Positions

Overview

  • I am an Assistant Professor in the UAB Department of Medicine’s Division of Clinical Immunology and Rheumatology, and have held that rank since 2018. I obtained my Master’s in Biochemistry in Eqypt where I focused on identifying polymorphisms in the methylenetetahydropholate reductase gene (MTHFR) in mothers of children with Down’s syndrome. I was recruited to UAB where I joined the laboratory of Dr. Harry W. Schroeder, Jr. While in his laboratory, first as a PhD student and then as a postdoctoral fellow, I gained extensive expertise in immunology (specifically B cell biology), learned numerous contemporary laboratory techniques, and gained critical thinking skills. In the course of my studies of the role of the surrogate light chain in B cell repertoire selection (which was published in the inaugural edition of Science Immunology), I observed that absence of the surrogate light chain led to bone fragility. This seminal observation led me to my current interest in bone biology and the interplay between early B cell progenitors and skeletal homeostasis. I am the first to show that the immunoglobulin lambda-like polypeptide 1 (i.e. the λ5 protein encoded by the IGLL1 gene), heretofore thought to be an early B cell specific protein, is also expressed in mesenchymal stromal/stem cells (MSCs). This discovery connects skeletal development with early B lymphocyte development and opens the gate for new research with the potential to develop new tools for treating Rheumatologic bone diseases.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Replacement of TCR Dβ With Immunoglobulin DH DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell DevelopmentFrontiers in Immunology.  11. 2020
    2020 Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig DH Gene SegmentFrontiers in Immunology.  11. 2020
    2020 Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody SelectionFrontiers in Immunology.  11. 2020
    2019 Disruption of the preB Cell Receptor Complex Leads to Decreased Bone MassFrontiers in Immunology.  10. 2019
    2018 The sequences encoded by immunoglobulin diversity (D H ) gene segments play key roles in controlling B-cell development, antigen-binding site diversity, and antibody productionImmunological Reviews.  284:106-119. 2018
    2018 In the absence of central pre-B cell receptor selection, peripheral selection attempts to optimize the antibody repertoire by enriching for CDR-H3 Y101Frontiers in Immunology.  9. 2018
    2017 Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD−iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3Autoimmunity.  50:42-51. 2017
    2016 VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites.Science Immunology.  1:aaf6628. 2016
    2016 VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sitesScience Immunology.  1. 2016
    2015 Violation of an evolutionarily conserved immunoglobulin diversity gene sequence preference promotes production of dsDNA-specific IgG antibodiesPLoS ONE.  10. 2015
    2013 Recirculating bone marrow B cells in C57BL/6 mice are more tolerant of highly hydrophobic and highly charged CDR-H3s than those in BALB/c miceEuropean Journal of Immunology.  43:629-640. 2013
    2012 Identification of eRF1 residues that play critical and complementary roles in stop codon recognitionRNA.  18:1210-1221. 2012
    2010 Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody productionCritical Reviews in Immunology.  30:327-344. 2010
    2008 MTHFR genetic polymorphism as a risk factor in Egyptian mothers with Down syndrome childrenDisease Markers.  24:19-26. 2008

    Research Overview

  • My long time interest is B cell biology and early B cell development including B cell repertoire development and function. This interest has been matured to osteoimmunology and the interaction between immune cells (specially early B cells) and skeletal system in normal physiology and Rheumatic Diseses such as Arthritis and SLE.
  • Teaching Overview

  • 1. Osteoimmunology: Interaction between immune cells and Bone. 2018, 2019 Post graduate course GBS 750: Nerves, Muscles, and Bones).

    2. Immunological Methods. 2018, 2019 post graduate Cancer Immunology course GBS774.
  • Education And Training

  • University of Alabama at Birmingham Medicine, Postdoctoral Research 2017
  • Doctor of Science in Microbiology, University of Alabama at Birmingham 2012
  • Master of Sciences or Mathematics in Biochemistry, Zagazig University 2007
  • Bachelor of Science or Mathematics in Pharmaceutical Sciences, Zagazig University 2001
  • Full Name

  • Mohamed Khass