Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Complex regulation of mitochondrial function during cardiac developmentJournal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  8. 2019
2019 Proteomics insight into the production of monoclonal antibodyBiochemical Engineering Journal.  177-185. 2019
2019 HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injuryJournal of Molecular and Cellular Cardiology.  130:36-48. 2019
2019 Novel biomanufacturing platform for large-scale and high-quality human T cells productionJournal of Biological Engineering.  13. 2019
2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in miceRedox Biology.  21. 2019
2019 Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction miceCardiovascular Research.  115:343-356. 2019
2018 Bioprocess development of antibody-drug conjugate production for cancer treatmentPLoS ONE.  13. 2018
2018 Mitochondrial-mediated oxidative Ca 2+ /calmodulin-dependent kinase II activation induces early afterdepolarizations in Guinea pig cardiomyocytes: An in silico studyJournal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  7. 2018
2018 Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus.Frontiers in Physiology.  9:1670. 2018
2017 Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 ExpressionScientific Reports.  7. 2017
2017 Knockout of the ATPase inhibitory factor 1 protects the heart from pressure overload-induced cardiac hypertrophyScientific Reports.  7. 2017
2017 Process engineering of cellulosic n-butanol production from corn-based biomass using Clostridium cellulovoransProcess Biochemistry.  62:144-150. 2017
2017 The amyloid precursor protein modulates α2A-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitmentFederation proceedings.  31:4434-4446. 2017
2017 Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α 2A adrenergic receptor ligandsNeuropharmacology.  116:38-49. 2017
2017 Comparative proteomic analysis of three Chinese hamster ovary (CHO) host cellsBiochemical Engineering Journal.  124:122-129. 2017
2016 Impaired mitochondrial network excitability in failing Guinea-pig cardiomyocytesCardiovascular Research.  109:79-89. 2016
2015 High-level expression of recombinant IgG1 by CHO K1 platformFrontiers of Chemical Science and Engineering.  9:376-380. 2015
2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overloadAJP - Heart and Circulatory Physiology.  308:H651-H663. 2015
2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overloadAJP - Heart and Circulatory Physiology.  308:H651-H663. 2015
2015 Comparative proteomics analysis of high n-butanol producing metabolically engineered Clostridium tyrobutyricumJournal of Biotechnology.  193:108-119. 2015
2015 Mitochondria-derived ROS bursts disturb Ca<sup>2+</sup> cycling and induce abnormal automaticity in guinea pig cardiomyocytes: A theoretical studyAJP - Heart and Circulatory Physiology.  308:H623-H636. 2015
2014 Targeted biopharmaceuticals for cancer treatmentCancer Letters.  352:145-151. 2014
2014 High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in ratsAJP - Heart and Circulatory Physiology.  307. 2014
2014 Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial functionAJP - Heart and Circulatory Physiology.  306. 2014
2014 Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytesPLoS ONE.  9. 2014
2014 Effects of regional mitochondrial depolarization on electrical propagation: Implications for arrhythmogenesisCirculation: Arrhythmia and Electrophysiology.  7:143-151. 2014
2013 HNO Enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerizationAntioxidants and Redox Signaling.  19:1185-1197. 2013
2012 Cardiac mitochondrial network excitability: Insights from computational analysisAJP - Heart and Circulatory Physiology.  302. 2012
2011 Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stressJournal of Molecular and Cellular Cardiology.  51:632-639. 2011
2010 A reaction-diffusion model of ROS-induced ROS release in a mitochondrial networkPLoS Computational Biology.  6. 2010
2009 Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytesBiophysical Journal.  97:1843-1852. 2009
2009 From mitochondrial dynamics to arrhythmiasThe International journal of biochemistry.  41:1940-1948. 2009
2008 From mitochondrial ion channels to arrhythmias in the heart: Computational techniques to bridge the spatio-temporal scalesPhilosophical Transactions A: Mathematical, Physical and Engineering Sciences.  366:3381-3409. 2008
2008 Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemiaJournal of Theoretical Biology.  254:466-475. 2008
2008 Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemiaAJP - Heart and Circulatory Physiology.  295. 2008
2008 Metabolic response to an acute jump in cardiac workload: Effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidationAJP - Heart and Circulatory Physiology.  294. 2008
2007 Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigsJournal of Physiology.  579:811-821. 2007
2006 Regulation of myocardial substrate metabolism during increased energy expenditure: Insights from computational studiesAJP - Heart and Circulatory Physiology.  291. 2006
2006 Role of cellular compartmentation in the metabolic response to stress: Mechanistic insights from computational modelsAnnals of the New York Academy of Sciences.  1080:120-139. 2006
2005 Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: Insights from in silico studiesJournal of Physiology.  569:925-937. 2005
2005 Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemiaAJP - Heart and Circulatory Physiology.  288. 2005
2005 Regulation of cardiac energetics: Role of redox state and cellular compartmentation during ischemiaAnnals of the New York Academy of Sciences.  1047:259-270. 2005

Education And Training

  • Doctor of Philosophy in Biomedical / Medical Engineering, Case Western Reserve University 2006
  • Full Name

  • Lufang Zhou