Positions

Overview

  • A postdoctoral researcher position is available immediately in the laboratory of Dr. Lufang Zhou in the Department of Medicine. We seek a motivated and creative individual to employ an innovative mitochondrial-targeted luminoptogenetics approach developed in the laboratory to specifically induce cardiomyocyte mitochondrial depolarization, and explore its acute and chronic effect on cardiac functions. This is a NIH funded R01 project.

    The successful applicant will be encouraged to develop their own research within the overall goals of this project, and to take advantage of the career development opportunities offered by the UAB Office of Postdoctoral Education (https://www.uab.edu/postdocs/). Interested individuals should contact Dr. Lufang Zhou via email at lfzhou@uab.edu and provide the following documents in one PDF:

    1) A cover letter including a brief summary of past research experience and future career goals.
    2) Curriculum vitae.
    3) Contact information for a minimum of three references.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Targeted EV to Deliver Chemotherapy to Treat Triple-Negative Breast Cancers 2022
    2022 Targeted Extracellular Vesicles Delivered Verrucarin A to Treat Glioblastoma.  Biomedicines.  10. 2022
    2021 Anti-SSTR2 antibody-drug conjugate for neuroendocrine tumor therapy.  Cancer Gene Therapy.  28:799-812. 2021
    2021 Anti-cd47 monoclonal antibody–drug conjugate: A targeted therapy to treat triple-negative breast cancers.  Vaccines.  9. 2021
    2021 Targeted liposomal chemotherapies to treat triple-negative breast cancer.  Cancers.  13. 2021
    2021 Antibody–drug conjugate to treat meningiomas.  Pharmaceuticals.  14. 2021
    2021 Investigation into the difference in mitochondrial-cytosolic calcium coupling between adult cardiomyocyte and hiPSC-CM using a novel multifunctional genetic probe 2021
    2021 Ablation of lncrna miat attenuates pathological hypertrophy and heart failure.  Theranostics.  11:7995-8007. 2021
    2021 Anti-EGFR antibody-drug conjugate for triple-negative breast cancer therapy 2021
    2020 Dual-targeted extracellular vesicles to facilitate combined therapies for neuroendocrine cancer treatment 2020
    2020 MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure 2020
    2020 Intracellular metabolism analysis of Clostridium cellulovorans via modeling integrating proteomics, metabolomics and fermentation.  Process Biochemistry.  89:9-19. 2020
    2020 Targeted Exosomes for Drug Delivery: Biomanufacturing, Surface Tagging, and Validation.  Biotechnology Journal.  15. 2020
    2019 Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.  Biophysical Journal.  117:631-645. 2019
    2019 Complex regulation of mitochondrial function during cardiac development 2019
    2019 Enhancing the engraftment of human induced pluripotent stem cell-derived cardiomyocytes via a transient inhibition of rho kinase activity.  Journal of Visualized Experiments.  2019. 2019
    2019 Proteomics insight into the production of monoclonal antibody.  Biochemical Engineering Journal.  145:177-185. 2019
    2019 HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injury.  Journal of Molecular and Cellular Cardiology.  130:36-48. 2019
    2019 Novel biomanufacturing platform for large-scale and high-quality human T cells production.  Journal of Biological Engineering.  13. 2019
    2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice.  Redox Biology.  21. 2019
    2019 Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice.  Cardiovascular Research.  115:343-356. 2019
    2018 Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus.  Frontiers in Physiology.  9. 2018
    2018 Bioprocess development of antibody-drug conjugate production for cancer treatment.  PLoS ONE.  13. 2018
    2018 Mitochondrial-mediated oxidative Ca2+/calmodulin-dependent kinase II activation induces early afterdepolarizations in Guinea pig cardiomyocytes: An in silico study 2018
    2017 Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 Expression.  Scientific Reports.  7. 2017
    2017 Knockout of the ATPase inhibitory factor 1 protects the heart from pressure overload-induced cardiac hypertrophy.  Scientific Reports.  7. 2017
    2017 Process engineering of cellulosic n-butanol production from corn-based biomass using Clostridium cellulovorans.  Process Biochemistry.  62:144-150. 2017
    2017 The amyloid precursor protein modulates α2A-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitment.  The FASEB Journal.  31:4434-4446. 2017
    2017 Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α2A adrenergic receptor ligands.  Neuropharmacology.  116:38-49. 2017
    2017 Comparative proteomic analysis of three Chinese hamster ovary (CHO) host cells.  Biochemical Engineering Journal.  124:122-129. 2017
    2016 Impaired mitochondrial network excitability in failing Guinea-pig cardiomyocytes.  Cardiovascular Research.  109:79-89. 2016
    2015 High-level expression of recombinant IgG1 by CHO K1 platform.  Frontiers of Chemical Science and Engineering.  9:376-380. 2015
    2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload 2015
    2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload 2015
    2015 Mitochondria-derived ROS bursts disturb Ca2+ cycling and induce abnormal automaticity in guinea pig cardiomyocytes: A theoretical study 2015
    2015 Comparative proteomics analysis of high n-butanol producing metabolically engineered Clostridium tyrobutyricum.  Journal of Biotechnology.  193:108-119. 2015
    2014 Targeted biopharmaceuticals for cancer treatment.  Cancer Letters.  352:145-151. 2014
    2014 High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats 2014
    2014 Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function 2014
    2014 Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytes.  PLoS ONE.  9. 2014
    2014 Effects of regional mitochondrial depolarization on electrical propagation: Implications for arrhythmogenesis.  Circulation: Arrhythmia and Electrophysiology.  7:143-151. 2014
    2013 HNO Enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.  Antioxidants and Redox Signaling.  19:1185-1197. 2013
    2012 Cardiac mitochondrial network excitability: Insights from computational analysis 2012
    2011 Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.  Journal of Molecular and Cellular Cardiology.  51:632-639. 2011
    2010 A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.  PLoS Computational Biology.  6. 2010
    2009 Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes.  Biophysical Journal.  97:1843-1852. 2009
    2009 From mitochondrial dynamics to arrhythmias 2009
    2008 From mitochondrial ion channels to arrhythmias in the heart: Computational techniques to bridge the spatio-temporal scales 2008
    2008 Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.  Journal of Theoretical Biology.  254:466-475. 2008
    2008 Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia 2008
    2008 Metabolic response to an acute jump in cardiac workload: Effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation 2008
    2007 Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs 2007
    2006 Regulation of myocardial substrate metabolism during increased energy expenditure: Insights from computational studies 2006
    2006 Role of cellular compartmentation in the metabolic response to stress: Mechanistic insights from computational models.  Annals of the New York Academy of Sciences.  1080:120-139. 2006
    2005 Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: Insights from in silico studies 2005
    2005 Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia 2005
    2005 Regulation of cardiac energetics: Role of redox state and cellular compartmentation during ischemia.  Annals of the New York Academy of Sciences.  1047:259-270. 2005

    Research Overview

  • Heart failure
    Cardiac electrophysiology
    Mitochondrial biology
    Computational modeling
    Cancer therapy

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Philosophy in Biomedical / Medical Engineering, Case Western Reserve University 2006

    • Full Name

  • Lufang Zhou