Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cellsProceedings of the National Academy of Sciences.  116:24583-24592. 2019
2019 Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1 +/−/ODC transgenic miceScientific Reports.  9. 2019
2019 Vimentin intermediate filament assembly regulates fibroblast invasion in fibrogenic lung injuryJCI insight.  4. 2019
2019 Global gene expression of histologically normal primary skin cells from BCNS subjects reveals "single-hit" effects that are influenced by rapamycinOncotarget.  10:1360-1387. 2019
2019 CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responsesPLoS ONE.  14. 2019
2019 The clinical course of actinic keratosis correlates with underlying molecular mechanismsBritish Journal of Dermatology2019
2018 Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysemaJCI insight.  3. 2018
2018 SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell CarcinomasJournal of Investigative Dermatology.  138:1716-1725. 2018
2018 Cutaneous exposure to lewisite causes acute kidney injury by invoking dna damage and autophagic responseAJP - Renal Physiology.  314:F1166-F1176. 2018
2018 214 High fat diet accelerates UVB-induced development of basal cell and squamous cell carcinoma in Ptch+/-/SKH-1 miceJournal of Investigative Dermatology.  138:S36-S36. 2018
2017 Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyondMolecular Carcinogenesis.  56:2543-2557. 2017
2017 Naproxen Inhibits UVB-induced Basal Cell and Squamous Cell Carcinoma Development in Ptch1+/−/SKH-1 Hairless MicePhotochemistry and Photobiology.  93:1016-1024. 2017
2017 The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical studyJournal of The American Academy of Dermatology.  77:33-41.e1. 2017
2017 IL-23 Inhibits Melanoma Development by Augmenting DNA repair and modulating T cell subpopulationsJournal of Immunology.  198:950-961. 2017
2017 Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentinAJP - Lung Cellular and Molecular Physiology.  313:L80-L91. 2017
2016 ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosisArchives of Biochemistry and Biophysics.  609:39-50. 2016
2016 Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototypeScientific Reports.  6. 2016
2016 AKT1 activation is obligatory for spontaneous BCC tumor growth in a murine model that mimics some features of basal cell nevus syndromeCancer Prevention Research.  9:794-802. 2016
2016 Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functionsToxicology and Applied Pharmacology.  308:46-58. 2016
2016 Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel AntidotesAmerican Journal of Pathology.  186:2637-2649. 2016
2016 Biological and environmental hazards associated with exposure to chemical warfare agents: arsenicalsAnnals of the New York Academy of Sciences.  1378:143-157. 2016
2016 A murine model for the development of melanocytic nevi and their progression to melanomaMolecular Carcinogenesis.  55:646-658. 2016
2016 Retinoid X receptor agonists upregulate genes responsible for the biosynthesis of all-trans-retinoic acid in human epidermisPLoS ONE.  11. 2016
2016 Ionizing Radiation Exposure and Basal Cell Carcinoma PathogenesisRadiation Research.  185:217-228. 2016
2016 Arsenic attenuates gli signaling, increasing or decreasing its transcriptional program in a context-dependent mannerMolecular Pharmacology.  89:226-232. 2016
2016 Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanomaOncotarget.  7:1227-1241. 2016
2016 Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis PigmentosaPLoS ONE.  11:e0154779. 2016
2015 Biochemical evaluation of antioxidant activity in extracts and polysaccharide fractions of seaweedsGlobal Journal of Environmental Science and Management.  1:47-62. 2015
2015 Aberrant GLI1 activation in DNA damage response, carcinogenesis and chemoresistanceCancers.  7:2330-2352. 2015
2015 Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless micePhotochemistry and Photobiology.  91:225-234. 2015
2015 Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cellsOncotarget.  6:28296-28311. 2015
2015 Immunoprevention of chemical carcinogenesis through early recognition of oncogene mutationsJournal of Immunology.  194:2683-2695. 2015
2015 In vivo suppression of heat shock protein (HSP)27 and HSP70 accelerates DMBA-induced skin carcinogenesis by inducing antigenic unresponsiveness to the initiating carcinogenic chemicalJournal of Immunology.  194:4796-4803. 2015
2015 IntroductionPhotochemistry and Photobiology.  91:139. 2015
2015 Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndromeOncotarget.  6:36789-36814. 2015
2014 Gli1 protein regulates the S-phase checkpoint in tumor cells via bid protein, and its inhibition sensitizes to DNA Topoisomerase 1 inhibitorsJournal of Biological Chemistry.  289:31513-31525. 2014
2014 Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating NotchBiochemical and Biophysical Research Communications.  451:394-401. 2014
2014 Sonic hedgehog signaling in basal cell nevus syndromeCancer Research.  74:4967-4975. 2014
2014 Inhibition of p38 MAPK signaling augments skin tumorigenesis via NOX2 driven ROS generationPLoS ONE.  9. 2014
