Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometryNature Immunology2019
2018 Monitoring the past and choosing the future: The prefrontal cortical influences on voluntary actionScientific Reports.  8. 2018
2018 Optimism and Psychological Resilience are Beneficially Associated with Measures of Clinical and Experimental Pain in Adults with or at Risk for Knee OsteoarthritisClinical Journal of Pain.  34:1164-1172. 2018
2018 Reply: Brain oscillations, inhibition and social inappropriateness in frontotemporal degenerationBrain.  141. 2018
2018 Activity and connectivity differences underlying inhibitory control across the adult life spanJournal of Neuroscience.  38:7887-7900. 2018
2018 Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissueArthritis Research.  20. 2018
2018 Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid ArthritisArthritis and Rheumatology.  70:841-854. 2018
2018 Neurophysiological signatures of Alzheimer's disease and frontotemporal lobar degeneration: Pathology versus phenotypeBrain.  141:2500-2510. 2018
2018 Reorganization of cortical oscillatory dynamics underlying disinhibition in frontotemporal dementiaBrain.  141:2486-2499. 2018
2016 Update on Importance of Diet in GoutAmerican Journal of Medicine.  129:1153-1158. 2016
2016 Convergent evidence for hierarchical prediction networks from human electrocorticography and magnetoencephalographyCortex.  82:192-205. 2016
2016 Atomoxetine restores the response inhibition network in Parkinson's diseaseBrain.  139:2235-2248. 2016
2016 Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's DiseaseNeuropsychopharmacology.  41:2171-2177. 2016
2016 Erratum: Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease (Neuropsychopharmacology (2016) 41 (2188) DOI: 10.1038/npp.2016.18)Neuropsychopharmacology.  41:2188. 2016
2016 Different decision deficits impair response inhibition in progressive supranuclear palsy and Parkinson's diseaseBrain.  139:161-173. 2016
2015 Improving response inhibition systems in frontotemporal dementia with citalopramBrain.  138:1961-1975. 2015
2015 Hierarchical organization of frontotemporal networks for the prediction of stimuli across multiple dimensionsJournal of Neuroscience.  35:9255-9264. 2015
2015 The prefrontal cortex achieves inhibitory control by facilitating subcortical motor pathway connectivityJournal of Neuroscience.  35:786-794. 2015
2015 The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritisGenes and Immunity.  16:446-451. 2015
2014 The binaural masking level difference: Cortical correlates persist despite severe brain stem atrophy in progressive supranuclear palsyJournal of Neurophysiology.  112:3086-3094. 2014
2014 Complementary and alternative medicine use in African Americans with rheumatoid arthritisArthritis Care and Research.  66:180-189. 2014
2014 Selection and stopping in voluntary action: A meta-analysis and combined fMRI studyNeuroImage.  86:381-391. 2014
2014 HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: Hierarchical classification systems, amino acid positions, and residuesArthritis and Rheumatology.  66:3274-3282. 2014
2013 Into the groove: Can rhythm influence Parkinson's disease?Neuroscience and Biobehavioral Reviews.  37:2564-2570. 2013
2013 Comparison of the disease activity score using erythrocyte sedimentation rate and C-reactive protein in African Americans with rheumatoid arthritisJournal of Rheumatology.  40:1812-1822. 2013
2013 Perseveration and choice in parkinson's disease: The impact of progressive frontostriatal dysfunction on action decisionsCerebral Cortex.  23:1572-1581. 2013
2013 Reorganisation of brain networks in frontotemporal dementia and progressive supranuclear palsyNeuroImage: Clinical.  2:459-468. 2013
2013 Gene expression patterns in peripheral blood cells associated with radiographic severity in African Americans with early rheumatoid arthritisRheumatology International.  33:129-137. 2013
2013 The impact of neurodegeneration on network connectivity: A study of change detection in frontotemporal dementiaJournal of Cognitive Neuroscience.  25:802-813. 2013
2012 Selection and inhibition mechanisms for human voluntary action decisionsNeuroImage.  63:392-402. 2012
2012 White matter pathology in Parkinson's disease: The effect of imaging protocol differences and relevance to executive functionNeuroImage.  62:1675-1684. 2012
2012 Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African AmericansArthritis and Rheumatism.  64:1355-1358. 2012
2012 Use of a multiethnic approach to identify rheumatoid- arthritis- susceptibility loci, 1p36 and 17q12American Journal of Human Genetics.  90:524-532. 2012
2011 Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severityNeurobiology of Disease.  43:79-85. 2011
2011 Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: The MOST studyAnnals of the Rheumatic Diseases.  70:805-811. 2011
2011 Magnetoencephalography of frontotemporal dementia: Spatiotemporally localized changes during semantic decisionsBrain.  134:2513-2522. 2011
2010 Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African AmericansArthritis and Rheumatism.  62:3547-3553. 2010
2010 Parkinson's disease and healthy aging: Independent and interacting effects on action selectionHuman Brain Mapping.  31:1886-1899. 2010
2010 Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: Influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferase in a cross-sectional studyArthritis Research.  12. 2010
2010 Measurement of erythrocyte methotrexate polyglutamate levels: Ready for clinical use in rheumatoid arthritis?Current Rheumatology Reports.  12:342-347. 2010
2010 Dynamic causal modelling of effective connectivity from fMRI: Are results reproducible and sensitive to Parkinson's disease and its treatment?NeuroImage.  52:1015-1026. 2010
2010 Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapyArthritis and Rheumatism.  62:1849-1861. 2010
2010 Action selection: A race model for selected and non-selected actions distinguishes the contribution of premotor and prefrontal areasNeuroImage.  51:888-896. 2010
2010 The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's diseaseNeurobiology of Aging.  31:1064-1068. 2010
2010 Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritisArthritis Research.  12. 2010
2010 Radiographic severity of rheumatoid arthritis in African Americans: Results from a multicenter observational studyArthritis Care and Research.  62:624-631. 2010
2010 Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African AmericansAnnals of the Rheumatic Diseases.  69:625-626. 2010
2010 Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American populationGenes and Immunity.  11:94-97. 2010
2010 Relation of synovitis to knee pain using contrast-enhanced MRIsAnnals of the Rheumatic Diseases.  69:1779-1783. 2010
2009 Tibiofemoral joint osteoarthritis: Risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis studyRadiology.  252:772-780. 2009
2009 Recent advances in personalizing rheumatoid arthritis therapy and managementPersonalized Medicine.  6:159-170. 2009
2009 An african ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in african americansPLoS Genetics.  5. 2009
2009 Retraction: an African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.PLoS Genetics.  5. 2009
2009 Understanding personalized medicine in rheumatoid arthritis: A clinician’s guide to the futureTherapeutic Advances in Musculoskeletal Disease.  1:97-105. 2009
2008 Cigarette smoking, disease severity and autoantibody expression in African Americans with recent-onset rheumatoid arthritisAnnals of the Rheumatic Diseases.  67:1529-1534. 2008
2008 ReplyArthritis and Rheumatism.  58:3635-3636. 2008
2008 Rule-selection and action-selection have a shared neuroanatomical basis in the human prefrontal and parietal cortexCerebral Cortex.  18:2275-2285. 2008
2008 Pharmacogenetics of etanercept in rheumatoid arthritisPharmacogenomics.  9:1011-1015. 2008
2008 The HLA-DRB1 shared epitope in Caucasians with rheumatoid arthritis: A lesson learned from tic-tac-toeArthritis and Rheumatism.  58:1211-1215. 2008
2008 Evaluating linkage disequilibrium and recombination provides a haplotype-tagging SNP panel of the major histocompatibility complex in African AmericansGenes and Immunity.  9:271-273. 2008
2008 The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixtureArthritis and Rheumatism.  58:349-358. 2008
2008 Does gamma-aminobutyric acid (GABA) influence the development of chronic inflammation in rheumatoid arthritis?Journal of Neuroinflammation.  5. 2008
2008 Dissociations in rod bisection: The effect of viewing conditions on perception and actionCortex.  44:1279-1287. 2008
2008 Parkinson's disease and dopaminergic therapy - Differential effects on movement, reward and cognitionBrain.  131:2094-2105. 2008
2006 Racial or ethnic differences in allele frequencies of sinqle-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritisAnnals of the Rheumatic Diseases.  65:1213-1218. 2006
2005 The effects of local and global processing demands on perception and actionBrain and Cognition.  59:71-81. 2005
2004 Genetic risk factors for infection in patients with early rheumatoid arthritisGenes and Immunity.  5:641-647. 2004
2004 Grasping at sticks: Pseudoneglect for perception but not actionExperimental Brain Research.  157:397-402. 2004
2003 Early rheumatoid arthritis in African-Americans: The CLEAR registryClinical and Experimental Rheumatology.  21. 2003
2002 Genetic influences on rheumatoid arthritis in African AmericansImmunologic Research.  26:15-26. 2002
2002 Polyarteritis nodosa and microscopic polyangiitis: etiologic and diagnostic considerations.Current Rheumatology Reports.  4:75-82. 2002
2001 New therapeutic approaches to the management of rheumatoid arthritisClinical immunotherapeutics.  15:379-393. 2001

