Positions

Overview

  • Dr. Dransfield completed his medical degree at the University of North Carolina at Chapel Hill in 1997, followed by residency in internal medicine and fellowship training in pulmonary and critical care medicine at the University of Alabama at Birmingham, where he served as Chief Fellow. He has been on the faculty at UAB since 2003 and is currently Associate Professor of Medicine in the Division of Pulmonary, Allergy and Critical Care Medicine. He serves as the Medical Director of the UAB Lung Health Center and is also the Medical Director of Pulmonary Rehabilitation. Dr. Dransfield is also the Director of the Bronchoscopy unit and the Lung Mass Clinic at the Birmingham VA Medical Center. He was named as a "Top 10 Teacher" in the Department of Medicine in 2006-2008, and in 2009 he was a recipient of the Cobbs-Rutsky Award for Clinical Excellence in Teaching. He was named one of America's Top Doctors for 2010-2016. Dr. Dransfield's clinical interests include chronic obstructive pulmonary disease (COPD) and lung cancer. He has particular interest in the care of patients with advanced COPD and directs the UAB Centers for Medicare and Medicaid Services Bundled Payments for Care Initiative for COPD. Dr. Dransfield also evaluates patients with suspected or confirmed thoracic malignancies.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition 2019
    2019 A genetic risk score associated with chronic obstructive pulmonary disease susceptibility and lung structure on computed tomography 2019
    2019 Adherence to Pulmonary Rehabilitation in COPD: A QUALITATIVE EXPLORATION OF PATIENT PERSPECTIVES ON BARRIERS AND FACILITATORS 2019
    2019 Blood eosinophils and treatment response with triple and dual combination therapy in chronic obstructive pulmonary disease: analysis of the IMPACT trial 2019
    2019 Misinterpretation of time-to-first event curves can lead to inappropriate treatment 2019
    2019 Radiographic Lung Volumes Predict Progression to COPD in Smokers with Preserved Spirometry in SPIROMICS. 2019
    2019 Arterial vascular pruning, right ventricular size, and clinical outcomes in chronic obstructive pulmonary disease a longitudinal observational study 2019
    2019 Chronic obstructive pulmonary disease in America's black population 2019
    2019 Video telehealth pulmonary rehabilitation intervention in chronic obstructive pulmonary disease reduces 30-day readmissions 2019
    2019 Reply to: Video Telehealth and Pulmonary Rehabilitation: Need for a Better Understanding. 2019
    2019 A Formative Evaluation of Patient and Family Caregiver Perspectives on Early Palliative Care in Chronic Obstructive Pulmonary Disease across Disease Severity 2019
    2019 Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study 2019
    2019 Eosinophil-guided treatment of COPD exacerbations: unfinished business 2019
    2019 The Peak Index: Spirometry Metric for Airflow Obstruction Severity and Heterogeneity 2019
    2019 Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study. 2019
    2019 Reply to: Not all Home-Based Exercise Programs are Home-Based Pulmonary Rehabilitation Programs. 2019
    2019 Application of the community health worker model in adult asthma and COPD in the U.S.: A systematic review 2019
    2019 Discriminative Accuracy of FEV1:FVC Thresholds for COPD-Related Hospitalization and Mortality 2019
    2019 It's more than low BMI: Prevalence of cachexia and associated mortality in COPD 2019
    2019 Towards eradication of chronic obstructive pulmonary disease: a Lancet Commission 2019
    2019 Determinants of cigarette smoking status in a national cohort of black and white adult ever smokers in the USA: A cross-sectional analysis of the REGARDS study 2019
    2019 Predictors of Response to Endobronchial Coil Therapy in Patients With Advanced Emphysema 2019
    2019 Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS 2019
    2019 Safety and tolerability of comprehensive research bronchoscopy in chronic obstructive pulmonary disease results from the SPIROMICS bronchoscopy substudy 2019
    2019 Aspirin Use and Respiratory Morbidity in COPD: A Propensity Score-Matched Analysis in Subpopulations and Intermediate Outcome Measures in COPD Study 2019
    2019 Effect of daily azithromycin therapy and adherence on readmission risk in COPD 2019
    2019 Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - A cross sectional analysis of the COPDGene cohort 2019
    2019 Alignment of inhaled chronic obstructive pulmonary disease therapies with published strategies :analysis of the Global Initiative for Chronic Obstructive Lung Disease recommendations in SpiroMics 2019
    2019 Impact of pre-enrolment medication use on clinical outcomes in SUMMIT. 2019
    2019 Reducing chronic obstructive pulmonary disease hospital readmissions: An official American Thoracic Society workshop report 2019
    2019 Life-course smoking trajectories and risk for emphysema in middle age: The CARDIA Lung study 2019
    2019 Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung 2019
    2019 Acquired cystic fibrosis transmembrane conductance regulator dysfunction and radiographic bronchiectasis in current and former smokers: A cross-sectional study 2019
    2019 COPD exacerbations and MACE: More than a chance encounter? 2019
