Positions

Overview

  • Scott M Wilson PhD
    Associated Professor
    Department of Neurobiology
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Examination of genetic and pharmacological tools to study the proteasomal deubiquitinating enzyme ubiquitin-specific protease 14 in the nervous systemJournal of Neurochemistry2020
    2019 Chronic over-expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in miceJournal of Neurochemistry.  148:386-399. 2019
    2017 Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease 2017
    2015 Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14Frontiers in Molecular Neuroscience.  8. 2015
    2015 Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junctionMolecular Neurodegeneration.  10. 2015
    2015 Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGSPLoS Genetics.  11. 2015
    2014 A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number 2014
    2013 Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (Usp14)PLoS ONE.  8. 2013
    2013 The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formationLearning and Memory.  21:748-752. 2013
    2013 Neuronal Ubiquitin HomeostasisCell Biochemistry and Biophysics.  67:67-73. 2013
    2012 Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent DeficitsPLoS ONE.  7. 2012
    2012 Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14 2012
    2011 Ubiquitin homeostasis is critical for synaptic development and function 2011
    2010 Enhancement of proteasome activity by a small-molecule inhibitor of USP14Nature.  467:179-184. 2010
    2009 The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions 2009
    2009 Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1 2009
    2009 The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in micePLoS Genetics.  5. 2009
    2009 Transgenic rescue of ataxia mice reveals a male-specific sterility defectDevelopmental Biology.  325:33-42. 2009
    2008 Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activityMolecular and Cellular Neuroscience.  39:539-548. 2008
    2008 Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.Molecular Brain.  1:17. 2008
    2006 Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14 2006
    2005 Loss of Usp14 results in reduced levels of ubiquitin in ataxia miceJournal of Neurochemistry.  95:724-731. 2005
    2003 Neurological disease: UPS stops delivering!Trends in Pharmacological Sciences.  24:18-23. 2003
    2002 Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific proteaseNature Genetics.  32:420-425. 2002
    2002 Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export 2002
    2001 Mutations in Cdh23 Cause Nonsyndromic Hearing Loss in waltzer MiceGenomics.  74:228-233. 2001
    2001 Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activityThe FASEB Journal.  15:1288-1290. 2001
    2000 A mutation in Rab27a causes the vesicle transport defects observed in ashen mice 2000
    2000 A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II 2000
    2000 The status of voltage-dependent calcium channels in alpha 1E knock-out mice 2000
    1994 Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. 1994
    1993 NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability.Molecular and Cellular Biology.  13:2730-2741. 1993
    1992 Legionella pneumophilia infection and cytokine productionAdvances in Experimental Medicine and Biology.  319. 1992

    Research Overview

  • My long-term research interest is to identify genetic pathways that control the development and function of the nervous system in the context of developing strategies to treat neurodegenerative disorders. By positionally cloning genes responsible for spontaneously occurring neurological mouse mutations, my laboratory identified Ubiquitin specific protease 14 and components of the ubiquitin proteasome pathway as critical regulators of neuronal signaling during development. In addition to investigating the mechanisms of ubiquitin homeostasis in regulating synaptic formation and function, my current research uses conditional inactivation of genes in mice and primary cell culture to study the essential roles of endosomal sorting in Schwann cells during peripheral nerve myelination.
  • Teaching Overview

  • NBL433/633 Diseases of the Nervous System
  • Teaching Activities

  • NBL433 - Diseases of the Nervous System (Fall Term 2019) 2019
  • NBL633 - Diseases of the Nervous System (Fall Term 2019) 2019
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2017) 2017
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2017) 2017
  • NBL240 - Special Topics Neuroscience 3 (Spring Term 2017) 2017
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2017) 2017
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2017) 2017
  • NBL399 - Senior Seminar in Neuroscience (Spring Term 2017) 2017
  • NBL401 - Collo in Basic Cog & Clin Neur (Spring Term 2017) 2017
  • NBL773 - Neuronal Signaling JC (Spring Term 2017) 2017
  • PY401 - Neuroscience Seminar (Spring Term 2017) 2017
  • STH201 - Research Approaches (Spring Term 2017) 2017
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2016) 2016
  • NBL399 - Senior Seminar in Neuroscience (Fall Term 2016) 2016
  • NBL399 - Senior Seminar in Neuroscience (Fall Term 2016) 2016
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2016) 2016
  • NBL399 - Senior Seminar in Neuroscience (Spring Term 2016) 2016
  • NBL399 - Senior Seminar in Neuroscience (Spring Term 2016) 2016
  • NBL773 - Neuronal Signaling JC (Spring Term 2016) 2016
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2015) 2015
  • NBL399 - Senior Seminar in Neuroscience (Fall Term 2015) 2015
  • GBS784 - STEM CELL BIOLOGY (Spring Term 2015) 2015
  • NBL773 - Neuronal Signaling JC (Spring Term 2015) 2015
  • GBS791 - GRADUATE NEUROSCIENCE DISCUSSION (Spring Term 2013) 2013
  • GBS791 - Grad Neuro Discussion (Spring Term 2012) 2012
  • NBL712 - Graduate Medical Neuroscience (Spring Term 2011) 2011
  • GBS732 - GRADUATE NEUROSCIENCE DISCUSSION (Spring Term 2011) 2011
  • NBL712 - Graduate Medical Neuroscience (Spring Term 2010) 2010
  • NEUR725 - Grd Neur Dicussion (Spring Term 2010) 2010
  • NBL725 - Sem Practice in Cell Mol Neuro (Fall Term 2009) 2009
  • CMB790 - CMB Laboratory Methods (Spring Term 2009) 2009
  • NEUR708 - Laboratory Methods (Spring Term 2009) 2009
  • CMB790 - CMB Laboratory Methods (Fall Term 2008) 2008
  • CMB790 - CMB Laboratory Methods (Spring Term 2008) 2008
  • CMB790 - CMB Laboratory Methods (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Genetics, University of Florida 1996
  • Full Name

  • Scott Wilson