• Dr. Birrer earned his undergraduate degree at Rensselaer Polytechnic Institute and graduated with a BS in Biology. He subsequently was accepted into the Medical Scientist Training Program at the Albert Einstein College of Medicine and completed his M.D. and Ph.D. in 1982 with his principle area of study in microbiology and immunology. He performed a medical internship at the Massachusetts General Hospital (MGH) and subsequently completed a residency in medicine at MGH. Dr. Birrer entered the medical oncology fellowship at the National Cancer Institute in Bethesda, Maryland and upon completion performed a postdoctoral fellowship in the laboratory of Dr. John Minna on the molecular genetics of lung cancer. After completing his fellowship, Dr. Birrer joined the faculty at the NCI in the Division of Cancer Treatment as an investigator in 1988. Three years later, Dr. Birrer was appointed as a senior investigator (with tenure) and established the molecular mechanism section in the Division of Cancer Prevention and Control. Over the next 17 years, Dr. Birrer held a number of positions including the Committee for the Protection of Human Subjects, Gynecologic Oncology Tumor Board, Extramural IRB, Clinical Oncology Fellowship Section Committee, Chair of the Gynecologic Oncology Working Group in the Division of Clinical Sciences and Deputy Branch Chief of the Cell and Cancer Biology Branch.

    Dr. Birrer is recognized nationally and internationally as an expert in gynecologic oncology. He has published over 270 peer reviewed manuscripts and another 27 book chapters and review articles. He has served in leadership positions within the greater gynecologic oncology community. He has been the Chair and Chair Emeritus of the DOD Ovarian Cancer Research Program, Chair of the Committee for Experimental Medicine of the Gynecologic Oncology Group, a member of the Gynecologic Cancer Steering Committee and Chair of the Translational Science Working Group of the Gynecologic Cancer Intergroup. Dr. Birrer has been a member of the Society of Gynecologic Oncology, American Society of Clinical Oncologists, American Association of Cancer Research and the International Gynecologic Cancer Society. He has been on the program committees of ASCO, SGO and IGCS.

    In November 2008, Dr. Birrer was appointed Professor of Medicine at the Harvard School of Medicine. Dr. Birrer assumed the position of Director of Gynecologic Medical Oncology at MGH and the Gynecologic Oncology Research Program. This program integrates important new discoveries in translational research into clinical trials.

    In August 2017, Dr. Birrer accepted the position of Director of the Comprehensive Cancer Center at the University of Alabama at Birmingham. He is a Professor of Medicine in the Division of Hematology-Oncology and holds the Evalina B. Spencer Chair in Oncology.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Anticancer immunotherapy by MFAP5 blockade inhibits fibrosis and enhances chemosensitivity in ovarian and pancreatic cancerCurrent Obesity Reports.  25:6417-6428. 2019
    2019 A phase I study of the PARP inhibitor niraparib in combination with bevacizumab in platinum-sensitive epithelial ovarian cancer: NSGO AVANOVA1/ENGOT-OV24Clinical Medicine Insights: Pediatrics.  84:791-798. 2019
    2019 Niraparib plus bevacizumab versus niraparib alone for platinum-sensitive recurrent ovarian cancer (NSGO-AVANOVA2/ENGOT-ov24): a randomised, phase 2, superiority trialLancet Oncology.  20:1409-1419. 2019
    2019 Final overall survival of a randomized trial of bevacizumab for primary treatment of ovarian cancerJournal of Clinical Oncology.  37:2317-2328. 2019
    2019 Erratum: The Immune Landscape of Cancer (Immunity (2018) 48(4) (812–830.e14), (S1074761318301213), (10.1016/j.immuni.2018.03.023))Immunity.  51:411-412. 2019
    2019 Results of an abbreviated Phase Ib study of the HDAC6 inhibitor ricolinostat and paclitaxel in recurrent ovarian, fallopian tube, or primary peritoneal cancerGynecologic Oncology Reports.  29:118-122. 2019
    2019 Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 studyJournal of Clinical Neurology (Seoul, Korea).  30:1080-1087. 2019
    2019 Antibody-Drug Conjugate-Based Therapeutics: State of the ScienceJNCI: Journal of the National Cancer Institute.  111:538-549. 2019
    2019 Real-Time Single-Walled Carbon Nanotube-Based Fluorescence Imaging Improves Survival after Debulking Surgery in an Ovarian Cancer ModelJournal of the Institute of Mathematics of Jussieu.  13:5356-5365. 2019
    2019 Final report on serial phase II trials of all-intraperitoneal chemotherapy with or without bevacizumab for women with newly diagnosed, optimally cytoreduced carcinoma of Müllerian originGynecologic Oncology.  153:223-229. 2019
    2019 GOG 8020/210: Risk stratification of lymph node metastasis, disease progression and survival using single nucleotide polymorphisms in endometrial cancer: An NRG oncology/gynecologic oncology group studyGynecologic Oncology.  153:335-342. 2019
    2019 Ovarian Cancer Maintenance: Practice-Changing Data Calls for Changing PracticeOncologist.  24:576-579. 2019
    2019 Review: Targeting the transforming growth factor-beta pathway in ovarian cancerPatient Care -Darien Connecticut then Montvale-.  11. 2019
    2019 Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular VesiclesHuman Gene Therapy Clinical Development.  27:255-268.e6. 2019
    2019 Is Targeting the Folate Receptor in Ovarian Cancer Coming of Age?Oncologist.  24:425-429. 2019
    2019 Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trialLancet Oncology.  20:570-580. 2019
    2019 Variation in resource utilization associated with the surgical management of ovarian cancerGynecologic Oncology.  152:587-593. 2019
    2019 Evaluation of prophylactic corticosteroid eye drop use in the management of corneal abnormalities induced by the antibody–drug conjugate mirvetuximab soravtansineCurrent Obesity Reports.  25:1727-1736. 2019
    2019 Overall survival and updated progression-free survival outcomes in a randomized phase II study of combination cediranib and olaparib versus olaparib in relapsed platinum-sensitive ovarian cancerJournal of Clinical Neurology (Seoul, Korea).  30:551-557. 2019
