Selected Publications

Academic Article

Year Title Altmetric
2020 Future treatments for hyperoxaluria 2020
2020 The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria 2020
2020 The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia. 2020
2020 Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma 2020
2020 Assessment of an Antibody-in-Lymphocyte Supernatant Assay for the Etiological Diagnosis of Pneumococcal Pneumonia in Children 2020
2020 Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leucocyte antigen locus 2020
2020 From genome-wide association studies to rational drug target prioritisation in inflammatory arthritis 2020
2019 Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent. 2019
2019 Use of gene expression studies to investigate the human immunological response to malaria infection 2019
2019 Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders 2019
2019 Comparative genetic architectures of schizophrenia in East Asian and European populations. 2019
2019 Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele 2019
2019 Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis 2019
2019 APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia. 2019
2019 Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk. 2019
2019 A polygenic resilience score moderates the genetic risk for schizophrenia. 2019
2019 Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity 2019
2019 GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores. 2019
2019 The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia. 2019
2019 Implementation of a genomic medicine multi-disciplinary team approach for rare disease in the clinical setting: A prospective exome sequencing case series 2019
2019 Highly Selective and Solvent-Dependent Reduction of Nitrobenzene to N-Phenylhydroxylamine, Azoxybenzene, and Aniline Catalyzed by Phosphino-Modified Polymer Immobilized Ionic Liquid-Stabilized AuNPs 2019
2019 Gene expression imputation across multiple brain regions provides insights into schizophrenia risk 2019
2019 Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. 2019
2019 Dietary oxalate and kidney stone formation 2019
2019 Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. 2019
2019 Optical spectroscopic properties recorded for simple BOPHY dyes in condensed media: The mirror-symmetry factor 2019
2019 A genetics-led approach defines the drug target landscape of 30 immune-related traits 2019
2019 The association between endometriosis and autoimmune diseases: A systematic review and meta-analysis 2019
2019 Transcriptomic signatures in sepsis and a differential response to steroids from the VaNISH randomized trial 2019
2018 Age at first birth in women is genetically associated with increased risk of schizophrenia 2018
2018 Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x) 2018
2018 Heteroatom Donor-Decorated Polymer-Immobilized Ionic Liquid Stabilized Palladium Nanoparticles: Efficient Catalysts for Room-Temperature Suzuki-Miyaura Cross-Coupling in Aqueous Media 2018
2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits 2018
2018 Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitis 2018
2018 APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies. 2018
2018 Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes 2018
2018 Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood. 2018
2018 A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. 2018
2018 Hydroxyproline metabolism and oxalate synthesis in primary hyperoxaluria 2018
2018 Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. 2018
2018 AltHapAlignR: Improved accuracy of RNA-seq analyses through the use of alternative haplotypes 2018
2018 Distinct HLA associations of LGI1 and CASPR2-antibody diseases 2018
2018 End-to-end communication in a linear supermolecule with a BOPHY centre and: N, N -dimethylanilino-based terminals 2018
