Positions

Overview

  • Suzanne E. Lapi, Ph.D. completed her undergraduate studies and Ph.D. at Simon Fraser University in Burnaby, BC, Canada. She went on to complete a postdoctoral appointment at UCSF working with Henry VanBrocklin, PhD on the development of imaging agents for PSMA in prostate cancer before being recruited as a faculty member at Washington University in St. Louis where she ultimately stayed on as a tenured Associate Professor until 2015.

    Dr. Lapi is currently an Associate Professor of Radiology and Chemistry and Cyclotron Facility Director where she oversees production of PET radionuclides and radiopharmaceuticals for preclinical and clinical trials. Her research interests are in the development and translation of new PET radionuclides and imaging agents. She is very interested in moving imaging agents forward to clinical use and she is currently producing isotopes and radiopharmaceuticals for several clinical trials. In particular, Dr. Lapi has extensive experience in the preclinical and clinical research use of 89Zr antibodies.

    Dr. Lapi has over 50 publications and a track record of grants in the area of isotope production, molecular imaging and training of the next generation of radiochemists. She is President of the Radiopharmaceutical Sciences Council of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and has been a Board member of the Nuclear Division of the American Chemical Society (ACS) for the past 4 years. She is a board member of the International Society of Radiopharmaceutical Sciences (ISRS) and has been active in many projects with the International Atomic Energy Agency (IAEA). She also continues to be a strong advocate of radiopharmaceutical sciences and the training of future radiochemists.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Isotope harvesting at FRIB: Additional opportunities for scientific discovery 2019
    2019 Panitumumab-IRDye800CW for Fluorescence-Guided Surgical Resection of Colorectal Cancer 2019
    2019 89Zr-DFO-Cetuximab as a Molecular Imaging Agent to Identify Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma 2019
    2019 Pulmonary carcinoid surface receptor modulation using histone deacetylase inhibitors 2019
    2019 Imaging of HER2 with [ 89 Zr]pertuzumab in response to T-DM1 therapy 2019
    2019 Manganese-52 production cross-section measurements via irradiation of natural chromium targets up to 20 MeV 2019
    2019 Pyrazolopyrimidinones, a novel class of copper-dependent bactericidal antibiotics against multi-drug resistant: S. aureus 2019
    2019 The surprisingly large neutron capture cross-section of 88 Zr 2019
    2019 A growth model of neuroendocrine tumor surrogates and the efficacy of a novel somatostatin-receptor–guided antibody-drug conjugate: Perspectives on clinical response? 2019
    2019 Current and future imaging methods for evaluating response to immunotherapy in neuro-oncology 2019
    2019 Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc 2019
    2019 Production of 15 O for medical applications via the 16 O(g,n) 15 O reaction 2019
    2019 Radiochlorine: An underutilized halogen tool 2019
    2019 Radiometals for imaging and theranostics, current production, and future perspectives 2019
    2019 The Impact of Positron Range on PET Resolution, Evaluated with Phantoms and PHITS Monte Carlo Simulations for Conventional and Non-conventional Radionuclides 2019
    2018 Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumonia 2018
    2018 Production and Use of the First-Row Transition Metal PET Radionuclides 43,44Sc, 52Mn, and 45Ti 2018
    2018 Evaluation of [ 89 Zr]trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancer 2018
    2018 Essential metal uptake in gram-negative bacteria: X-ray fluorescence, radioisotopes, and cell fractionation 2018
    2018 Targeting HER2 in Nuclear Medicine for Imaging and Therapy 2018
    2018 Impaired copper transport in schizophrenia results in a copper-deficient brain state: A new side to the dysbindin story 2018
    2017 Production of Zr-89 using sputtered yttrium coin targets 89Zr using sputtered yttrium coin targets 2017
    2017 Radiosynthesis and Biological Distribution of 18F-Labeled Perfluorinated Alkyl Substances 2017
    2017 White paper on nuclear astrophysics and low-energy nuclear physics, Part 2: Low-energy nuclear physics 2017
    2017 A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury 2017
    2017 Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52 2017
    2017 Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: Feasibility of an antibody-based companion diagnostic agent 2017
    2016 PET/MRI of hypoxic atherosclerosis using 64Cu-ATSM in a rabbit model 2016
    2016 [89Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast Cancer 2016
    2016 New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF-v107 Binding as Proof of Concept 2016
    2016 Imaging of hypoxia in mouse atherosclerotic plaques with 64Cu-ATSM 2016
    2016 Working Together to Advance Women in Nuclear Medicine. 2016
    2016 Calibration setting numbers for dose calibrators for the PET isotopes 52Mn, 64Cu, 76Br, 86Y, 89Zr, 124I 2016
    2016 Microfluidic preparation of a 89Zr-Labeled trastuzumab single-patient dose 2016
    2016 Development of 89Zr-ontuxizumab for in vivo TEM-1/endosialin PET applications 2016
    2016 Pretargeted immuno-PET: Overcoming limitations of space and time 2016
