancer Chemotherapy and Pharmacology.
46:235-240.
2000
|
|
| 2000
|
Modulation of plasma uridine concentration by 5- (phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase: Relevance to chemotherapy.
Cancer Chemotherapy and Pharmacology.
45:351-361.
2000
|
|
| 1999
|
The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression.
Journal of Biological Chemistry.
274:35255-35261.
1999
|
|
| 1999
|
Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from toxoplasma gondii.
Biochemical Pharmacology.
58:1457-1466.
1999
|
|
| 1999
|
Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus.
Molecular and Biochemical Parasitology.
103:1-14.
1999
|
|
| 1999
|
Uridine phosphorylase inhibitors: Chemical modification of benzyloxybenzyl-barbituric acid and its effects on UrdPase inhibition.
Bioorganic and Medicinal Chemistry Letters.
9:1477-1480.
1999
|
|
| 1999
|
Metabolism and selective toxicity of 6-nitrobenzylthioinosine in Toxoplasma gondii.
Antimicrobial Agents and Chemotherapy.
43:2437-2443.
1999
|
|
| 1996
|
5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration: Implications for chemotherapy.
Biochemical Pharmacology.
51:1601-1611.
1996
|
|
| 1996
|
Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii.
Biochemical Pharmacology.
51:1687-1700.
1996
|
|
| 1995
|
Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii.
Biochemical Pharmacology.
50:1685-1693.
1995
|
|
| 1995
|
Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii.
Biochemical Pharmacology.
49:1501-1512.
1995
|
|
| 1995
|
Enhancement of 5-Fluoro-2′-deoxyuridine Antitumor Efficacy by the Uridine Phosphorylase Inhibitor 5-(Benzyloxybenzyl)barbituric Acid Acyclonucleoside.
Cancer Research.
55:1092-1098.
1995
|
|
| 1995
|
Synthesis of [4-(hydroxy)tetrahydrofuran-2-yl]nucleosides as a novel class of uridine phosphorylase inhibitors
1995
|
|
| 1995
|
Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: implications for chemotherapy.
Cancer Chemotherapy and Pharmacology.
37:14-22.
1995
|
|
| 1994
|
Potentiation of 5-Fluorouracil Efficacy by the Dihydrouracil Dehydrogenase Inhibitor, 5-Benzyloxybenzyluracil.
Cancer Research.
54:5166-5170.
1994
|
|
| 1993
|
5-Benzylbarbituric acid derivatives, potent and specific inhibitors of uridine phosphorylase.
Biochemical Pharmacology.
46:1273-1283.
1993
|
|
| 1993
|
Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver. Possible relevance to chemotherapy with 5-fluoropyrimidines.
Biochemical Pharmacology.
45:667-673.
1993
|
|
| 1993
|
Differences in Activities and Substrate Specificity of Human and Murine Pyrimidine Nucleoside Phosphorylases: Implications for Chemotherapy with 5-Fluoropyrimidines.
Cancer Research.
53:3687-3693.
1993
|
|
| 1993
|
Phenylselenenyl- and Phenylthio-Substituted Pyrimidines as Inhibitors of Dihydrouracil Dehydrogenase and Uridine Phosphorylase.
Journal of Medicinal Chemistry.
36:4250-4254.
1993
|
|
| 1993
|
Synthesis of a new class of uridine phosphorylase inhibitors
1993
|
|
| 1992
|
Chemotherapy of schistosomiasis..
Rhode Island medicine.
75:212-216.
1992
|
|
| 1991
|
Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil. Possible relevance to regional chemotherapy.
Biochemical Pharmacology.
41:1887-1893.
1991
|
|
| 1991
|
Efficacy of combination therapy with tubercidin and nitrobenzylthioinosine 5'- monophosphate against chronic and advanced stages of schistosomiasis.
Biochemical Pharmacology.
41:815-820.
1991
|
|
| 1990
|
Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice.
Biochemical Pharmacology.
40:2479-2485.
1990
|
|
| 1990
|
Pyrimidine salvage pathways in adult Schistosoma mansoni.
International Journal for Parasitology.
20:37-44.
1990
|
|
| 1989
|
Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver.
Biochemical Pharmacology.
38:1471-1480.
1989
|
|
| 1989
|
Prevention for tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis.
Antimicrobial Agents and Chemotherapy.
33:824-827.
1989
|
|
| 1988
|
Synthesis of 5-benzyl and 5-benzyloxybenzyl 2,2'-anhydroudridines and related nucleoside analogs as inhibitors of uridine phosphorylase
1988
|
|
| 1988
|
Effect of the N-glycosidic bond conformation and modifications in the pentose moiety on the binding of nucleoside ligands to uridine phosphorylase.
Molecular Pharmacology.
34:104-110.
1988
|
|
| 1988
|
Uridine phosphorylase from Schistosoma mansoni.
Journal of Biological Chemistry.
263:6081-6086.
1988
|
|
| 1987
|
Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors.
Biochemical Pharmacology.
36:3815-3821.
1987
|
|
| 1987
|
New analogues of benzylacyclouridines, specific and potent inhibitors of uridine phosphorylase from human and mouse livers.
Biochemical Pharmacology.
36:2195-2201.