2018 Highly efficient aqueous phase reduction of nitroarenes catalyzed by phosphine-decorated polymer immobilized ionic liquid stabilized PdNPs 2018
2017 Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia 2017
2017 Thermally-Activated, Delayed Fluorescence in O,B,O- and N,B,O-Strapped Boron Dipyrromethene Derivatives 2017
2017 An investigational RNAi therapeutic targeting glycolate oxidase reduces oxalate production in models of primary hyperoxaluria 2017
2017 Highly efficient aqueous phase chemoselective hydrogenation of α,β-unsaturated aldehydes catalysed by phosphine-decorated polymer immobilized IL-stabilized PdNPs 2017
2017 Synthesis of 2-aminoBODIPYs by palladium catalysed amination 2017
2016 Probiotic properties of Oxalobacter formigenes: an in vitro examination 2016
2016 RNA interference in the treatment of renal stone disease: Current status and future potentials 2016
2016 Ascorbic acid intake and oxalate synthesis 2016
2016 Effects of alanine: Glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay 2016
2016 Triaryl-Like MONO-, BIS-, and TRISKITPHOS Phosphines: Synthesis, Solution NMR Studies, and a Comparison in Gold-Catalyzed Carbon-Heteroatom Bond Forming 5-exo-dig and 6-endo-dig Cyclizations 2016
2016 Oxalate Concentrations in Human Gastrointestinal Fluid 2016
2016 Lowering urinary oxalate excretion to decrease calcium oxalate stone disease 2016
2016 Metabolism of 13C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase 2016
2016 Oxalate formation from glyoxal in erythrocytes 2016
2016 Circularly Polarized Luminescence from Helically Chiral N,N,O,O-Boron-Chelated Dipyrromethenes 2016
2016 Efficient and selective oxidation of sulfides in batch and continuous flow using styrene-based polymer immobilised ionic liquid phase supported peroxotungstates 2016
2016 Proteome Dynamics of the Specialist Oxalate Degrader Oxalobacter formigenes. 2016
2016 Response of germfree mice to colonization by Oxalobacter formigenes and altered Schaedler flora 2016
2015 Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3 2015
2015 Synthesis of 3-aminoBODIPY dyes via copper-catalyzed vicarious nucleophilic substitution of 2-halogeno derivatives 2015
2015 Efficient and selective hydrogen peroxide-mediated oxidation of sulfides in batch and segmented and continuous flow using a peroxometalate-based polymer immobilised ionic liquid phase catalyst 2015
2015 Analysis of commercial kidney stone probiotic supplements 2015
2015 Oxalobacter formigenes colonization and oxalate dynamics in a mouse model 2015
2014 Palladium-catalyzed suzuki-miyaura cross-couplings with 2-diethylphosphonato-substituted aryl-and naphthylboronate esters as the nucleophilic partner: A complementary approach to the synthesis of biaryl monophosphonates 2014
2014 Fish oil supplementation and urinary oxalate excretion in normal subjects on a low-oxalate diet 2014
2014 An efficient Cu(II)-bis(oxazoline)-based polymer immobilised ionic liquid phase catalyst for asymmetric carbon-carbon bond formation 2014
2014 Reply 2014
2013 Internet program for facilitating dietary modifications limiting kidney stone risk 2013
2013 The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone disease 2013
2013 Electron-rich trialkyl-type dihydro-KITPHOS monophosphines: Efficient ligands for palladium-catalyzed suzuki-miyaura cross-coupling. Comparison with their biaryl-like KITPHOS monophosphine counterparts 2013
2013 The effects of oxazyme on oxalate degradation: Results and implications of in vitro experiments 2013
2012 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition 2012
2012 Synthesis of an electron-rich KITPHOS monophosphine, preparation of derived metal complexes and applications in catalysis 2012
2012 Sensitivity of human strains of oxalobacter formigenes to commonly prescribed antibiotics 2012
2012 The impact of dietary calcium and oxalate ratios on stone risk 2012
2012 Glyoxal formation and its role in endogenous oxalate synthesis 2012