    2019 Safety lead-in of the MEK inhibitor trametinib in combination with GSK2141795, an AKT inhibitor, in patients with recurrent endometrial cancer: An NRG Oncology/GOG studyGynecologic Oncology2019
    2018 ISG15 promotes ERK1 ISGylation, CD8+ T cell activation and suppresses ovarian cancer progressionPatient Care -Darien Connecticut then Montvale-.  10. 2018
    2018 Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumorsJournal of Pathology.  246:459-469. 2018
    2018 Comprehensive Molecular Characterization of the Hippo Signaling Pathway in CancerHuman Gene Therapy Clinical Development.  25:1304-1317.e5. 2018
    2018 A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β SuperfamilyAnnals of Tropical Medicine and Parasitology.  7:422-437.e7. 2018
    2018 Consensus on molecular subtypes of high-grade serous ovarian carcinomaCurrent Obesity Reports.  24:5037-5047. 2018
    2018 Safety and activity findings from a phase 1b escalation study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with carboplatin in patients with platinum-sensitive ovarian cancerGynecologic Oncology.  151:46-52. 2018
    2018 Integrative kinome profiling identifies mTORC1/2 inhibition as treatment strategy in ovarian clear cell CarcinomaCurrent Obesity Reports.  24:3928-3940. 2018
    2018 Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 PatientsJournal Of Marketing Theory & Practice.  34:211-224.e6. 2018
    2018 Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060))Lancet Public Health.  174:1034-1035. 2018
    2018 FORWARD I: A Phase III study of mirvetuximab soravtansine versus chemotherapy in platinum-resistant ovarian cancerFuture Oncology.  14:1669-1678. 2018
    2018 Erratum: The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (Cell Reports (2018) 23(1) (313–326.e5) (S2211124718304364) (10.1016/j.celrep.2018.03.075))Human Gene Therapy Clinical Development.  23:3698. 2018
    2018 Phase I study of MEDI3617, a selective angiopoietin-2 inhibitor alone and combined with carboplatin/paclitaxel, paclitaxel, or bevacizumab for advanced solid tumorsCurrent Obesity Reports.  24:2749-2757. 2018
    2018 Administration of the Tablet Formulation of Olaparib in Patients with Ovarian Cancer: Practical Guidance and ExpectationsOncologist.  23:697-703. 2018
    2018 Complete Remission Following Pembrolizumab in a Woman with Mismatch Repair-Deficient Endometrial Cancer and a Germline BRCA1 MutationOncologist.  23:650-653. 2018
    2018 The Immune Landscape of CancerImmunity.  48:812-830.e14. 2018
    2018 A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast CancersJournal Of Marketing Theory & Practice.  33:690-705.e9. 2018
    2018 Comparative Molecular Analysis of Gastrointestinal AdenocarcinomasJournal Of Marketing Theory & Practice.  33:721-735.e8. 2018
    2018 Genomic and Functional Approaches to Understanding Cancer AneuploidyJournal Of Marketing Theory & Practice.  33:676-689.e3. 2018
    2018 lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in CancerJournal Of Marketing Theory & Practice.  33:706-720.e9. 2018
    2018 A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient SamplesLancet Public Health.  173:386-399.e12. 2018
    2018 An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome AnalyticsLancet Public Health.  173:400-416.e11. 2018
    2018 Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of CancerLancet Public Health.  173:291-304.e6. 2018
    2018 Comprehensive Characterization of Cancer Driver Genes and MutationsLancet Public Health.  173:371-385.e18. 2018
    2018 Machine Learning Identifies Stemness Features Associated with Oncogenic DedifferentiationLancet Public Health.  173:338-354.e15. 2018
    2018 Oncogenic Signaling Pathways in The Cancer Genome AtlasLancet Public Health.  173:321-337.e10. 2018
    2018 Pathogenic Germline Variants in 10,389 Adult CancersLancet Public Health.  173:355-370.e14. 2018
    2018 Perspective on Oncogenic Processes at the End of the Beginning of Cancer GenomicsLancet Public Health.  173:305-320.e10. 2018
    2018 Driver Fusions and Their Implications in the Development and Treatment of Human CancersHuman Gene Therapy Clinical Development.  23:227-238.e3. 2018
    2018 Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome AtlasHuman Gene Therapy Clinical Development.  23:239-254.e6. 2018
    2018 Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous CarcinomasHuman Gene Therapy Clinical Development.  23:194-212.e6. 2018
    2018 Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer TypesHuman Gene Therapy Clinical Development.  23:213-226.e3. 2018
    2018 Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome AtlasHuman Gene Therapy Clinical Development.  23:172-180.e3. 2018
    2018 Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human CancersHuman Gene Therapy Clinical Development.  23:255-269.e4. 2018
    2018 Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor ContextHuman Gene Therapy Clinical Development.  23:297-312.e12. 2018
    2018 Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer TypesHuman Gene Therapy Clinical Development.  23:282-296.e4. 2018
    2018 Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology ImagesHuman Gene Therapy Clinical Development.  23:181-193.e7. 2018
    2018 Systematic Analysis of Splice-Site-Creating Mutations in CancerHuman Gene Therapy Clinical Development.  23:270-281.e3. 2018
    2018 The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell CarcinomaHuman Gene Therapy Clinical Development.  23:313-326.e5. 2018
    2018 Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II studyJournal of Clinical Neurology (Seoul, Korea).  29:917-923. 2018
    2018 Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome AtlasAnnals of Tropical Medicine and Parasitology.  6:282-300.e2. 2018
    2018 Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic PipelinesAnnals of Tropical Medicine and Parasitology.  6:271-281.e7. 2018
    2018 Mutations in homologous recombination genes and outcomes in ovarian carcinoma patients in GOG 218: An NRG oncology/Gynecologic oncology group studyCurrent Obesity Reports.  24:777-783. 2018
