Positions

Overview

  • Laurie E. Harrington received her B.S. degree from the University of Vermont in 1997 and her Ph.D. in Immunology from Emory University in 2001. In late 2001, she began her postdoctoral studies at the University of Alabama at Birmingham, investigating the heterogeneity of CD4 T cell responses during autoimmune and protective immune responses. Laurie joined the Department of Cell Biology, now Cell, Developmental and Integrative Biology, as an Assistant Professor in 2007.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T CellsCell Reports.  30:1898-1909.e4. 2020
    2019 STAT4 directs a protective innate lymphoid cell response to gastrointestinal infectionJournal of Immunology.  203:2472-2484. 2019
    2019 IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.Immunohorizons.  3:194-202. 2019
    2019 Inscribing the core memories of killersCellular and Molecular Immunology.  16:104-105. 2019
    2019 Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney diseasePhysiological Reports.  7. 2019
    2018 Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammationJournal of Experimental Medicine.  215:1803-1812. 2018
    2016 IL-10 regulates memory T Cell development and the balance between Th1 and follicular Th cell responses during an Acute Viral InfectionJournal of Immunology.  197:1308-1321. 2016
    2015 STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAEJournal of Neuroinflammation.  12. 2015
    2014 Astrocytes modulate the polarization of CD4+ T cells to Th1 cellsPLoS ONE.  9. 2014
    2014 IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanismsJournal of Neuroimmunology.  267:20-27. 2014
    2014 Therapeutic efficacy of suppressing the JAK/STAT pathway in multiple models of experimental autoimmune encephalomyelitisJournal of Immunology.  192:59-72. 2014
    2014 Tissue-resident T cells lose their S1P 1 exit visasCellular and Molecular Immunology.  11:221-223. 2014
    2014 Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factorsJournal of Leukocyte Biology.  95:705-713. 2014
    2013 Temporal requirements for B cells in the establishment of CD4 T cell memoryJournal of Immunology.  191:6052-6059. 2013
    2013 Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3Journal of Immunology.  190:5000-5011. 2013
    2013 Inflammatory T helper 17 cells promote depression-like behavior in miceBiological Psychiatry.  73:622-630. 2013
    2012 Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation 2012
    2011 Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitisJournal of Immunology.  187:4998-5006. 2011
    2011 Cytokines and the inception of CD8 T cell responses 2011
    2011 Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cellsJournal of Immunology.  186:1391-1398. 2011
    2010 Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levelsJournal of Immunology.  185:3643-3651. 2010
    2008 Memory CD4 T cells emerge from effector T-cell progenitorsNature.  452:356-360. 2008
    2007 Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiationJournal of Immunology.  179:6704-6714. 2007
    2007 Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10Nature Immunology.  8:931-941. 2007
    2007 IL-17 family cytokines and the expanding diversity of effector T cell lineagesAnnual Review of Immunology.  25:821-852. 2007
    2006 A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK CellsImmunity.  25:717-729. 2006
    2006 Expanding the effector CD4 T-cell repertoire: the Th17 lineageCurrent Opinion in Immunology.  18:349-356. 2006
    2006 Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell TiesImmunity.  24:677-688. 2006
    2006 Transforming growth factor-β induces development of the T H17 lineageNature.  441:231-234. 2006
    2005 Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesNature Immunology.  6:1123-1132. 2005
    2005 Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endotheliumAmerican Journal of Pathology.  167:1661-1675. 2005
    2002 Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivoJournal of Immunology.  169:3760-3770. 2002
    2002 CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cellsJournal of Immunology.  169:693-701. 2002
    2002 Dynamic regulation of T cell immunity by CD43Journal of Immunology.  168:6022-6031. 2002
    2002 Recombinant vaccinia virus-induced T-cell immunity: Quantitation of the response to the virus vector and the foreign epitopeJournal of Virology.  76:3329-3337. 2002
    2002 Yellow fever virus 17D envelope and NS3 proteins are major targets of the antiviral T cell response in miceVirology.  296:117-124. 2002
    2001 Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memoryJournal of Immunology.  167:5565-5573. 2001
    2001 Characterization of virus-mediated inhibition of mixed chimerism and allospecific toleranceJournal of Immunology.  167:4987-4995. 2001
    2000 Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycansJournal of Experimental Medicine.  191:1241-1246. 2000

    Chapter

    Year Title Altmetric
    2018 T Cell Development 2018
    2014 Immune Response to Viruses: Cell-Mediated Immunity 2014
    2008 Immune Response to Viruses: Cell-Mediated Immunity.  70-77. 2008

    Research Overview

  • My research interests focus on the development, fate, and function of specific subsets effector CD4 T cells following infection as well as during chronic autoimmunity, with the hope of gaining insights into how to both promote and dampen immune responses when necessary.
  • Teaching Activities

  • GBS744 - Mucosal Immunology (Spring Term 2021) 2021
  • GBSC723 - Career Dev Courses (Spring Term 2021) 2021
  • GBSC742 - Student Theme Meeting Course (Spring Term 2021) 2021
  • GBSC723 - Career Dev Courses (Fall Term 2020) 2020
  • GBSC742 - Student Theme Meeting Course (Fall Term 2020) 2020
  • GBS744 - Mucosal Immunology (Spring Term 2020) 2020
  • GBSC723 - Career Dev Courses (Spring Term 2020) 2020
  • GBSC742 - Student Theme Meeting Course (Spring Term 2020) 2020
  • GBSC723 - Career Dev Courses (Fall Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Fall Term 2019) 2019
  • GBS744 - Mucosal Immunology (Spring Term 2019) 2019
  • GBSC723 - Career Dev Courses (Spring Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Spring Term 2019) 2019
  • GBSC723 - Career Dev Courses (Fall Term 2018) 2018
  • GBSC742 - Student Theme Meeting Course (Fall Term 2018) 2018
  • GBS744 - Mucosal Immunology (Spring Term 2018) 2018
  • GBSC723 - Career Dev Courses (Spring Term 2018) 2018
  • GBSC723 - Career Dev Courses (Fall Term 2017) 2017
  • GBS744 - Mucosal Immunology (Spring Term 2017) 2017
  • GBSC723 - Career Dev Courses (Spring Term 2017) 2017
  • MIC741 - Topics in Professional Develop (Fall Term 2015) 2015
  • GBS741 - Lymphocyte Biology (Spring Term 2015) 2015
  • GBS787 - Special Topics (Fall Term 2014) 2014
  • MIC741 - Topics in Professional Develop (Fall Term 2014) 2014
  • GBS741 - Lymphocyte Biology (Spring Term 2014) 2014
  • MIC741 - Topics in Professional Develop (Fall Term 2013) 2013
  • GBS741 - Lymphocyte Biology (Spring Term 2013) 2013
  • MIC741 - Topics in Professional Develop (Fall Term 2012) 2012
  • MIC741 - Topics in Professional Develop (Fall Term 2011) 2011
  • MIC741 - Topics in Professional Develop (Spring Term 2011) 2011
  • MIC741 - Topics in Professional Develop (Fall Term 2010) 2010
  • MIC741 - Topics in Professional Develop (Spring Term 2010) 2010
  • CB745 - Protective/Pathogen T Cell Res (Fall Term 2009) 2009
  • MIC740 - Protective/Pathogen T Cell Res (Fall Term 2009) 2009
  • MIC741 - Topics in Professional Develop (Fall Term 2009) 2009
  • Full Name

  • Laurie Harrington