Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetesJournal of Biological Chemistry.  296. 2021
2020 Generation of retinaldehyde for retinoic acid biosynthesisBiomolecules.  10. 2020
2019 Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glandsJournal of Biological Chemistry.  294:17060-17074. 2019
2019 Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complexJournal of Biological Chemistry.  294:838-851. 2019
2008 Allosteric coupling in pyruvate dehydrogenase kinase 2Biochemistry.  47:8358-8366. 2008
2008 Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2Journal of Biological Chemistry.  283:15789-15798. 2008
2007 Corrigendum to "Identification of a novel PP2C-type mitochondrial phosphatase" [Biochem. Biophys. Res. Commun. 356 (2007) 38-44] (DOI:10.1016/j.bbrc.2007.02.108)Biochemical and Biophysical Research Communications.  361:1061. 2007
2007 Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2Biochemistry.  46:8592-8602. 2007
2007 Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2FEBS Letters.  581:2988-2992. 2007
2007 Identification of a novel PP2C-type mitochondrial phosphataseBiochemical and Biophysical Research Communications.  356:38-44. 2007
2006 Gender and post-ischemic recovery of hypertrophied rat heartsBMC Cardiovascular Disorders.  6. 2006
2005 The carboxy-terminal tail of pyruvate dehydrogenase kinase 2 is required for the kinase activityBiochemistry.  44:13573-13582. 2005
2005 Role of protein-protein interactions in the regulation of pyruvate dehydrogenase kinase activityBiochemical Journal.  387:147-153. 2005
2004 Regular exercise is associated with a protective metabolic phenotype in the rat heart 2004
2004 Probing a putative active site of the catalytic subunit of pyruvate dehydrogenase phosphatase 1 (PDP1c) by site-directed mutagenesis 2004
2003 Characterization of the isozymes of pyruvate dehydrogenase phosphatase: Implications for the regulation of pyruvate dehydrogenase activity 2003
2003 Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidneyDiabetes.  52:1371-1376. 2003
2003 Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase 2003
2002 Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complexBiochemical Journal.  366:129-136. 2002
2002 Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat heartsCardiovascular Research.  53:841-851. 2002
2001 Structure of pyruvate dehydrogenase kinase: Novel folding pattern for a serine protein kinaseJournal of Biological Chemistry.  276:37443-37450. 2001
2001 Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sitesBiochemical Journal.  358:69-77. 2001
2001 An Essential Role of Glu-243 and His-239 in the Phosphotransfer Reaction Catalyzed by Pyruvate Dehydrogenase KinaseJournal of Biological Chemistry.  276:17994-17999. 2001
2000 Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissuesArchives of Biochemistry and Biophysics.  381:1-7. 2000
2000 Experimental hyperthyroidism causes inactivation of the branched-chain α-ketoacid dehydrogenase complex in rat liverArchives of Biochemistry and Biophysics.  375:55-61. 2000
2000 Branched-chain α-keto acid dehydrogenase kinaseMethods in Enzymology.  324:162-178. 2000
2000 Determination of branched-chain α-keto acid dehydrogenase activity state and branched-chain α-keto acid dehydrogenase kinase activity and protein in mammalian tissuesMethods in Enzymology.  324:48-62. 2000
2000 Mammalian methylmalonate-semialdehyde dehydrogenaseMethods in Enzymology.  324:207-218. 2000
2000 Production of recombinant E1 component of branched-chain α-keto acid dehydrogenase complexMethods in Enzymology.  324:200-207. 2000
1999 Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamilyBiochemical Journal.  344:47-53. 1999
1999 Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetesDiabetes.  48:1593-1599. 1999
1998 Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulationJournal of Biological Chemistry.  273:17680-17688. 1998
1998 Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complexBiochemical Journal.  329:191-196. 1998
1998 Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: Potential mechanism contributing to increased lipid oxidation in insulin- resistant subjectsMolecular Genetics and Metabolism.  65:181-186. 1998
1998 Pyruvate dehydrogenase E1α isoform in rat testis: cDNA cloning, characterization, and biochemical comparison of the recombinant testis and liver enzymesComparative Biochemistry and Physiology - B: Comparative Biochemistry.  120:205-216. 1998
1998 Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heartBiochemical Journal.  329:197-201. 1998
1997 Regulation of mammalian pyruvate dehydrogenase kinaseFEBS Letters.  419:197-200. 1997
1997 Gender difference in regulation of branched-chain amino acid catabolismBiochemical Journal.  327:449-453. 1997
1997 Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complexJournal of Biological Chemistry.  272:19746-19751. 1997
1997 cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3β,5α-hydroxysteroidsJournal of Biological Chemistry.  272:7494-7500. 1997
1996 Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in humanJournal of Biological Chemistry.  271:22376-22382. 1996
1996 Erratum: Diversity of the pyruvate dehydrogenase kinase gene family in humans (Journal of Biological Chemistry (1995) 270 (28989-28994))Journal of Biological Chemistry.  271:1250. 1996
1995 Roles of amino acid residues surrounding phosphorylation site 1 of branched-chain α-ketoacid dehydrogenase (BCKDH) in catalysis and phosphorylation site recognition by BCKDH kinaseJournal of Biological Chemistry.  270:31071-31076. 1995
1995 Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase: Active-site amino acid sequence explains substrate specificity compared with liver isozymesJournal of Biological Chemistry.  270:3625-3630. 1995
1995 Regulation by physical training of enzyme activity and gene expression of branched-chain 2-oxo acid dehydrogenase complex in rat skeletal muscle 1995
1995 Dietary control and tissue specific expression of branched-chain α-ketoacid dehydrogenase KinaseArchives of Biochemistry and Biophysics.  316:148-154. 1995
1995 Diversity of the pyruvate dehydrogenase kinase gene family in humansJournal of Biological Chemistry.  270:28989-28994. 1995
1994 Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinaseJournal of Biological Chemistry.  269:29720-29724. 1994
1994 Site-directed mutagenesis of phosphorylation sites of the branched chain α-ketoacid dehydrogenase complexJournal of Biological Chemistry.  269:18583-18587. 1994
1994 Coordinated expression of valine catabolic enzymes during adipogenesis: Analysis of activity, mRNA, protein levels, and metabolic consequencesArchives of Biochemistry and Biophysics.  315:317-322. 1994
1994 Effect of dietary protein on the liver content and subunit composition of the branched-chain α-ketoacid dehydrogenase complexArchives of Biochemistry and Biophysics.  308:446-453. 1994
1993 Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinasesJournal of Biological Chemistry.  268:26602-26606. 1993
1992 Coenzyme A- and NADH-dependent esterase activity of methylmalonate semialdehyde dehydrogenase 1992
1992 Branched-chain α-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinasesJournal of Biological Chemistry.  267:13127-13130. 1992
1992 CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distributionJournal of Biological Chemistry.  267:19724-19729. 1992
1991 The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenaseArchives of Biochemistry and Biophysics.  290:21-26. 1991
1990 Purification and partial characterization of branched-chain α-ketoacid dehydrogenase kinase from rat liver and rat heartArchives of Biochemistry and Biophysics.  283:293-299. 1990

