Positions

Overview

  • Karin Hardiman, M.D., Ph.D., is an Associate Professor of Surgery in the UAB Division of Gastrointestinal Surgery. She was recruited from the University of Michigan in 2019 where she was in academic practice for eight years. Dr. Hardiman practices at the Birmingham VA and University Hospital. Her clinical interests are in colorectal cancer, anal cancer, inflammatory bowel disease and anorectal disease. She utilizes minimally invasive surgery where possible.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Multidisciplinary clinics for colorectal cancer may not provide more efficient coordination of care.  The American Journal of Surgery.  223:1167-1171. 2022
    2022 Ileostomy Patients Using Patient Engagement Technology Experience Decreased Length of Stay.  Journal of Gastrointestinal Surgery.  26:635-642. 2022
    2022 Inhibition of DNA-PK may improve response to neoadjuvant chemoradiotherapy in rectal cancer.  Neoplasia.  25:53-61. 2022
    2022 Sialyltransferase ST6GAL-1 mediates resistance to chemoradiation in rectal cancer.  Journal of Biological Chemistry.  298. 2022
    2021 Expert Commentary on Late and Long-term Symptom Management in Colorectal Cancer Survivorship.  Diseases of the Colon and Rectum.  64:1450-1451. 2021
    2021 NIH Funding of Researchers in Surgery: Decreased Career Development Awards Over Time.  Journal of Surgical Research.  266:6-12. 2021
    2021 The impact of an enhanced recovery program (ERP) on the costs of colorectal surgery.  The American Journal of Surgery.  222:186-192. 2021
    2021 Development and characteristics of a multidisciplinary colorectal cancer clinic.  The American Journal of Surgery.  221:826-831. 2021
    2021 Racial disparities exist in surgical outcomes for patients with inflammatory bowel disease.  The American Journal of Surgery.  221:668-674. 2021
    2021 The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surveillance and Survivorship Care of Patients after Curative Treatment of Colon and Rectal Cancer.  Diseases of the Colon and Rectum.  517-533. 2021
    2020 Hospital Variation in Readmissions and Visits to the Emergency Department Following Ileostomy Surgery.  Journal of Gastrointestinal Surgery.  24:2602-2612. 2020
    2020 The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Rectal Cancer.  Diseases of the Colon and Rectum.  63:1191-1222. 2020
    2020 Completeness of operative reports for rectal cancer surgery.  The American Journal of Surgery.  220:165-169. 2020
    2020 Use of Accelerated Induction Strategy of Infliximab for Ulcerative Colitis in Hospitalized Patients at a Tertiary Care Center.  Digestive Diseases and Sciences.  65:1800-1805. 2020
    2020 Characteristics of Patients Seeking Second Opinions at a Multidisciplinary Colorectal Cancer Clinic.  Diseases of the Colon and Rectum.  788-795. 2020
    2020 The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Left-Sided Colonic Diverticulitis.  Diseases of the Colon and Rectum.  728-747. 2020
    2019 Rectal cancer sub-clones respond differentially to neoadjuvant therapy.  Neoplasia.  21:1051-1062. 2019
    2019 Surgical management of primary colonic lymphoma: Big data for a rare problem.  Journal of Surgical Oncology.  120:431-437. 2019
    2019 Clinical and pathological outcomes of induction chemotherapy before neoadjuvant radiotherapy in locally-advanced rectal cancer.  Journal of Surgical Oncology.  120:308-315. 2019
    2019 Patient-Reported Unmet Needs in Colorectal Cancer Survivors after Treatment for Curative Intent.  Diseases of the Colon and Rectum.  62:815-822. 2019
    2019 Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies.  European Surgical Research.  59:361-370. 2019
    2018 Patient-reported outcomes and readmission after ileostomy creation in older adults.  American Surgeon.  84:1814-1818. 2018
    2018 Can ZEB2 Be Used as a Molecular Marker for Risk Stratification of Patients with Colorectal Cancer?.  JAMA Network Open.  1. 2018
    2018 Lymph node metastases in colon cancer are polyclonal.  Clinical Cancer Research.  24:2214-2224. 2018
    2018 Translational Research in Colorectal Cancer.  Clinics in Colon and Rectal Surgery.  31:145. 2018
