Positions

Overview

  • Dr. Kejin Hu received his PhD degree in molecular biology in 2003 from the University of Hong Kong. Before that, he conducted his master research program in fungal biochemistry at the Hong Kong Polytechnic University. He then conducted his first postdoctoral research in muscle development in C elegant at Cornell University. His second postdoctoral research is Tor signaling in budding yeast at the University of Pittsburgh. He received extensive training in human embryonic stem cell biology and pluripotency reprogramming at the University of Wisconsin-Madison. Dr. Hu established his own research lab in 2011 at UAB. His research interest includes molecular regulation of pluripotency, cellular reprogramming, and BET proteins.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Become Competent in Generating RNA-Seq Heat Maps in One Day for Novices Without Prior R Experience.  Methods in Molecular Biology.  2239:269-303. 2021
    2021 Evaluating Reprogramming Efficiency and Pluripotency of the Established Human iPSCS by Pluripotency Markers.  Methods in Molecular Biology.  2239:235-249. 2021
    2021 Reprogramming Human Fibroblasts to Induced Pluripotent Stem Cells Using the GFP-Marked Lentiviral Vectors in the Chemically Defined Medium.  Methods in Molecular Biology.  2239:101-116. 2021
    2020 Become competent within one day in generating boxplots and violin plots for a novice without prior r experience 2020
    2020 Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCs.  Scientific Reports.  10. 2020
    2020 Quick, Coordinated and Authentic Reprogramming of Ribosome Biogenesis during iPSC Reprogramming.  Cells.  9. 2020
    2020 A piano (Proper, insufficient, aberrant, and no reprogramming) response to the yamanaka factors in the initial stages of human ipsc reprogramming.  International Journal of Molecular Sciences.  21. 2020
    2020 Profiling and quantification of pluripotency reprogramming reveal that WNT pathways and cell morphology have to be reprogramed extensively.  Heliyon.  6. 2020
    2019 On Mammalian Totipotency: What Is the Molecular Underpinning for the Totipotency of Zygote? 2019
    2016 Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET Bromodomains.  Cell Reports.  16:3138-3145. 2016
    2016 The universal 3D3 antibody of human PODXL is pluripotent cytotoxic, and identifies a residual population after extended differentiation of pluripotent stem cells 2016
    2016 Ubiquitin regulates TORC1 in yeast Saccharomyces cerevisiae 2016
    2016 The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis.  Nature Communications.  7. 2016
    2015 Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells.  Stem Cell Research.  15:678-693. 2015
    2014 All roads lead to induced pluripotent stem cells: The technologies of iPSC generation 2014
    2014 Vectorology and factor delivery in induced pluripotent stem cell reprogramming 2014
    2011 Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells.  Blood.  117. 2011
    2009 Human induced pluripotent stem cells free of vector and transgene sequences.  Science.  324:797-801. 2009
    2007 A Zn-finger/FH2-domain containing protein, FOZI-1, acts redundantly with CeMyoD to specify striated body wall muscle fates in the Caenorhabditis elegans postembryonic mesoderm 2007
    2007 Food digestion by cathepsin L and digestion-related rapid cell differentiation in shrimp hepatopancreas 2007
    2006 Intron exclusion and the mystery of intron loss.  FEBS Letters.  580:6361-6365. 2006
    2006 Complete, precise, and innocuous loss of multiple introns in the currently intronless, active cathepsin L-like genes, and inference from this event.  Molecular Phylogenetics and Evolution.  38:685-696. 2006
    2004 Screening of fungi for chitosan producers, and copper adsorption capacity of fungal chitosan and chitosanaceous materials.  Carbohydrate Polymers.  58:45-52. 2004
    2004 Erratum: Shrimp cathepsin L encoded by an intronless gene has predominant expression in hepatopancreas, and occurs in the nucleus of oocyte (Comparative Biochemistry and Physiology Part B (2004) 137B 445 (21-33) DOI:10.1016/j.cbpc. 2003.09.010) 2004
    2004 Shrimp cathepsin L encoded by an intronless gene has predominant expression in hepatopancreas, and occurs in the nucleus of oocyte 2004
    1999 Rapid extraction of high-quality chitosan from Mycelia of Absidia Glauca.  Journal of Food Biochemistry.  23:187-196. 1999
    Profiling of the reprogramome and quantification of fibroblast reprogramming to pluripotency

    Book

    Year Title Altmetric
    2021 Preface.  Ed. 2239.  2021

    Teaching Overview

  • Dr. Hu teaches advanced stem cell biology (GBS 709).
    He also teaches journal club in stem cell biology.

    • Teaching Activities

    Education And Training

  • University of Wisconsin Primate Center, Postdoctoral Research 2011
  • University of Wisconsin Pharmacology, Postdoctoral Research 2007
  • Pittsburgh University Pharmacology & Chemical Biology, Postdoctoral Research 2006
  • Cornell University Molecular Biology and Genetics, Postdoctoral Research 2004
  • Doctor of Philosophy in Zoology / Animal Biology, The University of Hong Kong 2003
  • Master of Sciences or Mathematics in Biology, The Hong Kong Polytechnic University 1997

    • Full Name

  • Kejin Hu