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Ahmed Lazrak
Assistant Professor
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E-mail
lazrak@uab.edu
Phone
205-934-4253
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Ahmed Lazrak
Assistant Professor
Positions
Associate Scientist (C)
,
Minority Health & Research Center
,
General Clinical Research Center
2004 -
Assistant Professor (P)
,
Anesthesiology
,
School of Medicine
2009 -
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2021
Korean Red Ginseng aqueous extract improves markers of mucociliary clearance by stimulating chloride secretion
.
Journal of Ginseng Research
. 45:66-74.
2021
2020
Hyaluronan and halogen-induced airway hyperresponsiveness and lung injury
.
Annals of the New York Academy of Sciences
. 1479:29-43.
2020
2020
Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome
.
Redox Biology
. 36.
2020
2020
Upregulation of airway smooth muscle calcium-sensing receptor by low-molecular-weight hyaluronan
2020
2019
Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease
.
International Forum of Allergy and Rhinology
. 9:100-105.
2019
2018
Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis
.
JCI insight
. 3.
2018
2018
Therapeutic attenuation of the epithelial sodium channel with a SPLUNC1-derived peptide in airway diseases
2018
2017
Influenza virus infection alters ion channel function of airway and alveolar cells: Mechanisms and physiological sequelae
2017
2017
A novel role for primary cilia in airway remodeling
2017
2016
Mechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic Fibrosis
.
PLoS ONE
. 11.
2016
2016
A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator
.
The FASEB Journal
. 30:201-213.
2016
2015
Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection
.
The FASEB Journal
. 29:2712-2725.
2015
2015
Chlorine inhalation-induced myocardial depression and failure
.
Physiological Reports
. 3.
2015
2015
Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury
2015
2014
Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance
.
PLoS ONE
. 9.
2014
2014
A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation
.
American Journal of Respiratory and Critical Care Medicine
. 190:522-532.
2014
2014
Inter-a-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in DF508 mice
.
American Journal of Respiratory Cell and Molecular Biology
. 50:953-962.
2014
2013
The silent codon change I507-ATC→ATT contributes to the severity of the AF508 CFTR channel dysfunction
.
The FASEB Journal
. 27:4630-4645.
2013
2013
Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity
2013
2012
The CFTR and ENaC debate: How important is ENaC in CF lung disease?
2012
2012
Regulation of alveolar epithelial Na
+
channels by ERK1/2 in chlorine-breathing mice
.
American Journal of Respiratory Cell and Molecular Biology
. 46:342-354.
2012
2011
Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung
2011
2010
Inhibition of lung fluid clearance and epithelial Na
+
channels by chlorine, hypochlorous acid, and chloramines
.
Journal of Biological Chemistry
. 285:9716-9728.
2010
2009
Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species
.
The FASEB Journal
. 23:3829-3842.
2009
2009
α
1
-Antitrypsin inhibits epithelial Na
+
transport in vitro and in vivo
.
American Journal of Respiratory Cell and Molecular Biology
. 41:261-270.
2009
2009
Respiratory syncytial virus inhibits lung epithelial Na
+
channels by up-regulating inducible nitric-oxide synthase
.
Journal of Biological Chemistry
. 284:7294-7306.
2009
2006
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms
2006
2005
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism
.
Journal of Biological Chemistry
. 280:34218-34223.
2005
2005
WNK1 activates SGK1 to regulate the epithelial sodium channel
2005
2003
Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells
.
Free Radical Biology and Medicine
. 35:662-675.
2003
2003
cAMP-induced changes of apical membrane potentials of confluent H441 monolayers
2003
2002
Invited review: Biophysical properties of sodium channels in lung alveolar epithelial cells
2002
2002
Alveolar epithelial ion and fluid transport: Ca
2+
-dependent stimulation of alveolar fluid clearance in near-term fetal guinea pigs
2002
2002
cAMP regulation of Cl(-) and HCO(-)(3) secretion across rat fetal distal lung epithelial cells.
2002
2001
Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium.
2001
2001
Mechanisms of TNF-α stimulation of amiloride-sensitive sodium transport across alveolar epithelium
2001
2000
Biophysical properties and molecular characterization of amiloride- sensitive sodium channels in A549 cells
2000
2000
Mechanisms of increased Na
+
transport in ATII cells by cAMP: We agree to disagree and do more experiments
2000
2000
Modification of biophysical properties of lung epithelial Na
+
channels by dexamethasone
2000
1999
Chapter 13 Inhibition of Vectorial Na
+
Transport across Alveolar Epithelial Cells by Nitrogen-Oxygen Reactive Species
.
Current Topics in Membranes and Transport
. 47:219-238.
1999
1996
Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells
1996
1994
Ca-mediated and independent effects of arachidonic acid on gap junctions and Ca-independent effects of oleic acid and halothane
.
Biophysical Journal
. 67:1052-1059.
1994
1993
Gap junction gating sensitivity to physiological internal calcium regardless of pH in Novikoff hepatoma cells
.
Biophysical Journal
. 65:2002-2012.
1993
Book
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Year
Title
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2008
Chapter 3 Modulation of Lung Epithelial Sodium Channel Function by Nitric Oxide
. Ed. 61.
2008
Research
Investigator On
UAB Research and Development Program
awarded by
Cystic Fibrosis Foundation
2019 - 2023
Inhalation Toxicology of Chlorine Gas-on-a-Chip
awarded by
University of Pennsylvania
2020 - 2022
CIALIS® Reverses Halogen Induced Injury to Pregnant Animals and Their Offspring
awarded by
National Institute of Environmental Health Sciences/NIH/DHHS
2016 - 2021
Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment Strategies
awarded by
National Institute of Environmental Health Sciences/NIH/DHHS
2015 - 2021
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2016 - 2021
Private Grant
awarded by
HEART BIOTECH HOLDINGS, LLC
2015 - 2017
Synonymous Single Nucleotide Polymorphisms (sSNP) and CFTR Function
awarded by
Cystic Fibrosis Foundation
2014 - 2016
Background
Education And Training
Doctor of Philosophy Level Degree in Cell / Cellular and Molecular Biology,
1989
Contact
Full Name
Ahmed
Lazrak