Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Medications used to treat bladder disorders may alter effects of neuromodulationNeurourology and Urodynamics.  39:1313-1320. 2020
2020 Spinal Mobilization Prevents NGF-Induced Trunk Mechanical Hyperalgesia and Attenuates Expression of CGRPFrontiers in Neuroscience.  14. 2020
2020 Benzodiazepines suppress neuromodulatory effects of pudendal nerve stimulation on rat bladder nociceptionAnesthesia and Analgesia.  130:1077-1084. 2020
2020 Critical evaluation of animal models of visceral pain for therapeutics development: A focus on irritable bowel syndromeNeurogastroenterology and Motility.  32. 2020
2020 Effect of neuraxial analgesic procedures on intraoperative hemodynamics during routine clinical care of gynecological and general surgeries: A case–control query of electronic dataJournal of Pain Research.  13:1163-1172. 2020
2019 Neuromodulatory effects of pudendal nerve stimulation on bladder hypersensitivity are present in opioid-pretreated rats 2019
2019 In ResponseAnesthesia and Analgesia.  128:e33. 2019
2019 Cystitis-induced bladder pain is toll-like receptor 4 dependent in a transgenic autoimmune cystitis murine model: A mapp research network animal study 2019
2018 Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP network studyPLoS ONE.  13. 2018
2018 Neonatal bladder inflammation alters the role of the central amygdala in hypersensitivity produced by Acute Footshock stress in adult female ratsBrain Research.  1698:99-105. 2018
2018 Spinal mechanisms of pudendal nerve stimulation-induced inhibition of bladder hypersensitivity in ratsNeuroscience Letters.  686:181-185. 2018
2018 Urothelial bladder afferent neurons in the rat are anatomically and neurochemically distinct from non-urothelial afferentsBrain Research.  1689:45-53. 2018
2018 Ethnic Differences Identified by Pain Sensitivity Questionnaire Correlate with Clinical Pain Responses 2018
2018 Incidence of venous air embolism during endoscopic retrograde cholangiopancreatographyAnesthesia and Analgesia.  127:420-423. 2018
2017 Lesions of the central amygdala and ventromedial medulla reduce bladder hypersensitivity produced by acute but not chronic foot shockBrain Research.  1675:1-7. 2017
2017 Brain signature and functional impact of centralized pain: A multidisciplinary approach to the study of chronic pelvic pain (MAPP) network studyPAIN.  158:1979-1991. 2017
2017 The effect of sedation on cortical activation: A randomized study comparing the effects of sedation with midazolam, propofol, and dexmedetomidine on auditory processingAnesthesia and Analgesia.  124:1603-1610. 2017
2016 Screening and Optimization of Nerve Targets and Parameters Reveals Inhibitory Effect of Pudendal Stimulation on Rat Bladder Hypersensitivity 2016
2016 Symptom Variability and Early Symptom Regression in the MAPP Study: A Prospective Study of Urological Chronic Pelvic Pain Syndrome 2016
2016 Electrophysiological properties of lumbosacral primary afferent neurons innervating urothelial and non-urothelial layers of mouse urinary bladderBrain Research.  1648:81-89. 2016
2016 Bladder Distension Increases Blood Flow in Pain Related Brain Structures in Subjects with Interstitial Cystitis 2016
2016 The Association between Progesterone, Estradiol, and Oxytocin and Heat Pain Measures in Pregnancy: An Observational Cohort StudyAnesthesia and Analgesia.  123:396-401. 2016
2016 Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research NetworkNeuroImage: Clinical.  12:65-77. 2016
2015 Unique microstructural changes in the brain associated with urological chronic pelvic pain syndrome (UCPPS) revealed by diffusion tensor MRI, super-resolution track density imaging, and statistical parameter mapping: A MAPP network neuroimaging studyPLoS ONE.  10. 2015
2015 Serotonin enhances urinary bladder nociceptive processing via a 5-HT3 receptor mechanismNeuroscience Letters.  604:97-102. 2015
2015 Intranasal oxytocin administration is associated with enhanced endogenous pain inhibition and reduced negative mood statesClinical Journal of Pain.  31:757-767. 2015
2015 Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging StudyNeuroImage: Clinical.  8:493-502. 2015
2015 Increased Brain Gray Matter in the Primary Somatosensory Cortex is Associated with Increased Pain and Mood Disturbance in Patients with Interstitial Cystitis/Painful Bladder Syndrome 2015