    2019 Combined forced expiratory volume in 1 second and forced vital capacity bronchodilator response, exacerbations, and mortality in chronic obstructive pulmonary disease 2019
    2019 Inflammation and endothelial activation in early adulthood are associated with future emphysema: the CARDIA Lung Study 2019
    2019 Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease 2019
    2018 Centrilobular emphysema and coronary artery calcification: Mediation analysis in the SPIROMICS cohort 2018
    2018 Airway fractal dimension predicts respiratory morbidity and mortality in COPD 2018
    2018 Erratum: Airway fractal dimension predicts respiratory morbidity and mortality in COPD (Journal of Clinical Investigation (2018) 128:12 (5374–5382) DOI: 10.1172/JCI120693) 2018
    2018 Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease 2018
    2018 Longitudinal phenotypes and mortality in preserved ratio impaired spirometry in the COPDGene study 2018
    2018 Lung function in young adults and risk of cardiovascular events over 29 years: The CARDIA study 2018
    2018 New Spirometry Indices for Detecting Mild Airflow Obstruction 2018
    2018 Occupational exposures and computed tomographic imaging characteristics in the SpiromICS cohort 2018
    2018 Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics 2018
    2018 Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene 2018
    2018 Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema 2018
    2018 A multicenter randomized controlled trial of zephyr endobronchial valve treatment in heterogeneous emphysema (LIBERATE) 2018
    2018 Interpreting Recent Developments in COPD Treatments 2018
    2018 Interpreting Recent Developments in COPD Treatments. 2018
    2018 Visual Estimate of Coronary Artery Calcium Predicts Cardiovascular Disease in COPD 2018
    2018 Defining impaired respiratory health a paradigm shift for pulmonary medicine 2018
    2018 Genome-wide association study of lung function and clinical implication in heavy smokers 2018
    2018 Interstitial features at chest CT enhance the deleterious effects of emphysema in the COPDGene cohort 2018
    2018 Exacerbations of chronic obstructive pulmonary disease and cardiac events a post hoc cohort analysis from the SUMMIT randomized clinical trial 2018
    2018 NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort 2018
    2018 Rural residence and chronic obstructive pulmonary disease exacerbations: Analysis of the SPIROMICS cohort 2018
    2018 Respiratory symptoms in young adults and future lung disease the cardia lung study 2018
    2018 Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS. 2018
    2018 Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease 2018
    2018 B-blocker therapy and clinical outcomes in patients with moderate chronic obstructive pulmonary disease and heightened cardiovascular risk an observational substudy of SUMMIT 2018
    2018 Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years 2018
    2018 Paratracheal paraseptal emphysema and expiratory central airway collapse in smokers 2018
    2018 Single-inhaler triple therapy in symptomatic COPD patients: FULFIL subgroup analyses. 2018
    2018 Simultaneous LC–MS/MS analysis of eicosanoids and related metabolites in human serum, sputum and BALF 2018
    2018 Survival of Lung Transplant Candidates With COPD: BODE Score Reconsidered 2018
    2018 The "Obesity paradox" in chronic obstructive pulmonary disease: Can it be resolved? 2018
    2018 Association of thrombocytosis with COPD morbidity: The SPIROMICS and COPDGene cohorts 2018
    2018 CT measurements of central pulmonary vasculature as predictors of severe exacerbation in COPD 2018
    2018 Cigarette smoking and response to inhaled corticosteroids in COPD 2018
    2018 Clinical differences in COPD patients with variable patterns of hypoxemia 2018
    2018 Life-space mobility and clinical outcomes in COPD 2018
    2018 Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression 2018
    2018 Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS 2018
    2018 Once-daily single-inhaler triple versus dual therapy in patients with COPD 2018
    2018 Race and gender disparities are evident in COPD underdiagnoses across all severities of measured airflow obstruction 2018
    2018 The long-term oxygen treatment trial for chronic obstructive pulmonary disease: Rationale, design, and lessons learned 2018
    2017 Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort 2017
    2017 Chest computed tomography-derived low fat-free mass index and mortality in COPD 2017
    2017 Implications of DRG Classification in a Bundled Payment Initiative for COPD. 2017
    2017 Signs of gas trapping in normal lung density regions in smokers 2017
    2017 Social Determinants of Adherence to Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease 2017
    2017 Inhaled Steroids and Active Smoking Drive Chronic Obstructive Pulmonary Disease Symptoms and Biomarkers to a Greater Degree Than Airflow Limitation 2017
    2017 Computed tomography measure of lung at risk and lung function decline in chronic obstructive pulmonary disease 2017
    2017 Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients 2017
    2017 Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort 2017
    2017 Effect of beta-blockers on exacerbation rate and lung function in chronic obstructive pulmonary disease (COPD) 2017