    2018 Erratum: Publisher Correction: Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer (Nature communications (2017) 8 1 (2166))Nature Communications.  9:628. 2018
    2018 Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistanceJournal of Clinical Investigation.  128:589-606. 2018
    2018 Clinicopathologic characteristics associated with long-term survival in advanced epithelial ovarian cancer: an NRG Oncology/Gynecologic Oncology Group ancillary data studyGynecologic Oncology.  148:275-280. 2018
    2018 A review of mirvetuximab soravtansine in the treatment of platinum-resistant ovarian cancerFuture Oncology.  14:123-136. 2018
    2017 Differential Effects of EGFL6 on Tumor versus Wound AngiogenesisHuman Gene Therapy Clinical Development.  21:2785-2795. 2017
    2017 Dysregulation of miR-181c expression influences recurrence of endometrial endometrioid adenocarcinoma by modulating NOTCH2 expression: An NRG Oncology/Gynecologic Oncology Group studyGynecologic Oncology.  147:648-653. 2017
    2017 Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancerNature Communications.  8. 2017
    2017 Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue SarcomasLancet Public Health.  171:950-965.e28. 2017
    2017 An evaluation of progression free survival and overall survival of ovarian cancer patients with clear cell carcinoma versus serous carcinoma treated with platinum therapy: An NRG Oncology/Gynecologic Oncology Group experienceGynecologic Oncology.  147:243-249. 2017
    2017 Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples from relapsed epithelial ovarian cancer patients: A phase I expansion study of the FRα-targeting antibody-drug conjugate mirvetuximab soravtansineGynecologic Oncology.  147:402-407. 2017
    2017 Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group studyGynecologic Oncology.  147:396-401. 2017
    2017 How can molecular abnormalities influence our clinical approachJournal of Clinical Neurology (Seoul, Korea).  28:viii16-viii24. 2017
    2017 Tumor Microvessel Density as a Potential Predictive Marker for Bevacizumab Benefit: GOG-0218 Biomarker AnalysesJNCI: Journal of the National Cancer Institute.  109. 2017
    2017 Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trialLancet.  390:1949-1961. 2017
    2017 Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240)Lancet.  390:1654-1663. 2017
    2017 Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumorsBasic Research in Cardiology, Supplement.  123:3080-3087. 2017
    2017 High stathmin expression is a marker for poor clinical outcome in endometrial cancer: An NRG oncology group/gynecologic oncology group studyGynecologic Oncology.  146:247-253. 2017
    2017 Early tumor detection afforded by in vivo imaging of near-infrared II fluorescenceSoutheastern Teacher Education Journal.  134:202-215. 2017
    2017 Multiplex profiling identifies distinct local and systemic alterations during intraperitoneal chemotherapy for ovarian cancer: An NRG Oncology/Gynecologic Oncology Group StudyGynecologic Oncology.  146:137-145. 2017
    2017 Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancerNature Genetics.  49:680-691. 2017
    2017 Safety and activity of mirvetuximab soravtansine (IMGN853), a folate receptor alpha-targeting antibody-drug conjugate, in platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer: A phase i expansion studyJournal of Clinical Oncology.  35:1112-1118. 2017
    2017 Integrated genomic and molecular characterization of cervical cancerNature.  543:378-384. 2017
    2017 Maximizing Synergistic Activity When Combining RNAi and Platinum-Based Anticancer AgentsJournal of the American Chemical Society.  139:3033-3044. 2017
    2017 ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cellsGenes and Development.  31:318-332. 2017
    2017 A phase II evaluation of ixabepilone in the treatment of recurrent/persistent carcinosarcoma of the uterus, an NRG Oncology/Gynecologic Oncology Group studyGynecologic Oncology.  144:101-106. 2017
    2017 Extended carboplatin infusion does not reduce frequency of hypersensitivity reaction at initiation of retreatment in patients with recurrent platinum-sensitive ovarian cancerJournal of Allergy and Clinical Immunology: In Practice.  5:177-178. 2017
    2017 Integrated genomic analysis of clear cell ovarian cancers identified PRKCI as a potential therapeutic targetOncotarget.  8:96482-96495. 2017
    2017 Outcomes of women with high-grade and low-grade advanced-stage serous epithelial ovarian cancerObstetrics and Gynecology.  129:439-447. 2017
    2017 Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancerJournal of Clinical Neurology (Seoul, Korea).  28:512-518. 2017
    2016 Phase 1 and 2 study of carboplatin and pralatrexate in patients with recurrent, platinum-sensitive ovarian, fallopian tube, or primary peritoneal cancerBasic Research in Cardiology, Supplement.  122:3297-3306. 2016
    2016 Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody-drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pancreatic cancerJournal of Clinical Neurology (Seoul, Korea).  27:2124-2130. 2016
    2016 “Carcinosarcoma of the ovary, fallopian tube, and peritoneum: Prognostic factors and treatment modalities”Gynecologic Oncology.  142:248-254. 2016
    2016 Chemotherapy-induced nausea and vomitingNew England Journal of Medicine.  375:177-179. 2016
    2016 A randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancerGynecologic Oncology.  142:62-69. 2016
    2016 CD44 splice variant v8-10 as a marker of serous ovarian cancer prognosisPLoS ONE.  11. 2016
    2016 Making a Difference: Distinguishing Two Primaries from Metastasis in Synchronous Tumors of the Ovary and UterusJNCI: Journal of the National Cancer Institute.  108. 2016
    2016 Phase 1 Study of Monotherapy with KHK2866, an Anti-Heparin-Binding Epidermal Growth Factor-Like Growth Factor Monoclonal Antibody, in Patients with Advanced CancerTargeted Oncology.  11:317-327. 2016
    2016 Weekly Versus Every-3-Week Paclitaxel and Carboplatin for Ovarian CancerObstetrical and Gynecological Survey.  71:344-345. 2016
    2016 A SNaPshot of potentially personalized care: Molecular diagnostics in gynecologic cancerGynecologic Oncology.  141:108-112. 2016
