Browse
Browse
Home
People
Organizations
Research
Events
Capability Map
Markus Bredel M.D., Ph.D.
Professor
Close
E-mail
mbredel@uab.edu
Links
UAB Department of Radiation Oncology
Provider Directory
Visualizations
Co-author Network
Map of Science
Co-investigator Network
Markus Bredel M.D., Ph.D.
Professor
Positions
Senior Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
Professor (S)
,
Neurosurgery
,
School of Medicine
Professor (P)
,
Radiation Oncology
,
School of Medicine
Director
,
Radiation Oncology
,
School of Medicine
Senior Scientist
,
Neuro-Oncology
,
O'Neal Comprehensive Cancer Center
Scholar (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Professor (S)
,
Genetics
,
Academic Joint Departments
Professor (S)
,
Cell, Developmental and Integrative Biology (CDIB)
,
Academic Joint Departments
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2019
Differential escape mechanisms in cetuximab-resistant head and neck cancer cells
.
Biochemical and Biophysical Research Communications
. 517:36-42.
2019
2019
Diagnosing growth in low-grade gliomas with and without longitudinal volume measurements: A retrospective observational study
.
PLoS Medicine
. 16.
2019
2019
Stereotactic radiosurgery with MLC-defined arcs: Verification of dosimetry, spatial accuracy, and end-to-end tests
.
Journal of Applied Clinical Medical Physics
. 20:84-98.
2019
2019
Pathologic Predictors of Local Recurrence in Atypical Meningiomas Following Gross Total Resection
2019
2018
The virtual cone: A novel technique to generate spherical dose distributions using a multileaf collimator and standardized control-point sequence for small target radiation surgery
.
Advances in Radiation Oncology
. 3:421-430.
2018
2018
MicroRNA-31 is required for astrocyte specification
.
Glia
. 66:987-998.
2018
2018
A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation
2018
2018
Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal disease
.
Journal of Clinical Neuroscience
. 49:48-55.
2018
2018
Structural connectivity–based segmentation of the thalamus and prediction of tremor improvement following thalamic deep brain stimulation of the ventral intermediate nucleus
.
NeuroImage: Clinical
. 20:1266-1273.
2018
2017
Macropinocytosis of bevacizumab by glioblastoma cells in the perivascular niche affects their survival
.
Clinical Cancer Research
. 23:7059-7071.
2017
2017
Fractionated stereotactic radiation therapy for intact brain metastases
.
Advances in Radiation Oncology
. 2:564-571.
2017
2017
Epigenetic regulation of ZBTB18 promotes glioblastoma progression
2017
2017
KLF6 depletion promotes NF-κB signaling in glioblastoma
.
Oncogene
. 36:3562-3575.
2017
2017
Molecular-based recursive partitioning analysis model for glioblastoma in the temozolomide era a correlative analysis based on nrg oncology RTOG 0525
.
JAMA Oncology
. 3:784-792.
2017
2017
Distant brain recurrence in patients with five or more newly diagnosed brain metastases treated with focal stereotactic radiotherapy alone.
.
Journal of Radiosurgery and SBRT
. 4:255-263.
2017
2016
Coneless Linear Accelerator-Based Volumetric Modulated Arc Therapy Stereotactic Radiosurgery Technique for Functional Disorders.
2016
2016
Distant Brain Recurrence in Patients With 5 or More Newly Diagnosed Brain Metastases Treated With Stereotactic Radiosurgery (SRS) or Fractionated Stereotactic Radiation Therapy (FSRT) Alone.
2016
2016
Stereotactic Hypofractionated Radiation Therapy for Intact Brain Metastases.
2016
2016
A phase II trial evaluating the effects and intra-tumoral penetration of bortezomib in patients with recurrent malignant gliomas
.
Journal of Neuro-Oncology
. 129:139-146.
2016
2016
SU-F-J-96: Comparison of Frame-Based and Mutual Information Registration Techniques for CT and MR Image Sets.
.
Medical Physics
. 43:3428-3429.
2016
2015
Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition
.
BMC Cancer
. 15.
2015
2015
Neuronal activity promotes glioma growth through neuroligin-3 secretion
.
Cell
. 161:803-816.
2015
2015
Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy
.
Neuro-Oncology
. 17:392-406.
2015
2015
Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma
.
Oncotarget
. 6:17805-17816.
2015
2014
Hypofractionated stereotactic radiosurgery with concurrent bevacizumab for recurrent malignant gliomas: The University of Alabama at Birmingham experience
2014
2014
Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression
.
Journal of Clinical Investigation
. 124:2861-2876.
2014
2014
A20 expressing tumors and anticancer drug resistance
.