    2017 Measuring nitrate reductase activity from human and rodent tongues 2017
    2017 Pulmonary artery to aorta ratio is associated with cardiac structure and functional changes in mild-to-moderate COPD 2017
    2017 Association between cardiorespiratory fitness and lung health from young adulthood to middle ages 2017
    2017 Design of the subpopulations and intermediate outcome measures in COPD (SPIROMICS) AIR study 2017
    2017 Respiratory symptoms items from the COPD assessment test identify ever-smokers with preserved lung function at higher risk for poor respiratory outcomes an analysis of the subpopulations and intermediate outcome measures in COPD Study cohort 2017
    2017 Results of a Medicare Bundled Payments for care Improvement initiative for chronic obstructive pulmonary disease readmissions 2017
    2017 Ventricular Geometry From Non-contrast Non-ECG-gated CT Scans: An Imaging Marker of Cardiopulmonary Disease in Smokers 2017
    2017 Effect of fluticasone furoate and vilanterol on exacerbations of chronic obstructive pulmonary disease in patients with moderate airflow obstruction 2017
    2017 Lung Mass in Smokers 2017
    2017 Gender differences in first and secondhand smoke exposure, spirometric lung function and cardiometabolic health in the old order Amish: A novel population without female smoking 2017
    2017 GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease 2017
    2017 Acute exacerbations and lung function loss in smokers with and without chronic obstructive pulmonary disease 2017
    2017 A randomized trial of once-daily fluticasone furoate/vilanterol or vilanterol versus placebo to determine effects on arterial stiffness in COPD 2017
    2017 Biomechanical CT metrics are associated with patient outcomes in COPD 2017
    2017 Pulmonary rehabilitation improves outcomes in chronic obstructive pulmonary disease independent of disease burden 2017
    2016 Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study 2016
    2016 Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: A cohort study 2016
    2016 CT-derived Biomechanical Metrics Improve Agreement Between Spirometry and Emphysema 2016
    2016 A ferret model of COPD-related chronic bronchitis 2016
    2016 Beta-blockers in COPD: Time for reappraisal 2016
    2016 Cardiovascular disease in COPD: time to quash a silent killer 2016
    2016 A phase III randomised controlled trial of single-dose triple therapy in COPD: The IMPACT protocol 2016
    2016 Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD 2016
    2016 Pulmonary artery enlargement and cystic fibrosis pulmonary exacerbations: a cohort study 2016
    2016 Association between functional small airway disease and FEV1 decline in chronic obstructive pulmonary disease 2016
    2016 Meeting the challenge of COPD care delivery in the USA: A multiprovider perspective 2016
    2016 Pilot evaluation of ivacaftor for chronic bronchitis 2016
    2016 β-Blockers for the prevention of acute exacerbations of chronic obstructive pulmonary disease (βLOCK COPD): A randomised controlled study protocol 2016
    2016 Effect of endobronchial coils vs usual care on exercise tolerance in patients with severe emphysema: The renew randomized clinical trial 2016
    2016 Pulmonary artery enlargement is associated with cardiac injury during severe exacerbations of COPD 2016
    2016 Serum eosinophils as a COPD biomarker: Ready for prime time? 2016
    2016 Therapeutic approaches to acquired cystic fibrosis transmembrane conductance regulator dysfunction in Chronic bronchitis 2016
    2016 Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis and Other Diseases of Mucus Clearance 2016
    2016 Determinants of successful completion of pulmonary rehabilitation in COPD 2016
    2016 Risk factors for COPD exacerbations in inhaled medication users: The COPDGene study biannual longitudinal follow-up prospective cohort 2016
    2016 Association between expiratory central airway collapse and respiratory outcomes among smokers 2016
    2016 Depression is associated with readmission for acute exacerbation of chronic obstructive pulmonary disease 2016
    2016 Differences between absolute and predicted values of forced expiratory volumes to classify ventilatory impairment in chronic obstructive pulmonary disease 2016
    2016 COPD Overlap Syndromes: Asthma and Beyond. 2016
    2016 Arterial and venous pulmonary vascular morphology and their relationship to findings in cardiac magnetic resonance imaging in smokers 2016
    2016 Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study 2016
    2016 Sex-specific features of emphysema among current and former smokers with COPD 2016
    2016 β-Blockers are associated with a reduction in COPD exacerbations 2016
    2015 Recovery of acquired cystic fibrosis transmembrane conductance regulator dysfunction after smoking cessation 2015
    2015 Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study 2015
    2015 Anticholinergic vs long-acting β-Agonist in combination with inhaled corticosteroids in black adults with asthma: The BELT randomized clinical trial 2015
    2015 Benefits of completing pulmonary rehabilitation in patients with asthma 2015
    2015 Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: A secondary analysis of data from two parallel randomised controlled trials 2015
