Positions

Research Overview

  • MAJOR RESEARCH INTERESTS
    Mechanisms of human skeletal muscle regeneration and muscle mass regulation are the major emphases in our laboratory. Muscle atrophy and reduced functional capacity are well-established, deleterious consequences of acute (e.g., surgery, trauma, disuse, burn) and chronic (e.g., Parkinson’s disease, arthritis, cancer, heart failure, spinal cord injury) conditions—the most widespread and insidious of which is the degenerative process of normal aging. Our research priorities span three, inter-related focus areas: (i) to determine the cellular and molecular mechanisms driving muscle regeneration following damage, surgery, or injury, while identifying differences responsible for regeneration impairment in certain phenotypes; (ii) to determine key processes responsible for myofiber hypertrophy, and to exploit these processes with countermeasures to promote muscle re-growth in conditions that induce muscle atrophy; and (iii) to better understand the primary etiology of muscle atrophy in acute and chronic conditions. We have a keen interest in the role of proinflammatory cytokine signaling on skeletal muscle atrophy, regrowth, and regeneration, and recently identified a state of muscle inflammation susceptibility (MuIS) in humans involving TWEAK and TNF-α/NFĸB signaling that is noted in vivo and inhibits satellite (stem) cell behavior in vitro. We suspect MuIS is a key determinant of individual responsiveness to treatments promoting muscle re-growth including exercise training.
  • Principal Investigator On

  • Precision High Intensity Training through Epigenetics (PHITE)  awarded by Wright State University 2016 - 2021
  • WMD ECHO Detector  awarded by ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI 2020 - 2021
  • Peerless Operator Biologic Aptitude (Peerless)  awarded by FLORIDA INSTITUTE FOR HUMAN & MACHINE COGNITION 2019 - 2020
  • The Exercise and Physical Activity Collaborative Team (ExPact): A Proposed MoTrPAC Clinical Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2016 - 2020
  • Mechanisms of Exercise as a Rehabilitative Strategy in Human Parkinson's Disease  awarded by National Institute on Aging/NIH/DHHS 2019 - 2020
  • Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3  awarded by Northwestern University 2019 - 2020
  • National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Admin Oversight Component  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Coordinating Center  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • Rehabilitation Research Resource to Enhance Clinical Trials (REACT)  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • Interdisciplinary Training in Pathobiology and Rehabilitation Medicine  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2017 - 2020
  • Overcoming TWEAK Signaling to Restore Muscle and Mobility after Joint Replacement  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • Research Acceleration to Maximize Warrior Performance (RAMP)  awarded by Office of Naval Research 2018 - 2019
  • The Role of Inflammation on Muscle Growth in Aging Atrophied Adults  awarded by National Institute on Aging/NIH/DHHS 2017 - 2019
  • Novel Actions of Metformin to Augment Resistance Training Adaptations in Older Adults  awarded by UNIVERSITY OF KENTUCKY (RESEARCH FOUNDATION) 2014 - 2019
  • Interdisciplinary Training in Pathobiology and Rehabilitation Medicine  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2012 - 2017
  • Using in vitro Approaches to Improve Muscle Regrowth in Atrophied Older Humans  awarded by National Institute on Aging/NIH/DHHS 2012 - 2015
  • Establishing a State-of-the-Art Core Facility to Advance Interdisciplinary Exercise Medicine Research  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2013
  • Maximizing Mechanisms of Muscle Hypertrophy to Combat Sarcopenia in Older Adults  awarded by National Institute on Aging/NIH/DHHS 2007 - 2013
  • Regulation of Human Muscle Protein Metabolism Following Burn Injury  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2011 - 2013
  • Mechanisms of Skeletal Muscle Satellite Cell Regulation in Aging  awarded by National Institute on Aging/NIH/DHHS 2007 - 2010
  • Investigator On