2015 Oxytocin-a multifunctional analgesic for chronic deep tissue painCurrent Pharmaceutical Design.  21:906-913. 2015
2015 Sex differences in experimental measures of pain sensitivity and endogenous pain inhibition.Journal of Pain Research.  8:311-320. 2015
2015 The amygdala central nucleus is required for acute stress-induced bladder hyperalgesia in a rat visceral pain modelBrain Research.  1606:77-85. 2015
2015 Ultrasound-guided interventional procedures for chronic pain managementPain Management.  5:465-482. 2015
2014 Urological chronic pelvic pain syndrome symptom flares: Characterisation of the full range of flares at two sites in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research NetworkBJU International.  114:916-925. 2014
2014 The MAPP research network: A novel study of urologic chronic pelvic pain syndromesBMC Urology.  14. 2014
2014 An endogenous pain control system is altered in subjects with interstitial cystitis 2014
2014 Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome 2014
2014 Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network studyPAIN.  155:2502-2509. 2014
2014 Segmental hyperalgesia to mechanical stimulus in interstitial cystitis/bladder pain syndrome: Evidence of central sensitization 2014
2014 The MAPP research network: Design, patient characterization and operationsBMC Urology.  14. 2014
2014 Urological symptoms in a subset of patients with urological chronic pelvic pain syndrome and a polysymptomatic, polysyndromic pattern of presentation 2014
2013 Validation of the english language pain sensitivity questionnaire 2013
2013 New directions in the treatment of pelvic pain.Pain Management.  3:387-394. 2013
2013 Effect of sedation on pain perceptionAnesthesiology.  118:611-621. 2013
2013 Early-in-life bladder inflammation alters U50,488H but not morphine-induced inhibition of visceromotor responses to urinary bladder distensionNeuroscience Letters.  534:150-154. 2013
2013 Early in life bladder inflammation alters opioid peptide content in the spinal cord and bladder of adult female rats 2013
2013 Not always lost in translationPAIN.  154:775. 2013
2012 Effects of nicotine on spinal cord injury pain vary among subtypes of pain and smoking status: Results from a randomized, controlled experimentJournal of Pain.  13:1206-1214. 2012
2012 Quantitative changes in regional cerebral blood flow induced by cold, heat and ischemic pain: A continuous arterial spin labeling studyAnesthesiology.  117:857-867. 2012
2012 Intrathecal oxytocin inhibits visceromotor reflex and spinal neuronal responses to noxious distention of the rat urinary bladder 2012
2012 Assessment of locomotion in chlorine exposed mice by computer vision and neural networks 2012
2012 Effects of nicotine on spinal cord injury pain: A randomized, double-blind, placebo controlled crossover trialTopics in Spinal Cord Injury Rehabilitation.  18:101-105. 2012
2012 Minimally invasive interventional therapy for Tarlov cysts causing symptoms of interstitial cystitisPain Physician.  15:141-146. 2012
2011 Continuous infusion of bupivacaine for pain control after anterior iliac crest bone grafting for alveolar cleft repair in children 2011
2011 Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladderPAIN.  152:2117-2124. 2011
2011 Effects of acute adult and early-in-life bladder inflammation on bladder neuropeptides in adult female ratsBMC Urology.  11. 2011
2011 Footshock stress differentially affects responses of two subpopulations of spinal dorsal horn neurons to urinary bladder distension in ratsBrain Research.  1386:118-126. 2011
2010 Opioid blockade and inflammation reveal estrous cycle effects on visceromotor reflexes evoked by bladder distention 2010
2010 Impaired diffuse noxious inhibitory controls: An additional mechanism of pain in chronic pancreatitis?Clinical Gastroenterology and Hepatology.  8:647-648. 2010
2010 Temporal characteristics of cold pain perceptionNeuroscience Letters.  480:12-15. 2010
2010 Catastrophizing, Acceptance, and Interference: Laboratory Findings, Subjective Report, and Pain Willingness as a ModeratorHealth Psychology.  29:299-306. 2010
2010 Intravenous lidocaine reduces ischemic pain in healthy volunteers 2010
2010 Neonatal bladder inflammation alters activity of adult rat spinal visceral nociceptive neuronsNeuroscience Letters.  472:210-214. 2010
2010 Effect of Estrogen on Bladder Nociception in Rats 2010
