Selected Publications

Academic Article

Year Title Altmetric
2020 Parvalbumin interneurons provide spillover to newborn and mature dentate granule cellseLife.  9:1-23. 2020
2020 A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory NeuronsNeuroscience.  435:73-94. 2020
2019 The readily-releasable pool dynamically regulates multivesicular releaseeLife.  8. 2019
2019 Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved]F1000Research.  8. 2019
2018 Constitutive and synaptic activation of GIRK channels differentiates mature and newborn dentate granule cells 2018
2018 α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neuronsActa Neuropathologica Communications.  6:35. 2018
2017 Klotho regulates postnatal neurogenesis and protects against age-related spatial memory lossNeurobiology of Aging.  59:41-54. 2017
2017 Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activityeLife.  6. 2017
2017 Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity.eLife.  6. 2017
2017 Adult-born neurons modify excitatory synaptic transmission to existing neuronseLife.  6. 2017
2016 Low excitatory innervation balances high intrinsic excitability of immature dentate neuronsNature Communications.  7. 2016
2015 Development of glutamatergic innervation during maturation of adult-born neuronsFrontiers in Biology.  10:310-320. 2015
2015 Viral and transgenic reporters and genetic analysis of adult neurogenesisCold Spring Harbor perspectives in biology.  7. 2015
2015 Neurogliaform cells in cortical circuitsNature Reviews Neuroscience.  16:458-468. 2015
2015 New Neurons Don't Talk BackNeuron.  85:3-5. 2015
2014 Good housekeepingNeuron.  81:715-717. 2014
2014 Hilar mossy cells provide the first glutamatergic synapses to adult-born dentate granule cells 2014
2013 Distinct determinants of sparse activation during granule cell maturation 2013
2013 Spillover-Mediated Feedforward Inhibition Functionally Segregates Interneuron ActivityNeuron.  78:1050-1062. 2013
2013 GABA depolarization is required for experience-dependent synapse unsilencing in adult-born neurons 2013
2013 Dynamic functions of GABA signaling during granule cell maturationFrontiers in Neural Circuits2013
2012 Neuronal glutamate transporters regulate glial excitatory transmission 2012
2011 Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: I. Co-regulation by activityFrontiers in Neuroscience2011
2011 Enhanced integration of newborn neurons after neonatal insultsFrontiers in Neuroscience2011
2011 Ivy/neurogliaform interneurons coordinate activity in the neurogenic nicheNature Neuroscience.  14:1407-1409. 2011
2011 Desynchronization of Multivesicular Release Enhances Purkinje Cell OutputNeuron.  70:991-1004. 2011
2010 Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosisCell Stem Cell.  7:483-495. 2010
2010 Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1α 2010
2009 Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus 2009
2008 GABAergic signalling to adult-generated neurons 2008
2008 Integration of adult generated neurons during epileptogenesisEpilepsia.  49:3-12. 2008
2006 Seizures accelerate functional integration of adult-generated granule cells 2006
2006 Functional maturation of adult-generated granule cells 2006
2006 Delayed development of adult-generated granule cells in dentate gyrus 2006
2005 GABAergic signaling to newborn neurons in dentate gyrusJournal of Neurophysiology.  94:4528-4532. 2005
2005 New neurons in the adult mammalian brain: Synaptogenesis and functional integration 2005
2005 Quantal transmission: Not just for neuronsTrends in Neurosciences.  28:59-62. 2005
2004 A Transgenic Marker for Newly Born Granule Cells in Dentate Gyrus 2004
2004 GABA Release from Proopiomelanocortin Neurons 2004
2003 Synapse density regulates independence at unitary inhibitory synapses 2003
2001 Paradoxical reduction of synaptic inhibition by vigabatrinJournal of Neurophysiology.  86:596-603. 2001
2000 Slow desensitization regulates the availability of synaptic GABA(A) receptors 2000
1999 Glutamate transporters contribute to the time course of synaptic transmission in cerebellar granule cells 1999
1997 Metabotropic glutamate receptor mediated long-term depression in developing hippocampusNeuropharmacology.  36:831-844. 1997
1997 A role for adenosine A2 receptors in the induction of long-term potentiation in the CA1 region of rat hippocampusBrain Research.  756:184-190. 1997
1997 Prolonged physiological entrapment of glutamate in the synaptic cleft of cerebellar unipolar brush cellsJournal of Neurophysiology.  78:1320-1333. 1997
1996 Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor 1996
1995 AP5 blocks LTP in developing rat dentate gyrus and unmasks LTDExperimental Neurology.  131:83-92. 1995


Year Title Altmetric
2007 The use of reporter mouse lines to study neurogenesis.  81-100. 2007
2003 Measuring and Modeling the Spatiotemporal Profile of GABA at the Synapse. In Transmembrane Transporters 2003

Education And Training

  • Doctor of Philosophy in Neuroscience, Northwestern University 1997
  • Full Name

  • Linda Wadiche