Linda Wadiche

Linda Wadiche
Professor

Scientist (C), Integrative Center for Aging Research , School of Medicine
Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Scientist (C), Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED) , School of Dentistry
Associate Scientist (C), Civitan International Research Center , Academic Joint Departments
Associate Scientist (C), Center for Glial Biology in Medicine , Academic Joint Departments
Professor (P), Neurobiology , Academic Joint Departments
Associate Professor (S), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Climbing Fiber-Mediated Spillover Transmission to Interneurons Is Regulated by EAAT4. 2021
2020	RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis. Cell Reports. 32. 2020
2020	Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells. eLife. 9:1-23. 2020
2020	A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory Neurons. Neuroscience. 435:73-94. 2020
2019	The readily-releasable pool dynamically regulates multivesicular release. eLife. 8. 2019
2019	Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved]. F1000Research. 8. 2019
2018	Constitutive and synaptic activation of GIRK channels differentiates mature and newborn dentate granule cells 2018
2018	α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons. Acta Neuropathologica Communications. 6:35. 2018
2017	Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss. Neurobiology of Aging. 59:41-54. 2017
2017	Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity.. eLife. 6. 2017
2017	Adult-born neurons modify excitatory synaptic transmission to existing neurons. eLife. 6. 2017
2016	Low excitatory innervation balances high intrinsic excitability of immature dentate neurons. Nature Communications. 7. 2016
2015	Development of glutamatergic innervation during maturation of adult-born neurons. Frontiers in Biology. 10:310-320. 2015
2015	Viral and transgenic reporters and genetic analysis of adult neurogenesis. Cold Spring Harbor perspectives in biology. 7. 2015
2015	Neurogliaform cells in cortical circuits. Nature Reviews Neuroscience. 16:458-468. 2015
2015	New Neurons Don't Talk Back. Neuron. 85:3-5. 2015
2014	Good housekeeping. Neuron. 81:715-717. 2014
2014	Hilar mossy cells provide the first glutamatergic synapses to adult-born dentate granule cells 2014
2013	Distinct determinants of sparse activation during granule cell maturation 2013
2013	Spillover-Mediated Feedforward Inhibition Functionally Segregates Interneuron Activity. Neuron. 78:1050-1062. 2013
2013	GABA depolarization is required for experience-dependent synapse unsilencing in adult-born neurons 2013
2013	Dynamic functions of GABA signaling during granule cell maturation. Frontiers in Neural Circuits. 2013
2012	Neuronal glutamate transporters regulate glial excitatory transmission 2012
2011	Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: I. Co-regulation by activity. Frontiers in Neuroscience. 2011
2011	Enhanced integration of newborn neurons after neonatal insults. Frontiers in Neuroscience. 2011
2011	Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche. Nature Neuroscience. 14:1407-1409. 2011
2011	Desynchronization of Multivesicular Release Enhances Purkinje Cell Output. Neuron. 70:991-1004. 2011
2010	Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell. 7:483-495. 2010
2010	Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1α 2010
2009	Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus 2009
2008	GABAergic signalling to adult-generated neurons 2008
2008	Integration of adult generated neurons during epileptogenesis. Epilepsia. 49:3-12. 2008
2006	Seizures accelerate functional integration of adult-generated granule cells 2006
2006	Functional maturation of adult-generated granule cells 2006
2006	Delayed development of adult-generated granule cells in dentate gyrus 2006
2005	GABAergic signaling to newborn neurons in dentate gyrus. Journal of Neurophysiology. 94:4528-4532. 2005
2005	New neurons in the adult mammalian brain: Synaptogenesis and functional integration 2005
2005	Quantal transmission: Not just for neurons. Trends in Neurosciences. 28:59-62. 2005
2004	A Transgenic Marker for Newly Born Granule Cells in Dentate Gyrus 2004
2004	GABA Release from Proopiomelanocortin Neurons 2004
2003	Synapse density regulates independence at unitary inhibitory synapses 2003
2001	Paradoxical reduction of synaptic inhibition by vigabatrin. Journal of Neurophysiology. 86:596-603. 2001
2000	Slow desensitization regulates the availability of synaptic GABA(A) receptors 2000
1999	Glutamate transporters contribute to the time course of synaptic transmission in cerebellar granule cells 1999
1997	Metabotropic glutamate receptor mediated long-term depression in developing hippocampus. Neuropharmacology. 36:831-844. 1997
1997	A role for adenosine A2 receptors in the induction of long-term potentiation in the CA1 region of rat hippocampus. Brain Research. 756:184-190. 1997
1997	Prolonged physiological entrapment of glutamate in the synaptic cleft of cerebellar unipolar brush cells. Journal of Neurophysiology. 78:1320-1333. 1997
1996	Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor 1996
1995	AP5 blocks LTP in developing rat dentate gyrus and unmasks LTD. Experimental Neurology. 131:83-92. 1995

Chapter

Year	Title	Altmetric
2007	The use of reporter mouse lines to study neurogenesis. 81-100. 2007
2003	Measuring and Modeling the Spatiotemporal Profile of GABA at the Synapse. In Transmembrane Transporters 2003