  • Exercise for Memory Rehabilitation in Epilepsy  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2021 - 2026
  • Slow Wave Sleep as a Biomarker of Rehabilitation-Induced Cognitive Improvement in Parkinson's Disease  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2021 - 2026
  • Interconnections Among Cognition, Pain, and Physical Function in Aging  awarded by National Institute on Aging/NIH/DHHS 2020 - 2025
  • Evaluation of a Ketogenic Diet for Improvement of Neurological Recovery in Individuals with Acute Spinal Cord Injury  awarded by National Institute of Nursing Research/NIH/DHHS 2019 - 2024
  • ACES - ACE Inhibitors Combined with Exercise for Hypertensive Seniors  awarded by National Institute on Aging/NIH/DHHS 2017 - 2022
  • Smad Signaling in Skeletal Muscle as a Biomarker of Disease Progression in ALS  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2022
  • Targeting Skeletal Muscle to Improve Metabolic Health in Individuals with Spinal Cord Injury  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2017 - 2022
  • COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics Approaches  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2020 - 2021
  • MiR-486 is an Epigenetic Regulator of the Duchenne Muscular Dystrophy  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2020 - 2021
  • Treadmill Walking Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: A Systematically-Developed Randomized Controlled Trial  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2018 - 2020
  • National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Collaborative Opportunities  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Promo/Dissemination Component  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Tech Developments Component  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • Rehabilitation Research Resource to Enhance Clinical Trials (REACT)  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2015 - 2020
  • Resveratrol and Exercise to Treat Functional Limitations in Late Life  awarded by National Institute on Aging/NIH/DHHS 2018 - 2020
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Skeletal Muscle in Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2016 - 2019
  • Symptoms and Skeletal Muscle in Persons with Heart Failure with Preserved Ejection Fraction  awarded by National Institute of Nursing Research/NIH/DHHS 2017 - 2019
  • Race - Adiposity Interactions Regulate Mechanisms Determining Insulin Sensitivity  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2019
  • UAB Obesity Training Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2017
  • Exercise Intensity, Metabolic Rate & Insulin Sensitivity  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2016
  • Teaching Activities

  • PCL1180R - MUSCULOSKELETAL & SKIN REMEDIAL (Fall Term 2017) 2017
  • GBS750 - NERVES MUSCLES AND BONES (Spring Term 2017) 2017
  • PCL1180R - MUSCULOSKELETAL & SKIN REMEDIAL (Fall Term 2016) 2016 - 2017
  • GBS750 - NERVES MUSCLES AND BONES (Spring Term 2016) 2016
  • PCL1180R - MUSCULOSKELETAL & SKIN REMEDIAL (Fall Term 2015) 2015
  • GBS750 - Nerves Muscles & Bone (Spring Term 2015) 2015
  • GBSC700 - Journal Clubs (Spring Term 2015) 2015
  • PCL1180R - MUSCULOSKELETAL & SKIN REMEDIAL (Spring Term 2015) 2015
  • GBS746J - Exercise Med JC (Fall Term 2014) 2014
  • GBS746J - Exercise Med JC (Summer Term 2014) 2014
  • GBS746J - Exercise Med JC (Spring Term 2014) 2014
  • GBS750 - Nerves Muscles & Bone (Spring Term 2014) 2014
  • PCL1180R - MUSCULOSKELETAL & SKIN REMEDIAL (Spring Term 2014) 2014
  • GBS750 - NERVES MUSCLES AND BONES (Spring Term 2014) 2014
  • GBS746J - Exercise Med JC (Fall Term 2013) 2013
  • GBS746 - Special Topics (Spring Term 2013) 2013
  • GBS750 - Nerves Muscles & Bone (Spring Term 2013) 2013
  • GBS750 - NERVES MUSCLES AND BONES (Spring Term 2013) 2013
  • PCL1180R - MUSCULOSKELETAL & SKIN REMEDIAL (Fall Term 2012) 2012 - 2013
  • GBS746 - Special Topics Biomed Sci I (Fall Term 2012) 2012
  • GBS750 - Nerves Muscles & Bone (Spring Term 2012) 2012
  • PHY780 - Center Exercise Medicine JC (Spring Term 2012) 2012
  • PHY780 - Center Exercise Medicine JC (Fall Term 2011) 2011
  • GBS750 - Nerves Muscles & Bone (Spring Term 2011) 2011
  • PCL1180R - MUSCULOSKELETAL & SKIN REMEDIAL (Spring Term 2011) 2011
  • PCL1180 - MUSCULOSKELETAL & SKIN (Fall Term 2010) 2010
  • PCL1180 - MUSCULOSKELETAL/SKIN (Fall Term 2009) 2009
  • PCL1180 - MUSCULOSKELETAL / SKIN (Spring Term 2008) 2008
  • 01-230R - REMEDIAL PHYSIOLOGY (Fall Term 2007) 2007
  • 01-230 - MEDICAL PHYSIOLOGY (Spring Term 2007) 2007
  • 01-230 - MEDICAL PHYSIOLOGY (Spring Term 2007) 2007
  • Full Name

  • Marcas Bamman