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Lufang Zhou
Associate Professor
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E-mail
lfzhou@uab.edu
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Lufang Zhou
Associate Professor
Positions
Associate Professor (P)
,
Medicine - Cardiovascular Disease
,
Department of Medicine
2011 -
Assistant Professor (S)
,
Biomedical Engineering
,
School of Engineering
2011 -
Associate Scientist (C)
,
Nutrition Obesity Res Center (NORC)
,
Nutrition Sciences Research
2012 -
Associate Scientist (C)
,
Comprehensive Cardiovascular Center
,
School of Medicine
2012 -
Associate Scientist (C)
,
Comprehensive Diabetes Center
,
School of Medicine
2013 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
Altmetric
2020
Dual-targeted extracellular vesicles to facilitate combined therapies for neuroendocrine cancer treatment
2020
2020
MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure
2020
2020
Intracellular metabolism analysis of Clostridium cellulovorans via modeling integrating proteomics, metabolomics and fermentation
.
Process Biochemistry
. 89:9-19.
2020
2020
Anti-EGFR antibody-drug conjugate for triple-negative breast cancer therapy
2020
2020
Anti-SSTR2 antibody-drug conjugate for neuroendocrine tumor therapy
.
Cancer Gene Therapy
.
2020
2020
Targeted Exosomes for Drug Delivery: Biomanufacturing, Surface Tagging, and Validation
.
Biotechnology Journal
. 15.
2020
2019
Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision
.
Biophysical Journal
. 117:631-645.
2019
2019
Complex regulation of mitochondrial function during cardiac development
2019
2019
Enhancing the engraftment of human induced pluripotent stem cell-derived cardiomyocytes via a transient inhibition of rho kinase activity
.
Journal of Visualized Experiments
. 2019.
2019
2019
Proteomics insight into the production of monoclonal antibody
.
Biochemical Engineering Journal
. 145:177-185.
2019
2019
HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injury
.
Journal of Molecular and Cellular Cardiology
. 130:36-48.
2019
2019
Novel biomanufacturing platform for large-scale and high-quality human T cells production
.
Journal of Biological Engineering
. 13.
2019
2019
Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice
.
Redox Biology
. 21.
2019
2019
Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice
.
Cardiovascular Research
. 115:343-356.
2019
2018
Bioprocess development of antibody-drug conjugate production for cancer treatment
.
PLoS ONE
. 13.
2018
2018
Mitochondrial-mediated oxidative Ca
2+
/calmodulin-dependent kinase II activation induces early afterdepolarizations in Guinea pig cardiomyocytes: An in silico study
2018
2018
Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus.
.
Frontiers in Physiology
. 9:1670.
2018
2017
Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 Expression
.
Scientific Reports
. 7.
2017
2017
Knockout of the ATPase inhibitory factor 1 protects the heart from pressure overload-induced cardiac hypertrophy
.
Scientific Reports
. 7.
2017
2017
Process engineering of cellulosic n-butanol production from corn-based biomass using Clostridium cellulovorans
.
Process Biochemistry
. 62:144-150.
2017
2017
The amyloid precursor protein modulates α
2A
-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitment
.
The FASEB Journal
. 31:4434-4446.
2017
2017
Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α
2A
adrenergic receptor ligands
.
Neuropharmacology
. 116:38-49.
2017
2017
Comparative proteomic analysis of three Chinese hamster ovary (CHO) host cells
.
Biochemical Engineering Journal
. 124:122-129.
2017
2016
Impaired mitochondrial network excitability in failing Guinea-pig cardiomyocytes
.
Cardiovascular Research
. 109:79-89.
2016
2015
High-level expression of recombinant IgG1 by CHO K1 platform
.
Frontiers of Chemical Science and Engineering
. 9:376-380.
2015
2015
Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload
2015
2015
Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload
2015
2015
Mitochondria-derived ROS bursts disturb Ca
2+
cycling and induce abnormal automaticity in guinea pig cardiomyocytes: A theoretical study
2015
2015
Comparative proteomics analysis of high n-butanol producing metabolically engineered Clostridium tyrobutyricum
.
Journal of Biotechnology
. 193:108-119.
2015
2014
Targeted biopharmaceuticals for cancer treatment
.
Cancer Letters
. 352:145-151.
2014
2014
High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats
2014
2014
Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function
2014
2014
Inhibiting Na
+
/K
+
ATPase can impair mitochondrial energetics and induce abnormal Ca
2+
cycling and automaticity in guinea pig cardiomyocytes
.
