Selected Publications

Academic Article

Year Title Altmetric
2020 Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic Retina 2020
2020 LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target 2020
2019 Progenitor cell combination normalizes retinal vascular development in the oxygen-induced retinopathy (OIR) model 2019
2018 Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction 2018
2018 Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization 2018
2018 Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice 2018
2018 Enteral arg-gln dipeptide administration increases retinal docosahexaenoic acid and neuroprotectin D1 in a murine model of retinopathy of prematurity 2018
2018 Improving the Transduction of Bone Marrow-Derived Cells with an Integrase-Defective Lentiviral Vector 2018
2018 Chemical Proteomics Reveals Soluble Epoxide Hydrolase as a Therapeutic Target for Ocular Neovascularization 2018
2017 Ferrochelatase is a therapeutic target for ocular neovascularization 2017
2017 Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells 2017
2017 Erratum to: CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes (Journal of Molecular Medicine, (2016), 94, 11, (1255-1265), 10.1007/s00109-016-1433-0) 2017
2017 Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration 2017
2017 Oxidative stress-mediated NFeκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy 2017
2016 CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes 2016
2016 A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy 2016
2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 2016
2016 Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 2016
2016 PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration 2016
2015 Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus after Intravenous Injection 2015
2015 A simple optical coherence tomography quantification method for choroidal neovascularization 2015
2015 Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium 2015
2014 Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD 2014
2014 Regulation of retinal inflammation by rhythmic expression of miR-146a in diabetic Retina 2014
2014 Changes in the daily rhythm of lipid metabolism in the diabetic retina 2014
2014 Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms 2014
2014 CD82 restrains pathological Angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cells 2014
2014 Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes 2014
2014 Studying melanin and lipofuscin in RPE cell culture models 2014
2013 Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes 2013
2013 CNS inflammation and bone marrow neuropathy in type 1 diabetes 2013
2013 Enhancing the function of CD34+ cells by targeting plasminogen activator inhibitor-1 2013
2013 Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology 2013
2013 Pathogenic role of diabetes-induced PPAR-α down-regulation in microvascular dysfunction 2013
2013 Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development 2013
2013 Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization 2013
2013 Non-dimensional analysis of retinal microaneurysms: Critical threshold for treatment 2013
2013 Assessment of mitochondrial damage in retinal cells and tissues using quantitative polymerase chain reaction for mitochondrial DNA damage and extracellular flux assay for mitochondrial respiration activity 2013
2013 Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration 2013
2013 Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrow 2013
2012 Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation 2012
2012 Concentration dependence of vitamin C in combinations with vitamin e and zeaxanthin on light-induced toxicity to retinal pigment epithelial cells 2012
2012 Cytotoxicity of all-trans-retinal increases upon photodegradation 2012
2012 β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment 2012
2012 Consequences of oxidative stress in age-related macular degeneration 2012
2012 Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3 2012
2012 The 5HT 1a receptor agonist 8-OH DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium 2012
2012 Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate 2012
2012 γ-secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines 2012
2012 Nerve growth factor promotes endothelial progenitor cell-mediated angiogenic responses. 2012
2011 γ-secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1 2011
2011 αB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cells 2011
2011 Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase) 2011
2011 Epidermal growth factor: The driving force in initiation of RPE cell proliferation 2011
2011 PEDF regulates vascular permeability by a γ-secretase-mediated pathway 2011
2011 Involvement of the CD200 receptor complex in microglia activation in experimental glaucoma 2011
2011 Mitochondrial DNA damage and repair in rpe associated with aging and age-related macular degeneration 2011
2011 Transretinal degeneration in ageing human retina: A multiphoton microscopy analysis 2011
2011 Tear film volume and protein analysis in full-term newborn infants 2011
2011 A role for Notch signaling in corneal wound healing 2011
2011 Adhesion of laser in situ keratomileusis-like flaps in the cornea: Effects of crosslinking, stromal fibroblasts, and cytokine treatment 2011
