Laurie Harrington Ph.D.

Laurie Harrington Ph.D.
Professor

Scientist (C), Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC) , School of Medicine
Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine
Associate Scientist (C), Center for AIDS Research , School of Medicine
Scientist, Inflammation, Immunology and Immunotherapeutics , O'Neal Comprehensive Cancer Center
Senior Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Scientist (C), Multiple Sclerosis Center , Neurology
Professor (P), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments

Overview

Laurie E. Harrington received her B.S. degree from the University of Vermont in 1997 and her Ph.D. in Immunology from Emory University in 2001. In late 2001, she began her postdoctoral studies at the University of Alabama at Birmingham, investigating the heterogeneity of CD4 T cell responses during autoimmune and protective immune responses. Laurie joined the Department of Cell Biology, now Cell, Developmental and Integrative Biology, as an Assistant Professor in 2007.

Selected Publications

Academic Article

Year	Title	Altmetric
2022	A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice. Journal of the American Society of Nephrology. 33:747-768. 2022
2022	Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection. Science Immunology. 7. 2022
2020	Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells. Cell Reports. 30:1898-1909.e4. 2020
2019	STAT4 directs a protective innate lymphoid cell response to gastrointestinal infection. Journal of Immunology. 203:2472-2484. 2019
2019	IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis 2019
2019	Inscribing the core memories of killers. Cellular and Molecular Immunology. 16:104-105. 2019
2019	Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney disease. Physiological Reports. 7. 2019
2018	Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation. Journal of Experimental Medicine. 215:1803-1812. 2018
2016	IL-10 regulates memory T Cell development and the balance between Th1 and follicular Th cell responses during an Acute Viral Infection. Journal of Immunology. 197:1308-1321. 2016
2015	STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE. Journal of Neuroinflammation. 12. 2015
2014	Astrocytes modulate the polarization of CD4⁺ T cells to Th1 cells. PLoS One. 9. 2014
2014	IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms. Journal of Neuroimmunology. 267:20-27. 2014
2014	Therapeutic efficacy of suppressing the JAK/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. Journal of Immunology. 192:59-72. 2014
2014	Tissue-resident T cells lose their S1P 1 exit visas. Cellular and Molecular Immunology. 11:221-223. 2014
2014	Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factors. Journal of Leukocyte Biology. 95:705-713. 2014
2013	Temporal requirements for B cells in the establishment of CD4 T cell memory. Journal of Immunology. 191:6052-6059. 2013
2013	Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3. Journal of Immunology. 190:5000-5011. 2013
2013	Inflammatory T helper 17 cells promote depression-like behavior in mice. Biological Psychiatry. 73:622-630. 2013
2012	Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proceedings of the National Academy of Sciences of USA. 109:5004-5009. 2012
2011	Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis. Journal of Immunology. 187:4998-5006. 2011
2011	Cytokines and the inception of CD8 T cell responses. Trends in Immunology. 32:180-186. 2011
2011	Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells. Journal of Immunology. 186:1391-1398. 2011
2010	Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels. Journal of Immunology. 185:3643-3651. 2010
2008	Memory CD4 T cells emerge from effector T-cell progenitors. Nature. 452:356-360. 2008
2007	Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. Journal of Immunology. 179:6704-6714. 2007
2007	Regulatory T cells expressing interleukin 10 develop from Foxp3⁺ and Foxp3^- precursor cells in the absence of interleukin 10. Nature Immunology. 8:931-941. 2007
2007	IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annual Review of Immunology. 25:821-852. 2007
2006	A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK Cells. Immunity. 25:717-729. 2006
2006	Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Current Opinion in Immunology. 18:349-356. 2006
2006	Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties. Immunity. 24:677-688. 2006
2006	Transforming growth factor-β induces development of the T H17 lineage. Nature. 441:231-234. 2006
2005	Interleukin 17-producing CD4⁺ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nature Immunology. 6:1123-1132. 2005
2005	Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endothelium. American Journal of Pathology. 167:1661-1675. 2005
2002	Differential sensitivity of naive and memory CD8⁺ T cells to apoptosis in vivo. Journal of Immunology. 169:3760-3770. 2002
2002	CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8⁺ T cells. Journal of Immunology. 169:693-701. 2002
2002	Dynamic regulation of T cell immunity by CD43. Journal of Immunology. 168:6022-6031. 2002
2002	Recombinant vaccinia virus-induced T-cell immunity: Quantitation of the response to the virus vector and the foreign epitope. Journal of Virology. 76:3329-3337. 2002
2002	Yellow fever virus 17D envelope and NS3 proteins are major targets of the antiviral T cell response in mice. Virology. 296:117-124. 2002
2001	Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. Journal of Immunology. 167:5565-5573. 2001
2001	Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance. Journal of Immunology. 167:4987-4995. 2001
2000	Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans. Journal of Experimental Medicine. 191:1241-1246. 2000

Chapter

Year	Title	Altmetric
2018	T Cell Development 2018
2014	Immune Response to Viruses: Cell-Mediated Immunity 2014
2008	Immune Response to Viruses: Cell-Mediated Immunity. 70-77. 2008

Research Overview

My research interests focus on the development, fate, and function of specific subsets effector CD4 T cells following infection as well as during chronic autoimmunity, with the hope of gaining insights into how to both promote and dampen immune responses when necessary.