1987
|
|
| 1987
|
Metabolism of adenosine analogues by Schistosoma mansoni and the effect of nucleoside transport inhibitors.
Biochemical Pharmacology.
36:1099-1106.
1987
|
|
| 1987
|
Effects of N,N-dimethylformamide and sodium butyrate on enzymes of pyrimidine metabolism in cultured human tumor cells.
Leukemia Research.
11:855-861.
1987
|
|
| 1986
|
Inhibition of uridine phosphorylase from Escherichia coli by benzylacyclouridines.
Biochemical Pharmacology.
35:3853-3855.
1986
|
|
| 1985
|
Combination therapy of Schistosoma japonicum by tubercidin and nitrobenzylthioinosine 5′-monophosphate.
Biochemical Pharmacology.
34:3921-3923.
1985
|
|
| 1985
|
Enzymes off Uracil Catabolism in Normal and Neoplastic Human Tissues.
Cancer Research.
45:5405-5412.
1985
|
|
| 1985
|
Kinetic Studies of Thymidine Phosphorylase from Mouse Liver.
Biochemistry.
24:6799-6807.
1985
|
|
| 1985
|
Nucleotidase activities of human peripheral lymphocytes.
Biochemical Pharmacology.
34:3061-3070.
1985
|
|
| 1985
|
Kinetic studies of thymidine phosphorylase from mouse liver.
Proceedings of the American Association for Cancer Research.
VOL. 26.
1985
|
|
| 1985
|
New inhibitors of dihydrouracil dehydrogenase.
Proceedings of the American Association for Cancer Research.
VOL. 26.
1985
|
|
| 1984
|
Inhibition of Nucleoside Transport in Murine Lymphoma L5178Y Cells and Human Erythrocytes by the Uridine Phosphorylase Inhibitors 5-Benzylacyclouridine and 5-Benzyloxybenzylacyclouridine.
Cancer Research.
44:3744-3748.
1984
|
|
| 1984
|
Structure-activity relationship of pyrimidine base analogs as ligands of orotate phosphoribosyltransferase.
Biochemical Pharmacology.
33:2383-2395.
1984
|
|
| 1984
|
Potentiation of 5-Fluoro-2'-deoxyuridine Antineoplastic Activity by the Uridine Phosphorylase Inhibitors Benzylacyclouridine and Benzyloxybenzylacyclouridine.
Cancer Research.
44:1852-1856.
1984
|
|
| 1984
|
Enzymes of uridine 5′-monophosphate biosynthesis in Schistosoma mansoni.
Molecular and Biochemical Parasitology.
12:153-171.
1984
|
|
| 1984
|
Synthesis and Biological Activity of Hydroxymethyl Analogs of 5-Benzylacyclouridine and 5-Benzylckybenzyiacyclogridine
1984
|
|
| 1983
|
Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate.
1983
|
|
| 1983
|
Structure-activity relationship of ligands of the pyrimidine nucleoside phosphorylases.
Biochemical Pharmacology.
32:399-415.
1983
|
|
| 1983
|
Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate
1983
|
|
| 1982
|
5-Benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase.
Biochemical Pharmacology.
31:1857-1861.
1982
|
|
| 1982
|
Isolation and partial characterization of a 5'-nucleotidase specific for orotidine-5'-monophosphate.
1982
|
|
| 1982
|
Isolation and partial characterization of a 5'-nucleotidase specific for orotidine-5'-monophosphate
1982
|
|
| 1982
|
New inhibitors of the pyrimidine nucleoside phosphorylases.
Proceedings of the American Association for Cancer Research.
Vol. 23.
1982
|
|
| 1981
|
Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase.
Biochemical Pharmacology.
30:2097-2101.
1981
|
|
| 1981
|
A simple radioisotopic assay for nucleoside kinases employing alumina for separation of nucleosides and nucleotides.
Analytical Biochemistry.
111:67-71.
1981
|
|
| 1981
|
Benzyl acyclouridine, a new potent inhibitor of uridine phosphorylase.
Proceedings of the American Association for Cancer Research.
Vol. 22:833.
1981
|
|
| 1981
|
Isolation of OMPase, A 5'-nucleotidase specific for orotidine-5'-monophosphate.
The FASEB Journal.
40.
1981
|
|
| 1980
|
A genetic and dietary study of the physiology of pyrimidine synthesis in Drosophila melanogaster.
Journal of Insect Physiology.
26:735-740.
1980
|
|
| 1980
|
Acyclopyrimidine nucleosides, a new class of specific inhibitors of uridine phosphorylase.
Pharmacologist -Washington-.
22:449.
1980
|
|
| 1980
|
Studies on the utilization of dietary thymidine and thymine by Drosophila melanogaster larvae.
Journal of Insect Physiology.
26:775-780.
1980
|
|
| 1977
|
Survival of Drosophila melanogaster larvae on defined medium supplemented with naturally occurring nucleosides and nucleic acid bases.
Journal of Insect Physiology.
23:327-331.
1977
|
|
| 1974
|
Biology of 5-fluoro-2′-deoxyuridine sensitivity of Drosophila melanogaster larvae.
Journal of Insect Physiology.
20:1481-1490.
1974
|
|
| 1974
|
Crossbreeding and the effect of certain environmental factors on body weights of Barki and German Merino sheep
1974
|
|