    2015 Executive summary: prevention of acute exacerbation of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline 2015
    2015 Prevention of Acute Exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline 2015
    2015 Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease 2015
    2015 A randomised trial of lung sealant versus medical therapy for advanced emphysema 2015
    2015 A randomized, placebo-controlled trial of roflumilast effect on proline-glycine-proline and neutrophilic inflammation in chronic obstructive pulmonary disease 2015
    2015 Blood eosinophil counts as markers of response to inhaled corticosteroids in COPD? - Authors' reply 2015
    2015 Clinical and radiologic disease in smokers with normal spirometry 2015
    2015 Commentary on "Factors associated with emergency department visits in asthma exacerbation" 2015
    2015 IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease 2015
    2015 Lung cancer screening, version 1.2015: Featured updates to the NCCN guidelines 2015
    2015 Pneumonia risk with inhaled fluticasone furoate and vilanterol compared with vilanterol alone in patients with COPD 2015
    2015 Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary disease 2015
    2014 Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction: Authors' response 2014
    2014 Radiological correlates and clinical implications of the paradoxical lung function response to β2 agonists: An observational study 2014
    2014 Prediction of acute respiratory disease in current and former smokers with and without COPD 2014
    2014 Fluticasone propionate/salmeterol 250/50 μg versus salmeterol 50 μg after chronic obstructive pulmonary disease exacerbation 2014
    2014 Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease 2014
    2014 DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease 2014
    2014 Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene 2014
    2014 Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy 2014
    2014 Clinical and computed tomographic predictors of chronic bronchitis in COPD: A cross sectional analysis of the COPDGene study 2014
    2014 Computed tomographic measures of airway morphology in smokers and never-smoking normals 2014
    2014 Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease 2014
    2014 Impact of heterozygote CFTR Mutations in COPD patients with Chronic Bronchitis 2014
    2014 Pooled subpopulation analyses of the effects of roflumilast on exacerbations and lung function in COPD 2014
    2014 Determinants of arterial stiffness in COPD 2014
    2014 CT scan-measured pulmonary artery to aorta ratio and echocardiography for detecting pulmonary hypertension in severe COPD 2014
    2014 Cardiovascular disease in COPD: A call for action 2014
    2014 Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease 2014
    2014 Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction 2014
    2014 Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis 2014
    2014 Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patients 2014
    2014 Efficacy and safety of once-daily fluticasone furoate/vilanterol (100/25 mcg) versus twice-daily fluticasone propionate/salmeterol (250/50 mcg) in COPD patients 2014
    2014 FEV1/FEV6to diagnose airflow obstruction: Comparisons with computed tomography and morbidity indices 2014
    2014 Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease 2014
    2014 Simvastatin for the prevention of exacerbations in moderate-to-severe COPD 2014
    2014 The efficacy of restaging endobronchial ultrasound in patients with non-small cell lung cancer after preoperative therapy 2014
    2014 Tumour necrosis factor receptor-75 and risk of COPD exacerbation in the azithromycin trial 2014
    2013 Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function 2013
    2013 Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function. 2013
    2013 Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbations 2013
    2013 AECOPD: Acute exacerbations of chronic obstructive cardiopulmonary disease? 2013
    2013 Pathophysiology and clinical implications of pulmonary arterial enlargement in COPD 2013
    2013 Heritability of pulmonary function estimated from pedigree and whole-genome markers 2013
    2013 Author's reply 2013
    2013 Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications 2013
    2013 Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688)) 2013
    2013 Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: Two replicate double-blind, parallel-group, randomised controlled trials 2013
    2013 GOLD 2011 disease severity classification in COPDGene: A prospective cohort study 2013
    2013 Racial differences in CT phenotypes in COPD 2013
    2013 Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD 2013
    2013 Chronic obstructive pulmonary disease and cardiovascular disease 2013
    2013 Effect of emphysema on CT scan measures of airway dimensions in smokers 2013
    2012 The authors reply 2012
    2012 Restrictive lung disease: Not restricted to the lung? 2012
    2012 Restrictive lung disease: not restricted to the lung? [Editorial]. 2012
    2012 Pulmonary arterial enlargement and acute exacerbations of COPD 2012
    2012 Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease 2012
    2012 Feasibility of exercising adults with asthma: a randomized pilot study 2012
    2012 A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease 2012