    2016 Epithelial ovarian cancer: The molecular genetics of epithelial ovarian cancerJournal of Clinical Neurology (Seoul, Korea).  27:i4-i10. 2016
    2016 Inherited mutations in women with ovarian carcinomaJAMA Oncology.  2:482-490. 2016
    2016 Targeting the nuclear import receptor Kpnβ1 as an anticancer therapeuticMolecular Cancer Therapeutics.  15:560-573. 2016
    2016 Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group studyGynecologic Oncology.  141:43-48. 2016
    2016 Somatic mosaic mutations in PPM1D and TP53 in the blood of women with ovarian carcinomaJAMA Oncology.  2:370-372. 2016
    2016 Weekly vs. every-3-week paclitaxel and carboplatin for ovarian cancerNew England Journal of Medicine.  374:738-748. 2016
    2016 The doppelganger effect: Hidden duplicates in databases of transcriptome profilesJNCI: Journal of the National Cancer Institute.  108. 2016
    2015 Erratum: Common variants at 19p13 are associated with susceptibility to ovarian cancer (Nature Genetics (2010) 42 (880-884))Nature Genetics.  48:101. 2015
    2015 Sustained, low-dose intraperitoneal cisplatin improves treatment outcome in ovarian cancer mouse modelsJournal of Controlled Release.  220:358-367. 2015
    2015 Creation of a human secretome: A novel composite library of human secreted proteins: Validation using ovarian cancer gene expression data and a virtual secretome arrayCurrent Obesity Reports.  21:4960-4969. 2015
    2015 AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancerProceedings of the National Academy of Sciences.  112:E4418-E4427. 2015
    2015 Comparing platforms for messenger RNA expression profiling of archival formalin-fixed, paraffin-embedded tissuesJournal of Molecular Diagnostics.  17:374-381. 2015
    2015 Translational impact of nanoparticle-drug conjugate CRLX101 with or without bevacizumab in advanced ovarian cancerCurrent Obesity Reports.  21:808-818. 2015
    2015 A functional variant in HOXA 11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancerOncotarget.  6:34745-34757. 2015
    2015 Advances in the management of recurrent endometrial cancerHeadache.  38:206-212. 2015
    2015 Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancerOncotarget.  6:44551-44562. 2015
    2015 Erratum to Elagib et al., Jun Blockade of erythropoiesis: Role for repression of GATA-1 by HERP2 [Mol Cell Biol. 24, 17, (2004), 7779-7794]Molecular and Cellular Biology.  35:2215-2215. 2015
    2015 Exploring alternative ovarian cancer biomarkers using innovative nanotechnology strategiesInternational Journal of Oral Science.  34:75-82. 2015
    2015 Phase II study of the PI3K inhibitor pilaralisib (SAR245408; XL147) in patients with advanced or recurrent endometrial carcinomaGynecologic Oncology.  136:246-253. 2015
    2015 Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancerNature Reviews Cancer.  15:668-679. 2015
    2015 Spleen Tyrosine Kinase Confers Paclitaxel Resistance in Ovarian CancerJournal Of Marketing Theory & Practice.  28:7-9. 2015
    2014 Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubesProceedings of the National Academy of Sciences.  111:13948-13953. 2014
    2014 Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubesProceedings of the National Academy of Sciences.  111:13948-13953. 2014
    2014 FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesisOncogene.  33:4424-4432. 2014
    2014 Identification of LMX1B as a novel oncogene in human ovarian cancerOncogene.  33:4226-4235. 2014
    2014 Comparative meta-analysis of prognostic gene signatures for late-stage ovarian cancerJNCI: Journal of the National Cancer Institute.  106. 2014
    2014 Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samplesJNCI: Journal of the National Cancer Institute.  106. 2014
    2014 Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancerAnnals of the Rheumatic Diseases.  34:811-818. 2014
    2014 Advances in the diagnosis and treatment of uterine sarcomasFibers and Polymers.  17:339-345. 2014
    2014 Better therapeutic trials in ovarian cancerJNCI: Journal of the National Cancer Institute.  106. 2014
    2014 Calcium dependent FAK/CREB/TNNC1 signaling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potentialNature Communications.  5. 2014
    2014 Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: A randomised phase 2 studyLancet Oncology.  15:1207-1214. 2014
    2014 FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesisOncogene.  33:4424-4432. 2014
    2014 Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancerJournal of Autoimmunity.  35:546-553. 2014
    2014 Molecular subtypes of high-grade serous ovarian cancer: The holy grail?JNCI: Journal of the National Cancer Institute.  106. 2014
    2014 Ovarian cancer: targeting the untargetableJournal of Health Communication.  13-15. 2014
    2013 Ascites analysis by a microfluidic chip allows tumor-cell profilingProceedings of the National Academy of Sciences.  110. 2013
    2013 Ovarian cancer: Genomic analysisJournal of Clinical Neurology (Seoul, Korea).  24. 2013
    2013 curatedOvarianData: Clinically annotated data for the ovarian cancer transcriptomeJournal of Family Social Work.  2013. 2013
    2013 Gynecologic cancer intergroup (GCIG) endometrial cancer clinical trials planning meeting: Taking endometrial cancer trials into the translational eraInternational Journal of Gynecological Cancer.  23:1528-1534. 2013
    2013 FGF18 as a prognostic and therapeutic biomarker in ovarian cancerJournal of Clinical Investigation.  123:4435-4448. 2013
    2013 A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancerEuropean journal of cancer.  49:2972-2978. 2013
    2013 Patterns of recurrence in patients treated with bevacizumab in the primary treatment of advanced epithelial ovarian cancerInternational Journal of Gynecological Cancer.  23:1219-1225. 2013
    2013 TGF-β Modulates ovarian cancer invasion by upregulating CAF-Derived versican in the tumor microenvironmentCurrent Protocols in Toxicology.  73:5016-5028. 2013
    2013 p21-Activated Kinase 3 (PAK3) Is an AP-1 Regulated Gene Contributing to Actin Organisation and Migration of Transformed FibroblastsPLoS ONE.  8. 2013
