Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification 2018
2017 Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing 2017
2017 Efficient, ultra-high-Affinity chromatography in a one-step purification of complex proteins 2017
2017 LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism 2017
2016 Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification 2016
2016 O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis 2016
2016 Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytes 2016
2016 The universal 3D3 antibody of human PODXL is pluripotent cytotoxic, and identifies a residual population after extended differentiation of pluripotent stem cells 2016
2015 Model systems to study the life cycle of human papillomaviruses and HPV-associated cancers 2015
2015 Robust HPV-18 production in organotypic cultures of primary human keratinocytes 2015
2014 MicroRNAs are biomarkers of oncogenic human papillomavirus infections 2014
2013 Phylogenetic considerations in designing a broadly protective multimeric L2 vaccine 2013
2013 HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures 2013
2011 Construction of a full transcription map of human papillomavirus type 18 during productive viral infection. 2011
2011 PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro 2011
2011 Nonconserved lysine residues attenuate the biological function of the low-risk human papillomavirus E7 protein 2011
2011 Human papillomavirus (HPV) E7 induces prolonged G 2 following S phase reentry in differentiated human keratinocytes 2011
2011 Construction of a full transcription map of human papillomavirus type 18 during productive viral infection 2011
2010 Destabilization of TIP60 by Human Papillomavirus E6 Results in Attenuation of TIP60-Dependent Transcriptional Regulation and Apoptotic Pathway 2010
2009 Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6 2009
2009 Promotion of incisional wound repair by human mesenchymal stem cell transplantation 2009
2009 Robust production and passaging of infectious HPV in squamous epithelium of primary human keratinocytes 2009
2008 Casein kinase II motif-dependent phosphorylation of human papillomavirus E7 protein promotes p130 degradation and S-phase induction in differentiated human keratinocytes 2008
2008 Remodeling of the Human Papillomavirus Type 11 Replication Origin into Discrete Nucleoprotein Particles and Looped Structures by the E2 Protein 2008
2007 Mitogen-activated protein kinases activate the nuclear localization sequence of human papillomavirus type 11 E1 DNA helicase to promote efficient nuclear import 2007
2006 Conditionally activated E7 proteins of high-risk and low-risk human papillomaviruses induce S phase in postmitotic, differentiated human keratinocytes 2006
2006 Dynamic localization of the human papillomavirus type 11 origin binding protein E2 through mitosis while in association with the spindle apparatus 2006
2005 Immune responses to human papillomavirus in genital tract of women with cervical cancer 2005
2005 Analysis of HPV DNA replication using transient transfection and cell-free assays. 2005
2005 Retrovirus-mediated gene transfer to analyze HPV gene regulation and protein functions in organotypic "raft" cultures. 2005
2005 Simultaneous in situ detection of RNA, DNA, and protein using tyramide-coupled immunofluorescence. 2005
2004 Cyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase 2004
2004 HPV-18 confers resistance to TNF-α in organotypic cultures of human keratinocytes 2004
2004 Clonal selection for transcriptionally active viral oncogenes during progression to cancer 2004
2004 Global effects of human papillomavirus type 18 E6/E7 in an organotypic keratinocyte culture system 2004
2004 Analyses of melanoma-targeted oncolytic adenoviruses with tyrosinase enhancer/promoter-driven E1A, E4, or both in submerged cells and organotypic cultures 2004
2004 Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning 2004
2003 mRNA splicing regulates human papillomavirus type 11 E1 protein production and DNA replication 2003
2003 Activation of adenovirus early promoters and lytic phase in differentiated strata of organotypic cultures of human keratinocytes 2003
2002 Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 protein 2002
2002 The promoter of the human proliferating cell nuclear antigen gene is not sufficient for cell cycle-dependent regulation in organotypic cultures of keratinocytes 2002
2002 Alternative fates of keratinocytes transduced by human papillomavirus type 18 E7 during squamous differentiation 2002
2001 Human papillomavirus E6E7-mediated adenovirus cell killing: Selectivity of mutant adenovirus replication in organotypic cultures of human keratinocytes 2001
2001 p21cip1 degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7 2001
2001 Human papillomaviruses: A window into the mechanism and regulation of eucaryotic cellular DNA replication. 2001
2001 In situ analysis of the transcriptional activity of integrated viral DNA using tyramide-FISH. 2001
2001 Transduction of the E6 and E7 genes of epidermodysplasia-verruciformis-associated human papillomaviruses alters human keratinocyte growth and differentiation in organotypic cultures 2001
2001 Viral latency--the papillomavirus model. 2001
2000 Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription 2000
2000 The hinge of the human papillomavirus type 11 E2 protein contains major determinants for nuclear localization and nuclear matrix association 2000
2000 HeLa cells are phenotypically limiting in cyclin E/CDK2 for efficient human papillomavirus DNA replication 2000
1999 Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice 1999
1999 Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes 1999
1999 Human papillomavirus DNA replication: Interactions between the viral E1 protein and two subunits of human DNA polymerase α/primase 1999
1999 Human papillomavirus DNA replication compartments in a transient DNA replication system 1999
1999 A distal element in the HPV-11 upstream regulatory region contributes to promoter repression in basal keratinocytes in squamous epithelium 1999
1999 Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication 1999
1998 Human Hsp70 and Hsp40 chaperone proteins facilitate human papillomavirus-11 E1 protein binding to the origin and stimulate cell-free DNA replication 1998
1998 Post-transcriptional induction of p21cip1 protein by human papillomavirus E7 inhibits unscheduled DNA synthesis reactivated in differentiated keratinocytes 1998
1998 Transcription factor YY1 represses cell-free replication from human papillomavirus origins 1998
1998 The carboxyl-terminal region of the human papillomavirus type 16 E1 protein determines E2 protein specificity during DNA replication 1998
1998 Viral E6-E7 transcription in the basal layer of organotypic cultures without apparent p21cip1 protein precedes immortalization of human papillomavirus type 16- and 18-transfected human keratinocytes 1998
