Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Local SARS-CoV-2 Peptide-Specific Immune Responses in Lungs of Convalescent and Uninfected Human Subjects. 2022
2021 A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure.  Scientific Reports.  11. 2021
2021 Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 and fully protects mice from lethal challenge.  Vaccines.  9. 2021
2021 Influenza Antiviral Subversion: Now the Host Is in on the Act.  American Journal of Respiratory Cell and Molecular Biology.  65:1-3. 2021
2020 Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice. 2020
2020 Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis.  Cell Reports.  32. 2020
2020 The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.  Journal of Biological Chemistry.  295:1153-1164. 2020
2020 Pulmonary surfactant lipids inhibit infections with the pandemic H1N1 influenza virus in several animal models.  Journal of Biological Chemistry.  295:1704-1715. 2020
2020 SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAs.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  319:L444-L455. 2020
2018 Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection.  JCI insight.  3. 2018
2018 Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis.  JCI insight.  3. 2018
2018 ERS/ATS workshop report on respiratory health effects of household air pollution.  European Respiratory Journal.  51. 2018
2017 Influenza virus infection alters ion channel function of airway and alveolar cells: Mechanisms and physiological sequelae.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  313:L845-L858. 2017
2017 Use of ferrets for electrophysiologic monitoring of ion transport.  PLoS One.  12. 2017
2016 ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis.  Archives of Biochemistry and Biophysics.  609:39-50. 2016
2016 Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions.  Toxicology and Applied Pharmacology.  308:46-58. 2016
2016 Bik mediates caspase-dependent cleavage of viral proteins to promote influenza a virus infection.  American Journal of Respiratory Cell and Molecular Biology.  54:664-673. 2016
2016 Changes in HPBMC markers of immmune function following controlled short-term inhalation exposures of humans to hardwood smoke.  Inhalation Toxicology.  28:61-70. 2016
2016 Depressed hypoxic and hypercapnic ventilatory responses at early stage of lethal avian influenza a virus infection in mice.  PLoS One.  11. 2016
2015 Retraction notice to "The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model" [Braz. J. Infect. Dis. 18 (2014) 406-413] DOI: 10.1016/j.bjid.2013.12.008.  Brazilian Journal of Infectious Diseases.  19:677. 2015
2015 Renal systems biology of patients with systemic inflammatory response syndrome.  Kidney International.  88:804-814. 2015
2015 Ebola: History, treatment, and lessons from a new emerging pathogen.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  308:L307-L313. 2015
2014 Erratum to "The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model" [Braz. J. Infect. Dis. 18(4) (2014) 406-413].  Brazilian Journal of Infectious Diseases.  18:580. 2014
2014 Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.  American Journal of Respiratory and Critical Care Medicine.  190:445-455. 2014
2014 Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses.  Immunity and Ageing.  11. 2014
2014 Enhanced viral replication and modulated innate immune responses in infant airway epithelium following H1N1 infection.  Journal of Virology.  88:7412-7425. 2014
2014 Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium.  Journal of General Virology.  95:26-37. 2014
2014 The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: II. Comparison of responses to diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions.  Inhalation Toxicology.  26:651-667. 2014
2014 The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model.  Brazilian Journal of Infectious Diseases.  18:406-413. 2014
2013 Gestational exposure of mice to secondhand cigarette smoke causes bronchopulmonary dysplasia blocked by the nicotinic receptor antagonist mecamylamin.  Environmental Health Perspectives.  121:957-964. 2013
2012 Neurovirulence of H5N1 Infection in Ferrets Is Mediated by Multifocal Replication in Distinct Permissive Neuronal Cell Regions.  PLoS One.  7. 2012
2012 Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model.  PLoS One.  7. 2012
2012 Exhaled aerosol transmission of pandemic and seasonal H1N1 influenza viruses in the ferret.  PLoS One.  7. 2012
2012 Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge.  Journal of Virology.  86:4234-4244. 2012
2012 Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin.  Journal of Immunology.  188:2815-2824. 2012
2012 Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo.  Journal of Allergy and Clinical Immunology.  130. 2012
2011 Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets.  Vaccine.  29:6242-6251. 2011
2011 Engine-operating load influences diesel exhaust composition and cardiopulmonary and immune responses.  Environmental Health Perspectives.  119:1136-1141. 2011
2011 Enhanced immunogenicity, mortality protection, and reduced viral brain invasion by alum adjuvant with an H5N1 split-virion vaccine in the Ferret.  PLoS One.  6. 2011
2011 Regulation of STAT signaling in mouse bone marrow derived dendritic cells by respiratory syncytial virus.  Virus Research.  156:127-133. 2011
2011 Enhanced acetylation of alpha-tubulin in influenza A virus infected epithelial cells.  FEBS Letters.  585:128-132. 2011