    2016 Evaluation of Cu-64 and Ga-68 Radiolabeled Glucagon-Like Peptide-1 Receptor Agonists as PET Tracers for Pancreatic β cell Imaging 2016
    2015 Harvesting 67Cu from the Collection of a Secondary Beam Cocktail at the National Superconducting Cyclotron Laboratory 2015
    2015 Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[76Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging 2015
    2015 Preclinical positron emission tomographic imaging of acute hyperoxia therapy of chronic hypoxia during pregnancy 2015
    2015 Production and separation of 186gRe from proton bombardment of 186WC 2015
    2015 Investigating the pharmacokinetics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracer 2015
    2015 Evaluation of hypoxia with copper-labeled diacetyl-bis(N-Methylthiosemicarbazone) 2015
    2015 Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54 Mn radioisotopes 2015
    2015 Cyclotron production of high-specific activity 55Co and in vivo evaluation of the stability of 55Co metal-chelate-peptide complexes 2015
    2014 Feasibility of isotope harvesting at a projectile fragmentation facility: 67Cu 2014
    2014 Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor 2014
    2014 Design and construction of a water target system for harvesting radioisotopes at the National Superconducting Cyclotron Laboratory 2014
    2014 Glypican-3-targeted 89Zr PET imaging of hepatocellular carcinoma: Where antibody imaging dares to tread 2014
    2014 Evaluation of 89Zr-pertuzumab in Breast Cancer Xenografts 2014
    2014 Immuno-PET of epithelial ovarian cancer: harnessing the potential of CA125 for non-invasive imaging 2014
    2014 Investigation of a vitamin B12 conjugate as a PET imaging probe 2014
    2014 Specific activity measurement of 64Cu: A comparison of methods 2014
    2014 Synthesis, complex stability and small animal PET imaging of a novel 64 Cu-labelled cryptand molecule 2014
    2013 Imaging the L-Type Amino Acid Transporter-1 (LAT1) with Zr-89 ImmunoPET 2013
    2013 Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging 2013
    2013 Cyclotron Production of 99mTc using 100Mo2C targets 2013
    2013 Effects of Chelator Modifications on 68Ga-Labeled [Tyr 3]Octreotide Conjugates 2013
    2013 Designing the magic bullet? the advancement of immuno-PET into clinical use 2013
    2013 The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials 2013
    2013 A historical perspective on the specific activity of radiopharmaceuticals: What have we learned in the 35years of the ISRC? 2013
    2013 Detection of Rapalog-Mediated Therapeutic Response in Renal Cancer Xenografts Using 64 Cu-bevacizumab ImmunoPET 2013
    2013 An alternate approach to the production of radioisotopes for nuclear medicine applications 2013
    2013 Initial characterization of a dually radiolabeled peptide for simultaneous monitoring of protein targets and enzymatic activity 2013
    2013 Development and characterization of 89Zr-labeled panitumumab for immuno-positron emission tomographic imaging of the epidermal growth factor receptor. 2013
    2013 Development and characterization of 89Zr-labeled panitumumab for immuno-positron emission tomographic imaging of the epidermal growth factor receptor 2013
    2013 Imaging of CD47 expression in xenograft and allograft tumor models 2013
    2013 Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions 2013
    2012 Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis 2012
    2012 A semi-automated system for the routine production of copper-64 2012
    2012 A historical perspective on the specific activity of radiopharmaceuticals: What have we learned in the 35 years of the ISRC? 2012
    2012 The effects of iron and copper availability on the copper stoichiometry of marine phytoplankton 2012
    2012 89Zr-radiolabeled trastuzumab imaging in orthotopic and metastatic breast tumors 2012
    2011 The rise of metal radionuclides in medical imaging: Copper-64, zirconium-89 and yttrium-86 2011
    2011 A new and simple calibration-independent method for measuring the beam energy of a cyclotron 2011
    2010 Copper-uptake kinetics of coastal and oceanic diatoms 2010
    2009 Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer 2009
    2009 PET Imaging of Hypoxia 2009
    2008 Molecular sidebands of refractory elements for ISOL 2008
    2008 Erratum: Precise measurement of the β decay and electron capture of Na22, Au198, and Au196 in low-temperature metal hosts, and reexamination of lifetime modifications (Physical Review C (2008) 77 (065502)) 2008
    2008 Precise measurement of the β decay and electron capture of Na22, Au198, and Au196 in low-temperature metal hosts, and reexamination of lifetime modifications 2008
    2008 The effects of Cu and Fe availability on the growth and Cu:C ratios of marine diatoms 2008
    2007 55Cobalt complexes with pendant carbohydrates as potential PET imaging agents 2007
    2007 Production cross-sections of 181-186Re isotopes from proton bombardment of natural tungsten 2007
    2007 Visualization of the flow of a fiber suspension through a sudden expansion using PET 2007
    2006 Production of intense radioactive beams using low energy protons 2006
    2006 Production of intense radioactive beams at ISAC using low-energy protons 2006
    2005 Printed sources for Positron Emission Tomography (PET) 2005
    2004 Cellular and whole-plant chloride dynamics in barley: Insights into chloride-nitrogen interactions and salinity responses 2004