PLoS ONE
. 9.
2014
2014
Effects of regional mitochondrial depolarization on electrical propagation: Implications for arrhythmogenesis
.
Circulation: Arrhythmia and Electrophysiology
. 7:143-151.
2014
2013
HNO Enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization
.
Antioxidants and Redox Signaling
. 19:1185-1197.
2013
2012
Cardiac mitochondrial network excitability: Insights from computational analysis
2012
2011
Dynamic modulation of Ca
2+
sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress
.
Journal of Molecular and Cellular Cardiology
. 51:632-639.
2011
2010
A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network
.
PLoS Computational Biology
. 6.
2010
2009
Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes
.
Biophysical Journal
. 97:1843-1852.
2009
2009
From mitochondrial dynamics to arrhythmias
2009
2008
From mitochondrial ion channels to arrhythmias in the heart: Computational techniques to bridge the spatio-temporal scales
2008
2008
Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia
.
Journal of Theoretical Biology
. 254:466-475.
2008
2008
Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia
2008
2008
Metabolic response to an acute jump in cardiac workload: Effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation
2008
2007
Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs
2007
2006
Regulation of myocardial substrate metabolism during increased energy expenditure: Insights from computational studies
2006
2006
Role of cellular compartmentation in the metabolic response to stress: Mechanistic insights from computational models
.
Annals of the New York Academy of Sciences
. 1080:120-139.
2006
2005
Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD
+
: Insights from in silico studies
2005
2005
Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia
2005
2005
Regulation of cardiac energetics: Role of redox state and cellular compartmentation during ischemia
.
Annals of the New York Academy of Sciences
. 1047:259-270.
2005
Research
Principal Investigator On
Mitochondria-SR Redox Signaling and Ca2+ Handling in Healthy and Failing Hearts
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2015 - 2021
Cell Death Mechanisms in Induced Pluripotent Stem Cell-derived Cardiiomyocytes using Mitochondrial Optogenetics
awarded by
American Heart Association
2018 - 2020
Pannexin Channels in Cardiac Arrythmias
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2018 - 2020
A Novel Optogenetic Tool for Precise Mitochondrial Control
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2016 - 2019
Investigate the Effect of Mitochondrial Energy State on Ca2+ Sparks and Handling
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2011 - 2015
Investigator On
Identifying a New Biological Target for Breast Cancer Therapy That Contributes to Disparities for African-American Women
awarded by
National Cancer Institute/NIH/DHHS
2020 - 2025
Xanthine Oxidase and Bioenergetic Function in Volume Overload
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2010 - 2015
Teaching
Teaching Activities
BME798 - Non-Dissertation Research (Fall Term 2020)
2020
BME799 - Dissertation Research (Fall Term 2020)
2020
BME798 - Non-Dissertation Research (Summer Term 2020)
2020
BME799 - Dissertation Research (Summer Term 2020)
2020
BME670 - Quantitative Physiology (Spring Term 2020)
2020
BME770 - Quantitative Physiology (Spring Term 2020)
2020
BME798 - Non-Dissertation Research (Spring Term 2020)
2020
GBS751 - Heart Lung & Kidney (Spring Term 2020)
2020
BME798 - Non-Dissertation Research (Fall Term 2019)
2019
BME798 - Non-Dissertation Research (Summer Term 2019)
2019
BME798 - Non-Dissertation Research (Spring Term 2019)
2019
GBS751 - Heart Lung & Kidney (Spring Term 2019)
2019
BME798 - Non-Dissertation Research (Fall Term 2018)
2018
BME798 - Non-Dissertation Research (Summer Term 2018)
2018
BME670 - Quantitative Physiology (Spring Term 2018)
2018
BME770 - Quantitative Physiology (Spring Term 2018)
2018
BME798 - Non-Dissertation Research (Spring Term 2018)
2018
BME798 - Non-Dissertation Research (Fall Term 2017)
2017
BME798 - Non-Dissertation Research (Summer Term 2017)
2017
BME798 - Non-Dissertation Research (Spring Term 2017)
2017
BME798 - Non-Dissertation Research (Summer Term 2016)
2016
BME798 - Non-Dissertation Research (Spring Term 2013)
2013
Background
Education And Training
Doctor of Philosophy in Biomedical / Medical Engineering,
Case Western Reserve University
2006
Contact
Full Name
Lufang
Zhou