2010 Neonatal Bladder Inflammation Produces Functional Changes and Alters Neuropeptide Content in Bladders of Adult Female RatsJournal of Pain.  11:247-255. 2010
2010 ReplyJournal of Pain.  11:198. 2010
2009 Acute bladder inflammation differentially affects rat spinal visceral nociceptive neuronsNeuroscience Letters.  467:150-154. 2009
2009 Depressive symptoms and pain evaluations among persons with chronic pain: Catastrophizing, but not pain acceptance, shows significant effectsPAIN.  147:147-152. 2009
2009 Effects of Oxytocin and Prolactin on Stress-Induced Bladder Hypersensitivity in Female RatsJournal of Pain.  10:1065-1072. 2009
2009 Ice Water Testing Reveals Hypersensitivity in Adult Rats That Experienced Neonatal Bladder Inflammation: Implications for Painful Bladder Syndrome/Interstitial Cystitis 2009
2009 Emerging therapies and novel approaches to visceral painDrug Discovery Today: Therapeutic Strategies.  6:89-95. 2009
2008 Ethics in pain management of persons with spinal cord injuryTopics in Spinal Cord Injury Rehabilitation.  13:95-107. 2008
2008 Footshock-Induced Urinary Bladder Hypersensitivity: Role of Spinal Corticotropin-Releasing Factor ReceptorsJournal of Pain.  9:991-998. 2008
2008 Rostral Ventral Medulla Modulation of the Visceromotor Reflex Evoked by Urinary Bladder Distension in Female RatsJournal of Pain.  9:920-926. 2008
2008 The Common in Boston 2008
2007 Inflammation-Induced Enhancement of the Visceromotor Reflex to Urinary Bladder Distention: Modulation by Endogenous Opioids and the Effects of Early-in-Life Experience With Bladder InflammationJournal of Pain.  8:914-923. 2007
2007 Loss of cortical function in mice after decapitation, cervical dislocation, potassium chloride injection, and CO2 inhalation 2007
2007 Chronic psychological stress enhances nociceptive processing in the urinary bladder in high-anxiety ratsPhysiology and Behavior.  91:544-550. 2007
2006 Multidimensional outcomes analysis of intrathecal, oral opioid, and behavioral-functional restoration therapy for failed back surgery syndrome: A retrospective study with 4 years' follow-upNeuromodulation.  9:270-283. 2006
2006 Neonatal Urinary Bladder Inflammation Produces Adult Bladder HypersensitivityJournal of Pain.  7:469-479. 2006
2006 Which Spinal Cutaneous Nociceptive Neurons Are Inhibited by Intravenous Lidocaine in the Rat? 2006
2006 Characterization of thalamic neuronal responses to urinary bladder distention, including the effect of acute spinal lesions in the ratJournal of Pain.  7:218-224. 2006
2006 Inflammation and enhanced nociceptive responses to bladder distension produced by intravesical zymosan in the ratBMC Urology.  6. 2006
2005 Visceral nociceptive input to the area of the medullary lateral reticular nucleus ascends in the lateral spinal cordNeuroscience Letters.  381:329-333. 2005
2005 Morphine responses and experimental pain: Sex differences in side effects and cardiovascular responses but not analgesiaJournal of Pain.  6:116-124. 2005
2005 Effects of smoking on neuropathic pain in two people with spinal cord injuryJournal of Spinal Cord Medicine.  28:330-332. 2005
2005 Menstrual cycle affects bladder pain sensation in subjects with interstitial cystitis 2005
2005 Pelvic pain in women and men: Recent findingsCurrent Opinion in Anaesthesiology.  18:555-562. 2005
2005 Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis 2005
2005 Sex-related psychological predictors of baseline pain perception and analgesic responses to pentazocineBiological Psychology.  69:97-112. 2005
2005 The A118G single nucleotide polymorphism of the μ-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humansJournal of Pain.  6:159-167. 2005
2005 Visceral pain and life quality in persons with spinal cord injury: A brief reportJournal of Spinal Cord Medicine.  28:333-337. 2005
2004 Experimental Pain Models Reveal No Sex Differences in Pentazocine Analgesia in HumansAnesthesiology.  100:1263-1270. 2004
2004 One Thing Leads to AnotherAnesthesiology.  100:472-473. 2004
2004 Endogenous opioids, blood pressure, and diffuse noxious inhibitory controls: A preliminary studyPerceptual and Motor Skills.  99:679-687. 2004
2004 Reliable visceromotor responses are evoked by noxious bladder distention in mice 2004
2003 Interrater reliability of the International Association for the Study of Pain and Tunks' spinal cord injury pain classification schemesAmerican Journal of Physical Medicine and Rehabilitation.  82:437-440. 2003