Advances in Experimental Medicine and Biology
. 809:65-81.
2014
2014
Illuminating radiogenomic characteristics of glioblastoma multiforme through integration of MR imaging, messenger RNA expression, and DNA copy number variation
.
Radiology
. 270:212-222.
2014
2014
Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines
.
Radiotherapy and Oncology
. 111:468-474.
2014
2013
Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma
.
Clinical Cancer Research
. 19:6484-6494.
2013
2013
Feature selection and survival modeling in The Cancer Genome Atlas
.
International Journal of Nanomedicine
. 8:57-62.
2013
2013
RTOG 0211: A phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients
2013
2012
Laminin alpha 2 enables glioblastoma stem cell growth
.
Annals of Neurology
. 72:766-778.
2012
2012
Glioblastoma multiforme
.
Neurology Research International
. 2012.
2012
2012
Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma
.
Journal of Cellular and Molecular Medicine
. 16:545-554.
2012
2011
Gene-protein correlation in single cells
.
Neuro-Oncology
. 13:880-885.
2011
2011
The authors reply
.
New England Journal of Medicine
. 365:277-278.
2011
2011
Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2
.
Cell
. 146:53-66.
2011
2011
NFKBIA deletion in glioblastomas
.
New England Journal of Medicine
. 364:627-637.
2011
2011
Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3
.
Cancer Cell
. 19:498-511.
2011
2010
A phase 2 trial of single-agent bevacizumab given in an every-3-week schedule for patients with recurrent high-grade gliomas
.
Cancer
. 116:5297-5305.
2010
2009
Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults
.
BMC Cancer
. 9:372.
2009
2009
Translating biological insights into clinical endpoints in neuro-oncology
2009
2009
A network model of a cooperative genetic landscape in brain tumors
2009
2009
Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas
2009
2009
Role of IκBα as a negative regulator of EGFR and a molecular determinant of prognosis in glioblastoma multiforme.
.
Journal of Clinical Oncology
. 27:2028.
2009
2009
Genomics of human intracranial aneurysm wall
.
Stroke
. 40:1252-1261.
2009
2008
Use of gene signatures to improve risk estimation in cancer
2008
2008
Nomograms as clinicobiological predictors of survival in glioblastoma
2008
2007
Integrated high-resolution genome-wide analysis of gene dosage and gene expression in human brain tumors
.
Methods in Molecular Biology
. 377:187-202.
2007
2007
CHD5 Is a Tumor Suppressor at Human 1p36
.
Cell
. 128:459-475.
2007
2007
Integrated high-resolution genome-wide analysis of gene dosage and gene expression in human brain tumors.
.
Methods in Molecular Biology
. 377:187-202.
2007
2006
Tumor necrosis factor-α-induced protein 3 down-regulates nuclear factor-κB-mediated drug resistance in vitro and is a favorable clinical prognostic factor in human glioblastomas.
.
Journal of Clinical Oncology
. 24:1508.
2006
2006
Tumor necrosis factor-α-induced protein 3 as a putative regulator of nuclear factor-κB-mediated resistance to O
6
-alkylating agents in human glioblastomas
.
Journal of Clinical Oncology
. 24:274-287.
2006
2005
Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas
.
Cancer Research
. 65:8679-8689.
2005
2005
893 High-resolution Mapping of Human Glioma Genomes.
.
Neurosurgery
. 57:427-428.
2005
2005
High-resolution genome-wide mapping of genetic alterations in human glial brain tumors
.
Cancer Research
. 65:4088-4096.
2005
2005
Amplification of whole tumor genomes and gene-by-gene mapping of genomic aberrations from limited sources of fresh-frozen and paraffin-embedded DNA
2005
2005
DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomas.
.
International Journal of Oncology
. 26:1187-1192.
2005
2004
Chemogenomics: An emerging strategy for rapid target and drug discovery
.
Nature Reviews Genetics
. 5:262-275.
2004
2004
Genomics-based hypothesis generation: A novel approach to unravelling drug resistance in brain tumours?
2004
2003
Predicting outcome and tailoring treatment in high-grade gliomas
2003
2003
Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: Evidence for distinct angiogenic subtypes
.
Brain Pathology
. 13:133-143.
2003
2002
Expression of DNA topoisomerase IIα in oligodendroglioma
2002
2002
High expression of DNA topoisomerase IIα and Ki-67 antigen is associated with prolonged survival in glioblastoma patients
.
European journal of cancer
. 38:1343-1347.
2002
2002
DNA topoisomerase IIα predicts progression-free and overall survival in pediatric malignant non-brainstem gliomas
.
