Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Korean Red Ginseng aqueous extract improves markers of mucociliary clearance by stimulating chloride secretion.  Journal of Ginseng Research.  45:66-74. 2021
2020 Hyaluronan and halogen-induced airway hyperresponsiveness and lung injury.  Annals of the New York Academy of Sciences.  1479:29-43. 2020
2020 Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome.  Redox Biology.  36. 2020
2020 Upregulation of airway smooth muscle calcium-sensing receptor by low-molecular-weight hyaluronan 2020
2019 Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease.  International Forum of Allergy and Rhinology.  9:100-105. 2019
2018 Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis.  JCI insight.  3. 2018
2018 Therapeutic attenuation of the epithelial sodium channel with a SPLUNC1-derived peptide in airway diseases 2018
2017 Influenza virus infection alters ion channel function of airway and alveolar cells: Mechanisms and physiological sequelae 2017
2017 A novel role for primary cilia in airway remodeling 2017
2016 Mechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic Fibrosis.  PLoS ONE.  11. 2016
2016 A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator.  The FASEB Journal.  30:201-213. 2016
2015 Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection.  The FASEB Journal.  29:2712-2725. 2015
2015 Chlorine inhalation-induced myocardial depression and failure.  Physiological Reports.  3. 2015
2015 Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury 2015
2014 Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance.  PLoS ONE.  9. 2014
2014 A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.  American Journal of Respiratory and Critical Care Medicine.  190:522-532. 2014
2014 Inter-a-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in DF508 mice.  American Journal of Respiratory Cell and Molecular Biology.  50:953-962. 2014
2013 The silent codon change I507-ATC→ATT contributes to the severity of the AF508 CFTR channel dysfunction.  The FASEB Journal.  27:4630-4645. 2013
2013 Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity 2013
2012 The CFTR and ENaC debate: How important is ENaC in CF lung disease? 2012
2012 Regulation of alveolar epithelial Na + channels by ERK1/2 in chlorine-breathing mice.  American Journal of Respiratory Cell and Molecular Biology.  46:342-354. 2012
2011 Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung 2011
2010 Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines.  Journal of Biological Chemistry.  285:9716-9728. 2010
2009 Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species.  The FASEB Journal.  23:3829-3842. 2009
2009 α1-Antitrypsin inhibits epithelial Na+ transport in vitro and in vivo.  American Journal of Respiratory Cell and Molecular Biology.  41:261-270. 2009
2009 Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase.  Journal of Biological Chemistry.  284:7294-7306. 2009
2006 Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms 2006
2005 WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.  Journal of Biological Chemistry.  280:34218-34223. 2005
2005 WNK1 activates SGK1 to regulate the epithelial sodium channel 2005
2003 Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells.  Free Radical Biology and Medicine.  35:662-675. 2003
2003 cAMP-induced changes of apical membrane potentials of confluent H441 monolayers 2003
2002 Invited review: Biophysical properties of sodium channels in lung alveolar epithelial cells 2002
2002 Alveolar epithelial ion and fluid transport: Ca2+-dependent stimulation of alveolar fluid clearance in near-term fetal guinea pigs 2002
2002 cAMP regulation of Cl(-) and HCO(-)(3) secretion across rat fetal distal lung epithelial cells. 2002
2001 Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium. 2001
2001 Mechanisms of TNF-α stimulation of amiloride-sensitive sodium transport across alveolar epithelium 2001
2000 Biophysical properties and molecular characterization of amiloride- sensitive sodium channels in A549 cells 2000
2000 Mechanisms of increased Na+ transport in ATII cells by cAMP: We agree to disagree and do more experiments 2000
2000 Modification of biophysical properties of lung epithelial Na+ channels by dexamethasone 2000
1999 Chapter 13 Inhibition of Vectorial Na+ Transport across Alveolar Epithelial Cells by Nitrogen-Oxygen Reactive Species.  Current Topics in Membranes and Transport.  47:219-238. 1999
1996 Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells 1996
1994 Ca-mediated and independent effects of arachidonic acid on gap junctions and Ca-independent effects of oleic acid and halothane.  Biophysical Journal.  67:1052-1059. 1994
1993 Gap junction gating sensitivity to physiological internal calcium regardless of pH in Novikoff hepatoma cells.  Biophysical Journal.  65:2002-2012. 1993

Book

Year Title Altmetric
2008 Chapter 3 Modulation of Lung Epithelial Sodium Channel Function by Nitric Oxide.  Ed. 61.  2008

Education And Training

  • Doctor of Philosophy Level Degree in Cell / Cellular and Molecular Biology, 1989

    • Full Name

  • Ahmed Lazrak