    2012 A combined pulmonary-radiology workshop for visual evaluation of COPD: Study design, chest CT findings and concordance with quantitative evaluation 2012
    2012 Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy 2012
    2012 Lung volume reduction for advanced emphysema: Surgical and bronchoscopic approaches 2012
    2012 Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease 2012
    2012 Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort 2012
    2011 Quantitative CT assessment of emphysema and airways in relation to lung cancer risk 2011
    2011 The clinical features of the overlap between COPD and asthma 2011
    2011 Effect of fluticasone propionate/salmeterol on arterial stiffness in patients with COPD 2011
    2011 Azithromycin for prevention of exacerbations of COPD 2011
    2011 Elevated levels of NO are localized to distal airways in asthma 2011
    2011 Disease severity and symptoms among patients receiving monotherapy for COPD 2011
    2011 Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization 2011
    2011 Genome-wide association study of smoking behaviours in patients with COPD 2011
    2011 Racial differences in quality of life in patients with COPD 2011
    2011 The relationship between small pulmonary vascular alteration and aortic atherosclerosis in chronic obstructive pulmonary disease. Quantitative CT analysis 2011
    2010 CT emphysema predicts thoracic aortic calcification in smokers with and without COPD 2010
    2010 Determining the optimal pneumococcal vaccination strategy for adults: Is there a role for the pneumococcal conjugate vaccine? 2010
    2010 Lung Function in Young Adults Predicts Airflow Obstruction 20 Years Later 2010
    2010 Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease 2010
    2010 Biologic lung volume reduction therapy for advanced homogeneous emphysema 2010
    2010 Quantitative CT Measurement of Cross-sectional Area of Small Pulmonary Vessel in COPD. Correlations with Emphysema and Airflow Limitation 2010
    2010 Quantitative assessment of bronchial wall attenuation with thin-section CT: An indicator of airflow limitation in chronic obstructive pulmonary disease 2010
    2010 The true false negative rates of esophageal and endobronchial ultrasound in the staging of mediastinal lymph nodes in patients with non-small cell lung cancer 2010
    2009 Superior immune response to protein-conjugate versus free pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease 2009
    2009 Airway wall attenuation: A biomarker of airway disease in subjects with COPD 2009
    2009 N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD 2009
    2009 Biologic lung volume reduction in advanced upper lobe emphysema phase 2 results 2009
    2009 Racial and sex differences in chronic obstructive pulmonary disease susceptibility, diagnosis, and treatment 2009
    2009 Sequential comparison of tiotropium to high-dose ipratropium in patients with chronic obstructive pulmonary disease in a practice setting. 2009
    2008 Authors' response 2008
    2008 Primary Care of the Patient with Chronic Obstructive Pulmonary Disease-Part 4: Understanding the Clinical Manifestations of a Progressive Disease 2008
    2008 Asthma exacerbations in African Americans treated for 1 year with combination fluticasone propionate and salmeterol or fluticasone propionate alone 2008
    2008 Use of β blockers and the risk of death in hospitalised patients with acute exacerbations of COPD 2008
    2008 Studying COPD in African-Americans: Better late than never 2008
    2008 Authors' response 2008
    2008 Pneumococcal vaccination for patients with COPD: Current practice and future directions 2008
    2007 Gender differences in the severity of CT emphysema in COPD 2007
    2006 COPD: Racial Disparities in Susceptibility, Treatment, and Outcomes 2006
    2006 Racial and gender differences in susceptibility to tobacco smoke among patients with chronic obstructive pulmonary disease 2006
    2006 An unusual cause of chronic cough: Foreign body aspiration 2006
    2006 Improving the lung cancer resection rate in the US department of Veterans Affairs health system 2006
    2005 Maintenance pharmacotherapy of chronic obstructive pulmonary disease: An evidence-based approach 2005
    2004 Fluticasone propionate/salmeterol for the treatment of chronic-obstructive pulmonary disease 2004
    2004 Standardized guidelines for surveillance bronchoscopy reduce complications in lung transplant recipients 2004
    2003 A Mycotic Pulmonary Artery Aneurysm Presenting as an Endobronchial Mass 2003

    Research Overview

  • Dr. Dransfield's primary research interests are Clinical Trials, Epidemiology and outcomes of COPD. He is Principal Investigator for multiple clinical trials at the UAB Lung Health Center including the NIH sponsored COPD Clinical Research Network studies and COPDGene as well as multiple phase II-IV pharma sponsored projects. As Medical Director of the LHC he also oversees multiple translational research projects focusing on airways disease. The LHC has the capability for all aspects of pulmonary function testing as well as research bronchoscopy and has active collaborations across campus for mass spectrometry and proteomics, synthetic chemistry, biospecimen analysis and storage, and murine physiology and sample analysis.