    2013 Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31Nature Communications.  4. 2013
    2013 BRCA1 expression and improved survival in ovarian cancer patients treated with intraperitoneal cisplatin and paclitaxel: A Gynecologic Oncology Group StudyCochrane Library.  108:1231-1237. 2013
    2013 GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancerNature Genetics.  45:362-370. 2013
    2013 Low-grade and high-grade serous Mullerian carcinoma: Review and analysis of publicly available gene expression profilesGynecologic Oncology.  128:488-492. 2013
    2013 Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancerCurrent Obesity Reports.  19:809-820. 2013
    2013 Selumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: An open-label, Single-arm, Phase 2 studyLancet Oncology.  14:134-140. 2013
    2013 Inherited Variants in Regulatory T Cell Genes and Outcome of Ovarian CancerPLoS ONE.  8. 2013
    2013 Prognostically relevant gene signatures of high-grade serous ovarian carcinomaJournal of Clinical Investigation.  123:517-525. 2013
    2013 Clear cell cancer of the ovaryNorth American Journal of Aquaculture.  25:553-557. 2013
    2013 Integrated genomic characterization of endometrial carcinomaNature.  497:67-73. 2013
    2012 Uterine papillary serous cancer: A review of the literatureGynecologic Oncology.  127:651-661. 2012
    2012 SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRKThe Entrepreneurial Executive.  10:1462-1472. 2012
    2012 An RNA Interference Lethality Screen of the Human Druggable Genome to Identify Molecular Vulnerabilities in Epithelial Ovarian CancerPLoS ONE.  7. 2012
    2012 Clear cell carcinoma of the ovary: A review of the literatureGynecologic Oncology.  126:481-490. 2012
    2012 BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: A report from the Australian ovarian cancer study groupJournal of Clinical Oncology.  30:2654-2663. 2012
    2012 Reclassification of serous ovarian carcinoma by a 2-tier system: A Gynecologic Oncology Group studyBasic Research in Cardiology, Supplement.  118:3087-3094. 2012
    2012 Incorporation of bevacizumab in the primary treatment of ovarian cancerObstetrical and Gynecological Survey.  67:289-290. 2012
    2012 Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: A gynecologic oncology group studyGynecologic Oncology.  125:421-426. 2012
    2012 Carcinosarcoma of the ovary: A review of the literatureGynecologic Oncology.  125:271-277. 2012
    2012 ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approachesJournal of Public Health Management & Practice.  5:484-491. 2012
    2012 Common variation in nemo-like kinase is associated with risk of ovarian cancerNeurocritical Care.  21:523-528. 2012
    2012 Ovarian cancer risk associated with inherited inflammation- related variantsCurrent Protocols in Toxicology.  72:1064-1069. 2012
    2012 Genome wide DNA copy number analysis of serous type ovarian carcinomas identifies genetic markers predictive of clinical outcomePLoS ONE.  7. 2012
    2012 Multi-gene expression predictors of single drug responses to adjuvant chemotherapy in ovarian carcinoma: Predicting platinum resistancePLoS ONE.  7. 2012
    2012 Identification of a potential ovarian cancer stem cell gene expression profile from advanced stage papillary serous ovarian cancerPLoS ONE.  7. 2012
    2011 Incorporation of bevacizumab in the primary treatment of ovarian cancerNew England Journal of Medicine.  365:2473-2483. 2011
    2011 Inhibition of hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft modelPLoS ONE.  6. 2011
    2011 Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescenceCurrent Protocols in Toxicology.  71:6184-6194. 2011
    2011 CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancerCurrent Protocols in Toxicology.  71:5522-5534. 2011
    2011 Tissue-based immune monitoring I: Tumor core needle biopsies allow in-depth interrogation of the tumor microenvironmentCurrent Opinion in Pulmonary Medicine.  12:357-366. 2011
    2011 Tissue-based immune monitoring II: Multiple tumor sites reveal immunologic homogeneity in serous ovarian carcinomaCurrent Opinion in Pulmonary Medicine.  12:367-377. 2011
    2011 MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association ConsortiumNeurocritical Care.  20:1793-1797. 2011
    2011 Identification of novel therapeutic targets in microdissected clear cell ovarian cancersPLoS ONE.  6. 2011
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    2010 The Gynecologic Oncology Group ovarian treatment trials with specimen banking and translational researchThe Journal of behavioral economics.  3:98-112. 2010
    2009 A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2Journal Of Marketing Theory & Practice.  16:521-532. 2009
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    2009 Race does not impact outcome for advanced ovarian cancer patients treated with cisplatin/paclitaxel: Analysis of Gynecologic Oncology Group TrialsBasic Research in Cardiology, Supplement.  115:4210-4217. 2009
    2009 Prognostic relevance of c-MYC gene amplification and polysomy for chromosome 8 in suboptimally-resected, advanced stage epithelial ovarian cancers: A Gynecologic Oncology Group studyGynecologic Oncology.  114:472-479. 2009
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    2009 NORE1A tumor suppressor candidate modulates p21CIP1 via p53Current Protocols in Toxicology.  69:4629-4637. 2009
    2009 A key role for early growth response-1 and nuclear factor-κB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancerThe Entrepreneurial Executive.  7:755-764. 2009
    2009 Calcineurin activates cytoglobin transcription in hypoxic myocytesJournal of Biological Chemistry.  284:10409-10421. 2009
    2009 The karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferationInternational Journal of Cancer.  124:1829-1840. 2009
    2009 Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong womenInternational Journal of Cancer.  124:1358-1365. 2009
    2009 Debate: Treatment of patients with recurrent ovarian cancer should be treated with antiangiogenic agents in combination with chemotherapyThe Journal of behavioral economics.  2:12-15. 2009
