Positions

Overview

  • Dr. Manne obtained his M.S. (Biochemistry, Histochemistry, Parasitology, Zoonosis) and Ph.D. (energy metabolic pathways of endoparasites) degrees from Osmania University, Hyderabad, India. His postdoctoral training was in molecular immunology and vaccine development for malaria (Malaria Research Center, Delhi, India); in helicobacter infections (School of Microbiology, University of New South Wales, Sydney, Australia); and in histopathology, molecular tumor biology, and preclinical translational research of human malignancies at the University of Alabama at Birmingham (UAB). He also received certification in bioinformatics at UAB. Dr. Manne’s research on racial disparity in CRC has received considerable national and international recognition. In 2009, the Presidents Cancer Panel invited Dr. Manne to speak on “Biologic differences between ethnic groups and their clinical implications in cancer care,” and devoted to the topic, “America’s demographic and cultural transformation: implications for the cancer enterprise.” Currently, he is the Lead Principal Investigator of two Comprehensive Cancer Research Partnership between UAB Comprehensive Cancer Center and Tuskegee University, Tuskegee, AL and Morehouse School of Medicine, Atlanta, GA (U54); and Alabama State University, Montgomery, AL (P20) to Reduce Cancer Health Disparities by implementing innovative, multi-disciplinary, collaborative, population-based cancer control and prevention research and has contributed to education, training, and community outreach activities. These two programs are funded by the National Cancer Institute of the National Institute of Health.
  • Selected Publications

    Chapter

    Year Title Altmetric
    2012 Development and progression of colorectal neoplasia.  235-265. 2012

    Research Overview

  • Translational research in grastrointestinal malignancies and breast cancer - Dr. Manne’s present efforts are focused on population-based translational research for human neoplasias, with emphasis on colorectal and breast cancers. His laboratory, with projects funded by the National Cancer Institute and the Susan G. Komen Foundation, is evaluating molecular markers to identify aggressive phenotypic features of tumors to predict the efficacy of chemotherapeutic regimens and to assess clinical outcomes. Dr. Manne’s research and collaborative groups include experts in the fields of molecular biology, clinical oncology, pathology, epidemiology, statistics, and bioinformatics. For evaluating the clinical utility of genetic and phenotypic abnormalities in colorectal cancer, his group has developed strategies demonstrating that the utility of molecular biomarkers varies according to the anatomic location of tumors within the colorectum and with tumor stage, race/ethnicity, age, and gender. To validate the clinical utility of genetic and phenotypic markers, Dr. Manne’s laboratory is evaluating hundreds of colorectal cancer samples derived from African American and non-Hispanic Caucasian ethnic/racial backgrounds and collected from different institutions. Established molecular markers with be merged with other epidemiological, environmental, and socio-economic features to find the basis for racial disparities in colorectal and breast malignancies. Results from approaches involving biomarker discovery and bioinformatics will aid in developing predictive models specific for individual patients. The research interests of Dr. Manne also include use of genomics and proteomics for identification of early markers of cancers, specifically, identification of molecular signatures of benign colonic epithelium, which is at risk of developing colorectal neoplasias, and of other pre-malignant lesions. These studies will aid in the evaluation of molecular and pathologic characteristics of specimens and in the development of assays that relate to early detection, diagnosis, prognosis, and treatment of cancers.

    Keywords - Colorectal Cancer, Breast Cancer, Molecular Biomarkers, Racial/Ethnic Disparities, Cancer Control & Prevention
  • Principal Investigator On

  • 3/3 Morehouse Sch of Medicine/Tuskegee Univ/University of Alabama Ca Ctr Partnership - Research Projects  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: (Admin Supplement) to Support Development of PDX at UAB CCC  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Hedgehog/Gli1- Targeted Therapies to Overcome Ovarian Cancer Chemoresistance and Disease Recurrence  awarded by TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant - Tissue Procurement Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • 1/2 The Alabama State University/UAB Comprehensive Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • 1/2 The Alabama State University/UAB Comprehensive Cancer Center Partnership - Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • 1/2 The Alabama State University/UAB Comprehensive Cancer Center Partnership - Pilot Project #1  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Effects of NefM1 Peptide on Primary and Metastatic Colorectal Cancer Xenografts  awarded by Michigan State University 2013 - 2016
  • Predictive Molecular Markers of Colorectal Cancer  awarded by National Cancer Institute/NIH/DHHS 2009 - 2011
  • EDRN Project-Prognostic Markers in Lynch Syndrome Colorectal Cancers  awarded by CREIGHTON UNIVERSITY 2008 - 2011
  • Education And Training

  • Doctor of Philosophy in Zoology / Animal Biology, Osmania University 1987
  • Full Name

  • Upender Manne