  • Principal Investigator On

  • Private Grant  awarded by GALA THERAPEUTICS INC 2018 - 2024
  • Private Grant  awarded by NUVAIRA INC 2019 - 2024
  • UAB CF Research and Translation Core Center - A Multicenter Randomized, Double-blind, Phase 2, Placebo Controlled Study to Determine the Safety and Efficacy of Ivacaftor (VX-770) for the Treatment of Chronic Obstructive Pulmonary Disease (The Multicenter Topic Trial).  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB Mentoring Program In COPD Patient Oriented Research  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2022
  • SPIROMICS II: Biological Underpinnings of COPD Heterogeneity and Progression  awarded by University of California, San Francisco 2017 - 2022
  • Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)  awarded by COPD FOUNDATION 2016 - 2022
  • Private Grant  awarded by MEREO BIOPHARMA 4 LIMITED 2017 - 2021
  • Private Grant  awarded by PNEUMRX, INC. 2016 - 2021
  • Beta Blockers for the Prevention of Acute Exacerbations of COPD  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2015 - 2020
  • AZD9688: A First in Class Disease Modifying Therapy to Treat Alpha-1 Antitrypsin Deficiency a Genetically Linked Orphan Disease  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2018 - 2020
  • Genetic Epidemiology of COPD  awarded by NATIONAL JEWISH MEDICAL RESEARCH CENTER 2013 - 2020
  • Airways Clinical Research Centers (ACRC) Network  awarded by American Lung Association 2019 - 2020
  • Chronic Refractory Cough Cohort Study (COCO) Trial  awarded by American Lung Association 2018 - 2020
  • The American Lung Association (ALA) Lung Health Cohort  awarded by Northwestern University 2019 - 2020
  • Private Grant  awarded by PULMONX 2013 - 2020
  • Private Grant  awarded by PNEUMRX, INC. 2014 - 2020
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) (RETHINC)  awarded by COPD FOUNDATION 2018 - 2019
  • ANDDi - American Lung Association Novel Digital Diary Trial  awarded by American Lung Association 2018 - 2019
  • Private Grant  awarded by GlaxoSmithKline 2017 - 2019
  • Asthma BMI Baseline Study (ABBS)  awarded by American Lung Association 2018 - 2019
  • SPIROMICS GIC Support  awarded by University of North Carolina at Chapel Hill 2018 - 2019
  • Network Management Cote (NEMO) for the Pulmonary Trials Cooperative (PTC) (INSIGHT)  awarded by COPD FOUNDATION 2017 - 2019
  • Airways Clinical Research Centers (ACRC) Network  awarded by American Lung Association 2018 - 2019
  • Prostaglandin Inhibition for Emphysema  awarded by UNIVERSITY OF NEBRASKA 2015 - 2019
  • Private Grant  awarded by BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2016 - 2019
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) LEEP (Losartan Effects on Emphysema Progression) Trial  awarded by American Lung Association 2017 - 2019
  • The Association of Allergic Disease with Clinical Outcomes in COPD  awarded by Johns Hopkins University 2018
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) (RETHINC)  awarded by COPD FOUNDATION 2017 - 2018
  • Airways Clinical Research Centers (ACRC)  awarded by American Lung Association 2017 - 2018
  • Reliability of a Portable Device to Measure Respiratory and Step Rates  awarded by UNIVERSITY OF NEBRASKA, OMAHA 2017 - 2018
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) RETHINC (Redefining Therapy in Early COPD)  awarded by University of Pittsburgh 2017
  • Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) INSIGHT (Intervention Study in Overweight Patients with COPD)  awarded by University of Pittsburgh 2016 - 2017
  • Private Grant  awarded by PNEUMRX, INC. 2016 - 2017
  • Private Grant  awarded by ASTRAZENECA PHARMACEUTICALS LP 2014 - 2017
  • Airways Clinical Research Center (ACRC)  awarded by American Lung Association 2016 - 2017
  • Mucus Microstructure and Osmotic Pressure: Biomarkers for CB in COPD  awarded by Johns Hopkins University 2015 - 2017
  • Private Grant  awarded by YUNGJIN PHARM. CO.,LTD. 2015 - 2017