2003 The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans 2003
2003 Test-retest reliability of the Donovan spinal cord injury pain classification schemeSpinal Cord.  41:239-241. 2003
2003 A preliminary study of the optimal anesthesia positioning for the morbidly obese patientObesity Surgery.  13:4-9. 2003
2003 Do we need another animal pain model?Anesthesiology.  98:291. 2003
2003 Age-related differences in endogenous pain modulation: A comparison of diffuse noxious inhibitory controls in healthy older and younger adultsPAIN.  101:155-165. 2003
2003 Individual differences in diffuse noxious inhibitory controls (DNIC): Association with clinical variablesPAIN.  106:427-437. 2003
2003 Transnasal jet ventilation is useful adjunt to teach fibreoptic intubation: A preliminary report 2003
2003 Use of topiramate for spinal cord injury-related painJournal of Spinal Cord Medicine.  26:401-403. 2003
2002 Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the reflex responses to distension of the rat urinary bladderAnesthesiology.  96:1401-1409. 2002
2002 Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the spinal neuronal responses to distension of the rat urinary bladderAnesthesiology.  96:1410-1419. 2002
2002 Long-term use of gabapentin for treatment of pain after traumatic spinal cord injuryClinical Journal of Pain.  18:116-121. 2002
2002 Pain classification following spinal cord injury: The utility of verbal descriptorsSpinal Cord.  40:118-127. 2002
2002 Hypoxia following interscalene block 2002
2002 Pain classification following spinal cord injury: The utility of verbal descriptorsSpinal Cord.  40:118-127. 2002
2002 Reliability characteristics of the Donovan spinal cord injury pain classification systemArchives of Physical Medicine and Rehabilitation.  83:1290-1294. 2002
2002 Spinal neurophysiologic correlates of the analgesic actions of intravesical dimethyl sulfoxide and capsaicin in the ratJournal of Pain.  3:394-400. 2002
2002 Use of compounded topical analgesics - Results of an internet survey 2002
2001 Evidence for two populations of rat spinal dorsal horn neurons excited by urinary bladder distensionBrain Research.  923:147-156. 2001
2001 Pharmacology of peripheral analgesia.Pain Practice.  1:243-254. 2001
2001 Vigor of visceromotor responses to urinary bladder distension in rats increases with repeated trials and stimulus intensityNeuroscience Letters.  306:97-100. 2001
2001 Left vagus nerve stimulation suppresses experimentally induced pain [3] (multiple letters)Neurology.  56:985-986. 2001
2001 Inflammation enhances reflex and spinal neuron responses to noxious visceral stimulation in rats. 2001
2001 Characterization of pressor and visceromotor reflex responses to bladder distention in rats: Sources of variability and effect of analgesics 2001
2001 Chronic urologic pain syndromes.Current Pain and Headache Reports.  5:27-34. 2001
2001 Inflammation enhances reflex and spinal neuron responses to noxious visceral stimulation in rats 2001
2001 Systemic medicationsTopics in Spinal Cord Injury Rehabilitation.  7:57-72. 2001
2000 Evidence for ascending visceral nociceptive information in the dorsal midline and lateral spinal cordPAIN.  87:83-88. 2000
2000 Low intensity vagal nerve stimulation lowers human thermal pain thresholdsPAIN.  86:81-85. 2000
2000 Acute inflammation differentially alters the activity of two classes of rat spinal visceral nociceptive neuronsNeuroscience Letters.  281:131-134. 2000
2000 Intravenous lidocaine inhibits visceral nociceptive reflexes and spinal neurons in the ratAnesthesiology.  92:1685-1691. 2000
2000 Sex-related hormonal influences on pain and analgesic responsesNeuroscience and Biobehavioral Reviews.  24:485-501. 2000
1999 The effect of spinal analgesia on visceral nociceptive neurons in caudal medulla of the ratAnesthesia and Analgesia.  89:721-726. 1999
1999 Analgesia for trauma and burnsCritical Care Clinics.  15:167-184. 1999
1999 Kappa opioid receptor agonists differentially inhibit two classes of rat spinal neurons excited by colorectal distentionGastroenterology.  117:388-394. 1999
1999 Models of visceral nociception 1999
1999 TITLE: Cardiovascular and visceromotor responses to noxious visceral stimuli vary with the estrous cycle in rats 1999
1999 The effect of morphine on responses of nucleus ventroposterolateralis neurons to colorectal distension in the ratBrain Research Bulletin.  48:609-614. 1999