    Chapter

    Year Title Altmetric
    2014 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals.  47-79. 2014

    Principal Investigator On

  • Private Grant  awarded by IMAGINAB 2018 - 2026
  • Development of Novel Tataniu-45 PET Imaging Agents for PSMA  awarded by SOCIETY OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 2019 - 2021
  • Production of Radioisotopes of Scandium for Imaging and Therapy  awarded by Department of Energy 2019 - 2021
  • Radiolabeled Antibodies Targeting LAT1 for Imaging and Therapy of Prostate Cancer  awarded by National Cancer Institute/NIH/DHHS 2016 - 2020
  • Private Grant  awarded by NAVIDEA BIOPHARMACEUTICALS, INC. 2018 - 2020
  • Dermal Absorption of PFAS  awarded by LAST CALL FOUNDATION 2019
  • Therapeutic Radiopharmaceuticals Labelled with New Emerging Radionuclides (67Cu,186Re, 47Sc)  awarded by International Atomic Energy Agency 2016 - 2019
  • Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy  awarded by Department of Energy 2017 - 2019
  • Integrated Placental Imaging: Novel Methods for Probing Function and Metabolism  awarded by Washington University 2015 - 2019
  • Comprehensive Cancer Center Core Support Grant - Preclinical Imaging Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Support for Students, Postdoctoral Fellows and Trainees to Attend Nuclear and Radiochemistry Symposia at the Spring 2018 ACS Meeting  awarded by Department of Energy 2017 - 2018
  • GE FASTLab2 for the UAB Cyclotron Facility  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2016 - 2018
  • Preparing for Harvesting Radioisotopes from FRIB  awarded by Department of Energy 2016 - 2018
  • Private Grant  awarded by CELLDEX THERAPEUTICS, INC. 2017 - 2018
  • Production of the Medically Important Radionuclides: 52Mn and 90Nb  awarded by Department of Energy 2016 - 2018
  • Private Grant  awarded by ABBVIE INC 2016 - 2018
  • Imaging for Assessment and Prediction of Response to Therapy for Triple Negative Breast Cancer  awarded by National Cancer Institute/NIH/DHHS 2017 - 2018
  • Direct Production of 99mTc Using a Small Medical Cyclotron  awarded by Department of Energy 2016 - 2017
  • Full Name

  • Suzanne Lapi