Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Specific RANK Cytoplasmic Motifs Drive OsteoclastogenesisJournal of Bone and Mineral Research.  34:1938-1951. 2019
2019 Affinity purification of NF1 protein–protein interactors identifies keratins and neurofibromin itself as binding partnersGenes.  10. 2019
2019 Multi-Omics Profiling for NF1 Target Discovery in Neurofibromin (NF1) Deficient CellsProteomics.  19. 2019
2019 Heterozygous Pkhd1 C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidneyJournal of Youth and Adolescence.  316:F463-F472. 2019
2019 Truncating PKHD1 and PKD2 mutations alter energy metabolismJournal of Youth and Adolescence.  316:F414-F425. 2019
2019 Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glandsJournal of Biological Chemistry.  294:17060-17074. 2019
2019 Mks6 mutations reveal tissue-and cell type-specific roles for the cilia transition zoneFederation proceedings.  33:1440-1455. 2019
2018 NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancernpj Breast Cancer.  4. 2018
2018 A CreER mouse to study melanin concentrating hormone signaling in the developing brainJournal of Stroke.  56. 2018
2018 Neurofibromin (NF1) genetic variant structure–function analyses using a full-length mouse cDNAHuman Mutation.  39:816-821. 2018
2018 Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumorsOncogene.  37:1610-1623. 2018
2017 Improved Oviduct Transfer Surgery for Genetically Modified Rat Production.American Journal of Translational Research.  7. 2017
2017 Updated nomenclature for human and mouse neurofibromatosis type 1 genesNeurology Genetics.  3. 2017
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in miceJournal of Nonprofit and Public Sector Marketing.  112:532-542. 2016
2016 Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer.American Journal of Translational Research.  6. 2016
2016 Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technologyThe AUPHA Exchange.  9:1169-1179. 2016
2016 Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type IThe AUPHA Exchange.  9:759-767. 2016
2016 Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human DiseasePLoS Genetics.  12. 2016
2016 The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotypeCurrent Protocols in Toxicology.  76:3978-3988. 2016
2016 NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1Human Molecular Genetics.  25:1703-1713. 2016
2016 Novel hypomorphic alleles of the mouse tyrosinase gene induced by CRISPR-Cas9 nucleases cause non-albino pigmentation phenotypesPLoS ONE.  11. 2016
2016 Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouseAging Today.  412:208-218. 2016
2016 CRYβA3/A1-crystallin knockout develops nuclear cataract and causes impaired lysosomal cargo clearance and calpain activationPLoS ONE.  11. 2016
2015 KIAA0556 is a novel ciliary basal body component mutated in Joubert syndromeGenome Biology.  16. 2015
2015 Mitochondrial genetics regulate breast cancer Tumorigenicity and Metastatic potentialCurrent Protocols in Toxicology.  75:4429-4436. 2015
2013 Erratum: Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload (Biochemical Journal (2013) 455 (157-167))European Journal of Histochemistry.  456:147. 2013
2013 Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overloadEuropean Journal of Histochemistry.  455:157-167. 2013
2013 Effects of risperidone on energy balance in female C57BL/6J miceObesity Research.  21:1850-1857. 2013
2013 An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissueJournal of Oral Rehabilitation.  2. 2013
2013 Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant miceProceedings of the National Academy of Sciences.  110:7796-7801. 2013
2012 Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesisJournal of Oral Rehabilitation.  1. 2012
2012 Noninvasive bioluminescence imaging in small animalsILAR news.  53:103-115. 2012
2012 Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosisACM Computing Surveys.  29:315-325. 2012
2011 ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptorJournal of Biological Chemistry.  286:39654-39662. 2011
2011 Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclastsPLoS ONE.  6. 2011
2011 Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulationAging Today.  360:66-76. 2011
2010 Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndromeNeurobiology of Disease.  39:169-180. 2010
2009 Risperidone alters food intake, core body temperature, and locomotor activity in micePhysiology and Behavior.  96:457-463. 2009
2009 Generating conditional mutants to analyze ciliary functions: the use of Cre-lox technology to disrupt cilia in specific organs.Methods in Cell Biology.  93:305-330. 2009
2009 Utilization of conditional alleles to study the role of the primary cilium in obesity.Methods in Cell Biology.  94:162-179. 2009
2008 Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid MetabolismAnnales de Zootechnie.  8:468-481. 2008
2008 G2E3 is a dual function ubiquitin ligase required for early embryonic developmentJournal of Biological Chemistry.  283:22304-22315. 2008
2008 Noninvasive bioluminescence imaging in small animalsILAR news.  49:103-115. 2008
2007 Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signalingBiomarker Insights.  46:11389-11397. 2007
2007 Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney DiseaseCell Structure and Function.  17:1586-1594. 2007
2007 Structural insights into the role of the ACTH receptor cysteine residues on receptor functionFamily Process.  293. 2007
2007 Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2Journal of Biological Chemistry.  282:22448-22459. 2007
2007 No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugsInternational Journal of Obesity.  31:1014-1022. 2007
2006 Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone miceJournal of Immunology.  177:8748-8756. 2006
2005 HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in micePsychopharmacology.  180:279-285. 2005
2005 Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistanceProceedings of the National Academy of Sciences.  102:6207-6212. 2005
2003 Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structuresSimulation in Healthcare.  4. 2003
2003 Putative targets of CNS melanocortin receptor activityOnkologie.  994:211-217. 2003
2000 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse.Journal of Physician Assistant Education.  141:3518-3521. 2000
2000 Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2Nature Genetics.  24:403-409. 2000
2000 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouseJournal of Physician Assistant Education.  141:3518-3521. 2000
1998 Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonistsFamily Process.  274. 1998
1998 Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists.BMC Pharmacology.  274:R931-R938. 1998
1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndromeFederation proceedings.  11. 1997
1997 Analysis of osteocalcin expression in transgenic mice reveals a species difference in vitamin D regulation of mouse and human osteocalcin genesJournal of Bone and Mineral Research.  12:1570-1576. 1997
1997 Structural organization of the human vitamin D receptor chromosomal gene and its promoter.Molecular Endocrinology -Baltimore-.  11:1165-1179. 1997
1997 Targeted disruption of the melanocortin-4 receptor results in obesity in miceLancet Public Health.  88:131-141. 1997
1997 Role of melanocortlnergic neurons in feeding and the agouti obesity syndromeNature.  385:165-168. 1997
1997 Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the Agouti obesity syndromeMolecular Endocrinology -Baltimore-.  11:630-637. 1997
1997 Structural organization of the human vitamin D receptor chromosomal gene and its promoterMolecular Endocrinology -Baltimore-.  11:1165-1179. 1997
1996 Melanocortin antagonists define two distinct pathways of cardiovascular control by α- and γ-melanocyte-stimulating hormonesJournal of Neuroscience.  16:5182-5188. 1996
1996 The melanocortin receptors: Agonists, antagonists, and the hormonal control of pigmentationRecent Progress in Hormone Research.  51:287-317. 1996
1995 Cyclic Lactam α-Melanotropin Analogues of Ac-Nle4-cyclo[Asp5, D-Phe7, Lys10] α-Melanocyte-Stimulating Hormone-(4-10)-NH2 with Bulky Aromatic Amino Acids at Position 7 Show High Antagonist Potency and Selectivity at Specific Melanocortin ReceptorsJournal of Medicinal Chemistry.  38:3454-3461. 1995
1995 Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heartMolecular Endocrinology -Baltimore-.  9:637-645. 1995
1993 Recombinant creatine kinase proteins and proposed standards for creatine kinase isoenzyme and subform assaysJournal of the Reticuloendothelial Society.  39:1598-1601. 1993
1993 The human osteocalcin promoter directs bone-specific vitamin D-regulatable gene expression in transgenic miceMolecular Endocrinology -Baltimore-.  7:462-467. 1993
1988 Point mutations in the human vitamin D receptor gene associated with hypocalcemic ricketsScience.  242:1702-1705. 1988