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    2009 Inflammatory cytokine tumor necrosis factor α confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cellsNeoplasia : An International Journal for Oncology Research.  11:529-541. 2009
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    2008 Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chipGenome Biology.  9. 2008
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    2008 CON: Therapy for a patient with platinum-resistant/refractory ovarian cancer should not be selected based on results of an in vitro extreme drug sensitivity/resistance assayThe Journal of behavioral economics.  1:99-103. 2008
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    2008 Highlights from the 2008 Annual Meeting of the American Association for Cancer Research.Gynecologic Oncology.  110:5-6. 2008
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    2007 EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathwaysJournal of Cellular Physiology.  212:489-497. 2007
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    2007 Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomasJournal of Clinical Oncology.  25:2281-2287. 2007
    2007 Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profilingOncogene.  26:1971-1982. 2007
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    2006 Thymosin β4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblastsCurrent Protocols in Toxicology.  66:701-712. 2006
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    2005 Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analysesCurrent Obesity Reports.  11:6880-6888. 2005
    2005 Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancerCurrent Obesity Reports.  11:6422-6430. 2005
    2005 Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancersCurrent Obesity Reports.  11:6300-6310. 2005
    2005 Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cellsJournal of Biological Chemistry.  280:16728-16738. 2005
    2005 RRP22 is a farnesylated, nucleolar, ras-related protein with tumor suppressor potentialCurrent Protocols in Toxicology.  65:3117-3125. 2005
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    2004 Jun blockade of erythropoiesis: Role for repression of GATA-1 by HERP2Molecular and Cellular Biology.  24:7779-7794. 2004
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    2004 Reversible regulation of the transformed phenotype of ornithine decarboxylase- and ras-overexpressing cells by dominant-negative mutants of c-JunCurrent Protocols in Toxicology.  64:3772-3779. 2004
    2004 DNA copy number abnormality of oral squamous cell carcinoma detected with cDNA array-based comparative genomic hybridization [4]FEMS Microbiology Letters.  151:90-92. 2004
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    2004 N-(4-hydroxyphenyl) retinamide (4HPR) enhances TRAIL-mediated apoptosis through enhancement of a mitochondrial-dependent amplification loop in ovarian cancer cell linesChinese Journal of Cancer.  11:527-541. 2004
    2004 Synthesis of Flexible Sulfur-Containing Heteroarotinoids That Induce Apoptosis and Reactive Oxygen Species with Discrimination between Malignant and Benign CellsJournal of Medicinal Chemistry.  47:999-1007. 2004
    2004 Cyclooxygenase-2 expression predicts recurrence of cervical dysplasia following loop electrosurgical excision procedureGynecologic Oncology.  92:596-602. 2004
    2003 Choice of Normal Ovarian Control Influences Determination of Differentially Expressed Genes in Ovarian Cancer Expression Profiling StudiesCurrent Obesity Reports.  9:4811-4818. 2003
    2003 MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cellsFree Radical Biology and Medicine.  35:978-993. 2003
    2003 Clinicopathological analysis of c-kit expression in carcinosarcomas and leiomyosarcomas of the uterine corpusGynecologic Oncology.  91:3-8. 2003
    2003 AP-1 complexes containing cJun and JunB cause cellular transformation of Ratla fibroblasts and share transcriptional targetsOncogene.  22:5619-5629. 2003
    2003 Cross-talk between JNK/SAPK and ERK/MAPK pathways: Sustained activation of JNK blocks ERK activation by mitogenic factorsJournal of Biological Chemistry.  278:26715-26721. 2003
    2003 Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: Increased expression of stathmin is necessary for cJun-mediated anchorage-independent growthOncogene.  22:2710-2722. 2003
    2003 Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: A Gynecologic Oncology Group StudyCurrent Protocols in Toxicology.  63:1235-1241. 2003
    2003 A link between histone deacetylase inhibitors and NF- kappaB signaling.Urban Education.  2:452-453. 2003
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    2003 Restoration of an impaired TGF-beta1 autocrine growth-inhibitory circuit results in growth inhibition of ovarian epithelial cancer cells and complete inhibition of their tumorigenicityExperimental Heat Transfer.  27:380-388. 2003
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    2002 Age-dependent changes in breast cancer hormone receptors and oxidant stress markersActa Physica Polonica B.  76:221-236. 2002
    2002 Retinoblastoma protein-mediated apoptosis after γ-irradiationJournal of Biological Chemistry.  277:44969-44979. 2002
    2002 CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potentialOncogene.  21:4435-4447. 2002
    2001 Ovarian tumors of low malignant potential: Can molecular biology solve this enigma?JNCI: Journal of the National Cancer Institute.  93:1122-1123. 2001
    2001 Abnormal fragile histidine triad (FHIT) expression in advanced cervical carcinoma: A poor prognostic factorCurrent Protocols in Toxicology.  61:4382-4385. 2001
    2001 The c-Jun NH2-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastineCurrent Protocols in Toxicology.  61:4450-4458. 2001
    2001 In situ detection of unexpected patterns of mutant p53 gene expression in non-small cell lung cancersOncogene.  20:2579-2586. 2001
    2001 The role of p27 in endometrial carcinomaGynecologic Oncology.  81:242-246. 2001
    2000 Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpointOncogene.  19:6082-6090. 2000
