Selected Publications

Academic Article

Year Title Altmetric
2022 Validation of single-gene noninvasive prenatal testing for sickle cell diseaseAmerican Journal of Hematology.  97:E270-E273. 2022
2020 A CRISPR-Cas9, Crelox, and Flp-FRT Cascade Strategy for the Precise and Efficient Integration of Exogenous DNA into Cellular GenomesThe Crispr Journal.  3:470-486. 2020
2018 Human leukocyte antigen class I and II knockout human induced pluripotent stem cell–derived cells: Universal donor for cell therapyJournal of the American Heart Association.  7. 2018
2018 Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1Blood Advances.  2:2829-2836. 2018
2018 Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid HomeostasisStem Cells.  36:1368-1379. 2018
2018 Bone Marrow Transplantation after Nonmyeloablative Treosulfan Conditioning Is Curative in a Murine Model of Sickle Cell DiseaseBiology of Blood and Marrow Transplantation.  24:1554-1562. 2018
2016 Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene CorrectionScientific Reports.  6. 2016
2016 The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiationEMBO Reports.  17:887-900. 2016
2015 Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene TargetingCell Reports.  12:1668-1677. 2015
2012 Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cellsCell Stem Cell.  10:570-582. 2012
2012 SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency 2012
2011 PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramingStem Cells.  29:229-240. 2011
2010 KLF1 regulates BCL11A expression and γ- to β-globin gene switchingNature Genetics.  42:742-744. 2010
2009 Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cellsStem Cells.  27:1042-1049. 2009
2008 SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilationNature Medicine.  14:773-777. 2008
2006 Correction of sickle cell disease by homologous recombination in embryonic stem cellsBlood.  108:1183-1188. 2006
2006 Differential binding of erythroid krupple-like factor to embryonic/fetal globin gene promoters during developmentJournal of Biological Chemistry.  281:16052-16057. 2006
2003 Correction of a mouse model of sickle cell disease: Lentiviral/ antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cellsBlood.  102:4312-4319. 2003
2000 Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic interventionBlood.  96. 2000
1995 Autonomous, erythroid-specific DNAse I hypersensitive site formed by human β-globin locus control region (LCR) 5' HS 2 in transgenic miceDevelopmental Biology.  169:728-732. 1995
1995 End joining of genomic DNA and transgene DNA in fertilized mouse eggsGene.  165:173-181. 1995
1991 Human β-globin locus control region: Analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice 1991

Education And Training

  • Doctor of Philosophy in Biochemistry, University of Alabama at Birmingham 1995
  • Bachelor of Science or Mathematics in Microbiology, University of Alabama 1984
  • Full Name

  • Kevin Pawlik