Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species.  Redox Biology.  43. 2021
2021 Korean Red Ginseng aqueous extract improves markers of mucociliary clearance by stimulating chloride secretion.  Journal of Ginseng Research.  45:66-74. 2021
2020 Hyaluronan and halogen-induced airway hyperresponsiveness and lung injury.  Annals of the New York Academy of Sciences.  1479:29-43. 2020
2020 Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome.  Redox Biology.  36. 2020
2020 Upregulation of airway smooth muscle calcium-sensing receptor by lowmolecular- weight hyaluronan 2020
2019 Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease.  International Forum of Allergy and Rhinology.  9:100-105. 2019
2018 Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis.  JCI insight.  3. 2018
2018 Therapeutic attenuation of the epithelial sodium channel with a SPLUNC1-derived peptide in airway diseases 2018
2017 Influenza virus infection alters ion channel function of airway and alveolar cells: Mechanisms and physiological sequelae 2017
2017 A novel role for primary cilia in airway remodeling 2017
2016 Mechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic Fibrosis.  PLoS ONE.  11. 2016
2016 A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator.  The FASEB Journal.  30:201-213. 2016
2015 Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection.  The FASEB Journal.  29:2712-2725. 2015
2015 Chlorine inhalation-induced myocardial depression and failure.  Physiological Reports.  3. 2015
2015 Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury 2015
2014 Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance.  PLoS ONE.  9. 2014
2014 A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.  American Journal of Respiratory and Critical Care Medicine.  190:522-532. 2014
2014 Inter-a-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in DF508 mice.  American Journal of Respiratory Cell and Molecular Biology.  50:953-962. 2014
2013 The silent codon change I507-ATC→ATT contributes to the severity of the AF508 CFTR channel dysfunction.  The FASEB Journal.  27:4630-4645. 2013
2013 Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity 2013
2012 The CFTR and ENaC debate: How important is ENaC in CF lung disease? 2012
2012 Regulation of alveolar epithelial Na + channels by ERK1/2 in chlorine-breathing mice.  American Journal of Respiratory Cell and Molecular Biology.  46:342-354. 2012
2011 Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung 2011
2010 Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines.  Journal of Biological Chemistry.  285:9716-9728. 2010
2009 Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species.  The FASEB Journal.  23:3829-3842. 2009
2009 α1-Antitrypsin inhibits epithelial Na+ transport in vitro and in vivo.  American Journal of Respiratory Cell and Molecular Biology.  41:261-270. 2009
2009 Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase.  Journal of Biological Chemistry.  284:7294-7306. 2009
2006 Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms 2006
2005 WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.  Journal of Biological Chemistry.  280:34218-34223. 2005
2005 WNK1 activates SGK1 to regulate the epithelial sodium channel 2005
2003 Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells.  Free Radical Biology and Medicine.  35:662-675. 2003
2003 cAMP-induced changes of apical membrane potentials of confluent H441 monolayers 2003
2002 Invited review: Biophysical properties of sodium channels in lung alveolar epithelial cells 2002
2002 Alveolar epithelial ion and fluid transport: Ca2+-dependent stimulation of alveolar fluid clearance in near-term fetal guinea pigs 2002
2002 cAMP regulation of Cl(-) and HCO(-)(3) secretion across rat fetal distal lung epithelial cells. 2002
2001 Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium. 2001
2001 Mechanisms of TNF-α stimulation of amiloride-sensitive sodium transport across alveolar epithelium 2001
2000 Biophysical properties and molecular characterization of amiloride- sensitive sodium channels in A549 cells 2000
2000 Mechanisms of increased Na+ transport in ATII cells by cAMP: We agree to disagree and do more experiments 2000
2000 Modification of biophysical properties of lung epithelial Na+ channels by dexamethasone 2000
1999 Chapter 13 Inhibition of Vectorial Na+ Transport across Alveolar Epithelial Cells by Nitrogen-Oxygen Reactive Species.  Current Topics in Membranes and Transport.  47:219-238. 1999
1997 Studying electric field effects on embryonic myocytes 1997
1996 Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells 1996
1994 Ca-mediated and independent effects of arachidonic acid on gap junctions and Ca-independent effects of oleic acid and halothane.  Biophysical Journal.  67:1052-1059. 1994
1993 Gap junction gating sensitivity to physiological internal calcium regardless of pH in Novikoff hepatoma cells.  Biophysical Journal.  65:2002-2012. 1993

Book

Year Title Altmetric
2008 Chapter 3 Modulation of Lung Epithelial Sodium Channel Function by Nitric Oxide.  Ed. 61.  2008

Chapter

Year Title Altmetric
2008 Current Topics in Membranes, Modulation of lung epithelial sodium channel function by nitric oxide.  43-43. 2008

Education And Training

  • Doctor of Philosophy Level Degree in Cell / Cellular and Molecular Biology, 1989

    • Full Name

  • Ahmed Lazrak