2012 Hydroxyproline metabolism in mouse models of primary hyperoxaluria 2012
2012 Metabolism of [ 13C 5]hydroxyproline in vitro and in vivo: Implications for primary hyperoxaluria 2012
2012 Asymmetric carbonyl-ene and Friedel-Crafts reactions catalysed by Lewis acid platinum group metal complexes of the enantiopure atropisomeric biaryl-like diphosphine (S)-Me 2-CATPHOS: A comparison with BINAP 2012
2012 Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometry 2012
2012 An efficient recyclable peroxometalate-based polymer-immobilised ionic liquid phase (PIILP) catalyst for hydrogen peroxide-mediated oxidation 2012
2011 Variability in urinary oxalate measurements between six international laboratories 2011
2011 Ruthenium complexes of κ(P)-and κ(P)-η6- coordinated KITPHOS monophosphines: Efficient catalysts for the direct ortho arylation of 2-phenylpyridine and N-phenylpyrazole with aryl chlorides 2011
2011 Re: Oxalate and sucralose absorption in idiopathic calcium oxalate stone formers 2011
2011 Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: Implications for hydroxyproline metabolism in primary hyperoxaluria 2011
2011 Impact of dietary calcium and oxalate, and oxalobacter formigenes colonization on urinary oxalate excretion 2011
2011 Metabolism of primed, constant infusions of [1,2-13C 2] glycine and [1-13C1] phenylalanine to urinary oxalate 2011
2011 Gold-catalyzed cyclizations: A comparative study of ortho,ortho'- substituted KITPHOS monophosphines with their biaryl monophosphine counterpart SPHOS 2011
2011 Oxalate and sucralose absorption in idiopathic calcium oxalate stone formers 2011
2010 Metabolism of fructose to oxalate and glycolate 2010
2010 Efficient cycloisomerization of propargyl amides by electrophilic gold(I) complexes of KITPHOS monophosphines: A comparative study 2010
2010 Ortho, ortho′-Substituted KITPHOS monophosphines: Highly efficient ligands for palladium-catalyzed C-C and C-N bond formation 2010
2009 Rhodium complexes of (R)-Me-CATPHOS and (R)-(S)-JOSIPHOS: highly enantioselective catalysts for the asymmetric hydrogenation of (E)- and (Z)-β-aryl-β-(enamido)phosphonates 2009
2009 Intravenous ascorbic acid infusions and oxalate production 2009
2009 Increased protein intake on controlled oxalate diets does not increase urinary oxalate excretion 2009
2009 Effect of soda consumption on urinary stone risk parameters 2009
2009 Gold(I) complexes of KITPHOS monophosphines: Efficient cycloisomerisation catalysts 2009
2008 Electron-rich, bicyclic biaryl-like KITPHOS monophosphines via [4+2] cycloaddition between 1-alkynylphosphine oxides and anthracene: Highly efficient ligands for palladium-catalysed C-N and C-C bond formation 2008
2008 Biaryl-like CATPHOS diphosphines via double diels-alder cycloaddition between 1,4-bis(diphenylphosphinoyl)buta-1,3-diyne and anthracenes: Efficient ligands for the palladium-catalyzed amination of aromatic bromides and α-arylation of ketones 2008
2008 Synthesis of highly substituted pyrrolidines via palladium-catalyzed cyclization of 5-vinyloxazolidinones and activated alkenes 2008
2008 Oxazoline-substituted prolinamide-based organocatalysts for the direct intermolecular aldol reaction between cyclohexanone and aromatic aldehydes 2008
2007 Efficient asymmetric carbonyl-ene reactions catalyzed by platinum metal lewis acid complexes of conformationally flexible NUPHOS diphosphines: A comparison with BINAP 2007
2007 Metal-dependent reactivity of electrophilic platinum group metal lewis acid catalysts: Competitive alkene dimerization, intramolecular friedel-crafts alkylation, and carbonyl-ene reactivity 2007
2007 Rhodium-catalyzed double [2 + 2 + 2] cycloaddition of 1,4- bis(diphenylphosphinoyl)buta-1,3-diyne with tethered diynes: A modular, highly versatile single-pot synthesis of NU-BIPHEP biaryl diphosphines 2007
2007 Variability of Oxalobacter Formigenes and Oxalate in Stool Samples 2007
