Lori McMahon Wakefield

Lori McMahon Wakefield
Dean of the Graduate School

Senior Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine
Senior Scientist (C), Integrative Center for Aging Research , School of Medicine
Senior Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Scientist (C), Center for Cardiovascular Biology (Retired Org) , Medicine - Cardiovascular Disease
Associate Scientist (C), Alzheimer's Disease Center , Neurology
Investigator (C), Evelyn F. McKnight Brain Institute , Neurology
Associate Scientist (C), Civitan International Research Center , Academic Joint Departments
Assistant Professor (S), Neurobiology , Academic Joint Departments
Professor (P), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments
Senior Scientist (C), Center for Exercise Medicine , Cell, Developmental and Integrative Biology (CDIB)
Senior Scientist (C), Center for Integrated Systems , Electrical & Computer Engineering

Overview

Dr. Lori McMahon received her B.A., summa cum laude in Biology and Chemistry from Southern Illinois University at Edwardsville and her Ph.D. from Saint Louis University Health Sciences Center in St. Louis, Missouri. Dr. McMahon obtained postdoctoral training at Duke University Medical Center in the Department of Neurobiology and, in 1998, joined the faculty of UAB as an Assistant Professor in the Department of Physiology and Biophysics. She is currently the Jarman F. Lowder Professor of Neuroscience in the Department of Cell, Developmental, and Integrative Biology, Director of the UAB Comprehensive Neuroscience Center, and Dean of the UAB Graduate School. She is a basic neuroscientist whose laboratory research focuses on pathophysiological changes in neural circuit function in various rodent models of neurological and neuropsychiatric diseases.