2014 Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathwayCancer Prevention Research.  7:186-198. 2014
2014 Fisetin inhibits human melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFκB signaling pathwaysPLoS ONE.  9. 2014
2014 Soluble E-cadherin: A critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signalingOncogene.  33:225-235. 2014
2014 Cyclooxygenases: Mediators of UV-induced skin cancer and potential targets for preventionJournal of Investigative Dermatology.  134:2497-2502. 2014
2014 Cytokines and chemokines: Disease models, mechanisms, and therapiesMediators of Inflammation.  2014. 2014
2014 GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axisOncotarget.  5:12151-12165. 2014
2014 Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in ptch+/- miceAmerican Journal of Pathology.  184:1529-1540. 2014
2014 Role of CRD-BP in the growth of human basal cell carcinoma cellsJournal of Investigative Dermatology.  134:1718-1724. 2014
2014 The mechanistic basis of arsenicosis: Pathogenesis of skin cancerCancer Letters.  354:211-219. 2014
2013 Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by Targeting Akt-ERK axisPLoS ONE.  8. 2013
2013 Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruptionToxicology and Applied Pharmacology.  272:879-887. 2013
2013 Delphinidin Reduces Cell Proliferation and Induces Apoptosis of Non-Small-Cell Lung Cancer Cells by Targeting EGFR/VEGFR2 Signaling PathwaysPLoS ONE.  8. 2013
2013 Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related proteinBiochemical and Biophysical Research Communications.  438:607-612. 2013
2013 Chlorine induces the unfolded protein response in murine lungs and skinAmerican Journal of Respiratory Cell and Molecular Biology.  49:197-203. 2013
2013 Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosisJournal of Applied Toxicology.  33:828-837. 2013
2013 Fisetin inhibits growth, induces G2/M arrest and apoptosis of human epidermoid carcinoma A431 cells: Role of mitochondrial membrane potential disruption and consequent caspases activationExperimental Dermatology.  22:470-475. 2013
2013 Grape seeds: Ripe for cancer chemopreventionCancer Prevention Research.  6:617-621. 2013
2013 Milestones in photocarcinogenesis.Journal of Investigative Dermatology.  133:E13-E17. 2013
2013 Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine modelBiochemical and Biophysical Research Communications.  435:557-561. 2013
2013 Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesisToxicology and Applied Pharmacology.  268:249-255. 2013
2013 Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine modelToxicology and Applied Pharmacology.  266:233-244. 2013
2012 Introduction to the special issue honoring professor David R. BickersPhotochemistry and Photobiology.  88:1035-1036. 2012
2012 Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathwayPhotochemistry and Photobiology.  88:1149-1156. 2012
2012 Nitric oxide donor exisulind is an effective inhibitor of murine photocarcinogenesisPhotochemistry and Photobiology.  88:1141-1148. 2012
2012 Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCsBiochemical and Biophysical Research Communications.  425:177-181. 2012
2012 D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesisHuman and Experimental Toxicology.  31:798-811. 2012
2012 Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signalingPLoS ONE.  7. 2012
2012 IL-17 mediated inflammation promotes tumor growth and progression in the skinPLoS ONE.  7. 2012
2011 Unfolded protein response signaling and MAP kinase pathways underlie pathogenesis of arsenic-induced cutaneous inflammationCancer Prevention Research.  4:2101-2109. 2011
2011 Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: Role of TGFβ signaling pathwayMolecular Carcinogenesis.  50:516-527. 2011
2011 Liver Kinase B1 (LKB1) in the pathogenesis of epithelial cancersCancer Letters.  306:1-9. 2011
2011 Rapamycin and mTORC1 inhibition in the mouse: Skin cancer preventionCancer Prevention Research.  4:957-961. 2011
2011 Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent inhibition of sirtuinJournal of Biological Chemistry.  286:19100-19108. 2011
2011 Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathwayBiochemical and Biophysical Research Communications.  408:363-368. 2011
2011 Role of epidermal primary cilia in the homeostasis of skin and hair folliclesDevelopment.  138:1675-1685. 2011
2011 Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinomaArchives of Biochemistry and Biophysics.  508:204-211. 2011
2011 Pathogenesis of nonmelanoma skin cancers in organ transplant recipientsArchives of Biochemistry and Biophysics.  508:159-163. 2011
2011 New Agents for Prevention of Ultraviolet-Induced Nonmelanoma Skin CancerSeminars in Cutaneous Medicine and Surgery.  30:6-13. 2011
2011 Pharmacological Activation of p53 in Cancer CellsCurrent Pharmaceutical Design.  17:631-639. 2011
2011 Prospects for skin cancer treatment and prevention: The potential contribution of an engineered virusJournal of Investigative Dermatology.  131:559-561. 2011
2011 Resveratrol targets transforming growth factor-Β2 signaling to block UV-induced tumor progressionJournal of Investigative Dermatology.  131:195-202. 2011