Principal Investigator On

  • Novel Grafted Terpolymers for Targeted Delivery of CRISPR/Cas9- Mediated Precise Genome Editing to the Brain  awarded by Yale University 2019 - 2022
  • NF1 Gene Rescue in Translational Animal Models  awarded by GILBERT FAMILY FOUNDATION'S GENE THERAPY INITIATIVE, LLC (GTI) 2018 - 2021
  • Comprehensive Cancer Center Core Support Grant - Transgenic Animal Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Collaboration Agreement regarding Manufacture of Genetically modified Animals  awarded by INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH - PUNE (IISER-PUNE) 2017 - 2020
  • Rheumatic Diseases Research Core Centers - Core D: Analytical Genomics and Transgenics Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Comprehensive Cancer Center Core Support Grant - Transgenic Animal Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Transgenic Animal Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Active - Transgenic Animal/Embryonic Stem Cell - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Cryopreservation Resources and Emergency Backup Plans for UAB Mouse Models  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2013 - 2015
  • Rheumatic Diseases Core Center: Core D - Gene Targeting Core Facility  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • UAB Core Center for Basic Skeletal Research - Core B  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Role of the MC3-R in Obesity and Metabolic Syndrome  awarded by VANDERBILT UNIVERSITY 2008 - 2011
  • Regulation of RNA Editing in the CNS  awarded by VANDERBILT UNIVERSITY 2007 - 2011
  • Comprehensive Cancer Center Core Support Grant - Transgenic Animal  awarded by National Cancer Institute/NIH/DHHS 2006 - 2011
  • UAB High Throughput DNA AutoGenPrep 965 (SIG)  awarded by National Center for Research Resources/NIH/DHHS 2010 - 2011
  • Investigator On

  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB Diabetes Research Center - Animal Physiology Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2022
  • UAB Nutrition Obesity Research Center - Animal Models Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2022
  • Exon Skipping to Treat NF1  awarded by GILBERT FAMILY FOUNDATION'S GENE THERAPY INITIATIVE, LLC (GTI) 2018 - 2021
  • Exploring Nonsense Suppression as a Treatment for NF1  awarded by GILBERT FAMILY FOUNDATION'S GENE THERAPY INITIATIVE, LLC (GTI) 2018 - 2021
  • NF1 RNA Repair Based on Therapeutic Ribozymes  awarded by GILBERT FAMILY FOUNDATION'S GENE THERAPY INITIATIVE, LLC (GTI) 2018 - 2021
  • Understanding Ciliary Functions in Mammalian Development  awarded by University of California, San Francisco 2016 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Engineered Models Resource - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • The Hepato/Renal Fibrocystic Disease Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • A Novel Role for IGF-1 Receptor in Growth Hormone Action  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2019
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2018
  • UAB Nutrition Obesity Research Center - Animal Models Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2018
  • RANK Signaling in Osteoclast Differentiation and Function  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2018
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017
  • UAB Nutrition Obesity Research Center (NORC) - Animal Models Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2017
  • UAB Nutrition Obesity Research Center - NORC Core C - Animal Models Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Human Heme Oxygenase-1 Gene Regulation in Renal Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2006 - 2012
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • UAB Core Center for Basic Skeletal Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2010 - 2012
  • Education And Training

  • Doctor of Philosophy, Baylor College of Medicine 1994
  • Full Name

  • Robert Kesterson