Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I 2020
2020 Pulmonary surfactant lipids inhibit infections with the pandemic H1N1 influenza virus in several animal models 2020
2019 Headline earnings per share: financial managers’ perceptions and actual disclosure practices in South Africa 2019
2018 Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection 2018
2018 Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis 2018
2018 ERS/ATS workshop report on respiratory health effects of household air pollution 2018
2017 Influenza virus infection alters ion channel function of airway and alveolar cells: Mechanisms and physiological sequelae 2017
2017 Use of ferrets for electrophysiologic monitoring of ion transport 2017
2016 ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis 2016
2016 Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions 2016
2016 Bik mediates caspase-dependent cleavage of viral proteins to promote influenza a virus infection 2016
2016 Changes in HPBMC markers of immmune function following controlled short-term inhalation exposures of humans to hardwood smoke 2016
2016 Depressed hypoxic and hypercapnic ventilatory responses at early stage of lethal avian influenza a virus infection in mice 2016
2015 Retraction notice to "The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model" [Braz. J. Infect. Dis. 18 (2014) 406-413] DOI: 10.1016/j.bjid.2013.12.008 2015
2015 Renal systems biology of patients with systemic inflammatory response syndrome 2015
2015 Ebola: History, treatment, and lessons from a new emerging pathogen 2015
2014 Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses 2014
2014 Enhanced viral replication and modulated innate immune responses in infant airway epithelium following H1N1 infection 2014
2014 Erratum to "The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model" [Braz. J. Infect. Dis. 18(4) (2014) 406-413] 2014
2014 Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium 2014
2014 Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes 2014
2014 The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: II. Comparison of responses to diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions 2014
2014 The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model 2014
2013 Gestational exposure of mice to secondhand cigarette smoke causes bronchopulmonary dysplasia blocked by the nicotinic receptor antagonist mecamylamin 2013
2012 Neurovirulence of H5N1 Infection in Ferrets Is Mediated by Multifocal Replication in Distinct Permissive Neuronal Cell Regions 2012
2012 Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model 2012
2012 Exhaled aerosol transmission of pandemic and seasonal H1N1 influenza viruses in the ferret 2012
2012 Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge 2012
2012 Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin 2012
2012 Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo 2012
2011 Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets 2011
2011 Engine-operating load influences diesel exhaust composition and cardiopulmonary and immune responses 2011
2011 Enhanced immunogenicity, mortality protection, and reduced viral brain invasion by alum adjuvant with an H5N1 split-virion vaccine in the Ferret 2011
2011 Regulation of STAT signaling in mouse bone marrow derived dendritic cells by respiratory syncytial virus 2011
2011 Enhanced acetylation of alpha-tubulin in influenza A virus infected epithelial cells 2011
2011 Higher level of replication efficiency of 2009 (H1N1) pandemic influenza virus than those of seasonal and avian strains: Kinetics from epithelial cell culture and computational modeling 2011
2010 Interference with intraepithelial TNF-α signaling inhibits CD8 + T-cell-mediated lung injury in influenza infection 2010
2010 Response network analysis of differential gene expression in human epithelial lung cells during avian influenza infections 2010
2010 Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitro 2010
2010 Respiratory syncytial virus impairs macrophage IFN-α/β- and IFN-γ-stimulated transcription by distinct mechanisms 2010
2009 Ferret model of avian influenza demonstrates dose and strain dependant pathology and viral load in brain 2009
2009 Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells 2009
2008 Human metapneumovirus inhibits IFN-α signaling through inhibition of STAT1 phosphorylation 2008
2008 The SARS-CoV ferret model in an infection-challenge study 2008
2007 Transactivation of lung lysozyme expression by Ets family member ESE-1 2007
2007 Respiratory syncytial virus infection in anesthetized weanling rather than adult rats prolongs the apneic responses to right atrial injection of capsaicin 2007
2007 Computational prediction of novel components of lung transcriptional networks 2007
2006 Differential expression of spleen tyrosine kinase Syk isoforms in tissues: Effects of the microbial flora 2006
2006 Health effects of subchronic exposure to environmental levels of hardwood smoke 2006
2006 Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model 2006
2006 The immunobiology of respiratory syncytial virus infection 2006
2005 Increased mortality associated with TCDD exposure in mice infected with influenza A virus is not due to severity of lung injury or alterations in Clara cell protein content 2005
2005 Inhaled diesel engine emissions reduce bacterial clearance and exacerbate lung disease to Pseudomonas aeruginosa infection in vivo 2005
2004 Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies 2004
2004 IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection 2004
2004 Effects of low sulfur fuel and a catalyzed particle trap on the composition and toxicity of diesel emissions 2004
2003 Acute inflammatory response and remodeling of airway epithelium after subspecies B1 human adenovirus infection of the mouse lower respiratory tract 2003
2003 Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection 2003
2003 Increased susceptibility to rsv infection by exposure to inhaled diesel engine emissions 2003
2002 Pseudomonas aeruginosa and tumor necrosis factor-α attenuate Clara cell secretory protein promoter function 2002
2001 CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model 2001
2000 Regulation of GADD153 mRNA expression by hypoxia in pulmonary artery smooth muscle cells 2000
2000 Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo 2000
2000 Adenoviral E3-14.7K protein in LPS-induced lung inflammation 2000
2000 Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after acute viral infection 2000
1999 CCSP deficiency does not alter surfactant homeostasis during adenoviral infection 1999
1999 SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection 1999
1998 Clara cell secretory protein decreases lung inflammation after acute virus infection 1998
1998 Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses 1998
1998 Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression 1998
1996 Regulation of ornithine decarboxylase by hypoxia in pulmonary artery smooth muscle cells 1996
1996 Regulation of ornithine decarboxylase by hypoxia in pulmonary artery smooth muscle cells 1996

Education And Training

  • Doctor of Philosophy in Pharmaceutics and Drug Design, University of Kentucky 1995

    • Full Name

  • Kevin Harrod