Research Overview

  • Dr. Hughes’ research interest is in identifying pharmacogenetic markers for treatment response and toxicity in subjects with rheumatoid arthritis. She has also investigated genetic markers for susceptibility and severity in African-American subjects with rheumatoid arthritis. Her research interests have recently expanded to include analysis of genetic markers in inflammatory and adipokine genes for association with osteoarthritis.
  • Investigator On

  • Evolving Adaptive and Effector Mechanisms from Pre-RA Through Established Disease  awarded by Northwestern University 2016 - 2020
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2019 - 2020
  • The Rheumatoid Arthritis Synovial Tissue Network (REASON)  awarded by Northwestern University 2014 - 2019
  • Ethnic Differences in Response to Painful Stimuli  awarded by University of Florida 2018 - 2019
  • Private Grant  awarded by BIOMET BIOLOGICS, LLC 2016 - 2018
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2016 - 2018
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2015 - 2018
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida 2014 - 2018
  • Centers of Research Translation (CoRT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2017
  • Dissection of the ACPA Response in African-Americans with Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2011 - 2016
  • Genome-Wide Association Study in African-Americans With Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2016
  • UAHSF General Endowment Fund Scholar (HSF-GEF)  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2012 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center - Project 3  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Education And Training

  • Doctor of Medicine, University of Alabama at Birmingham 1996
  • Physicians Medical Center Carraway, Internship 1997
  • Physicians Medical Center Carraway, Residency 1999
  • UAB Hospital, Postdoctoral Fellowship 2003
  • Full Name

  • Laura Hughes