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Kevin Harrod
Professor
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E-mail
kharrod@uab.edu
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Kevin Harrod
Professor
Positions
Senior Scientist (C)
,
UAB Immunology Institute
,
School of Medicine
Senior Scientist (C)
,
UWIRC Microbiome Center
,
School of Medicine
Senior Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
Senior Scientist (C)
,
Cystic Fibrosis Research Center
,
School of Medicine
Professor (P)
,
Anesthesiology
,
School of Medicine
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2023
Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection.
.
JCI Insight
. 8.
2023
2022
Local SARS-CoV-2 Peptide-Specific Immune Responses in Lungs of Convalescent and Uninfected Human Subjects.
2022
2022
A single intranasal administration of AdCOVID protects against SARS-CoV-2 infection in the upper and lower respiratory tracts
.
Human Vaccines and Immunotherapeutics
. 18.
2022
2021
A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure
.
Scientific Reports
. 11.
2021
2021
Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 and fully protects mice from lethal challenge
.
Vaccines
. 9.
2021
2021
Influenza Antiviral Subversion: Now the Host Is in on the Act
.
American Journal of Respiratory Cell and Molecular Biology
. 65:1-3.
2021
2020
Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice.
2020
2020
Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis
.
Cell Reports
. 32.
2020
2020
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I
.
Journal of Biological Chemistry
. 295:1153-1164.
2020
2020
Pulmonary surfactant lipids inhibit infections with the pandemic H1N1 influenza virus in several animal models
.
Journal of Biological Chemistry
. 295:1704-1715.
2020
2020
SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAs
2020
2018
Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection
.
JCI Insight
. 3.
2018
2018
Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis
.
JCI Insight
. 3.
2018
2018
ERS/ATS workshop report on respiratory health effects of household air pollution
.
European Respiratory Journal
. 51.
2018
2017
Influenza virus infection alters ion channel function of airway and alveolar cells: Mechanisms and physiological sequelae
2017
2017
Use of ferrets for electrophysiologic monitoring of ion transport
.
PLoS One
. 12.
2017
2016
ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis
.
Molecular cell biology research communications : MCBRC
. 609:39-50.
2016
2016
Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions
.
Toxicology and Applied Pharmacology
. 308:46-58.
2016
2016
Bik mediates caspase-dependent cleavage of viral proteins to promote influenza a virus infection
.
American Journal of Respiratory Cell and Molecular Biology
. 54:664-673.
2016
2016
Changes in HPBMC markers of immmune function following controlled short-term inhalation exposures of humans to hardwood smoke
.
Inhalation Toxicology
. 28:61-70.
2016
2016
Depressed hypoxic and hypercapnic ventilatory responses at early stage of lethal avian influenza a virus infection in mice
.
PLoS One
. 11.
2016
2015
Retraction notice to "The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model" [Braz. J. Infect. Dis. 18 (2014) 406-413] DOI: 10.1016/j.bjid.2013.12.008
.
Brazilian Journal of Infectious Diseases
. 19:677.
2015
2015
Renal systems biology of patients with systemic inflammatory response syndrome
.
Kidney International
. 88:804-814.
2015
2015
Ebola: History, treatment, and lessons from a new emerging pathogen
2015
2014
Erratum to "The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model" [Braz. J. Infect. Dis. 18(4) (2014) 406-413]
.
Brazilian Journal of Infectious Diseases
. 18:580.
2014
2014
Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes
.
American Journal of Respiratory and Critical Care Medicine
. 190:445-455.
2014
2014
Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses
.
Immunity and Ageing
. 11.
2014
2014
Enhanced viral replication and modulated innate immune responses in infant airway epithelium following H1N1 infection
.
Journal of Virology
. 88:7412-7425.
2014
2014
Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium
.
Journal of General Virology
. 95:26-37.
2014
2014
The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: II. Comparison of responses to diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions
.
Inhalation Toxicology
. 26:651-667.
2014
2014
The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model
.
Brazilian Journal of Infectious Diseases
. 18:406-413.
2014
2013
Gestational exposure of mice to secondhand cigarette smoke causes bronchopulmonary dysplasia blocked by the nicotinic receptor antagonist mecamylamin
.
Environmental Health Perspectives
. 121:957-964.
