Positions

Overview

  • Dr. Knight’s laboratory is focused on better understanding the neural substrates of human learning, memory, and emotion using magnetic resonance imaging (MRI) techniques that include functional MRI, diffusion tensor imaging, and magnetic resonance spectroscopy. Behavioral and MRI studies from the lab investigate questions that are important for understanding healthy, as well as dysfunctional, emotion processes.

    Recent work from the Knight lab has investigated the neural circuitry that supports emotion regulation processes. Disruption of these processes appears to play an important role in the emotional dysfunction associated with mood and anxiety disorders. Studies from the Knight lab will help determine neural mechanisms that mediate susceptibility/resilience to stress, and offer insights into the development of emotion-related disorders.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Negative life experiences contribute to racial differences in the neural response to threat 2019
    2019 Amygdala and Prefrontal Cortex Activity Varies with Individual Differences in the Emotional Response to Psychosocial Stress 2019
    2019 Emotion Socialization and Internalizing Problems in Late Adolescence and Emerging Adulthood: Coping Styles as Mediators 2019
    2018 Characteristics of child physical and sexual abuse as predictors of psychopathology 2018
    2018 Psychosocial stress reactivity is associated with decreased whole-brain network efficiency and increased amygdala centrality. 2018
    2018 Trauma exposure acutely alters neural function during Pavlovian fear conditioning 2018
    2018 Anticipatory prefrontal cortex activity underlies stress-induced changes in Pavlovian fear conditioning 2018
    2018 Comparison of reproducibility of single voxel spectroscopy and whole-brain magnetic resonance spectroscopy imaging at 3T 2018
    2018 Anticipatory stress associated with functional magnetic resonance imaging: Implications for psychosocial stress research 2018
    2018 Pavlovian conditioned diminution of the neurobehavioral response to threat 2018
    2018 White matter microstructure varies with post-traumatic stress severity following medical trauma 2018
    2017 Factor structure of the emotions as a child scale in late adolescence and emerging adulthood 2017
    2017 Glutamate/glutamine concentrations in the dorsal anterior cingulate vary with Post-Traumatic Stress Disorder symptoms 2017
    2017 Emotion socialization as a predictor of physiological and psychological responses to stress 2017
    2017 Differentiation chronic post traumatic stress disorder patients from healthy subjects using objective and subjective sleep-related parameters 2017
    2016 The hippocampal response to psychosocial stress varies with salivary uric acid level 2016
    2016 Neural mechanisms of human temporal fear conditioning 2016
    2016 Prefrontal cortex activity is associated with biobehavioral components of the stress response 2016
    2016 Exploring the neurocircuitry underpinning predictability of threat in soldiers with PTSD compared to deployment exposed controls 2016
    2016 Effect of continuous and partial reinforcement on the acquisition and extinction of human conditioned fear 2016
    2016 Abnormalities in large scale functional networks in unmedicated patients with schizophrenia and effects of risperidone 2016
    2015 Affective state and locus of control modulate the neural response to threat 2015
    2015 Controllability modulates the neural response to predictable but not unpredictable threat in humans 2015
    2015 Influence of early life stress on intra- and extra-amygdaloid causal connectivity 2015
    2015 Influence of Early Life Stress on Intra- and Extra-Amygdaloid Causal Connectivity 2015
    2014 Threat-related learning relies on distinct dorsal prefrontal cortex network connectivity 2014
    2014 The amygdala mediates the emotional modulation of threat-elicited skin conductance response 2014
    2014 Threat-related learning relies on distinct dorsal prefrontal cortex network connectivity 2014
    2013 Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: A randomized clinical trial 2013
    2013 Aberrant intrinsic connectivity of hippocampus and amygdala overlap in the fronto-insular and dorsomedial-prefrontal cortex in major depressive disorder 2013
    2013 Negative, but not positive emotional images modulate the startle response independent of conscious awareness 2013
    2013 Human trace fear conditioning: Right-lateralized cortical activity supports trace-interval processes 2013
    2013 Abnormal ECG patterns in chronic post-war PTSD patients: A pilot study 2013
    2013 Neural substrates underlying learning-related changes of the unconditioned fear response 2013
    2012 Neural mechanisms underlying the conditioned diminution of the unconditioned fear response 2012
    2011 Investigating the neural mechanisms of aware and unaware fear memory with FMRI. 2011
    2011 Conditioned diminution of the unconditioned skin conductance response 2011
    2011 Investigating the neural mechanisms of aware and unaware fear memory with fMRI 2011
    2010 Learning-related diminution of unconditioned SCR and fMRI signal responses 2010
    2009 Neural substrates of explicit and implicit fear memory 2009
    2008 Neural correlates of unconditioned response diminution during Pavlovian conditioning 2008
    2007 Impact of Continuous Versus Intermittent CS-UCS Pairing on Human Brain Activation During Pavlovian Fear Conditioning 2007
    2006 Human amygdala activity during the expression of fear responses 2006
    2006 The role of awareness in delay and trace fear conditioning in humans 2006
    2005 The role of the human amygdala in the production of conditioned fear responses 2005
    2005 The effect of education on age-related functional activation during working memory 2005
    2004 Neural Substrates Mediating Human Delay and Trace Fear Conditioning 2004
    2004 Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning 2004
    2004 Autonomic fear responses and human amygdala activity: An event-related fMRI study 2004
    2003 Expression of conditional fear with and without awareness 2003
    2003 Functional MRI of human amygdala activity during Pavlovian fear conditioning: Stimulus processing versus response expression 2003
    1999 Functional MRI of human pavlovian fear conditioning: Patterns of activation as a function of learning 1999
    1998 Functional imaging of human conditional fear 1998
    1997 Pavlovian fear conditioning in humans: An fMRI study 1997