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice. Neurobiology of Disease. 158. 2021
2021	PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons 2021
2021	Basal Synaptic Transmission and Long-Term Plasticity at CA3-CA1 Synapses Are Unaffected in Young Adult PINK1-Deficient Rats. Frontiers in Neuroscience. 15. 2021
2021	Feasibility of cerium-doped LSO particles as a scintillator for x-ray induced optogenetics 2021
2021	Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience. 2021
2021	Heightened hippocampal β-adrenergic receptor function drives synaptic potentiation and supports learning and memory in the TgF344-AD rat model during prodromal Alzheimer's disease 2021
2021	Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment. iScience. 24. 2021
2021	Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats. Neurobiology of Disease. 150. 2021
2021	Increased Excitability and Heightened Magnitude of Long-Term Potentiation at Hippocampal CA3–CA1 Synapses in a Mouse Model of Neonatal Hyperoxia Exposure. Frontiers in Synaptic Neuroscience. 12. 2021
2020	Increased O-GlcNAcylation rapidly decreases GABAAR currents in hippocampus but depresses neuronal output. Scientific Reports. 10. 2020
2020	Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability. eLife. 9:1-25. 2020
2020	The gut microbiome as a therapeutic target for cognitive impairment 2020
2019	Early Life Supraphysiological Levels of Oxygen Exposure Permanently Impairs Hippocampal Mitochondrial Function. Scientific Reports. 9. 2019
2019	Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation. Frontiers in Synaptic Neuroscience. 11. 2019
2019	Rats bred for high anxiety exhibit distinct fear-related coping behavior, hippocampal physiology, and synaptic plasticity-related gene expression 2019
2019	Diverse mechanisms lead to common dysfunction of striatal cholinergic interneurons in distinct genetic mouse models of Dystonia 2019
2019	LSO:Ce Inorganic Scintillators Are Biocompatible With Neuronal and Circuit Function. Frontiers in Synaptic Neuroscience. 11. 2019
2019	Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOE ε3, but not APOE ε4, targeted replacement mice. Neurobiology of Aging. 81:9-21. 2019
2019	Organic Fluorophore Coated Polycrystalline Ceramic LSO:Ce Scintillators for X-ray Bioimaging 2019
2018	Supraphysiological Levels of Oxygen Exposure During the Neonatal Period Impairs Signaling Pathways Required for Learning and Memory. Scientific Reports. 8. 2018
2018	Corrigendum to “Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model” [Neurobiology of Disease Volume 110, February 2018, Pages 166–179] (S0969996117302759) (10.1016/j.nbd.2017.11.014)). Neurobiology of Disease. 118:177-178. 2018
2018	Intravascular ketamine increases theta-burst but not high frequency tetanus induced LTP at CA3-CA1 synapses within three hours and devoid of an increase in spine density. Frontiers in Synaptic Neuroscience. 10. 2018
2018	Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy 2018
2018	Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model. Neurobiology of Disease. 110:166-179. 2018
2017	Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia. Experimental Neurology. 295:162-175. 2017
2017	Acute increases in protein O-GlcNAcylation dampen epileptiform activity in hippocampus 2017
2017	GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity 2017
2017	O-GlcNAcylation and neurodegeneration. Brain Research Bulletin. 133:80-87. 2017
2017	Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult mice. Neurobiology of Learning and Memory. 141:209-216. 2017
2016	17β estradiol recruits GluN2B-containing NMDARs and ERK during induction of long-term potentiation at temporoammonic-CA1 synapses 2016
2014	Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia 2014
2014	An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. Journal of Neurophysiology. 112:2388-2397. 2014
2014	Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice. Biological Psychiatry. 75:198-206. 2014
2014	O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses 2014
2014	17β Estradiol increases resilience and improves hippocampal synaptic function in helpless ovariectomized rats. Psychoneuroendocrinology. 42:77-88. 2014
2014	Estradiol replacement extends the window of opportunity forhippocampal function. Neurobiology of Aging. 35:2183-2192. 2014
2014	Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein. Neurobiology of Learning and Memory. 114:193-197. 2014
2014	Noradrenergic sympathetic sprouting and cholinergic reinnervation maintains non-amyloidogenic processing of AβPP. Journal of Alzheimer's Disease. 38:867-879. 2014
2014	Simvastatin treatment enhances NMDAR-mediated synaptic transmission by upregulating the surface distribution of the GluN2B subunit. Cellular and Molecular Neurobiology. 34:693-705. 2014
2013	Estradiol-induced increase in novel object recognition requires hippocampal NR2B-containing NMDA receptors 2013
2012	G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation 2012
2012	Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine 2012
2012	Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. Neuroscience. 202:1-9. 2012
2010	Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. Neuropsychopharmacology. 35:1761-1774. 2010
2010	Sympathetic sprouting in visual cortex stimulated by cholinergic denervation rescues expression of two forms of long-term depression at layer 2/3 synapses. Neuroscience. 168:591-604. 2010
2010	Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice. Neuroscience. 166:435-444. 2010
2009	Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3-CA1 synapses. Psychoneuroendocrinology. 34. 2009
2008	Layer 2/3 synapses in monocular and binocular regions of tree shrew visual cortex express mAChR-dependent long-term depression and long-term potentiation. Journal of Neurophysiology. 100:336-345. 2008
2008	Coactivation of M1 muscarinic and α1 adrenergic receptors stimulates extracellular signal-regulated protein kinase and induces long-term depression at CA3-CA1 synapses in rat hippocampus 2008
2007	Muscarinic receptor-dependent long-term depression in rat visual cortex is PKC independent but requires ERK1/2 activation and protein synthesis. Journal of Neurophysiology. 98:1862-1870. 2007
2006	Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses. Journal of Neurophysiology. 96:3114-3121. 2006
2006	Estradiol-induced increase in the magnitude of long-term potentiation is prevented by blocking NR2B-containing receptors 2006
2006	Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses 2006
2006	Glycine-gated chloride channels depress synaptic transmission in rat hippocampus. Journal of Neurophysiology. 95:2366-2379. 2006
2005	Estrogen-induced increase in the magnitude of long-term potentiation occurs only when the ratio of NMDA transmission to AMPA transmission is increased 2005
2004	Novel Form of Long-Term Synaptic Depression in Rat Hippocampus Induced by Activation of α1 Adrenergic Receptors. Journal of Neurophysiology. 91:1071-1077. 2004
2003	Immunolocalization of the acid-sensing ion channel 2a in the rat cerebellum. Histochemistry and Cell Biology. 119:437-446. 2003
2003	Strychnine-sensitive glycine receptors depress hyperexcitability in rat dentate gyrus. Journal of Neurophysiology. 89:1339-1342. 2003
2002	Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices. Journal of Neurophysiology. 87:1515-1525. 2002
1998	Functionally distinct groups of interneurons identified during rhythmic carbachol oscillations in hippocampus in vitro 1998
1997	Depressing transmission in GABAergic hippocampal neurons. Molecular Psychiatry. 2:434-436. 1997
1997	Hippocampal interneurons are excited via serotonin-gated ion channels. Journal of Neurophysiology. 78:2493-2502. 1997
1997	Hippocampal interneurons express a novel form of synaptic plasticity. Neuron. 18:295-305. 1997
1994	Nicotinic receptor activation facilitates GABAergic neurotransmission in the avian lateral spiriform nucleus.. Neuroscience. 59:689-698. 1994
1993	Different responses to opioids measured in terminals and somas of Edinger-Westphal neurons.. Neuroscience. 57:425-432. 1993
1991	The cannabinoid receptor: Biochemical and cellular properties in neuroblastoma cells 1991