2011 Higher level of replication efficiency of 2009 (H1N1) pandemic influenza virus than those of seasonal and avian strains: Kinetics from epithelial cell culture and computational modeling.  Journal of Virology.  85:1125-1135. 2011
2010 Interference with intraepithelial TNF-α signaling inhibits CD8 + T-cell-mediated lung injury in influenza infection.  Viral Immunology.  23:639-645. 2010
2010 Response network analysis of differential gene expression in human epithelial lung cells during avian influenza infections.  BMC Bioinformatics.  11. 2010
2010 Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitro.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  298. 2010
2010 Respiratory syncytial virus impairs macrophage IFN-α/β- and IFN-γ-stimulated transcription by distinct mechanisms.  American Journal of Respiratory Cell and Molecular Biology.  42:404-414. 2010
2009 Ferret model of avian influenza demonstrates dose and strain dependant pathology and viral load in brain.  Procedia in Vaccinology.  1:30-34. 2009
2009 Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells.  FEBS Letters.  583:2517-2520. 2009
2008 Human metapneumovirus inhibits IFN-α signaling through inhibition of STAT1 phosphorylation.  American Journal of Respiratory Cell and Molecular Biology.  38:661-670. 2008
2008 The SARS-CoV ferret model in an infection-challenge study.  Virology.  374:151-163. 2008
2007 Transactivation of lung lysozyme expression by Ets family member ESE-1.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  293. 2007
2007 Respiratory syncytial virus infection in anesthetized weanling rather than adult rats prolongs the apneic responses to right atrial injection of capsaicin.  Journal of Applied Physiology.  102:2201-2206. 2007
2007 Computational prediction of novel components of lung transcriptional networks.  Bioinformatics.  23:21-29. 2007
2006 Differential expression of spleen tyrosine kinase Syk isoforms in tissues: Effects of the microbial flora.  Histochemistry and Cell Biology.  126:495-505. 2006
2006 Health effects of subchronic exposure to environmental levels of hardwood smoke.  Inhalation Toxicology.  18:523-539. 2006
2006 Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  290. 2006
2006 The immunobiology of respiratory syncytial virus infection.  Clinical and Applied Immunology Reviews.  6:37-52. 2006
2005 Increased mortality associated with TCDD exposure in mice infected with influenza A virus is not due to severity of lung injury or alterations in Clara cell protein content.  Chemico-Biological Interactions.  155:181-190. 2005
2005 Inhaled diesel engine emissions reduce bacterial clearance and exacerbate lung disease to Pseudomonas aeruginosa infection in vivo.  Toxicological Sciences.  83:155-165. 2005
2004 Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies.  Journal of Virology.  78:14003-14011. 2004
2004 IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection.  Journal of Immunology.  173:4040-4049. 2004
2004 Effects of low sulfur fuel and a catalyzed particle trap on the composition and toxicity of diesel emissions.  Environmental Health Perspectives.  112:1307-1312. 2004
2003 Acute inflammatory response and remodeling of airway epithelium after subspecies B1 human adenovirus infection of the mouse lower respiratory tract.  Journal of Medical Virology.  71:233-244. 2003
2003 Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection.  Journal of Immunology.  171:1051-1060. 2003
2003 Increased susceptibility to rsv infection by exposure to inhaled diesel engine emissions.  American Journal of Respiratory Cell and Molecular Biology.  28:451-463. 2003
2002 Pseudomonas aeruginosa and tumor necrosis factor-α attenuate Clara cell secretory protein promoter function.  American Journal of Respiratory Cell and Molecular Biology.  26:216-223. 2002
2001 CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  281. 2001
2000 Regulation of GADD153 mRNA expression by hypoxia in pulmonary artery smooth muscle cells.  Research communications in molecular pathology and pharmacology.  108:3-14. 2000
2000 Adenoviral E3-14.7K protein in LPS-induced lung inflammation.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  278. 2000
2000 Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after acute viral infection.  American Journal of Respiratory Cell and Molecular Biology.  22:34-44. 2000
2000 Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  279. 2000
1999 CCSP deficiency does not alter surfactant homeostasis during adenoviral infection.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  277. 1999
1999 SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  277. 1999
1998 Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses.  Human Gene Therapy.  9:2207-2222. 1998
1998 Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression.  Human Gene Therapy.  9:1885-1898. 1998
1998 Clara cell secretory protein decreases lung inflammation after acute virus infection.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  275. 1998
1996 Regulation of ornithine decarboxylase by hypoxia in pulmonary artery smooth muscle cells.  American Journal of Physiology.  271. 1996
1996 Regulation of ornithine decarboxylase by hypoxia in pulmonary artery smooth muscle cells.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  271. 1996

Chapter

Year Title Altmetric
2014 Emergence and Pathogenesis of Avian Influenza in Humans 2014

Principal Investigator On

Investigator On

Education And Training

  • Doctor of Philosophy in Pharmaceutics and Drug Design, University of Kentucky 1995

    • Full Name

  • Kevin Harrod