2013
2012
Neurovirulence of H5N1 Infection in Ferrets Is Mediated by Multifocal Replication in Distinct Permissive Neuronal Cell Regions
.
PLoS One
. 7.
2012
2012
Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model
.
PLoS One
. 7.
2012
2012
Exhaled aerosol transmission of pandemic and seasonal H1N1 influenza viruses in the ferret
.
PLoS One
. 7.
2012
2012
Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge
.
Journal of Virology
. 86:4234-4244.
2012
2012
Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin
.
Journal of Immunology
. 188:2815-2824.
2012
2012
Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo
.
Journal of Allergy and Clinical Immunology
. 130.
2012
2011
Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets
.
Vaccine
. 29:6242-6251.
2011
2011
Engine-operating load influences diesel exhaust composition and cardiopulmonary and immune responses
.
Environmental Health Perspectives
. 119:1136-1141.
2011
2011
Enhanced immunogenicity, mortality protection, and reduced viral brain invasion by alum adjuvant with an H5N1 split-virion vaccine in the Ferret
.
PLoS One
. 6.
2011
2011
Regulation of STAT signaling in mouse bone marrow derived dendritic cells by respiratory syncytial virus
.
Virus Research
. 156:127-133.
2011
2011
Enhanced acetylation of alpha-tubulin in influenza A virus infected epithelial cells
.
FEBS Letters
. 585:128-132.
2011
2011
Higher level of replication efficiency of 2009 (H1N1) pandemic influenza virus than those of seasonal and avian strains: Kinetics from epithelial cell culture and computational modeling
.
Journal of Virology
. 85:1125-1135.
2011
2010
Interference with intraepithelial TNF-α signaling inhibits CD8
+
T-cell-mediated lung injury in influenza infection
.
Viral Immunology
. 23:639-645.
2010
2010
Response network analysis of differential gene expression in human epithelial lung cells during avian influenza infections
.
BMC Bioinformatics
. 11.
2010
2010
Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitro
2010
2010
Respiratory syncytial virus impairs macrophage IFN-α/β- and IFN-γ-stimulated transcription by distinct mechanisms
.
American Journal of Respiratory Cell and Molecular Biology
. 42:404-414.
2010
2009
Ferret model of avian influenza demonstrates dose and strain dependant pathology and viral load in brain
.
Procedia in Vaccinology
. 1:30-34.
2009
2009
Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells
.
FEBS Letters
. 583:2517-2520.
2009
2008
Human metapneumovirus inhibits IFN-α signaling through inhibition of STAT1 phosphorylation
.
American Journal of Respiratory Cell and Molecular Biology
. 38:661-670.
2008
2008
The SARS-CoV ferret model in an infection-challenge study
.
Virology
. 374:151-163.
2008
2007
Transactivation of lung lysozyme expression by Ets family member ESE-1
2007
2007
Respiratory syncytial virus infection in anesthetized weanling rather than adult rats prolongs the apneic responses to right atrial injection of capsaicin
.
Journal of Applied Physiology
. 102:2201-2206.
2007
2007
Computational prediction of novel components of lung transcriptional networks
.
Bioinformatics
. 23:21-29.
2007
2006
Differential expression of spleen tyrosine kinase Syk isoforms in tissues: Effects of the microbial flora
.
Histochemistry and Cell Biology
. 126:495-505.
2006
2006
Health effects of subchronic exposure to environmental levels of hardwood smoke
.
Inhalation Toxicology
. 18:523-539.
2006
2006
Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model
2006
2006
The immunobiology of respiratory syncytial virus infection
.
Clinical and Applied Immunology Reviews
. 6:37-52.
2006
2005
Increased mortality associated with TCDD exposure in mice infected with influenza A virus is not due to severity of lung injury or alterations in Clara cell protein content
.
Chemico-Biological Interactions
. 155:181-190.
2005
2005
Inhaled diesel engine emissions reduce bacterial clearance and exacerbate lung disease to Pseudomonas aeruginosa infection in vivo
.
Toxicological Sciences
. 83:155-165.
2005
2004
Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies
.
Journal of Virology
. 78:14003-14011.
2004
2004
IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection
.
Journal of Immunology
. 173:4040-4049.
2004
2004
Effects of low sulfur fuel and a catalyzed particle trap on the composition and toxicity of diesel emissions
.