Teaching Activities

  • GBS746 - Special Topics (Summer Term 2021) 2021
  • GBS781 - Molecular Enzymology (Spring Term 2021) 2021
  • GBS788 - Special Topics (Fall Term 2020) 2020
  • GBS746 - Special Topics (Summer Term 2020) 2020
  • GBS781 - Molecular Enzymology (Spring Term 2020) 2020
  • GBS781 - Molecular Enzymology (Spring Term 2019) 2019
  • GBS781 - Molecular Enzymology (Spring Term 2018) 2018
  • GBS781 - Molecular Enzymology (Spring Term 2017) 2017
  • GBS781 - Molecular Enzymology (Spring Term 2016) 2016
  • GBS781 - Molecular Enzymology (Spring Term 2015) 2015
  • GBS781 - Molecular Enzymology (Spring Term 2014) 2014
  • GBS707 - CORE COURSE I: BIOCHEMISTRY/METABOLISM (Fall Term 2013) 2013
  • GBS781 - Molecular Enzymology (Spring Term 2013) 2013
  • GBS781 - MOLECULAR ENZYMOLOGY (Spring Term 2013) 2013
  • GBS707 - CORE COURSE I: BIOCHEMISTRY/METABOLISM (Fall Term 2012) 2012
  • GBS781 - Molecular Enzymology (Spring Term 2012) 2012
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011) 2011
  • GBS707 - CORE COURSE I: BIOCHEMISTRY/METABOLISM (Fall Term 2011) 2011
  • GBS781 - Molecular Enzymology (Spring Term 2011) 2011
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2010) 2010
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010) 2010
  • GBS707 - CORE COURSE I: BIOCHEMISTRY/METABOLISM (Fall Term 2010) 2010
  • CMB713 - CMB I Biomolecules (Fall Term 2009) 2009
  • 01-115 - CMB1 BIOMOLECULES (Fall Term 2009) 2009
  • CMB713 - CMB I Biomolecules (Fall Term 2008) 2008
  • 01-115 - CMB1 BIOMOLECULES (Fall Term 2008) 2008
  • CMB713 - CMB I Biomolecules (Fall Term 2007) 2007
  • 01-115 - CMB1 BIOMOLECULES (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Moscow State University named after M.V. Lomonosov 1986
  • Full Name

  • Kirill Popov