2011 TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestineGastroenterology.  140:242-253. 2011
2010 Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion responseInvestigational New Drugs.  28:703-713. 2010
2010 Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosisCancer Research.  70:6566-6576. 2010
2010 The other end of the rainbow: Infrared and skinJournal of Investigative Dermatology.  130:1496-1499. 2010
2010 Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosisMolecular Carcinogenesis.  49:290-301. 2010
2010 Basal cell carcinoma chemoprevention with nonsteroidal anti-inflammatory drugs in genetically predisposed PTCH1+/- humans and miceCancer Prevention Research.  3:25-34. 2010
2010 Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humansCancer Prevention Research.  3:8-11. 2010
2009 Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: Involvement of inflammation, Ras-ERK pathway and apoptosisLife Sciences.  85:196-205. 2009
2009 Multiple molecular targets of resveratrol: Anti-carcinogenic mechanismsArchives of Biochemistry and Biophysics.  486:95-102. 2009
2009 Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesisChemico-Biological Interactions.  179:145-153. 2009
2009 Nutraceuticals as natural healers: Emerging evidencesAfrican Journal of Biotechnology.  8:891-898. 2009
2009 When apoptosis meets autophagy: deciding cell fate after trauma and sepsisMolecular Medicine Today.  15:129-138. 2009
2009 Low intensity shear stress increases endothelial ELR+ CXC chemokine production via a focal adhesion kinase-p38β MAPK-NF-κB pathwayJournal of Biological Chemistry.  284:5945-5955. 2009
2009 Guilandina bonduc L. possesses antioxidant activity and precludes ferric nitrilotriacetate (Fe-NTA) induced renal toxicity and tumor promotion responseJournal of Environmental Pathology, Toxicology and Oncology.  28:163-175. 2009
2008 Two new bioactive oleanane triterpene glycosides from Terminalia arjuna.Natural Product Letters.  22:1285-1294. 2008
2008 Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesisMolecular Cancer Therapeutics.  7:2042-2050. 2008
2008 Two new bioactive oleanane triterpene glycosides from Terminalia arjunaNatural Product Letters.  22:1279-1288. 2008
2008 Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcoholCancer Research.  68:7439-7447. 2008
2008 A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosisJournal of Immunology.  181:3077-3088. 2008
2008 Topically applied vitamin E prevents massive cutaneous inflammatory and oxidative stress responses induced by double application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in miceChemico-Biological Interactions.  172:195-205. 2008
2008 Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless micePhotochemistry and Photobiology.  84:522-527. 2008
2008 Quercus infectoria galls possess antioxidant activity and abrogates oxidative stress-induced functional alterations in murine macrophagesChemico-Biological Interactions.  171:272-282. 2008
2008 Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinomaNeoplasia : An International Journal for Oncology Research.  10:1411-1420. 2008
2007 CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in miceJournal of Clinical Investigation.  117:3753-3764. 2007
2007 Resveratrol: A review of preclinical studies for human cancer preventionToxicology and Applied Pharmacology.  224:274-283. 2007
2007 Sixtieth birthday of Dr. Hasan Mukhtar, a man with vision: Thirty-five years of dedicated efforts in developing preventive toxicology and chemoprevention of cancerToxicology and Applied Pharmacology.  224:207-208. 2007
2007 Protective effect of Rumex patientia (English Spinach) roots on ferric nitrilotriacetate (Fe-NTA) induced hepatic oxidative stress and tumor promotion responseFood and Chemical Toxicology.  45:1821-1829. 2007
2007 Endothelial nitric oxide synthase gene variants contribute to oxidative stress in COPDBiochemical and Biophysical Research Communications.  361:182-188. 2007
2007 Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: Implications for cancer preventionFood and Chemical Toxicology.  45:1634-1640. 2007
2007 Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary diseaseClinica Chimica Acta.  382:37-42. 2007
2007 Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicityFood and Chemical Toxicology.  45:910-920. 2007
2007 Effect of pre-treatment of almond oil on ultraviolet B-induced cutaneous photoaging in miceJournal of Cosmetic Dermatology.  6:14-19. 2007
2007 Protective effect of Didymocarpus pedicellata on ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and hyperproliferative responseChemico-Biological Interactions.  165:33-44. 2007
2006 Augmentation and proliferation of T lymphocytes and Th-1 cytokines by Withania somnifera in stressed miceInternational Immunopharmacology.  6:1394-1403. 2006
2006 Hedgehog signalling in skin development and cancerExperimental Dermatology.  15:667-677. 2006
2006 Catechin prevents tamoxifen-induced oxidative stress and biochemical perturbations in miceToxicology.  225:109-118. 2006
2006 Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in miceFood and Chemical Toxicology.  44:984-993. 2006