1998 A case of spinal cord injury-related pain with baseline rCBF brain SPECT imaging and beneficial response to gabapentinPAIN.  78:139-143. 1998
1998 Characterization of neurons in the area of the medullary lateral reticular nucleus responsive to noxious visceral and cutaneous stimuliBrain Research.  802:163-174. 1998
1998 The development of tolerance to intrathecal morphine in rat models of visceral and cutaneous painNeuroscience Letters.  248:33-36. 1998
1998 A psychophysical study of discomfort produced by repeated filling of the urinary bladderPAIN.  76:61-69. 1998
1998 Case report on gabapentin [3] 1998
1998 The effect of morphine on responses of mediodorsal thalamic nuclei and nucleus submedius neurons to colorectal distension in the ratBrain Research.  779:41-52. 1998
1997 Intrathecal Strychnine but not Bicuculline Antagonizes Spinal Cord Stimulation-Produced Inhibition of Heat-Evoked and "Allodynia-like" Responses in Rats 1997
1995 Quantitative effects of “spinal” analgesics on cardiovascular, motor and medullary neuronal measures of visceral nociception 1995
1994 Intrathecal morphine and lidocaine block ascending visceral nociceptive information: Inhibition of medullary nociceptive neurons 1994
1991 Further behavioral evidence that colorectal distension is a 'noxious' visceral stimulus in ratsNeuroscience Letters.  131:113-116. 1991
1991 Neonatal capsaicin treatment abolishes the nociceptive responses to intravenous 5-HT in the ratBrain Research.  542:212-218. 1991
1991 Central mechanisms of visceral painCanadian Journal of Physiology and Pharmacology.  69:627-634. 1991
1991 Interactions between visceral and cutaneous nociception in the rat. I. Noxious cutaneous stimuli inhibit visceral nociceptive neurons and reflexesJournal of Neurophysiology.  66:20-28. 1991
1991 Interactions between visceral and cutaneous nociception in the rat. II. Noxious visceral stimuli inhibit cutaneous nociceptive neurons and reflexesJournal of Neurophysiology.  66:29-39. 1991
1990 Vagal afferent-mediated inhibition of a nociceptive reflex by intravenous serotonin in the rat. I. CharacterizationBrain Research.  524:90-100. 1990
1990 A psychophysiological study in humans using phasic colonic distension as a noxious visceral stimulusPAIN.  43:377-386. 1990
1990 Visceral pain: a review of experimental studiesPAIN.  41:167-234. 1990
1989 Characterization of superficial T13-L2 dorsal horn neurons encoding for colorectal distension in the rat: comparison with neurons in deep laminaeBrain Research.  486:301-309. 1989
1989 Differential effects of morphine and clonidine on visceral and cutaneous spinal nociceptive transmission in the ratJournal of Neurophysiology.  62:220-230. 1989
1988 Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the ratBrain Research.  450:153-169. 1988
1988 Characterization of neurons responsive to noxious colorectal distension in the T13-L2 spinal cord of the ratJournal of Neurophysiology.  60:1419-1438. 1988
1987 Contribution of the site of heating to variability in the latency of the rat tail flick reflexBrain Research.  426:169-172. 1987
1987 A distension control device useful for quantitative studies of hollow organ sensationPhysiology and Behavior.  41:635-638. 1987
1987 Characterization of neuronal responses to noxious visceral and somatic stimuli in the medial lumbosacral spinal cord of the ratJournal of Neurophysiology.  57:1867-1892. 1987
1987 Quantitative comparison of inhibition of visceral and cutaneous spinal nociceptive transmission from the midbrain and medulla in the ratJournal of Neurophysiology.  58:850-865. 1987
1986 Centrifugal modulation of the rat tail flick reflex evoked by graded noxious heating of the tailBrain Research.  386:41-52. 1986

Chapter

Year Title Altmetric
2018 Urogenital and pelvic pain.  271-278. 2018
2010 Pain from Abdominal Organs.  174-193. 2010
2008 Applied physiology: Persistent visceral pain.  37-47. 2008
2008 Chronic abdominal, groin, and perineal pain of visceral origin.  549-569. 2008
2006 Sensory systems.  257-266. 2006
2006 Visceral Pain.  85-94. 2006
2001 Methods in visceral pain research.  93-108. 2001

Education And Training

  • Doctor of Medicine, University of Iowa 1988
  • University of Iowa Hospitals and Clinics, Residency 1992
  • University of Iowa Hospitals and Clinics, Postdoctoral Fellowship 1993
  • Full Name

  • Timothy Ness