2007 Action of reactive oxygen species on colonic mucus secretions 2007
2007 Phosphorus NMR and ab initio modelling of P-N bond rotamers of a sterically crowded chiral β-P4S3 diamide 2007
2007 Intestinal and renal handling of oxalate loads in normal individuals and stone formers 2007
2007 Asymmetric hydrogenation of ketones with ruthenium complexes of rac- and enantiopure (S,S)-1,2-bis((diphenylphosphino)methyl)cyclohexane: A comparative study with rac- and (R)-BINAP 2007
2007 Recyclable copper catalysts based on imidazolium-tagged bis(oxazolines): A marked enhancement in rate and enantioselectivity for Diels-Alder reactions in ionic liquid 2007
2006 Asymmetric platinum group metal-catalyzed carbonyl-ene reactions: Carbon-carbon bond formation versus isomerization 2006
2006 Hydroxyproline ingestion and urinary oxalate and glycolate excretion 2006
2006 Modular synthesis of a new class of bis(amino-oxazoline) using palladium-catalyzed Buchwald-Hartwig amination methodology 2006
2006 Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2 2006
2006 Phosphorus NMR characterisation of P-N bond rotamers of a α-P 4S3 amide with a conformationally constrained chiral substituent 2006
2006 Enantiospecific formation of 3,6-dihydro-1H-pyridin-2-ones: Low-pressure palladium-catalysed decarboxylative carbonylation of 3-tosyl-5-vinyloxazolidin- 2-ones 2006
2006 The first insoluble polymer-bound palladium complexes of 2-pyridyldiphenylphosphine: Highly efficient catalysts for the alkoxycarbonylation of terminal alkynes 2006
2005 Synthesis of highly substituted pyrrolidines via palladium catalysed formal [2+3] cycloaddition of 5-vinyloxazolidin-2-ones to activated alkenes 2005
2005 Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux 2005
2005 Ruthenium complexes of six-electron-donor NUPHOS-Type diphosphines: Highly selective catalysts for the hydrocarboxylation of terminal alkynes 2005
2005 2-Aryl-5,5-bisoxazolin-2-yl[1,3]dioxanes as solution phase and immobilised ligands for highly enantioselective cyclopropanations 2005
2005 Mitochondrial hydroxyproline metabolism: Implications for primary hyperoxaluria 2005
2004 Highly efficient asymmetric hetero-diels-alder reactions of carbonyl compounds catalyzed by Lewis acid platinum complexes of conformationally flexible NUPHOS-type diphosphines 2004
2004 Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease 2004
2004 Responsiveness to a pandemic alert: Use of reverse genetics for rapid development of influenza vaccines 2004
2004 Comparative study of diastereoisomer interconversion in chiral BINOL-ate and diamine platinum complexes of conformationally flexible NUPHOS diphosphines 2004
2003 Highly Efficient Asymmetric Lewis Acid Catalysis with Platinum Group Complexes of Conformationally Flexible 1,3-Butadiene-Bridged Diphosphines, NUPHOS 2003
2003 Ruthenium complexes of the 1,4-bis(diphenylphosphino)-1,3-butadiene-bridged diphosphine 1,2,3,4-Me4-NUPHOS: Solvent-dependent interconversion of four- and six-electron donor coordination and transfer hydrogenation activity 2003
2003 Diastereoselective synthesis of 3,6-disubstituted 3,6-dihydropyridin-2-ones 2003
2003 Total synthesis of deoxymannojirimycin and D-mannolactam via carbonylation of 5-vinyloxazolidin-2-ones 2003
2002 Diastereospecific carbonylation of π-allylpalladium complexes to give 3,6-disubstituted 3,6-dihydro-1H-pyridin-2-ones 2002
2002 Iminophosphines: Synthesis, formation of 2,3-dihydro-1 H-benzo[1,3]azaphosphol-3-ium salts and N-(pyridin-2-yl)-2-diphenylphosphinoylaniline, coordination chemistry and applications in platinum group catalyzed Suzuki coupling reactions and hydrosilylations 2002
2002 Synthesis of a new class of 1,4-bis(diphenylphosphino)-1,3-butadiene bridged diphosphine, NUPHOS, via zirconium-mediated reductive coupling of alkynes and diynes: Applications in palladium-catalyzed cross-coupling reactions 2002
