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Kevin Pawlik
Associate Professor
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kpawlik@uab.edu
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Kevin Pawlik
Associate Professor
Positions
Associate Scientist (C)
,
Center for Biophysical Sciences and Engineering (CBSE)
,
School of Optometry
Associate Professor (P)
,
Biochemistry & Molecular Genetics
,
Academic Joint Departments
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2020
A CRISPR-Cas9, Crelox, and Flp-FRT Cascade Strategy for the Precise and Efficient Integration of Exogenous DNA into Cellular Genomes
2020
2018
Human leukocyte antigen class I and II knockout human induced pluripotent stem cell–derived cells: Universal donor for cell therapy
2018
2018
Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1
.
Blood Advances
. 2:2829-2836.
2018
2018
Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis
.
STEM CELLS
. 36:1368-1379.
2018
2018
Bone Marrow Transplantation after Nonmyeloablative Treosulfan Conditioning Is Curative in a Murine Model of Sickle Cell Disease
.
Biology of Blood and Marrow Transplantation
. 24:1554-1562.
2018
2016
Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction
.
Scientific Reports
. 6.
2016
2016
The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation
.
EMBO Reports
. 17:887-900.
2016
2015
Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene Targeting
.
Cell Reports
. 12:1668-1677.
2015
2012
Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells
.
Cell Stem Cell
. 10:570-582.
2012
2012
SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency
2012
2011
PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprograming
.
STEM CELLS
. 29:229-240.
2011
2010
KLF1 regulates BCL11A expression and γ- to β-globin gene switching
.
Nature Genetics
. 42:742-744.
2010
2009
Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells
.
STEM CELLS
. 27:1042-1049.
2009
2008
SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation
.
Nature Medicine
. 14:773-777.
2008
2006
Correction of sickle cell disease by homologous recombination in embryonic stem cells
.
Blood
. 108:1183-1188.
2006
2006
Differential binding of erythroid krupple-like factor to embryonic/fetal globin gene promoters during development
.
Journal of Biological Chemistry
. 281:16052-16057.
2006
2003
Correction of a mouse model of sickle cell disease: Lentiviral/ antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells
.
Blood
. 102:4312-4319.
2003
2000
Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic intervention
.
Blood
. 96.
2000
1995
Autonomous, erythroid-specific DNAse I hypersensitive site formed by human β-globin locus control region (LCR) 5' HS 2 in transgenic mice
.
Developmental Biology
. 169:728-732.
1995
1995
End joining of genomic DNA and transgene DNA in fertilized mouse eggs
.
Gene
. 165:173-181.
1995
1991
Human β-globin locus control region: Analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice
1991
Research
Principal Investigator On
Upgrade of the UAB Stem Cell Institute HiSeq 2000
awarded by
UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
Investigator On
Private Grant
awarded by
GLOBAL BLOOD THERAPEUTICS, INC.
Background
Education And Training
Doctor of Philosophy in Biochemistry,
University of Alabama at Birmingham
1995
Bachelor of Science or Mathematics in Microbiology,
University of Alabama
1984
Contact
Full Name
Kevin
Pawlik