    Chapter

    Year Title Altmetric
    2016 Anticipation and the neural response to threat.  219-228. 2016

    Teaching Activities

  • PY756 - Research Sem Behav Neurosci (Fall Term 2019) 2019
  • PY798 - Predoctoral Degree Grad Res (Fall Term 2019) 2019
  • PY799 - Doctoral Dissertation Research (Fall Term 2019) 2019
  • PY253 - Brain Mind and Behavior (Summer Term 2019) 2019
  • PY361 - Psychology of Learning (Summer Term 2019) 2019
  • PY798 - Predoctoral Degree Grad Res (Summer Term 2019) 2019
  • PY799 - Doctoral Dissertation Research (Summer Term 2019) 2019
  • PY756 - Research Sem Behav Neurosci (Spring Term 2019) 2019
  • PY798 - Predoctoral Degree Grad Res (Spring Term 2019) 2019
  • PY799 - Doctoral Dissertation Research (Spring Term 2019) 2019
  • PY756 - Research Sem Behav Neurosci (Fall Term 2018) 2018
  • PY798 - Predoctoral Degree Grad Res (Fall Term 2018) 2018
  • PY799 - Doctoral Dissertation Research (Fall Term 2018) 2018
  • PY361 - Psychology of Learning (Summer Term 2018) 2018
  • PY798 - Predoctoral Degree Grad Res (Summer Term 2018) 2018
  • PY799 - Doctoral Dissertation Research (Summer Term 2018) 2018
  • PY361 - Psychology of Learning (Spring Term 2018) 2018
  • PY756 - Research Sem Behav Neurosci (Spring Term 2018) 2018
  • PY798 - Predoctoral Degree Grad Res (Spring Term 2018) 2018
  • PY799 - Doctoral Dissertation Research (Spring Term 2018) 2018
  • PY253 - Brain Mind and Behavior (Spring Term 2018) 2018
  • PY361 - Psychology of Learning (Fall Term 2017) 2017
  • PY756 - Research Sem Behav Neurosci (Fall Term 2017) 2017
  • PY798 - Predoctoral Degree Grad Res (Fall Term 2017) 2017
  • PY799 - Doctoral Dissertation Research (Fall Term 2017) 2017
  • PY253 - Brain Mind and Behavior (Fall Term 2017) 2017
  • PY253 - Brain Mind and Behavior (Summer Term 2017) 2017
  • PY253 - Brain Mind and Behavior (Spring Term 2017) 2017
  • PY253 - Brain Mind and Behavior (Summer Term 2016) 2016
  • PY253 - Brain Mind and Behavior (Spring Term 2016) 2016
  • PY253 - Brain Mind and Behavior (Summer Term 2015) 2015
  • PY253 - Brain Mind and Behavior (Spring Term 2015) 2015
  • PY253 - Brain Mind and Behavior (Fall Term 2014) 2014
  • PY253 - Brain Mind and Behavior (Summer Term 2014) 2014
  • PY253 - Brain Mind and Behavior (Spring Term 2014) 2014
  • PY253 - Brain Mind and Behavior (Fall Term 2013) 2013
  • PY253 - Brain Mind and Behavior (Spring Term 2013) 2013
  • PY253 - Brain Mind and Behavior (Fall Term 2012) 2012
  • PY253 - Brain Mind and Behavior (Spring Term 2012) 2012
  • PY253 - Brain Mind and Behavior (Fall Term 2011) 2011
  • PY420 - Psychology of Strengths & Virt (Fall Term 2011) 2011
  • PY253 - Brain Mind and Behavior (Spring Term 2011) 2011
  • PY253 - Brain Mind and Behavior (Fall Term 2010) 2010
  • PY420 - Contemporary Issues in Psych (Fall Term 2010) 2010
  • PY253 - Brain Mind and Behavior (Spring Term 2010) 2010
  • PY253 - Brain Mind and Behavior (Spring Term 2010) 2010
  • PY253 - Brain Mind and Behavior (Fall Term 2009) 2009
  • PY420 - Contemporary Issues in Psych (Fall Term 2009) 2009
  • PY791 - Special Topics in Psychology (Fall Term 2009) 2009
  • PY253 - Brain Mind and Behavior (Spring Term 2009) 2009
  • PY420 - Contemporary Issues in Psych (Spring Term 2009) 2009
  • PY791 - Special Topics in Psychology (Spring Term 2009) 2009
  • PY253 - Brain Mind and Behavior (Fall Term 2008) 2008
  • PY420 - Contemporary Issues in Psych (Fall Term 2008) 2008
  • PY253 - Brain Mind and Behavior (Spring Term 2008) 2008
  • PY420 - Contemporary Issues in Psych (Spring Term 2008) 2008
  • Full Name

  • David Knight