2006 Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathwaysExperimental Dermatology.  15:538-546. 2006
2006 Molecular target-based therapy of pancreatic cancerCancer Research.  66:2403-2413. 2006
2006 Oxidative stress in the pathogenesis of skin diseaseJournal of Investigative Dermatology.  126:2565-2575. 2006
2005 Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancerJournal of Investigative Dermatology.  125:818-825. 2005
2005 Inhibitory effect of 18β3-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in miceRedox Report.  10:151-157. 2005
2005 Two new compounds from the galls of Quercus infectoria with nitric oxide and superoxide inhibiting abilityPharmaceutical Biology.  43:317-323. 2005
2005 Mitochondrial damage mediates genotoxicity of arsenic in mammalian cellsCancer Research.  65:3236-3242. 2005
2005 Vitamin E inhibits hepatic oxidative stress, toxicity and hyperproliferation in rats treated with the renal carcinogen ferric nitrilotriacetateRedox Report.  10:62-70. 2005
2005 Elevated polyamines lead to selective induction of apoptosis and inhibition of tumorigenesis by (-)-epigallocatechin-3-gallate (EGCG) in ODC/Ras transgenic miceCarcinogenesis.  26:119-124. 2005
2005 Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless miceJournal of Investigative Dermatology.  124:1318-1325. 2005
2004 Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of fas expression and apoptosisCancer Research.  64:7545-7552. 2004
2004 Low iron diet retards 12-O-tetradecanoyl phorbol-13-acetate-mediated tumor promotion in murine skinArchives of Toxicology.  78:283-289. 2004
2004 Nimbidin suppresses functions of macrophages and neutrophils: Relevance to its antiinflammatory mechanismsPhytotherapy Research.  18:419-424. 2004
2004 Immunoprevention of Basal Cell Carcinomas with Recombinant Hedgehog-interacting ProteinJournal of Experimental Medicine.  199:753-761. 2004
2004 Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless miceToxicology and Applied Pharmacology.  195:370-378. 2004
2004 Free radical generating agents lead to the rapid progression of benign skin tumors to carcinoma in iron-overloaded miceArchives of Toxicology.  78:139-146. 2004
2004 Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- miceJournal of Clinical Investigation.  113:867-875. 2004
2004 Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association.Cell Cycle.  3:205-211. 2004
2004 Antiinflammatory evaluation of alcoholic extract of galls of Quercus infectoriaJournal of Ethnopharmacology.  90:285-292. 2004
2004 Roles of Catalase and Hydrogen Peroxide in Green Tea Polyphenol-Induced Chemopreventive EffectsJournal of Pharmacology and Experimental Therapeutics.  308:317-323. 2004
2003 Cyclooxygenases in the skin: Pharmacological and toxicological implicationsToxicology and Applied Pharmacology.  192:294-306. 2003
2003 Glyceryl trinitrate, a nitric oxide donor, abrogates ferric nitrilotriacetate-induced oxidative stress and renal damageArchives of Biochemistry and Biophysics.  418:71-79. 2003
2003 Baculoviral p35 inhibits oxidant-induced activation of mitochondrial apoptotic pathwayBiochemical and Biophysical Research Communications.  307:483-490. 2003
2003 Antioxidants prevent UV-induced apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation in Spodoptera frugiperda (Sf9) cellsCell Biology International.  27:483-490. 2003
2003 Palm oil alleviates 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion response in murine skinCancer Letters.  192:151-160. 2003
2003 Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosisAnticancer Research.  23:1533-1539. 2003
2003 Progressive iron overload enhances chemically mediated tumor promotion in murine skinArchives of Biochemistry and Biophysics.  409:262-273. 2003
2003 Host-pathogen interactions during apoptosisJournal of Biosciences.  28:349-358. 2003
2002 Protoporphyrin-IX accumulation and cutaneous tumor regression in mice using a ferrochelatase inhibitorCancer Letters.  187:9-16. 2002
2002 Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomasBiochemical and Biophysical Research Communications.  298:377-382. 2002
2002 Induction of p57 is required for cell survival when exposed to green tea polyphenolsAnticancer Research.  22:4115-4120. 2002
2002 Iron augments stage-I and stage-II tumor promotion in murine skinCancer Letters.  183:113-122. 2002
2002 Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: Implications for therapeutic approachesPhotochemistry and Photobiology.  76:73-80. 2002
2002 Low iron state is associated with reduced tumor promotion in a two-stage mouse skin carcinogenesis modelFood and Chemical Toxicology.  40:1105-1111. 2002
2002 Oxidative stress and experimental carcinogenesisIndian Journal of Experimental Biology.  40:656-667. 2002
2002 Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor developmentPhotochemistry and Photobiology.  75:58-67. 2002
2002 Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development.Photochemistry and Photobiology.  75:58-67. 2002
2002 Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53Journal of Investigative Dermatology.  118:818-824. 2002