1997 Transcription activities of human papillomavirus type 11 E6 promoter- proximal elements in raft and submerged cultures of foreskin keratinocytes 1997
1996 Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: Activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q 1996
1995 Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal dlfferentiated keratinocytes 1995
1995 The functions of human papillomavirus type 11 E1, E2, and E2C proteins in cell-free DNA replication 1995
1994 Cell-free replication of the human papillomavirus DNA with homologous viral E1 and E2 proteins and human cell extracts 1994
1994 Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements 1994
1994 High-efficiency transfection of primary human keratinocytes with positively charged lipopolyamine:DNA complexes 1994
1994 Induction of proliferating cell nuclear antigen in differentiated keratinocytes of human papillomavirus-infected lesions 1994
1994 Papillomavirus DNA replication 1994
1994 Reply 1994
1994 Structure and expression of the human gene for the α subunit of prolyl 4- hydroxylase. The two alternatively spliced types of mRNA correspond to two homologous exons the sequences of which are expressed in a variety of tissues 1994
1993 Identification of Alternatively Spliced mRNAs and Localization of 5' Ends by Polymerase Chain Reaction Amplification. 1993
1993 Regulation of the human papillomavirus type 11 E6 promoter by viral and host transcription factors in primary human keratinocytes 1993
1992 Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins 1992
1992 Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteins 1992
1992 Human papillomavirus type 16 and 18 gene expression in cervical neoplasias 1992
1992 Intermolecular triplex formation distorts the DNA duplex in the regulatory region of human papillomavirus type-11 1992
1992 Production of human papillomavirus and modulation of the infectious program in epithelial raft cultures 1992
1992 Properties of bovine papillomavirus E1 mutants 1992
1992 Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection 1992
1991 Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells 1991
1991 An E1M--E2C fusion protein encoded by human papillomavirus type 11 is asequence-specific transcription repressor. 1991
1991 An E1M∧E2C Fusion Protein Encoded by Human Papillomavirus Type 11 Is a Sequence-Specific Transcription Repressor 1991
1991 Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene 1991
1991 Characterization of the 3′ half of the human type IV collagen α5 gene that is affected in the Alport syndrome 1991
1990 Infectious cycle of human papillomavirus type 11 in human foreskin xenografts in nude mice 1990
1990 Structure of the human laminin B1 chain gene 1990
1990 Structure of the human type IV collagenase gene 1990
1990 Human papillomavirus type 1 produces redundant as well as polycistronic mRNAs in plantar warts 1990
1990 Identification of mutations in the COL4A5 collagen gene in Alport syndrome 1990
1989 Characterization of an HPV type 11 isolate propagated in human foreskin implants in nude mice 1989
1989 Characterization of cDNAs of spliced HPV-11 E2 mRNA and other HPV mRNAs recovered via retrovirus-mediated gene transfer 1989
1989 Characterization of rare human papillomavirus type 11 mRNAs coding for regulatory and structural proteins, using the polymerase chain reaction 1989
1989 Differentiation-linked human papillomavirus types 6 and 11 transcription in genital condylomata revealed by in situ hybridization with message-specific RNA probes 1989
1989 Identification of a novel constitutive enhancer element and an associated binding protein: Implications for human papillomatovirus type 11 enhancer regulation 1989
1989 Mapping the genetic organization of RNA by electron microscopy 1989
1989 Papillomavirus-associated inductions of cellular proteins in mouse C127 cells: Correlation with the presence of open reading frame E2 1989
1988 Characterization of the human gene for a polypeptide that acts both as the β subunit of prolyl 4-hydroxylase and as protein disulfide isomerase 1988
1988 Functional mapping of the human papillomavirus type 11 transcriptional enhancer and its interaction with the trans-acting E2 proteins. 1988
1988 Regulation of human papillomavirus type 11 enhancer and E6 promoter by activating and repressing proteins from the E2 open reading frame: Functional and biochemical studies 1988
1987 A human papilloma virus type 11 transcript encoding an E1^E4 protein 1987
1987 Enhancers and trans-acting E2 transcriptional factors of papillomaviruses 1987
1987 Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata 1987
1987 Identification and mapping of human papillomavirus type 1 RNA transcripts recovered from plantar warts and infected epithelial cell cultures 1987
1985 Characterization of 64-, 123- and 182-base-pair exons in the mouse α2(IV) collagen gene 1985
1982 Structure of two human α-tubulin genes 1982
1981 Structural variation among human beta-tubulin genes. 1981
1981 Sequences of human adenovirus Ad3 and Ad7 DNAs encoding the promoter and first leader segment of late RNAs 1981
1981 Structural variation among human β-tubulin genes 1981
1980 Incomplete splicing and deficient accumulation of the fiber messenger RNA in monkey cells infected by human adenovirus type 2 1980
1980 Patterns and consequences of adenoviral RNA splicing Ex pluribus unum - Ex uno plura 1980
1979 RNA transcription and splicing at early and intermediate times after adenovirus-2 infection 1979
1979 Complex splicing patterns of RNAs from the early regions of adenovirus-2 1979
1979 Comparison of late mRNA splicing among class B and class C adenoviruses 1979
1978 Inversion of the G DNA segment of phage Mu controls phage infectivity 1978
1978 Adjacent insertion sequences IS2 and IS5 in bacteriophage mu mutants and an IS5 in a lambda darg bacteriophage 1978
1978 Heteroduplex electron microscopy of phage Mu Mutants containing IS1 insertions and chloramphenicol resistance transposons 1978
1977 Electron microscopic characterization of DNAs of non-defective deletion mutants of bacteriophage Mu 1977
1977 Sequence arrangements of the Escherichia coli chromosome and of putative insertion sequences, as revealed by electron microscopic heteroduplex studies 1977
1977 Underwound loops in self-renatured DNA can be diagnostic of inverted duplications and translocated sequences 1977
1976 The invertible DNA segments of coliphages Mu and P1 are identical 1976
1974 Electron microscopic mapping of the attachment sites on SV40 DNA during lytic infection 1974
1974 Electron microscope study of the structures of λdv DNAs 1974
1973 DNA substrate site for the ecoRII. Restriction endonuclease and modification methylase 1973
1973 Electron microscope mapping of the distribution of ribosomal genes of the Bacillus subtilis chromosome 1973
1973 Electron microscope study of the structures of the Bacillus subtilis prophages, SPO2 and φ105 1973
1972 Map of the partial sequence homology between DNA molecules of Bacillus subtilis bacteriophages SPO2 and φ105 1972