International Journal of Cancer
. 99:817-820.
2002
2002
Expression of DNA topoisomerase IIalpha in oligodendroglioma.
2002
2002
DNA topoisomerase IIα expression in optic pathway gliomas of childhood
.
European journal of cancer
. 38:393-400.
2002
2002
Brain-tumour drug resistance: The bare essentials
2002
2001
Anticancer drug resistance in primary human brain tumors
.
Brain Research Reviews
. 35:161-204.
2001
1999
Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II - Preclinical studies in a nude mouse model
.
Neurosurgery
. 45:1208-1215.
1999
1999
Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood
.
Clinical Cancer Research
. 5:1786-1792.
1999
1999
Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion
.
Journal of Neuro-Oncology
. 41:9-20.
1999
1999
The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas
.
Brain Research Reviews
. 29:232-249.
1999
1998
Application of signal transduction inhibition as a therapeutic strategy for central nervous system tumors
.
Pediatric Neurosurgery
. 29:228-244.
1998
1998
Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth
.
Neurosurgery
. 43:124-132.
1998
1997
Basic fibroblast growth factor expression as a predictor of prognosis in pediatric high-grade gliomas
.
Clinical Cancer Research
. 3:2157-2164.
1997
1997
The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy
1997
Chapter
Filter
Year
Title
Altmetric
2014
Primary Tumors of the Nervous System
2014
2013
Primary Tumors of the Nervous System
. 1-22.
2013
Research
Principal Investigator On
Aberrant NFkB Signaling in Alzheimer's Disease and its Effects on Neural Stem Cells.
awarded by
ALZHEIMER'S OF CENTRAL ALABAMA
Identifying Activators and Inhibitors of Neural Stem Cell Growth
awarded by
ALZHEIMER'S OF CENTRAL ALABAMA
Integrated Pharmacogenomic/Pharmacokinomic Approach to Optimize GBM Therapy
awarded by
National Brain Tumor Society
NFKBIA Deletions in DIPG
awarded by
Stanford University
Private Grant
awarded by
VARIAN MEDICAL SYSTEMS, INC.
Tissue-Regulated Lineage-Specific Splicing in Glioblastoma Pathogenesis
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
Investigator On
Contemporary Therapeutics for Anaplastic Gliomas
awarded by
National Cancer Institute/NIH/DHHS
Contemporary Therapeutics for Anaplastic Gliomas - Brain Tumor Tissue Core
awarded by
National Cancer Institute/NIH/DHHS
ECOG-ACRIN Purchase Service Agreement
awarded by
Eastern Cooperative Oncology Group
Markers of Cardiotoxicity with Radiation Therapy in Breast Cancer
awarded by
University of Pennsylvania
Markers of Cardiotoxicity with Radiation Therapy in Breast Cancer-Fixed Price
awarded by
University of Pennsylvania
NRG Oncology Member Institution Clinical Trial Fixed Price Subaward Agreement
awarded by
NRG ONCOLOGY FOUNDATION
Pragmatic Phase III Randomized Trial of Proton vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial
awarded by
University of Pennsylvania
Private Grant
awarded by
NOVOCURE, INC.
Private Grant
awarded by
NOVOCURE, INC.
Private Grant
awarded by
VARIAN MEDICAL SYSTEMS, INC.
Private Grant
awarded by
BLUE EARTH DIAGNONSTICS LTD ^
Private Grant
awarded by
MERCK SHARP & DOHME CORP
TBCRC 038: Diversity in the Tumor Genome and Microenvironment as Drivers of DCIS Progession
awarded by
Duke University
Targeting the JAK/STAT-3 Pathway Signaling Axis in Glioma
awarded by
National Cancer Institute/NIH/DHHS
The Role of CK2 in Glioblastoma Development
awarded by
National Cancer Institute/NIH/DHHS
UAB NRG Oncology Master Institution Purchased Service Agreement
awarded by
NRG ONCOLOGY FOUNDATION
UAB NRG Oncology Member Institution Purchased Service Agreement
awarded by
NRG ONCOLOGY FOUNDATION
UAB NRG Oncology Member Institution Purchased Service Agreement
awarded by
NRG ONCOLOGY FOUNDATION
XUAB 17109-TBCRC 038: Diversity in the Tumor Genome and Microenvironment as Drivers of DCIS Progression
awarded by
Johns Hopkins University
Background
Education And Training
UAB Hospital, Residency
Stanford University School of Medicine, Postdoctoral Fellowship
Doctor of Medicine,
University of Vienna
2001
Doctor of Philosophy in Medical Neurobiology,
Free University of Berlin
2001
Contact
Full Name
Markus
Bredel