Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinomaInternational Journal of Molecular Sciences.  23. 2022
2021 The Omic Insights on Unfolding Saga of COVID-19Frontiers in Immunology.  12. 2021
2021 Nanotherapeutic approaches to target mitochondria in cancerLife Sciences.  281. 2021
2021 The mitochondrial landscape of ovarian cancer: Emerging insightsCarcinogenesis.  42:663-671. 2021
2021 COVID-19: Impact on linguistic and genetic isolates of IndiaGenes and Immunity2021
2021 Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19 2021
2020 Mitochondria in Ovarian Aging and Reproductive LongevityAgeing Research Reviews.  63. 2020
2020 Natural agents targeting mitochondria in cancerInternational Journal of Molecular Sciences.  21:1-30. 2020
2020 Decoding sars-cov-2 hijacking of host mitochondria in covid-19 pathogenesis 2020
2020 Mitochondria in skin health, aging, and diseaseCell Death and Disease.  11. 2020
2019 Mitochondrial localization, import, and mitochondrial function of the androgen receptorJournal of Biological Chemistry.  294:6621-6634. 2019
2018 Reversing wrinkled skin and hair loss in mice by restoring mitochondrial functionCell Death and Disease.  9. 2018
2018 Single molecule mtDNA fiber FISH for analyzing numtogenesisAnalytical Biochemistry.  552:45-49. 2018
2017 Epigenetic modification of miR-663 controls mitochondriatonucleus retrograde signaling and tumor progressionJournal of Biological Chemistry.  292:20694-20706. 2017
2017 Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma 2017
2016 Sustained early disruption of mitochondrial function contributes to arsenic-induced prostate tumorigenesis 2016
2014 OXPHOS dysfunction regulates integrin-β1 modifications and enhances cell motility and migrationHuman Molecular Genetics.  24:1977-1990. 2014
2014 Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasisCell Cycle.  13:2056-2255. 2014
2013 Natural selection of mitochondria during somatic lifetime promotes healthy agingFrontiers in Neuroenergetics2013
2013 Systems biology approaches to evaluate arsenic toxicity and carcinogenicity: An overviewInternational Journal of Hygiene and Environmental Health.  216:574-586. 2013
2013 NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injuryJournal of Immunology.  190:1714-1724. 2013
2012 Is there a link between mitochondrial reserve respiratory capacity and aging?Journal of Aging Research.  2012. 2012
2012 Mitochondrial regulation of epigenetics and its role in human diseasesEpigenetics.  7:326-334. 2012
2011 The importance of mitochondrial DNA in aging and cancerJournal of Aging Research.  2011. 2011
2011 Distinct functions of evolutionary conserved MSF1 and Late Embryogenesis Abundant (LEA)-like domains in mitochondriaJournal of Biological Chemistry.  286:39141-39152. 2011
2011 Genetic insights into OXPHOS defect and its role in cancer 2011
2011 Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone 2011
2010 Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairmentJournal of Cellular Biochemistry.  111:574-584. 2010
2010 NADPH oxidase 4 is an oncoprotein localized to mitochondriaCancer Biology and Therapy.  10:223-231. 2010
2010 Vital function of PRELI and essential requirement of its LEA motifCell Death and Disease.  1. 2010
2010 SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during StressCancer Cell.  17:41-52. 2010
2010 Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RASQ61LCancer Biology and Therapy.  9:122-133. 2010
2009 MtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in miceJournal of Human Genetics.  54:647-654. 2009
2009 Mutations in mitochondrial DNA polymerase-γ promote breast tumorigenesisJournal of Human Genetics.  54:516-524. 2009
2009 Cancer cell mitochondria confer apoptosis resistance and promote metastasisCancer Biology and Therapy.  8:1378-1385. 2009
2009 Cancer cell mitochondria confer apoptosis resistance and promote metastasisCancer Biology and Therapy.  8:69-76. 2009
2009 Fluctuation anaLysis calculator: A web tool for the determination of mutation rate using Luria-Delbück fluctuation analysisBioinformatics.  25:1564-1565. 2009
2009 p53 regulates mtDNA copy number and mitocheckpoint pathwayJournal of Carcinogenesis.  8. 2009
2008 A novel role for mitochondria in regulating epigenetic modification in the nucleusCancer Biology and Therapy.  7:1182-1190. 2008
2008 Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletionCancer Biology and Therapy.  7:1732-1743. 2008
2007 Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiaeCancer Research.  67:9740-9749. 2007
2007 Mitochondria and human cancerCurrent Molecular Medicine.  7:121-131. 2007
2006 Saccharomyces cerevisiae polymerase ζ functions in mitochondria 2006
2006 Mitochondria damage checkpoint, aging, and cancerAnnals of the New York Academy of Sciences.  1067:182-190. 2006
2006 Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancerCancer Biology and Therapy.  5:967-975. 2006
2005 Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesisGene.  354:140-146. 2005
2005 Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancerCancer Research.  65:1105-1111. 2005
2005 Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumorsCancer Biology and Therapy.  4:1367-1373. 2005
2004 Cellular aging of mitochondrial DNA-depleted cellsBiochemical and Biophysical Research Communications.  325:1399-1405. 2004
2004 Mitochondria damage checkpoint in apoptosis and genome stabilityFEMS Yeast Research.  5:127-132. 2004
2004 Resistance of mitochondrial DNA-depleted cells against cell death: Role of mitochondrial superoxide dismutaseJournal of Biological Chemistry.  279:7512-7520. 2004
2004 Genome-wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiaeAnnals of the New York Academy of Sciences.  1011:284-298. 2004
2004 Mitochondrial dysfunction is a common phenotype in aging and cancerAnnals of the New York Academy of Sciences.  1019:260-264. 2004
2002 Mitochondria as targets for detection and treatment of cancer.Expert Reviews in Molecular Medicine.  4:1-19. 2002
2001 Human Homolog of the MutY Repair Protein (hMYH) Physically Interacts with Proteins Involved in Long Patch DNA Base Excision RepairJournal of Biological Chemistry.  276:5547-5555. 2001
2000 The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashionFree Radical Biology and Medicine.  29:1043-1050. 2000
2000 The human cyclin B1 protein modulates sensitivity of DNA mismatch repair deficient prostate cancer cell lines to alkylating agentsExperimental Cell Research.  257:127-134. 2000
1997 A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein AJournal of Biological Chemistry.  272:6561-6566. 1997
1996 Urinary incontinence during pregnancy in a racially mixed sample: Characteristics and predisposing factors 1996

Book

Year Title Altmetric
2009 Mitochondria and cancer 2009
2006 Oxidative stress, disease and cancer 2006
2006 Preface 2006

Chapter

Year Title Altmetric
2014 Leptin Signaling in the Regulation of Stem and Cancer Stem Cells.  347-360. 2014
2009 Mitochondria and cancer.  1-21. 2009
2006 Oxidative stress and multistage carcinogenesis.  705-732. 2006

Education And Training

  • Doctor of Philosophy in Biology, 1989
  • Master of Science in Biology, 1981
  • Bachelor of Science or Mathematics in Biology, 1978
  • Full Name

  • Keshav Singh