2011 In pursuit of new anti-angiogenic therapies for cancer treatment 2011
2011 Placenta growth factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeability 2011
2010 Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane 2010
2010 The importance of Mitochondria in age-related and inherited eye disorders 2010
2009 Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock 2009
2009 Activation of the β-catenin signaling pathway and its impact on RPE cell cycle 2009
2009 Topography of neuron loss in the retinal ganglion cell layer in human glaucoma 2009
2009 Using LC3 to monitor autophagy flux in the retinal pigment epithelium 2009
2009 Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation 2009
2009 Erratum: "Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair" (Molecular Theraphy (2009) 10.1038/mt.2009.145) 2009
2009 Lipofuscin phototoxicity: Reality or myth? 2009
2009 Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development 2009
2009 Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas 2009
2009 Effect of signal intensity normalization on the multivariate analysis of spectral data in complex 'real-world' datasets 2009
2009 Effects on collagen orientation in the cornea after trephine injury 2009
2009 Activation of the wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models 2009
2009 Advanced glycation end product (AGE) accumulation on Bruch's membrane: Links to age-related RPE dysfunction 2009
2009 Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair 2009
2008 Mitochondrial DNA damage and its potential role in retinal degeneration 2008
2008 Tear sample collection using cellulose acetate absorbent filters 2008
2008 Carbomer and sodium hyaluronate eyedrops for moderate dry eye treatment 2008
2008 Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation 2008
2008 Retinal pigment epithelium lipofuscin proteomics 2008
2008 Intraretinal leakage and oxidation of LDL in diabetic retinopathy 2008
2008 γ-Secretase: A multifaceted regulator of angiogenesis: Angiogenesis Review Series 2008
2008 The phototoxicity of aged human retinal melanosomes 2008
2008 Quantification of retinal transneuronal degeneration in human glaucoma: A novel multiphoton-DAPI approach 2008
2008 The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy 2008
2008 A missense mutation in the murine Opa3 gene models human Costeff syndrome 2008
2008 Erythropoietin: When liability becomes asset in neurovascular repair 2008
2007 Retinal and choroidal microangiopathies: Therapeutic opportunities 2007
2007 A role for notch signaling in human corneal epithelial cell differentiation and proliferation 2007
2007 Choroidal neovascularization: New dynamics of the VEGF signaling system 2007
2007 Poly(ADP-ribose) polymerase offers protection against oxidative and alkylation damage to the nuclear and mitochondrial genomes of the retinal pigment epithelium 2007
2007 L-carnitine protects human retinal pigment epithelial cells from oxidative damage 2007
2007 Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function 2007
2007 Connective tissue structure of the tree shrew optic nerve and associated ageing changes 2007
2007 Vascular endothelial growth factor C promotes survival of retinal vascular endothelial cells via vascular endothelial growth factor receptor-2 2007
2007 Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch's membrane leading to accurate, nondestructive prediction of ocular aging 2007
2006 Protein quality control by the ubiquitin proteolytic pathway: Roles in resistance to oxidative stress and disease 2006
2006 The contribution of DNA repair and antioxidants in determining cell type-specific resistance to oxidative stress 2006
2006 Dietary antioxidants provide differential subcellular protection in epithelial cells 2006
2006 VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cells 2006
2006 Decreased pigment epithelium-derived factor expression in human breast cancer progression 2006
2006 Differential regulation of key stages in early corneal wound healing by TGF-β isoforms and their inhibitors 2006
2006 Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1 2006
2006 Effects of VEGFR-1, VEGFR-2, and IGF-IR hammerhead ribozymes on glucose-mediated tight junction expression in cultured human retinal endothelial cells 2006
2006 Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eye 2006
2006 Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOS 2006
2005 Evidence of a distinct lipid fraction in historical parchments: A potential role in degradation? 2005
2005 Placenta growth factor is over-expressed and has prognostic value in human breast cancer 2005
2005 Blue light induces mitochondrial DNA damage and free radical production in epithelial cells 2005
2005 Antioxidant up-regulation and increased nuclear DNA protection play key roles in adaptation to oxidative stress in epithelial cells 2005
2005 Angiopoietin concentrations in diabetic retinopathy 2005
2005 Hepatocyte growth factor and keratinocyte growth factor regulation of epithelial and stromal corneal wound healing 2005
2005 RPE lipofuscin and its role in retinal pathobiology 2005
2004 Do blue light filters confer protection against age-related macular degeneration? 2004
2004 RPE transplantation: The challenges and the future 2004
2004 The photoreactivity of ocular lipofuscin 2004