    2000 Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosisJournal of Biological Chemistry.  275:35669-35672. 2000
    2000 c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylaseJournal of Cell Biology.  151:801-809. 2000
    2000 Alterations in the gene expression profile of MCF-7 breast tumor cells in response to c-JunInternational Journal of Cancer.  88:180-190. 2000
    2000 TNF-α gene expression in macrophages: Regulation by NF-κB is independent of c-Jun or C/EBPβJournal of Immunology.  164:4277-4285. 2000
    2000 Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1WAF1/MDA6)Journal of Biological Chemistry.  275:18-28. 2000
    2000 Activator protein-1 mediates induced but not basal epidermal growth factor receptor gene expression.Molecular Medicine.  6:17-27. 2000
    2000 Age-specific survival of women with endometrioid adenocarcinoma of the uterusGynecologic Oncology.  79:86-89. 2000
    2000 Endocervical cancer is associated with an increase in the ligands and receptors for transforming growth factor-β and a contrasting decrease in p27(Kip1 1)Gynecologic Oncology.  78:113-122. 2000
    2000 Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway.International Journal of Oncology.  16:413-422. 2000
    2000 p27 and cyclin D1 abnormalities in uterine papillary serous carcinomaGynecologic Oncology.  77:439-445. 2000
    1999 cJun overexpression in MCF-7 breast cancer cells produces a tumorigenic, invasive and hormone resistant phenotypeOncogene.  18:6063-6070. 1999
    1999 Abnormal Fhit expression in malignant and premalignant lesions of the cervixCurrent Protocols in Toxicology.  59:5270-5274. 1999
    1999 c-Jun triggers apoptosis in human vascular endothelial cellsBiologie Aujourd'hui.  85:387-393. 1999
    1999 JunB forms the majority of the AP-1 complex and is a target for redox regulation by receptor tyrosine kinase and G protein-coupled receptor agonists in smooth muscle cellsJournal of Biological Chemistry.  274:6003-6010. 1999
    1999 Frequent loss of KAI1 expression in squamous and lymphoid neoplasms: An immunohistochemical study of archival tissuesOmega.  154:1665-1671. 1999
    1998 Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cellsOncogene.  16:2787-2796. 1998
    1998 Identification of domains of c-Jun mediating androgen receptor transactivationOncogene.  16:2001-2009. 1998
    1998 Retinoic acid receptor β expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamideJNCI: Journal of the National Cancer Institute.  90:597-605. 1998
    1998 PACAP(6-38) inhibits the growth of prostate cancer cellsJournal of Peptide Science.  125:131-139. 1998
    1998 Alterations in differentiation and apoptosis induced by bufalin in cJun overexpressing U-937 cellsInternational Journal of Oncology.  12:403-409. 1998
    1998 AP1 regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cellsMolecular and Cellular Biology.  18:3699-3707. 1998
    1998 RRR-α-tocopheryl succinate induction of prolonged activation of c-jun amino-terminal kinase and c-jun during induction of apoptosis in human MDA- MB-435 breast cancer cellsMolecular Carcinogenesis.  22:247-257. 1998
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    1998 The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; A potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicityLeukemia.  12:1843-1850. 1998
    1998 Tumor necrosis factor alpha gene regulation: Enhancement of C/EBPβ- induced activation by c-JunMolecular and Cellular Biology.  18:2815-2824. 1998
    1997 Involvement of activator protein-1 (AP-1) in induction of apoptosis by Vitamin E succinate in human breast cancer cellsMolecular Carcinogenesis.  19:180-190. 1997
    1997 Breast cancer cells have lower activating protein 1 transcription factor activity than normal mammary epithelial cells1Current Protocols in Toxicology.  57:3046-3054. 1997
    1997 PACAP hybrid: A new PACAP receptor antagonistLife Sciences.  61:631-639. 1997
    1997 FHIT gene expression in human ovarian, endometrial, and cervical cancer cell linesCurrent Protocols in Toxicology.  57:2112-2115. 1997
    1997 The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatinJournal of Biological Chemistry.  272:14041-14044. 1997
    1997 Analysis of Ki-ras, p53, and MDM2 genes in uterine leiomyomas and leiomyosarcomasGynecologic Oncology.  65:330-335. 1997
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    1996 Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase CMolecular Pharmacology.  49:788-795. 1996
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    1995 Regulation of urokinase-type plasminogen activator expression by the v-mos oncogeneOncogene.  11:2638-2648. 1995
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    1994 Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cellsProceedings of the National Academy of Sciences.  91:609-613. 1994
    1994 Constitutive cJun expression induces partial macrophage differentiation in U-937 cellsThe Entrepreneurial Executive.  5:439-446. 1994
    1994 Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude miceThe Entrepreneurial Executive.  5:9-16. 1994
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    1993 Suppression of oncogene-induced transformation by a deletion mutant of c-junOncogene.  8:877-886. 1993
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    1992 Regions within the c-Myc protein that are necessary for transformation are also required for inhibition of differentiation of murine erythroleukemia cells.The Entrepreneurial Executive.  3:183-190. 1992
    1991 Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cells linesJNCI: Journal of the National Cancer Institute.  83:938-943. 1991
    1991 A complex pattern of translational initiation and phosphorylation in L-myc proteinsOncogene.  6:371-378. 1991
    1991 Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73Nature.  354:494-496. 1991
    1991 The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation.The Entrepreneurial Executive.  2:475-482. 1991
    1991 The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cellsMolecular and Cellular Biology.  11:6286-6295. 1991
    1990 Expression of the atrial natriuretic factor gene in small cell lung cancer tumors and tumor cell linesJNCI: Journal of the National Cancer Institute.  82:305-310. 1990