  • Private Grant  awarded by BOSTON SCIENTIFIC CORPORATION 2011 - 2016
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION 2015 - 2016
  • Age Related Differences in Parametrics Response Mapping in COPD (Martinez Supplement)  awarded by University of Michigan 2015 - 2016
  • (Spiromics) SubPopulations and InteRmediate Outcome Measures in COPD Study  awarded by WAKE FOREST UNIVERSITY 2012 - 2016
  • (Spiromics) SubPopulations and InteRmediate Outcome Measures in COPD Study - Administrative Core  awarded by WAKE FOREST UNIVERSITY 2012 - 2016
  • (Spiromics) SubPopulations and InteRmediate Outcome Measures in COPD Study - Bronchoscopy - Project 1  awarded by WAKE FOREST UNIVERSITY 2012 - 2016
  • (Spiromics) SubPopulations and InteRmediate Outcome Measures in COPD Study - Exacerbation - Project 2  awarded by WAKE FOREST UNIVERSITY 2012 - 2016
  • Reliability of a Portable Device to Measure Respiratory and Step Rates  awarded by UNIVERSITY OF NEBRASKA 2015 - 2016
  • Private Grant  awarded by GlaxoSmithKline 2014 - 2016
  • Symbicort in HRCT-Defined Airway Predominant COPD  awarded by NATIONAL JEWISH MEDICAL RESEARCH CENTER 2014 - 2016
  • Private Grant  awarded by OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION, INC 2011 - 2015
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION 2015
  • Pharmacogenomics of Inhaled Corticosteroids to Reduce COPD Exacerbations  awarded by Brigham and Women's Hospital 2013 - 2015
  • Kit Inhibition in Asthma (KIA)  awarded by Brigham and Women's Hospital 2012 - 2015
  • Private Grant  awarded by GlaxoSmithKline 2013 - 2015
  • Private Grant  awarded by PEARL THERAPEUTICS 2013 - 2015
  • Private Grant  awarded by PEARL THERAPEUTICS 2014
  • COPD Clinical Research Network: STATCOPE Protocol  awarded by University of Minnesota 2011 - 2014
  • Private Grant  awarded by BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2013 - 2014
  • Private Grant  awarded by MedImmune 2012 - 2014
  • Private Grant  awarded by JANSSEN RESEARCH & DEVELOPMENT, LLC 2010 - 2014
  • Computed Tomographic Characterization of Subjects Enrolled in the STATCOPE Investigation  awarded by Brigham and Women's Hospital 2011 - 2014
  • Private Grant  awarded by GlaxoSmithKline 2011 - 2013
  • Private Grant  awarded by AERIS THERAPEUTICS, INC. 2012 - 2013
  • Private Grant  awarded by Pfizer Pharmaceuticals 2012 - 2013
  • Private Grant  awarded by BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2010 - 2013
  • Private Grant  awarded by GlaxoSmithKline 2012 - 2013
  • Private Grant  awarded by OLMSTED MEDICAL CENTER 2010 - 2012
  • Private Grant  awarded by GlaxoSmithKline 2011 - 2012
  • Private Grant  awarded by GlaxoSmithKline 2010 - 2012
  • Genetic Epidemiology of Chronic Obstructive Pulmonary Disease  awarded by NATIONAL JEWISH MEDICAL RESEARCH CENTER 2007 - 2012
  • Private Grant  awarded by BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2010 - 2012
  • Private Grant  awarded by GlaxoSmithKline 2010 - 2012
  • Private Grant  awarded by BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2009 - 2012
  • Private Grant  awarded by GlaxoSmithKline 2010 - 2012
  • Private Grant  awarded by ALLEGRO DIAGNOSTICS, INC. 2009 - 2012
  • Private Grant  awarded by GlaxoSmithKline 2009 - 2012
  • Development of a Tuberculosis-Specific Cultural Competency Guide for TB Program Staff Working with Foreign-Born Clients  awarded by SOUTHEASTERN NATIONAL TUBERCULOSIS CENTER 2010 - 2011
  • Private Grant  awarded by GlaxoSmithKline 2009 - 2011
  • UAB/BVAMC Clinical Center in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2008 - 2011
  • Private Grant  awarded by GlaxoSmithKline 2009 - 2011
  • Investigator On

  • A Novel Exosomal Inflammatory Pathway  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2023
  • Translational Program in CFTR-Related Airway Diseases  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2023
  • Private Grant  awarded by ASTRAZENECA PHARMACEUTICALS LP 2018 - 2023
