Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Differential escape mechanisms in cetuximab-resistant head and neck cancer cells 2019
2019 Diagnosing growth in low-grade gliomas with and without longitudinal volume measurements: A retrospective observational study 2019
2019 Stereotactic radiosurgery with MLC-defined arcs: Verification of dosimetry, spatial accuracy, and end-to-end tests 2019
2019 Pathologic Predictors of Local Recurrence in Atypical Meningiomas Following Gross Total Resection 2019
2018 The virtual cone: A novel technique to generate spherical dose distributions using a multileaf collimator and standardized control-point sequence for small target radiation surgery 2018
2018 MicroRNA-31 is required for astrocyte specification 2018
2018 A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation 2018
2018 Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal disease 2018
2018 Structural connectivity–based segmentation of the thalamus and prediction of tremor improvement following thalamic deep brain stimulation of the ventral intermediate nucleus 2018
2017 Macropinocytosis of bevacizumab by glioblastoma cells in the perivascular niche affects their survival 2017
2017 Fractionated stereotactic radiation therapy for intact brain metastases 2017
2017 Epigenetic regulation of ZBTB18 promotes glioblastoma progression 2017
2017 KLF6 depletion promotes NF-κB signaling in glioblastoma 2017
2017 Molecular-based recursive partitioning analysis model for glioblastoma in the temozolomide era a correlative analysis based on nrg oncology RTOG 0525 2017
2017 Distant brain recurrence in patients with five or more newly diagnosed brain metastases treated with focal stereotactic radiotherapy alone. 2017
2016 Coneless Linear Accelerator-Based Volumetric Modulated Arc Therapy Stereotactic Radiosurgery Technique for Functional Disorders. 2016
2016 Distant Brain Recurrence in Patients With 5 or More Newly Diagnosed Brain Metastases Treated With Stereotactic Radiosurgery (SRS) or Fractionated Stereotactic Radiation Therapy (FSRT) Alone. 2016
2016 Stereotactic Hypofractionated Radiation Therapy for Intact Brain Metastases. 2016
2016 A phase II trial evaluating the effects and intra-tumoral penetration of bortezomib in patients with recurrent malignant gliomas 2016
2016 SU-F-J-96: Comparison of Frame-Based and Mutual Information Registration Techniques for CT and MR Image Sets. 2016
2015 Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition 2015
2015 Neuronal activity promotes glioma growth through neuroligin-3 secretion 2015
2015 Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy 2015
2015 Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma 2015
2014 Hypofractionated stereotactic radiosurgery with concurrent bevacizumab for recurrent malignant gliomas: The University of Alabama at Birmingham experience 2014
2014 Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression 2014
2014 A20 expressing tumors and anticancer drug resistance 2014
2014 Illuminating radiogenomic characteristics of glioblastoma multiforme through integration of MR imaging, messenger RNA expression, and DNA copy number variation 2014
2014 Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines 2014
2013 Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma 2013
2013 Feature selection and survival modeling in The Cancer Genome Atlas 2013
2013 RTOG 0211: A phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients 2013
2012 Laminin alpha 2 enables glioblastoma stem cell growth 2012
2012 Glioblastoma multiforme 2012
2012 Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma 2012
2011 Gene-protein correlation in single cells 2011
2011 The authors reply 2011
2011 Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2 2011
2011 Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3 2011
2011 NFKBIA deletion in glioblastomas 2011
2010 A phase 2 trial of single-agent bevacizumab given in an every-3-week schedule for patients with recurrent high-grade gliomas 2010
2009 Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults 2009
2009 Translating biological insights into clinical endpoints in neuro-oncology 2009
2009 A network model of a cooperative genetic landscape in brain tumors 2009
2009 Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas 2009
2009 Role of IκBα as a negative regulator of EGFR and a molecular determinant of prognosis in glioblastoma multiforme. 2009
2009 Genomics of human intracranial aneurysm wall 2009
2008 Use of gene signatures to improve risk estimation in cancer 2008
2008 Nomograms as clinicobiological predictors of survival in glioblastoma 2008
2007 Integrated high-resolution genome-wide analysis of gene dosage and gene expression in human brain tumors 2007
2007 CHD5 Is a Tumor Suppressor at Human 1p36 2007
2007 Integrated high-resolution genome-wide analysis of gene dosage and gene expression in human brain tumors. 2007
2006 Tumor necrosis factor-α-induced protein 3 down-regulates nuclear factor-κB-mediated drug resistance in vitro and is a favorable clinical prognostic factor in human glioblastomas. 2006
2006 Tumor necrosis factor-α-induced protein 3 as a putative regulator of nuclear factor-κB-mediated resistance to O6-alkylating agents in human glioblastomas 2006
2005 Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas 2005
2005 893 High-resolution Mapping of Human Glioma Genomes. 2005
2005 High-resolution genome-wide mapping of genetic alterations in human glial brain tumors 2005
2005 Amplification of whole tumor genomes and gene-by-gene mapping of genomic aberrations from limited sources of fresh-frozen and paraffin-embedded DNA 2005
2005 DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomas. 2005
2004 Chemogenomics: An emerging strategy for rapid target and drug discovery 2004
2004 Genomics-based hypothesis generation: A novel approach to unravelling drug resistance in brain tumours? 2004
2003 Predicting outcome and tailoring treatment in high-grade gliomas 2003
2003 Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: Evidence for distinct angiogenic subtypes 2003
2002 Expression of DNA topoisomerase IIα in oligodendroglioma 2002
2002 High expression of DNA topoisomerase IIα and Ki-67 antigen is associated with prolonged survival in glioblastoma patients 2002
2002 DNA topoisomerase IIα predicts progression-free and overall survival in pediatric malignant non-brainstem gliomas 2002
2002 Expression of DNA topoisomerase IIalpha in oligodendroglioma. 2002
2002 DNA topoisomerase IIα expression in optic pathway gliomas of childhood 2002
2002 Brain-tumour drug resistance: The bare essentials 2002
2001 Anticancer drug resistance in primary human brain tumors 2001
1999 Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II - Preclinical studies in a nude mouse model 1999
1999 Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood 1999
1999 Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion 1999
1999 The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas 1999
1998 Application of signal transduction inhibition as a therapeutic strategy for central nervous system tumors 1998
1998 Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth 1998
1997 Basic fibroblast growth factor expression as a predictor of prognosis in pediatric high-grade gliomas 1997
1997 The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy 1997

Chapter

Year Title Altmetric
2014 Primary Tumors of the Nervous System 2014
2013 Primary Tumors of the Nervous System.  1-22. 2013

Education And Training

  • UAB Hospital, Residency 2014
  • Stanford University School of Medicine, Postdoctoral Fellowship 2005
  • Full Name

  • Markus Bredel