2001 Selectivity for the methoxycarbonylation of ethylene versus CO-ethylene copolymerization with catalysts based on C4-bridged bidentate phosphines and phospholes 2001
2001 Zirconium-mediated synthesis of a new class of 1,4-bis(diphenylphosphino)-1,3-butadiene-bridged diphosphine, NUPHOS: Highly efficient catalysts for palladium-mediated cross couplings 2001
2001 New phosphorus sulfide cyanides and amides: Assigning phosphorus NMR spectra of polycyclic compounds using low-level ab initio calculations of shieldings 2001
2000 Remarkable differences in catalyst activity and selectivity for the production of methyl propanoate versus CO-ethylene copolymer by a series of palladium complexes of related C4-bridged diphosphines 2000
2000 Synthesis of δ-lactones from 2-alkynyl epoxides and 4-alkynyl-1,3-dioxolan-2-ones by palladium catalysed carbonylation and conjugate nucleophilic addition 2000
2000 Enantioselective synthesis of 3,6-dihydro-1H-pyridin-2-ones: Unexpected regioselectivity in the palladium-catalyzed decarboxylative carbonylation of 5-vinyloxazolidin-2-ones [1] 2000
1996 Cleavage of MEM ethers by tetrahalozincate reagents 1996
1996 Asymmetric copper-catalysed alkene cyclopropanation and aziridination using tartrate-derived bis-oxazoline ligands 1996
1996 New Tartrate-Derived Bis-Oxazoline Ligands for Enantioselective Cyclopropanation and Aziridination of Alkenes 1996
1995 Synthesis of N-p-Toluenesulphonyl-2-alkenyl aziridines by regioselective aziridination of 1,3-dienes 1995
1994 An examination of the structures of iodosylbenzene (PhIO) and the related imido compound, PhINSO2-4-Me-C6H4, by X-ray powder diffraction and EXAFS (extended X-ray absorption fine structure) spectroscopy 1994
1991 Total synthesis of the anthelmintic macrolide avermectin B1a 1991
1991 Synthesis of the alkaloids (-)-heliotridane and (-)-isoretronecanol via π-allyltricarbonyliron lactam complexes. 1991
1990 Total Synthesis of Avermectin B1a: Synthesis of the Carbohydrate Bis-Oleandrose Fragment and Coupling to the Avermectin B1a Aglycone 1990
1990 Alkenylcyclic sulphites as novel precursors for the preparation of π-allyltricarbonyliron lactone complexes 1990
1990 Assessment of butene-1,4-diols as starting materials for the preparation of π-Allyltricarbonyliron complexes 1990


Year Title Altmetric
2015 Role of Oxalobacter formigenes colonization in calcium oxalate kidney stone disease.  77-84. 2015
2008 Recent Developments in Alkyne Carbonylation.  251-290. 2008
2007 Carbenes and Nitrenes.  175-193. 2007
2007 Carbenes and Nitrenes.  213-230. 2007
2007 Carbenes and Nitrenes.  183-200. 2007

Investigator On

  • Obesity and Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Glycolate Metabolism and Kidney Oxalate  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • 4-Hydroxy-2-Oxoglutarate Metabolism in PH3  awarded by Oxalosis and Hyperoxaluria Foundation 2020 - 2021
  • Influence of Obesity on Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2020
  • Influence of Obesity on Endogenous Oxalate Synthesis - Project  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2020
  • Inhibition of Oxalate Synthesis by RNA Interference Rare Kidney Stone Consortium  awarded by MAYO CLINIC 2017 - 2018
  • Mitochondrial Metabolism in Primary Hyperoxaluria  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2018
  • Glyoxal: A Novel Source of Endogenous Oxalate Synthesis and Its Clinical Contribution to Kidney Stones  awarded by UROLOGY CARE FOUNDATION 2016 - 2018
  • Hydroxyproline Dehydrogenase as a Target for Lowering Urinary Oxalate Excretion  awarded by WAKE FOREST UNIVERSITY 2015 - 2017
  • Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2016
  • Hydroxyproline Catabolism and Hyperoxaluria  awarded by WAKE FOREST UNIVERSITY 2012 - 2014
  • Phenotypic Changes Associated with PH3  awarded by WAKE FOREST UNIVERSITY 2012 - 2013
  • Education And Training

  • Doctor of Philosophy in Physiology, Newcastle University 2001
  • Full Name

  • John Knight