Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary HyperoxaluriaACS Medicinal Chemistry Letters.  12:1116-1123. 2021
2021 Effect of alanine supplementation on oxalate synthesis 2021
2021 Plant-Based Milk Alternatives and Risk Factors for Kidney Stones and Chronic Kidney DiseaseJournal of Renal Nutrition2021
2020 Dietary Oxalate Induces Urinary Nanocrystals in HumansKidney International Reports.  5:1040-1051. 2020
2020 End points for clinical trials in primary hyperoxaluriaClinical Journal of the American Society of Nephrology.  15:1056-1065. 2020
2020 Future treatments for hyperoxaluriaCurrent Opinion in Urology.  30:171-176. 2020
2020 The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria 2020
2019 Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity 2019
2019 Dietary oxalate and kidney stone formation 2019
2018 Hydroxyproline metabolism and oxalate synthesis in primary hyperoxaluriaJournal of the American Society of Nephrology.  29:1615-1623. 2018
2017 An investigational RNAi therapeutic targeting glycolate oxidase reduces oxalate production in models of primary hyperoxaluriaJournal of the American Society of Nephrology.  28:494-503. 2017
2016 Probiotic properties of Oxalobacter formigenes: an in vitro examination 2016
2016 RNA interference in the treatment of renal stone disease: Current status and future potentialsInternational Journal of Surgery.  36:713-716. 2016
2016 Ascorbic acid intake and oxalate synthesisUrolithiasis.  44:289-297. 2016
2016 Effects of alanine: Glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay 2016
2016 Oxalate Concentrations in Human Gastrointestinal Fluid 2016
2016 Lowering urinary oxalate excretion to decrease calcium oxalate stone diseaseUrolithiasis.  44:27-32. 2016
2016 Metabolism of 13C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase 2016
2016 Oxalate formation from glyoxal in erythrocytesUrology.  88:226.e11-226.e15. 2016
2016 Proteome Dynamics of the Specialist Oxalate Degrader Oxalobacter formigenes.Journal of Proteomics and Bioinformatics.  9:19-24. 2016
2016 Response of germfree mice to colonization by Oxalobacter formigenes and altered Schaedler floraApplied and Environmental Microbiology.  82:6952-6960. 2016
2015 Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3 2015
2015 Analysis of commercial kidney stone probiotic supplementsUrology.  85:517-521. 2015
2015 Oxalobacter formigenes colonization and oxalate dynamics in a mouse modelApplied and Environmental Microbiology.  81:5048-5054. 2015
2014 Fish oil supplementation and urinary oxalate excretion in normal subjects on a low-oxalate dietUrology.  84:779-782. 2014
2014 ReplyUrology.  84:782. 2014
2013 Internet program for facilitating dietary modifications limiting kidney stone riskCanadian Journal of Urology.  20:6922-6926. 2013
2013 The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone diseaseUrolithiasis.  41:187-196. 2013
2013 The effects of oxazyme on oxalate degradation: Results and implications of in vitro experiments 2013
2012 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition 2012
2012 Sensitivity of human strains of oxalobacter formigenes to commonly prescribed antibioticsUrology.  79:1286-1289. 2012
2012 The impact of dietary calcium and oxalate ratios on stone riskUrology.  79:1226-1229. 2012
2012 Glyoxal formation and its role in endogenous oxalate synthesisAdvances in Urology2012
2012 Hydroxyproline metabolism in mouse models of primary hyperoxaluria 2012
2012 Metabolism of [ 13C 5]hydroxyproline in vitro and in vivo: Implications for primary hyperoxaluria 2012
2012 Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometryAnalytical Biochemistry.  421:121-124. 2012
2011 Variability in urinary oxalate measurements between six international laboratoriesNephrology Dialysis Transplantation.  26:3954-3959. 2011
2011 Re: Oxalate and sucralose absorption in idiopathic calcium oxalate stone formers 2011
2011 Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: Implications for hydroxyproline metabolism in primary hyperoxaluriaPLoS ONE.  6. 2011
2011 Impact of dietary calcium and oxalate, and oxalobacter formigenes colonization on urinary oxalate excretion 2011
2011 Metabolism of primed, constant infusions of [1,2-13C 2] glycine and [1-13C1] phenylalanine to urinary oxalate 2011
2011 Oxalate and sucralose absorption in idiopathic calcium oxalate stone formersUrology.  78:475.e9-475.e13. 2011
2010 Metabolism of fructose to oxalate and glycolateHormone and Metabolic Research.  42:868-873. 2010
2009 Intravenous ascorbic acid infusions and oxalate production 2009
2009 Increased protein intake on controlled oxalate diets does not increase urinary oxalate excretionUrolithiasis.  37:63-68. 2009
2009 Effect of soda consumption on urinary stone risk parameters 2009
2007 Variability of Oxalobacter Formigenes and Oxalate in Stool Samples 2007
2007 Action of reactive oxygen species on colonic mucus secretionsFree Radical Biology and Medicine.  43:800-808. 2007
2007 Intestinal and renal handling of oxalate loads in normal individuals and stone formersUrolithiasis.  35:111-117. 2007
2006 Hydroxyproline ingestion and urinary oxalate and glycolate excretionKidney International.  70:1929-1934. 2006
2006 Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2Nephrology Dialysis Transplantation.  21:2292-2295. 2006
2005 Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux 2005
2005 Mitochondrial hydroxyproline metabolism: Implications for primary hyperoxaluriaAmerican Journal of Nephrology.  25:171-175. 2005
2004 Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease 2004

Chapter

Year Title Altmetric
2015 Role of Oxalobacter formigenes colonization in calcium oxalate kidney stone disease.  77-84. 2015

Investigator On

  • 4-Hydroxy-2-Oxoglutarate Metabolism in PH3  awarded by Oxalosis and Hyperoxaluria Foundation
  • Effect of Weight Loss on Urinary Oxalate Excretion in Obese Calcium Oxalate Kidney Stone Formers  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Glycolate Metabolism and Kidney Oxalate  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Glyoxal: A Novel Source of Endogenous Oxalate Synthesis and Its Clinical Contribution to Kidney Stones  awarded by UROLOGY CARE FOUNDATION
  • Hydroxyproline Catabolism and Hyperoxaluria  awarded by WAKE FOREST UNIVERSITY
  • Hydroxyproline Dehydrogenase as a Target for Lowering Urinary Oxalate Excretion  awarded by WAKE FOREST UNIVERSITY
  • Influence of Obesity on Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Influence of Obesity on Endogenous Oxalate Synthesis - Project  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers-Project-Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Inhibition of Oxalate Synthesis by RNA Interference Rare Kidney Stone Consortium  awarded by MAYO CLINIC
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mitochondrial Metabolism in Primary Hyperoxaluria  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Obesity and Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Oxalate Formation from Ascorbic Acid  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Phenotypic Changes Associated with PH3  awarded by WAKE FOREST UNIVERSITY
  • The Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Education And Training

  • Doctor of Philosophy in Physiology, Newcastle University 2001
  • Full Name

  • John Knight