2001 Chemoprevention of basal cell carcinomas in the ptc1+/- mouse-green and black teaSkin Pharmacology and Applied Skin Physiology.  14:358-362. 2001
2001 Chemopreventive effects of green tea polyphenols correlate with reversible induction of p57 expressionAnticancer Research.  21:3743-3748. 2001
2001 Pyrazole aroyl hydrazones as ligands-I 1,3-diphenylpyrazole-4-carboxaldehyde benzoyl hydrazone as ligand for metal complexesPakistan Journal of Scientific and Industrial Research.  44:268-272. 2001
2001 Chemopreventive effects of green tea polyphenols correlate with reversible induction of p57 expression.Anticancer Research.  21:3743-3748. 2001
2001 Inhibition of benzo[a]pyrene- and cyclophoshamide-induced mutagenicity by Cinnamomum cassiaMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  480-481:179-188. 2001
2001 Nitroglycerin: A NO donor inhibits TPA-mediated tumor promotion in murine skinCarcinogenesis.  22:1207-1211. 2001
2001 Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in ratsFood and Chemical Toxicology.  39:19-28. 2001
2001 Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicityProceedings of the National Academy of Sciences.  98:1643-1648. 2001
2001 Ultraviolet B (UVB)-induced COX-2 expression in murine skin: An immunohistochemical studyBiochemical and Biophysical Research Communications.  280:1042-1047. 2001
2000 Mechanism of ultraviolet B-induced cell cycle arrest in G2/M phase in immortalized skin keratinocytes with defective p53Biochemical and Biophysical Research Communications.  277:107-111. 2000
2000 Induction of hepatic antioxidants in freshwater catfish (Channa punctatus Bloch) is a biomarker of paper mill effluent exposureBBA - General Subjects.  1523:37-48. 2000
2000 In vitro inhibition of carcinogen-induced mutagenicity by Cassia occidentalis and Emblica officinalisDrug and Chemical Toxicology.  23:477-484. 2000
2000 Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant propertiesCancer Letters.  153:1-5. 2000
2000 Pyrazole aroyl hydrazones as ligands: Complexes of 1,3-diphenylpyrazole -4-carboxaldehyde 2-chlorobenzoylhydrazone with Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), Sn(II), Bi(III) and Pb(II)Pakistan Journal of Scientific and Industrial Research.  43:38-41. 2000
2000 Evaluation of the efficacy of Lawsonia alba in the alleviation of carbon tetrachloride-induced oxidative stressJournal of Ethnopharmacology.  69:157-164. 2000
2000 Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in miceHuman and Experimental Toxicology.  19:377-384. 2000
2000 Novel approaches to chemoprevention of skin cancerJournal of Dermatology.  27:691-695. 2000
1999 Evidence that ferric nitrilotriacetate mediates oxidative stress by down-regulating DT-diaphorase activity: Implications for carcinogenesisCancer Letters.  141:151-157. 1999
1999 Age-dependent renal accumulation of 4-hydroxy-2-nonenal (HNE)-modified proteins following parenteral administration of ferric nitrilotriacetate commensurate with its differential toxicity: Implications for the involvement of HNE-protein adducts in oxidative stress and carcinogenesisArchives of Biochemistry and Biophysics.  365:101-112. 1999
1999 The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathwayProceedings of the National Academy of Sciences.  96:4838-4843. 1999
1999 Copper-nitrilotriacetate (Cu-NTA) is a potent inducer of proliferative response both in liver and kidney but is a complete renal carcinogenInternational Journal of Oncology.  14:799-806. 1999
1999 Potassium bromate (KBrO3) induces renal proliferative response and damage by elaborating oxidative stressCancer Letters.  135:181-188. 1999
1999 Reconstituted 3-dimensional human skin as a novel in vitro model for studies of carcinogenesisBiochemical and Biophysical Research Communications.  254:49-53. 1999
1999 Ellagic acid ameliorates nickel induced biochemical alterations: Diminution of oxidative stressHuman and Experimental Toxicology.  18:691-698. 1999
1999 Ferrochelatase, a novel target for photodynamic therapy of cancer.Oncology Reports.  6:1439-1442. 1999
1999 Glutathione redox system in oxidative lung injuryCritical Reviews in Toxicology.  29:543-568. 1999
1999 Glyceryl trinitrate, a nitric oxide donor, suppresses renal oxidant damage caused by potassium bromateRedox Report.  4:263-269. 1999
1999 Green tea protects against psoralen plus ultraviolet A-induced photochemical damage to skinJournal of Investigative Dermatology.  113:1070-1075. 1999
1999 In vitro cultured Spodoptera frugiperda insect cells: Model for oxidative stress-induced apoptosisJournal of Biosciences.  24:13-19. 1999
1999 Nordihydroguairetic acid is a potent inhibitor of ferric-nitrilotriacetate-mediated hepatic and renal toxicity, and renal tumour promotion, in miceCarcinogenesis.  20:599-606. 1999
1999 Photoprotective effect of black tea extracts against UVB-induced phototoxicity in skinPhotochemistry and Photobiology.  70:637-644. 1999
1999 Protective effect of Cassia occidentalis extract on chemical-induced chromosomal aberrations in miceDrug and Chemical Toxicology.  22:643-653. 1999
1998 Susceptibility to the biological effects of polyaromatic hydrocarbons is influenced by genes of the major histocompatibility complexProceedings of the National Academy of Sciences.  95:14915-14919. 1998