Principal Investigator On

Investigator On

  • Cervical Cancer Derived Xenografts (PDX) and Organoid Raft Cultures to Evaluate Pathway Specific Therapeutic Agents.  awarded by National Cancer Institute/NIH/DHHS 2019 - 2020
  • In Vitro Assessment for Antimicrobial Activity - B07 HHSN27200002 Comprehensive Virus Panel 2  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2019
  • In Vitro Assessment for Antimicrobial Activity - B09 HHSN27200003 Comprehensive Panel for Viruses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2019
  • In Vitro Assessment for Antimicrobial Activity - B12 HHSN27200005 Comprehensive Panel for Viruses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2019
  • In Vitro Assessments for Antimicrobial Activity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2019
  • In Vitro Assessments for Antimicrobial Activity - B14 - HHSN27200004 Papillomavirus Assay  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2019
  • In Vitro Assessments for Antimicrobial Activity - B16 - HHSN27200007 Comprehensive Panel for Viruses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2019
  • Private Grant  awarded by PHOTONMD 2017 - 2019
  • Role of Matrix Metalloproteinases in Reepithelialization  awarded by Plastic Surgery Foundation 2017 - 2019
  • Private Grant  awarded by NOVAN, INC. 2015 - 2018
  • Private Grant  awarded by ANTIVA BIOSCIENCES, INC. 2016 - 2017
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • UAB Skin Disease Research Center - Skin Cell Culture Core - Core B  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • Role of Adipose-Derived Stromal Cell Conditioned Media in Wound Healing  awarded by SOUTHEASTERN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGEONS 2013 - 2015
  • Acceleration of Skin Repair by Adipose-Derived Mesenchymal Cells  awarded by SOUTHEASTERN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGEONS 2011 - 2013

    • Education And Training

  • Doctor of Philosophy in Chemistry, California Institute of Technology 1973

    • Full Name

  • Louise Chow