2004 Age-related changes in the photoreactivity of retinal lipofuscin granules: Role of chloroform-insoluble components 2004
2004 Stem cells in the eye 2004
2004 Ageing of the retinal pigment epithelium: Implications for transplantation 2004
2004 Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2 2004
2003 Activation of Vascular Endothelial Growth Factor Receptor-1 Sustains Angiogenesis and Bcl-2 Expression Via the Phosphatidylinositol 3-Kinase Pathway in Endothelial Cells 2003
2002 Photoreactivity of aged human RPE melanosomes: A comparison with lipofuscin 2002
2002 The pathogenesis of diabetic retinopathy: Old concepts and new questions 2002
2001 Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin 2001
2001 Retinal photodamage 2001
2001 Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells 2001
2001 Oxygen modulates the release of urokinase and plasminogen activator inhibitor-1 by retinal pigment epithelial cells 2001
2001 Macular pigment and risk for age-related macular degeneration in subjects from a northern European population 2001
2001 Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease 2001
2001 The role of the retinal pigment epithelium: Topographical variation and ageing changes 2001
2000 Regulation of tyrosinase expression and activity in cultured human retinal pigment epithelial cells 2000
2000 Apoptosis in the endothelium of human corneas for transplantation 2000
2000 Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin 2000
2000 Adenovirus-mediated gene transfer to human lens epithelial cells in organ culture 2000
2000 IL-10 and antibodies to TGF-β2 and PDGF inhibit RPE-mediated retinal contraction 2000
2000 Expression of a single pair of desmosomal glycoproteins renders the corneal epithelium unique amongst stratified epithelia 2000
2000 A fluorescent compound of lipofuscin, A2-E, is a photosensitizer in human retinal pigment epithelial cells 2000
2000 Centration of donor trephination in human corneal transplantation 2000
2000 Influence of pigment content, intracellular calcium and cyclic AMP on the ability of human retinal pigment epithelial cells to contract collagen gels 2000
2000 Optimization of non-viral gene transfer to human primary retinal pigment epithelial cells 2000
2000 Protein kinase C isoenzyme expression in retinal cells 2000
2000 The role of oxidative stress in the pathogenesis of age-related macular degeneration 2000
1999 The photoreactivity of the retinal age pigment lipofuscin 1999
1999 Positive correlation between mammalian life span and cellular resistance to stress 1999
1999 A role for hepatocyte growth factor in diabetic retinopathy? 1999
1999 Growth factor staining patterns in the pig retina following retinal laser photocoagulation 1999
1999 Immunolocalisation of the VEGF receptors FLT-1, KDR, and FLT-4 in diabetic retinopathy 1999
1999 Lipofuscin turnover [1] (multiple letters) 1999
1999 Macular pigment and age related macular degeneration 1999
1999 Ophthalmology in the post-genomic era 1999
1999 Oxidative damage and age-related macular degeneration. 1999
1999 Three dimensional analysis of microaneurysms in the human diabetic retina 1999
1998 Involvement of calcium in retinal pigment epithelial cell proliferation and pigmentation 1998
1998 Fluorescence properties of autofluorescent granules generated by cultured human RPE cells 1998
1998 Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media 1998
1998 Adhesion of IOLs to the posterior capsule. 1998
1998 Endothelial viability of organ-cultured corneas following penetrating keratoplasty 1998
1998 Increased expression of placenta growth factor in proliferative diabetic retinopathy 1998
1998 Lens epithelial cell proliferation, migration, and metaplasia following capsulorhexis 1998
1998 The effects of growth factors and conditioned media on the proliferation of human corneal epithelial cells and keratocytes 1998
1998 VEGF localisation in diabetic retinopathy 1998
1997 Melanogenesis in cultured canine RPE cells 1997
1997 Cell attachment to, and contraction of, the retina in vitro 1997
1997 A role for vitamin A in the formation of ocular lipofuscin 1997
1997 Intravitreal growth factors in proliferative diabetic retinopathy: Correlation with neovascular activity and glycaemic management 1997
1996 Oxygen modulates the response of the retinal pigment epithelium to basic fibroblast growth factor and epidermal growth factor by receptor regulation 1996
1996 Aerobic photoreactions of retinal pigment granules with aging 1996
1996 The effect of growth factors and conditioned media on the proliferation of human corneal epithelial cells and keratocytes 1996
1996 The potential phototoxicity of retinal lipofuscin 1996
1996 VEGF distribution in proliferative diabetic retinopathy 1996
1996 A simple organ culture model for assessing the effects of growth factors on corneal re-epithelialization 1996
1996 Diurnal variations in human corneal thickness 1996
1996 Dual immunodetection and hybridisation in situ of opsin mrna and rhodopsin protein in retinal sections 1996
1996 Immunocytochemical study of retinal diode laser photocoagulation in the rat 1996
1996 Retinal pigment epithelial dystrophy in Briard dogs 1996
1996 The effect of scatter laser photocoagulation on intravitreal levels of growth factors in the miniature pig 1996