Environmental Health Perspectives
. 112:1307-1312.
2004
2003
Acute inflammatory response and remodeling of airway epithelium after subspecies B1 human adenovirus infection of the mouse lower respiratory tract
.
Journal of Medical Virology
. 71:233-244.
2003
2003
Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection
.
Journal of Immunology
. 171:1051-1060.
2003
2003
Increased susceptibility to rsv infection by exposure to inhaled diesel engine emissions
.
American Journal of Respiratory Cell and Molecular Biology
. 28:451-463.
2003
2002
Pseudomonas aeruginosa and tumor necrosis factor-α attenuate Clara cell secretory protein promoter function
.
American Journal of Respiratory Cell and Molecular Biology
. 26:216-223.
2002
2001
CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model
2001
2000
Regulation of GADD153 mRNA expression by hypoxia in pulmonary artery smooth muscle cells
.
Research communications in molecular pathology and pharmacology
. 108:3-14.
2000
2000
Adenoviral E3-14.7K protein in LPS-induced lung inflammation
2000
2000
Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after acute viral infection
.
American Journal of Respiratory Cell and Molecular Biology
. 22:34-44.
2000
2000
Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo
2000
1999
CCSP deficiency does not alter surfactant homeostasis during adenoviral infection
.
American Journal of Physiology
. 277.
1999
1999
SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection
.
American Journal of Physiology
. 277.
1999
1998
Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses
.
Human gene therapy. Clinical development
. 9:2207-2222.
1998
1998
Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression
.
Human gene therapy. Clinical development
. 9:1885-1898.
1998
1998
Clara cell secretory protein decreases lung inflammation after acute virus infection
.
American Journal of Physiology
. 275.
1998
1996
Regulation of ornithine decarboxylase by hypoxia in pulmonary artery smooth muscle cells
.
American Journal of Physiology
. 271.
1996
1996
Regulation of ornithine decarboxylase by hypoxia in pulmonary artery smooth muscle cells
.
American Journal of Physiology
. 271.
1996
Chapter
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2014
Emergence and Pathogenesis of Avian Influenza in Humans
. 473-494.
2014
Research
Principal Investigator On
CF, Ivacaftor and COVID-19 Interventions
awarded by
Cystic Fibrosis Foundation ^
Development of Animal Models for Evaluation of Medical Countermeasures for SARS-CoV-2
awarded by
LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE
Exacerbation of Influenza Secondary Infections in Cystic Fibrosis
awarded by
Cystic Fibrosis Foundation ^
Influenza Regulation of Epithelial Pneumococcal Host Defense
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Novel SARS-CoV-2 Antivirals Targeting Viral Encoded Ion Channels
awarded by
American Lung Association
PATH’s iOWH032 for SARS-CoV-2 Antiviral Activity
awarded by
PATH FOUNDATION
Private Grant
awarded by
AIRWAY THERAPEUTICS, LLC
Targeting MMP9 to Improve Outcomes in Serious Influenza Infections
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Investigator On
Animal Models of Infectious Diseases, Part A, A Small Animal Product Screening, Biodefense and Emerging Disease Agents
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Influenza Secondary Pneumococcal Models of Infection
awarded by
University of Maryland
Lung Macrophage Metabolic Reprogramming in Asbestos-Induced Toxicity
awarded by
National Institute of Environmental Health Sciences/NIH/DHHS
Matrikines and COPD-PH COVID-19
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Novel Therapeutic Targets for Fluoroacetate-induced Toxicities
awarded by
National Institute of Environmental Health Sciences/NIH/DHHS
Private Grant
awarded by
ALTIMMUNE INC^
Program on Cellular Metabolism and Lung Fibrosis
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
PspA Binds Necroptotic Cells to Cause Disease and Transmit
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
The Impact of SARS-CoV-2 Immune Dysregulation on Antifungal Immunity
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
The Impact of SARS-CoV-2 Immune Dysregulation on Antifungal Immunity
awarded by
American Lung Association
UAB Research Education Program for Residents and Fellows in Neuroscience
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
Background
Education And Training
Doctor of Philosophy in Pharmaceutics and Drug Design,
University of Kentucky
1995
Contact
Full Name
Kevin
Harrod