    1989 A transfected L-myc gene can substitute for c-myc in blocking murine erythroleukemia differentiationMolecular and Cellular Biology.  9:2734-2737. 1989
    1989 Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms Rat-1a cells as a single geneProceedings of the National Academy of Sciences.  86:2257-2261. 1989
    1989 Genetic changes in the pathogenesis of lung cancerJournal of Cardiovascular Electrophysiology.  40:305-317. 1989
    1989 Transcription factors and recessive oncogenes in the pathogenesis of human lung cancerInternational Journal of Cancer.  44:32-34. 1989
    1989 Transcription factors and recessive oncogenes in the pathogenesis of human lung cancer.International Journal of Cancer Supplement.  4:32-34. 1989
    1989 p53: A frequent target for genetic abnormalities in lung cancerScience.  246:491-494. 1989
    1988 L-myc cooperates with ras to transform primary rat embryo fibroblasts.Molecular and Cellular Biology.  8:2668-2673. 1988
    1988 Molecular genetics of lung cancerSeminars in Oncology.  15:226-235. 1988
    1988 Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancerMolecular and Cellular Biology.  8:3373-3381. 1988
    1988 Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processingMolecular and Cellular Biology.  8:186-195. 1988
    1988 The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAsMolecular and Cellular Biology.  8:4381-4388. 1988
    1987 Differential diagnosis of jaundice in lymphoma patients.Seminars in Liver Disease.  7:269-277. 1987
    1986 Chromosomal deletion, gene amplification, alternative processing, and autocrine growth factor production in the pathogenesis of human lung cancer.Princess Takamatsu symposia.  17:109-122. 1986


    Year Title Altmetric
    2017 Translational Advances in Gynecologic Cancers 2017
    2017 Translational Advances in Gynecologic Cancers: Introduction 2017
    2014 Uncommon Gynecologic Cancers 2014


    Year Title Altmetric
    2017 Ovarian Cancer Genomics.  19-34. 2017
    2015 Molecular biology of gynecologic cancers 2015
    2015 Molecular Biology of Gynecologic Cancers 2015
    2013 Molecular pathogenesis of gynecologic cancers.  30-59. 2013
    2012 Ovarian cancer.  381-401. 2012
    2011 Discovery of novel targets.  35-50. 2011
    2008 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways, Potential Targets, and Noise.  149-164. 2008
    2007 Molecular profiling in ovarian cancer.  63-82. 2007

    Principal Investigator On

  • Private Grant  awarded by IMMUNOGEN, INC. 2019 - 2024
  • Private Grant  awarded by DECIPHERA PHARMACEUTICALS. LLC 2018 - 2023
  • Private Grant  awarded by MILLENNIUM PHARMACEUTICALS, INC. 2018 - 2023
  • Private Grant  awarded by IMMUNOGEN, INC. 2017 - 2022
  • Identification of an Immune/Methylation Signature Predicting for Recurrence in Early Stage Ovarian Cancer  awarded by DOD - Department of Defense 2019 - 2021
  • Overcoming PAAP Inhibitor Resistance of BACA-Deficient Ovarian Cancers  awarded by DOD - Department of Defense 2018 - 2021
  • Proteomic, Genomic, and Longitudinal Paths to Ovarian Cancer Biomarker Discovery  awarded by MASSACHUSETTS GENERAL HOSPITAL 2018 - 2021
  • Treatment Of Recurrent, Platinum-Resistant Ovarian Cancer With Glutaminase 1 And PARP Inhibitors  awarded by DOD - Department of Defense 2018 - 2021
  • Mechanisms of Sensitivity and Resistance to Mirvetuximab Soravtansine: Ovarian Cancer and Mesothelioma  awarded by NATIONAL COMPREHENSIVE CANCER NETWORK 2018 - 2020
  • The Genomic, Epigenomic and Quality-of-Life Characteristics of Long-Term Survivors of Ovarian Cancer  awarded by DOD - Department of Defense 2018 - 2020
  • Proteogenomic Studies Aimed at Understanding Ovarian Tumor Responses to Agents Targeting the DNA Damage Response and Translating this Knowledge into Clinical Benefit  awarded by Hutchinson (Fred) Cancer Research Center 2017 - 2020
  • Validation of a Genomic Signature that Predicts for Sub-Optimal Debulking of Epithelial Ovarian Cancer  awarded by National Cancer Institute/NIH/DHHS 2018 - 2020
  • NRG Oncology Biospecimen Bank  awarded by NRG ONCOLOGY FOUNDATION 2017 - 2020
  • NRG Oncology Network Group Operations Center  awarded by NRG ONCOLOGY FOUNDATION 2019 - 2020
  • ACS Institutional Research Grant  awarded by American Cancer Society, Inc. 2017 - 2019
  • Identification of Novel Ovarian Cancer Oncogenes that Function by Regulating Exosome Function  awarded by DOD - Department of Defense 2018 - 2019
  • UAB NRG Oncology Master Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Admin Supplements to Stimulate Research in Non-AIDS Defining Cancers (NADCs)  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Administrative Supplement to Stimulate Research in HIV/AIDS Cancer Research  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Administrative Supplements to Strengthen NCI-Supported Community Outreach Capacity through Community Health Educators (CHEs) of the National Outreach Network (NON)  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Developmental Funds  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • NRG Oncology Network Group Operations Center  awarded by NRG ONCOLOGY FOUNDATION 2017 - 2019
  • The FGF18/FGFR4 Amplicon: Novel Therapeutic Biomarkers For Ovarian Cancer  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • ACS Institutional Research Grant  awarded by American Cancer Society, Inc. 2019
  • No Evidence of Disease Documentary Screening  awarded by STONE SOUP PRODUCTIONS 2018
  • Alabama Lung Cancer Awareness Screening Education Project (ALCASE)  awarded by LUNG CANCER ALLIANCE 2018
  • Education And Training

  • Doctor of Medicine, Yeshiva University 1982
  • Doctor of Science or Mathematics in Microbiology and Immunology, Yeshiva University 1982
  • Master of Sciences or Mathematics in Microbiology and Immunology, Yeshiva University 1982
  • Bachelor of Science or Mathematics in Biology, Rensselaer Polytechnic Institute 1976
  • Massachusetts General Hospital, Internship 1983
  • Massachusetts General Hospital, Residency 1985
  • National Cancer Institute, Postdoctoral Fellowship 1988
  • Full Name

  • Michael J. Birrer