1998 Augmentation of 12-O-tetradecanoyl 13-phorbol acetate-mediated tumor promoting response by the porphyrin photosensitization of 7,12-dimethyl benz[a]anthracene-initiated murine skin: Role of in situ generated reactive oxygen speciesCancer Letters.  135:53-60. 1998
1998 Responses of circulating fish phagocytes to paper mill effluent exposureBulletin of Environmental Contamination and Toxicology.  61:746-753. 1998
1998 Attenuation of iron-nitrilotriacetate (Fe-NTA)-mediated renal oxidative stress, toxicity and hyperproliferative response by the prophylactic treatment of rats with garlic oilFood and Chemical Toxicology.  36:485-495. 1998
1998 Ferric nitrilotriacetate promotes N-diethylnitrosamine-induced renal tumorigenesis in the rat: Implications for the involvement of oxidative stressCarcinogenesis.  19:1133-1139. 1998
1998 Effect of iron overload on the benzoyl peroxide-mediated tumor promotion in mouse skinCancer Letters.  126:135-142. 1998
1998 Iron overload augments 7,12-dimethylbenz(a)anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin tumorigenesisSkin Pharmacology and Applied Skin Physiology.  11:98-103. 1998
1998 α-tocopherol (vitamin-E) ameliorates ferric nitrilotriacetate (Fe-NTA)-dependent renal proliferative response and toxicity: Diminution of oxidative stressHuman and Experimental Toxicology.  17:163-171. 1998
1998 Drought tolerance by lentil rhizobia (Rhizobium leguminosarum) from arid and semiarid areas of PakistanLetters in Applied Microbiology.  26:38-42. 1998
1997 Effect of peanut plants incorporated as green manure on the growth and grain yield of succeeding wheatJournal of Agronomy and Crop Science.  179:135-138. 1997
1997 Evidence that Fe-NTA-induced renal prostaglandin F2α is responsible for hyperplastic response in kidney: Implications for the role of cyclooxygenase-dependent arachidonic acid metabolism in renal tumor promotionBiochemistry and Molecular Biology International.  42:1115-1124. 1997
1997 Analgesic activity of bacosine, a new triterpene isolated from Bacopa monnieriFitoterapia.  68:361-365. 1997
1997 Evidence that iron-overload promotes 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in miceRedox Report.  3:303-309. 1997
1997 Mechanism of asbestos-mediated DNA damage: role of heme and heme proteins.Environmental Health Perspectives.  105 Suppl 5:1109-1112. 1997
1996 L-2-oxothiazolidine-4-carboxylate, an in situ inducer of glutathione, protects against paraquat-mediated pulmonary damage in ratMedical Science Research.  24:699-701. 1996
1996 Glutathione metabolizing enzymes and oxidative stress in ferric nitrilotriacetate mediated hepatic injury.Redox Report.  2:385-391. 1996
1996 Coordination of copperpolyamine complex with imidazoles potentiates its superoxide dismutase mimicking activity and abolishes its interaction with albuminBiochemistry and Molecular Biology International.  39:813-821. 1996
1996 Paraquat induced DNA damage by reactive oxygen speciesBiochemistry and Molecular Biology International.  39:63-67. 1996
1996 Porphyrin-mediated photosensitization has a weak tumor promoting activity in mouse skin: Possible role of in situ-generated reactive oxygen speciesCarcinogenesis.  17:2023-2028. 1996
1995 Novel copper superoxide dismutase mimics and damage mediated by O2.-.Nutrition.  11:559-563. 1995
1995 Ferric nitrilotriacetate (Fe-NTA) is a potent hepatic tumor promoter and acts through the generation of oxidative stressBiochemical and Biophysical Research Communications.  212:557-563. 1995
1995 Evidence that in situ generated reactive oxygen species act as a potent stage i tumor promoter in mouse skinBiochemical and Biophysical Research Communications.  209:698-705. 1995
1995 Augmentation of chrysotile-induced oxidative stress by BHA in mice lungsFood and Chemical Toxicology.  33:209-215. 1995
1995 Crude extracts of hepatoprotective plants, Solanum nigrum and Cichorium intybus inhibit free radical-mediated DNA damageJournal of Ethnopharmacology.  45:189-192. 1995
1995 Metabolic requirements for induction of contact hypersensitivity to immunotoxic polyaromatic hydrocarbonsJournal of Immunology.  155:3530-3537. 1995
1994 Differential Role of Hydrogen Peroxide and Organic Peroxides Augmenting Asbestos-Mediated DNA Damage: Implications for Asbestos Induced CarcinogenesisBiochemical and Biophysical Research Communications.  200:687-694. 1994
1993 Synthesis and reactivity in inorganic and metal-organic chemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  23:a-b. 1993
1993 Asbestos induced oxidative injury to DNAAnnals of Occupational Hygiene.  37:315-319. 1993
1993 Free radicals and trace elementsJournal of Trace Elements in Experimental Medicine.  6:65-73. 1993
1993 Ras protein p21 processing enzyme farnesyltransferase in chemical carcinogen—induced murine skin tumorsMolecular Carcinogenesis.  8:290-298. 1993
1992 Synthesis and Reactivity in Inorganic and Metal-organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  22:a-b. 1992
1992 Synthesis and Reactivity in Inorganic and Metal-organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  22:a-b. 1992