  • Asthma Cohort Support Contract  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2013 - 2023
  • Roflumilast or Azithromycin to Prevent COPD Exacerbation (RELIANCE)  awarded by UNIVERSITY OF ILLINOIS (CHICAGO) 2018 - 2023
  • UAB CF Research and Translation Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Private Grant  awarded by GlaxoSmithKline 2018 - 2022
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2016 - 2021
  • Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of Chronic Obstructive Pulmonary Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2021
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION 2016 - 2020
  • Fibroblast Growth Factor 23/Klotho Crosstalk and Airway Epithelial Senescence in COPD  awarded by National Institute on Aging/NIH/DHHS 2018 - 2020
  • Acquired Deficiency of Innate Immunity (Ficolin-2) Among Elderly Adults  awarded by National Institute on Aging/NIH/DHHS 2015 - 2020
  • Network Medicine Approaches to Cachexia in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2020
  • Private Grant  awarded by Bayer AG 2017 - 2019
  • Lung Function Decline and Disease Risk from Young Adulthood to Middle Age  awarded by Northwestern University 2014 - 2019
  • A Pilot Study of the Effect of the CFTR Potentiator Ivacaftor in COPD (P-Topic)  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2019
  • Private Grant  awarded by VERACYTE, INC. 2015 - 2018
  • Private Grant  awarded by GlaxoSmithKline 2017 - 2018
  • UAB Lung Imaging Core  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2018
  • Private Grant  awarded by PEARL THERAPEUTICS 2018
  • Private Grant  awarded by MEREO BIOPHARMA 4 LIMITED 2018
  • Private Grant  awarded by PROTERIXBIO, INC. 2016 - 2018
  • Private Grant  awarded by ASTRAZENECA PHARMACEUTICALS LP 2015 - 2018
  • Evaluation of the Relationship Between Daytime Activity and Sleep on Asthma Symptoms in Pregnant Asthmatic Patients (B Well Mom Ancillary Study)  awarded by Northwestern University 2015 - 2018
  • Private Grant  awarded by FOREST RESEARCH INSTITUTE, INC. 2013 - 2017
  • COPD Get With it Program: Exercise Intervention to Reduce Hospital Readmissions  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2014 - 2017
  • PGP: A Possible Biomarker for COPD Exacerbations/ Progression  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2017
  • Molecular Pathogenesis and Phenotype of Acquired CFTR Dysfunction in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016
  • HL-A New Pathway for Neutrophil-Induced Airway Inflammation  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016
  • Acquired LTA4H Dysfunction in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2016
  • Private Grant  awarded by GlaxoSmithKline 2014 - 2016
  • Differentiation of Regulatory Myeloid-Derived Cells by Reactive Oxygen Species  awarded by PARKER B. FRANCIS FOUNDATION 2013 - 2016
  • Prevalence and Implications of Diastolic Dysfunction in Acute Exacerbations of Chronic Obstructive Pulmonary Disease  awarded by American Heart Association 2013 - 2016
  • Private Grant  awarded by GlaxoSmithKline 2015 - 2016
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2014 - 2016
  • Molecular Pathogenesis and Phenotype of Acquired CFTR Dysfunction in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2011 - 2016
  • LOTT Regional Clinical Centers  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2006 - 2016
  • Long Term Oxygen Treatment Trial (LOTT) Pharmacogenomics Ancillary Study  awarded by Brigham and Women's Hospital 2009 - 2015
  • Private Grant  awarded by GlaxoSmithKline 2014 - 2015
  • Private Grant  awarded by FOREST LABORATORIES, INC. 2012 - 2014
  • Second-Hand Smoke and Myeloid Cells in Asthma  awarded by Flight Attendant Medical Research Institute 2011 - 2014
  • Education And Training

  • UAB Hospital, Internship 1998
  • UAB Hospital, Residency 2000
  • UAB Hospital, Postdoctoral Fellowship 2003
  • Full Name

  • Mark Dransfield