1996 Three dimensional analysis of the retinal vasculature using immunofluorescent staining and confocal laser scanning microscopy 1996
1995 Hypoxia induces HSP 70 gene expression in human hepatoma (HEP G2) cells 1995
1995 Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species 1995
1995 Massive proliferation of lens epithelial remnants after Nd-YAG laser capsulotomy 1995
1995 Oxygen modulates production of bFGF and TGF-β by retinal cells in vitro 1995
1994 Effect of 'Hypoxia' on the Proliferation of Microvascular Cells in Vitro 1994
1994 Cell attachment to standard and surface-modified intraocular lenses 1994
1994 Membrane-bound carbonic anhydrase in human retinal pigment epithelium 1994
1994 Oxygen regulation of TGF-β1 mRNA in human hepatoma (HEP G2) cells 1994
1994 Production of IGF-I and IGF binding proteins by retinal cells in vitro 1994
1994 Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epithelium 1994
1994 Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathy 1994
1993 Glycan localization within the human interphotoreceptor matrix and photoreceptor inner and outer segments 1993
1993 Lipofuscin is a photoinducible free radical generator 1993
1992 Biological activities of vitreous gel, retrohyaloid fluid and subretinal fluid from diabetic and non-diabetic eyes 1992
1992 Modulators and milieu in preretinal neovascularisation 1992
1991 Chapter 6 Ageing of the retinal pigment epithelium 1991
1991 Effect of varying oxygen concentrations on the proliferation of retinal microvascular cells in vitro 1991
1991 Temporal variations in the ionic transport across rabbit retinal pigment epithelium 1991
1990 Formation of "vessel-like" structures by retinal capillary endothelial cells in culture 1990
1990 Age-related changes in the morphology, absorption and fluorescence of melanosomes and lipofuscin granules of the retinal pigment epithelium 1990
1990 Cell culture 1990
1990 Inhibition of microvascular endothelial cell proliferation by vitreous following retinal scatter photocoagulation 1990
1990 Regional distribution of lysosomal enzymes in the canine retinal pigment epithelium 1990
1990 Time-Resolved Fluorescence Spectroscopy of the Retinal Pigment Epithelium: Age-Related Studies 1990
1989 Inherited retinal dystrophies: Cell biology and interacting co-factors 1989
1989 Growth characteristics of central and peripheral bovine corneal epithelial cells in vitro 1989
1989 The formation of autofluorescent granules in cultured human RPE 1989
1989 Assessment of corneal wound repair in vitro 1989
1989 Effect of the fluorinated gases SF6 and C3F8 on ocular tissues following laser treatment 1989
1989 Transplantation of retinal pigment epithelium using a pars plana approach 1989
1988 A microsystem to assay lysosomal enzyme activities in cultured retinal pigment epithelial cells 1988
1988 Editorial: Research reviews from the institute of ophthalmology 1988
1988 Effects of vitreous from photocoagulated eyes on retinal micro vascular cells in culture: A preliminary report 1988
1988 Growth of pure cultures of retinal pigment epithelial cells using chorioretinal biopsies from the pig 1988
1988 The cytoskeletal elements of human retinal pigment epithelium: in vitro and in vivo. 1988
1988 Vasoproliferative retinopathies: Clinical, morphogenetic and modulatory aspects 1988
1987 Growth of retinal capillary endothelia using pericyte conditioned medium 1987
1987 Retinal pigment epithelial cells produce mitogenic factors for retinal microvascular cells in culture: A preliminary report 1987
1986 Investigations of cytoskeletal elements in cultured bovine meshwork cells 1986
1986 The generation of dense granules within cultured human retinal pigment epithelial cells at senescence 1986
1986 Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: A model for aging 1986
1986 He-Ne laser stimulation of human fibroblast proliferation and attachment in vitro 1986
1986 Human retinal pigment epithelial cells in the vitreous of the owl monkey 1986
1985 An analysis of some behavioural characteristics of normal and dystrophic human RPE cells in tissue culture 1985
1985 Repigmentation of human retinal pigment epithelial cells in vitro 1985
1984 Retinitis pigmentosa: a quantitative study of the apical membrane of normal and dystrophic human retinal pigment epithelial cells in tissue culture in relation to phagocytosis 1984
1983 Retinitis pigmentosa: A preliminary report on tissue culture studies of retinal pigment epithelial cells from eight affected human eyes 1983
1982 Human retinal pigment epithelial cells in tissue culture: A means of studying inherited retinal diseases 1982


Year Title Altmetric
2016 A non-canonical role for β-secretase in the retina.  333-339. 2016
2013 Stem Cells in the Eye.  1399-1412. 2013
2013 Ageing of the Retina and Retinal Pigment Epithelium.  45-63. 2013
2012 Cell Death, Apoptosis, and Autophagy in Retinal Injury.  537-552. 2012
2012 The role of mitochondrial oxidative stress in retinal dysfunction.  203-239. 2012
2012 Transformation of progenitor cells for treatment of retinal disease.  419-435. 2012
2007 Hematopoietic stem cells in vascular development and ocular neovascularization.  78-96. 2007
2007 Stem cells in the eye.  1011-1023. 2007

Education And Training

  • Doctor of Philosophy in Engineering Science, 1982
  • Full Name

  • Michael Boulton