1992 Synthesis and Reactivity in Inorganic and Metal-Organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  22:a-b. 1992
1992 Synthesis and Reactivity in Inorganic and Metal-Organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  22:a-b. 1992
1992 Synthesis and Reactivity in Inorganic and Metal-Organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  22:a-b. 1992
1992 Synthesis and Reactivity in Inorganic and Metal-organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  22:a-b. 1992
1992 PHOTODYNAMIC THERAPY OF CHEMICALLY‐ AND ULTRAVIOLET B RADIATION‐INDUCED MURINE SKIN PAPILLOMAS BY CHLOROALUMINUM PHTHALOCYANINE TETRASULFONATEPhotochemistry and Photobiology.  56:43-50. 1992
1992 Photodynamic effects of chloroaluminum phthalocyanine tetrasulfonate are mediated by singlet oxygen: In vivo and in vitro studies utilizing hepatic microsomes as a model membrane sourceArchives of Biochemistry and Biophysics.  294:30-37. 1992
1992 Synthesis and Reactivity in Inorganic and Metal-organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  22:a-b. 1992
1991 All-trans retinoic acid protects against conversion of chemically induced and ultraviolet b radiation-induced skin papillomas to carcinomasCarcinogenesis.  12:2325-2329. 1991
1991 Photodynamic therapy of murine skin tumors using Photofrin®-IIPhotodermatology, Photoimmunology & Photomedicine.  8:169-175. 1991
1991 Synthesis and reactivity in inorganic and metal-organic chemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  21:a-b. 1991
1991 Synthesis and Reactivity in Inorganic and Metal-organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  21:a-b. 1991
1991 Synthesis and reactivity in inorganic and metal-organic chemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  21:a-b. 1991
1991 Synthesis and Reactivity in Inorganic and Metal-Organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  21:a-b. 1991
1991 Synthesis and reactivity in inorganic and Metal-Organic chemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  21:a-b. 1991
1991 Synthesis and Reactivity in Inorganic and Metal-organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  21:a-b. 1991
1991 Synthesis and reactivity in inorganic and metal-organic chemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  21:a-b. 1991
1991 Cadmium-mediated Induction of Cellular Defence Mechanism: A Novel Example for the Development of Adaptive Response against a ToxicantIndustrial Health.  29:1-9. 1991
1991 Involvement of singlet oxygen in chloroaluminum phthalocyanine tetrasulfonate-mediated photoenhancement of lipid peroxidation in rat epidermal microsomesCancer Letters.  56:125-129. 1991
1991 Synthesis and Reactivity in Inorganic and Metal-organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  21:a-b. 1991
1990 Evidence for the involvement of singlet oxygen in the photodestruction by chloroaluminum phthalocyanine tetrasulfonateBiochemical and Biophysical Research Communications.  173:34-41. 1990
1990 Nickel-mediated inhibition in the glutathione-dependent protection against lipid peroxidationBiochemistry International.  20:495-501. 1990
1990 Inhibition of benzoyl peroxide-mediated tumor promotion in 7,12-dimethylbenz(a)anthracene-Initiated skin of sencar mice by antioxidants nordihydroguaiaretic acid and diallyl sulfideJournal of Investigative Dermatology.  94:162-165. 1990
1990 Synthesis and Reactivity, in Inorganic and Metal-Organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  20:a-b. 1990
1989 Effect of Dietary Tannic Acid on Epidermal, Lung, and Forestomach Polycyclic Aromatic Hydrocarbon Metabolism and Tumorigenicity in Sencar MiceCancer Research.  49:5784-5788. 1989
1989 Malignant conversion of UV radiation and chemically induced mouse skin benign tumors by free-radical-generating compoundsCarcinogenesis.  10:1841-1845. 1989
1989 Evidence for the metabolism of tumor promoter organic hydroperoxides into free radicals by human carcinoma skin keratinocytes: An ESR-spin trapping studyCarcinogenesis.  10:1499-1503. 1989
1989 A novel mechanism for the generation of superoxide anions in hematoporphyrin derivative-mediated cutaneous photosensitization. Activation of the xanthine oxidase pathwayJournal of Clinical Investigation.  83:1137-1143. 1989
1989 Antimutagenic activity of green tea polyphenolsMutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure.  223:273-285. 1989
1989 Evaluation of nickel complexes of bioligands - Effect on distribution profileResearch communications in chemical pathology and pharmacology.  65:253-256. 1989
1989 Inhibition of the high affinity Fc receptor (Fc(γ)RI) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicalsJournal of Biological Chemistry.  264:11407-11413. 1989
1989 Skin chemical carcinogenesisClinics in Dermatology.  7:1-10. 1989
1989 Synthesis and Reactivity in Inorganic and Metal-organic ChemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  19:a-b. 1989
1988 Alleviation of nickel-induced biochemical alterations by chelating agentsToxicological Sciences.  11:285-292. 1988
1988 Alleviation of nickel-induced biochemical alterations by chelating agentsToxicological Sciences.  11:285-292. 1988
