Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Antibody–drug conjugate to treat meningiomas.  Pharmaceuticals.  14. 2021
2021 Investigation into the difference in mitochondrial-cytosolic calcium coupling between adult cardiomyocyte and hiPSC-CM using a novel multifunctional genetic probe 2021
2021 Anti-EGFR antibody-drug conjugate for triple-negative breast cancer therapy 2021
2020 Dual-targeted extracellular vesicles to facilitate combined therapies for neuroendocrine cancer treatment 2020
2020 MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure 2020
2020 Intracellular metabolism analysis of Clostridium cellulovorans via modeling integrating proteomics, metabolomics and fermentation.  Process Biochemistry.  89:9-19. 2020
2020 Anti-SSTR2 antibody-drug conjugate for neuroendocrine tumor therapy.  Cancer Gene Therapy.  2020
2020 Targeted Exosomes for Drug Delivery: Biomanufacturing, Surface Tagging, and Validation.  Biotechnology Journal.  15. 2020
2019 Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.  Biophysical Journal.  117:631-645. 2019
2019 Complex regulation of mitochondrial function during cardiac development 2019
2019 Enhancing the engraftment of human induced pluripotent stem cell-derived cardiomyocytes via a transient inhibition of rho kinase activity.  Journal of Visualized Experiments.  2019. 2019
2019 Proteomics insight into the production of monoclonal antibody.  Biochemical Engineering Journal.  145:177-185. 2019
2019 HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injury.  Journal of Molecular and Cellular Cardiology.  130:36-48. 2019
2019 Novel biomanufacturing platform for large-scale and high-quality human T cells production.  Journal of Biological Engineering.  13. 2019
2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice.  Redox Biology.  21. 2019
2019 Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice.  Cardiovascular Research.  115:343-356. 2019
2018 Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus.  Frontiers in Physiology.  9. 2018
2018 Bioprocess development of antibody-drug conjugate production for cancer treatment.  PLoS ONE.  13. 2018
2018 Mitochondrial-mediated oxidative Ca2+/calmodulin-dependent kinase II activation induces early afterdepolarizations in Guinea pig cardiomyocytes: An in silico study 2018
2017 Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 Expression.  Scientific Reports.  7. 2017
2017 Knockout of the ATPase inhibitory factor 1 protects the heart from pressure overload-induced cardiac hypertrophy.  Scientific Reports.  7. 2017
2017 Process engineering of cellulosic n-butanol production from corn-based biomass using Clostridium cellulovorans.  Process Biochemistry.  62:144-150. 2017
2017 The amyloid precursor protein modulates α2A-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitment.  The FASEB Journal.  31:4434-4446. 2017
2017 Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α2A adrenergic receptor ligands.  Neuropharmacology.  116:38-49. 2017
2017 Comparative proteomic analysis of three Chinese hamster ovary (CHO) host cells.  Biochemical Engineering Journal.  124:122-129. 2017
2016 Impaired mitochondrial network excitability in failing Guinea-pig cardiomyocytes.  Cardiovascular Research.  109:79-89. 2016
2015 High-level expression of recombinant IgG1 by CHO K1 platform.  Frontiers of Chemical Science and Engineering.  9:376-380. 2015
2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload 2015
2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload 2015
2015 Mitochondria-derived ROS bursts disturb Ca2+ cycling and induce abnormal automaticity in guinea pig cardiomyocytes: A theoretical study 2015
2015 Comparative proteomics analysis of high n-butanol producing metabolically engineered Clostridium tyrobutyricum.  Journal of Biotechnology.  193:108-119. 2015
2014 Targeted biopharmaceuticals for cancer treatment.  Cancer Letters.  352:145-151. 2014
2014 High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats 2014
2014 Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function 2014
2014 Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytes.  PLoS ONE.  9. 2014
2014 Effects of regional mitochondrial depolarization on electrical propagation: Implications for arrhythmogenesis.  Circulation: Arrhythmia and Electrophysiology.  7:143-151. 2014
2013 HNO Enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.  Antioxidants and Redox Signaling.  19:1185-1197. 2013
2012 Cardiac mitochondrial network excitability: Insights from computational analysis 2012
2011 Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.  Journal of Molecular and Cellular Cardiology.  51:632-639. 2011
2010 A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.  PLoS Computational Biology.  6. 2010
2009 Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes.  Biophysical Journal.  97:1843-1852. 2009
2009 From mitochondrial dynamics to arrhythmias 2009
2008 From mitochondrial ion channels to arrhythmias in the heart: Computational techniques to bridge the spatio-temporal scales 2008
2008 Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.  Journal of Theoretical Biology.  254:466-475. 2008
2008 Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia 2008
2008 Metabolic response to an acute jump in cardiac workload: Effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation 2008
2007 Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs 2007
2006 Regulation of myocardial substrate metabolism during increased energy expenditure: Insights from computational studies 2006
2006 Role of cellular compartmentation in the metabolic response to stress: Mechanistic insights from computational models.  Annals of the New York Academy of Sciences.  1080:120-139. 2006
2005 Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: Insights from in silico studies 2005
2005 Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia 2005
2005 Regulation of cardiac energetics: Role of redox state and cellular compartmentation during ischemia.  Annals of the New York Academy of Sciences.  1047:259-270. 2005

Research Overview

  • Mitochondrial dysfunction and heart disease
    Optogenetics and luminoptogenetics

    • Education And Training

  • Doctor of Philosophy in Biomedical / Medical Engineering, Case Western Reserve University 2006

    • Full Name

  • Lufang Zhou