Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Distinct genomic landscapes of gastroesophageal adenocarcinoma depending on PD-L1 expression identify mutations in RASā€“MAPK pathway and TP53 as potential predictors of immunotherapy efficacyAnnals of Oncology.  32:906-916. 2021
2021 The landscape of alterations in DNA damage response pathways in colorectal cancerClinical Cancer Research.  27:3234-3242. 2021
2021 The prevalence and clinical relevance of 2R/2R TYMS genotype in patients with gastrointestinal malignancies treated with fluoropyrimidine-based chemotherapy regimens 2021
2021 Clinical and Hematological Predictors of High-Grade Immune-Related Adverse Events Associated With Immune Checkpoint InhibitorsJournal of Clinical Medicine Research.  13:268-275. 2021
2020 Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal CancerClinical Colorectal Cancer.  19:e281-e287. 2020
2020 Exosomal formulation escalates cellular uptake of honokiol leading to the enhancement of its antitumor efficacyACS Omega.  5:23299-23307. 2020
2020 Comprehensive analysis of expression, clinicopathological association and potential prognostic significance of rabs in pancreatic cancerInternational Journal of Molecular Sciences.  21:1-14. 2020
2020 Epidermal growth factor receptor-activating mutation(E746_T751>VP) in pancreatic ductal adenocarcinoma responds to erlotinib, followed by epidermal growth factor receptor resistance-mediating mutation (A647T): A case report and literature reviewJournal of Cancer Research and Therapeutics.  16:950-954. 2020
2020 Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer.Journal of Biological Chemistry.  295:8413-8424. 2020
2020 Prolonged response to liposomal irinotecan in a patient with stage iv pancreatic/bile duct cancer previously treated with FOLFIRINOX and gemcitabine plus nab-paclitaxelCurrent Oncology.  27:e222-e225. 2020
2019 Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applicationsScientific Reports.  9. 2019
2019 The Prevalence of DPYD*9A (c.85T>C) Genotype and the Genotype-Phenotype Correlation in Patients with Gastrointestinal Malignancies Treated With Fluoropyrimidines: Updated AnalysisClinical Colorectal Cancer.  18:e280-e286. 2019
2019 Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinomaJournal of Gastrointestinal Oncology.  10:695-702. 2019
2019 Vitamin B12 deficiency presenting as pseudothrombotic microangiopathy: A case report and literature review 2019
2018 Germline pharmacogenomics of DPYD*9A (c.85T>C) variant in patients with gastrointestinal malignancies treated with fluoropyrimidinesJournal of Gastrointestinal Oncology.  9:416-424. 2018
2017 Molecular drivers of pancreatic cancer pathogenesis: Looking inward to move forwardInternational Journal of Molecular Sciences.  18. 2017
2017 Syndrome of Inappropriate Anti-Diuretic Hormone Secretion Secondary to Strongyloides stercoralis Infection in an Allogeneic Stem Cell Transplant Patient: A Case Report and Literature ReviewTransplantation Proceedings.  49:373-377. 2017
2017 Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCKBritish Journal of Cancer.  116:609-619. 2017
2016 Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talkCarcinogenesis.  37:1052-1061. 2016
2016 MYB promotes desmoplasia in pancreatic cancer through direct transcriptional up-regulation and cooperative action of sonic hedgehog and adrenomedullinJournal of Biological Chemistry.  291:16263-16270. 2016
2016 Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancerScientific Reports.  6. 2016
2015 Full dose neoadjuvant FOLFIRINOX is associated with prolonged survival in patients with locally advanced pancreatic adenocarcinomaPancreatology.  15:667-673. 2015

Chapter

Year Title Altmetric
2018 Exosomes: Key supporters of tumor metastasis.  261-283. 2018

Education And Training

  • Bachelor of Medicine & Surgery (MBBS), University of Jordan 2006
  • Full Name

  • Moh'd Khushman