1988 Comparative effects of chelating drugs on trace metal and biochemical alterations in the ratBulletin of Environmental Contamination and Toxicology.  41:172-184. 1988
1988 In situ evidence for the involvement of superoxide anions in cutaneous porphyrin photosensitizationBiochemical and Biophysical Research Communications.  151:1054-1059. 1988
1988 Effect of exposure to toxic gas on the population of Bhopal: Part III--Assessment of toxic manifestations in humans--haematological and biochemical studies.Indian Journal of Experimental Biology.  26:165-172. 1988
1988 Influence of partial hepatectomy on the metabolic disposition of nickel in ratsBulletin of Environmental Contamination and Toxicology.  40:439-443. 1988
1988 Involvement of superoxide anions in cutaneous porphyrin photosensitization: An in vivo studyProceedings of SPIE.  847:193-200. 1988
1988 Dietary anticarcinogens and cancer prevention.Cleveland Clinic Journal of Medicine.  55:507-508. 1988
1988 Differential role of reactive oxygen intermediates in photofrin-I- and photofrin-II-mediated photoenhancement of lipid peroxidation in epidermal microsomal membranesJournal of Investigative Dermatology.  90:652-657. 1988
1988 Inhibition of the skin tumorigenicity of (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene by tannic acid, green tea polyphenols and quercetin in Sencar miceCancer Letters.  42:7-12. 1988
1987 Role of glutathione metabolizing enzymes in nickel mediated induction of hepatic glutathioneResearch communications in chemical pathology and pharmacology.  57:421-426. 1987
1987 Evidence for the involvement of hydroxyl radicals in nickel mediated enhancement of lipid peroxidation: Implications for nickel carcinogenesisBiochemical and Biophysical Research Communications.  147:1276-1281. 1987
1987 Evaluation of chelating drugs on the toxicity, excretion, and distribution of nickel in poisoned ratsToxicological Sciences.  9:26-33. 1987
1987 Studies on the schiff base complexes of oxovanadium(Iv)Synthesis and Reactivity in Inorganic and Metal Organic Chemistry.  17:723-745. 1987
1987 Cytochrome P-450 dependent metabolism of testosterone in rat skinBiochemical and Biophysical Research Communications.  145:749-753. 1987
1987 Evaluation of chelating drugs on the toxicity, excretion, and distribution of nickel in poisoned ratsFundamental and applied toxicology : official journal of the Society of Toxicology.  9:26-33. 1987
1987 Pharmacokinetics and metabolic disposition of nickel in poisoned rats - Effect of chelating drugsChemosphere.  16:259-267. 1987
1986 Evaluation of LD50 of some polyaminocarboxylic acids used as chelating drugs in metal intoxicationToxicology Letters.  32:37-40. 1986
1986 Removal of nickel by chelating drugs from the organs of nickel poisoned ratsChemosphere.  15:813-821. 1986
1985 Synthesis and reactivity of some α,α'-bis(2- and 4- substituted benzoyletllurium dichloridesSynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  15:1043-1059. 1985
1981 Selective spectrophotometric determination of uranium(VI) using salicylaldimine antipyrineFresenius' Journal of Analytical Chemistry.  305:410. 1981
1970 Synthesis and reactivity in inorganic and metal-organic chemistrySynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  22:a-b. 1970

Chapter

Year Title Altmetric
2017 UV and skin: Photocarcinogenesis.  67-103. 2017
2015 Cutaneous Toxicology of Arsenic.  301-314. 2015

Investigator On

  • RXR Rexinoids for Cancer Chemoprevention  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • RXR Rexinoids for Cancer Chemoprevention - Program Integration and Management  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • RXR Rexinoids for Cancer Chemoprevention - Project 1: Evaluation if UAB30 on Skin Cancer Biomarkers in Human Renal Transplant Recipients  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • RXR Rexinoids for Cancer Chemoprevention - Project 3: Molecular Targets of Rexinoid Action in Skin  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • Topical Chemoprevention of Skin Cancer Biomarkers  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • RT-SQuARED-M Method to Study the Precise Role of Mitochondria in the Oxidative Damage Caused by Environmental Toxins  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2018 - 2020
  • Dietary Prevention of Photodamage in Skin with Grapes: A Human Clinical Study  awarded by California Table Grape Commission 2014 - 2018
  • RT-SQuARED-M Method to Study the Precise Role of Mitochondria in the Oxidative Damage Caused by Environmental Toxins  awarded by National Institute of Environmental Health Sciences/NIH/DHHS 2015 - 2018
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • UAB Skin Disease Research Center - Administrative Core - Core A  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • The Effect of Polypodium Leucotomos on UV-Induced Photodamage in Skin  awarded by HENRY FORD HOSPITAL 2014 - 2015
  • Education And Training

  • Doctor of Philosophy Level Degree in Chemistry, Aligarh Muslim University 1980
  • Master of Sciences or Mathematics in Inorganic Chemistry, University of Lucknow 1977
  • Bachelor of Science or Mathematics in Chemistry, University of Lucknow 1975
  • Full Name

  • Mohammad Athar