    2018 Update on Sporadic Colorectal Cancer Genetics.  Clinics in Colon and Rectal Surgery.  31:147-152. 2018
    2018 Prevention and management of colostomy complications: Retraction and stenosis.  Diseases of the Colon and Rectum.  61:1344-1347. 2018
    2017 Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer.  Proceedings of the National Academy of Sciences of USA.  114:E9608-E9617. 2017
    2017 BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.  eLife.  6. 2017
    2017 Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency.  Oncotarget.  8:65090-65099. 2017
    2016 Patient autonomy–centered self-care checklist reduces hospital readmissions after ileostomy creation.  Surgery.  160:1302-1308. 2016
    2016 Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.  Cell Metabolism.  24:447-461. 2016
    2016 Sensitivity of KRAS-Mutant colorectal cancers to combination therapy that cotargets MEK and CDK4/6.  Clinical Cancer Research.  22:405-414. 2016
    2016 HIF-3α1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling.  Oncotarget.  7:11567-11579. 2016
    2016 Intra-tumor genetic heterogeneity in rectal cancer.  Laboratory Investigation.  96:4-15. 2016
    2014 Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model.  PLoS One.  9. 2014
    2014 Surgery for diverticulitis in the 21st century a systematic review.  JAMA Surgery.  149:292-302. 2014
    2014 Sigmoid diverticulitis: A systematic review.  JAMA: Journal of the American Medical Association.  311:287-297. 2014
    2013 Human pancreatic cancer fusion 2 (HPC2) 1-B3: A novel monoclonal antibody to screen for pancreatic ductal dysplasia.  Cancer Cytopathology.  121:37-46. 2013
    2013 Laparoscopic colectomy reduces morbidity and mortality in obese patients.  Surgical Endoscopy: surgical and interventional techniques.  27:2907-2910. 2013
    2012 Effect of Surgical Approach on 30-Day Mortality and Morbidity After Elective Colectomy: A NSQIP Study.  Journal of Gastrointestinal Surgery.  16:1212-1217. 2012
    2011 Specialized practice reduces inpatient mortality, length of stay, and cost in the care of colorectal patients.  Diseases of the Colon and Rectum.  54:780-786. 2011
    2009 Disparities in the treatment of colon cancer in octogenarians.  The American Journal of Surgery.  197:624-628. 2009
    2009 What to do when the pathology from last week's laparoscopic cholecystectomy is malignant and T1 or T2.  Journal of Gastrointestinal Surgery.  13:2037-2039. 2009
    2008 Demographic and socioeconomic trends in the use of laparoscopic appendectomy from 1997 to 2003.  The American Journal of Surgery.  195:580-584. 2008
    2004 Regulation of amiloride-sensitive Na+ transport by basal nitric oxide.  American Journal of Respiratory Cell and Molecular Biology.  30:720-728. 2004
    2004 Upregulation of Alveolar Epithelial Active Na+ Transport Is Dependent on β2-Adrenergic Receptor Signaling.  Circulation Research.  94:1091-1100. 2004
    2002 Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epithelia.  Journal of Biological Chemistry.  277:43041-43049. 2002
    2001 Lack of amiloride-sensitive transport across alveolar and respiratory epithelium of iNOS(-/-) mice in vivo.  American Journal of Physiology: Lung Cellular and Molecular Physiology.  281. 2001
    2001 Modification of sodium transport and alveolar fluid clearance by hypoxia: Mechanisms and physiological implications.  American Journal of Respiratory Cell and Molecular Biology.  25:538-541. 2001

    Chapter

    Year Title Altmetric
    2022 Mechanisms of lymphatic spread in colon cancer: Insights from molecular and genetic studies.  43-55. 2022
    2018 Evaluation and management of gastrointestinal cancer.  266-276. 2018

    Research Overview

  • Dr. Hardiman’s primary research interests are in improving the treatment of colon and rectal cancer via basic and translational research. She has an NIH-funded laboratory studying the role of intra-tumor genetic heterogeneity in colorectal cancer metastasis and response to therapy. She also investigates the importance of multidisciplinary cancer care and survivorship care.

    Keywords - colon and rectal surgery, intestinal surgery

    • Principal Investigator On

    Education And Training

  • Oregon Health & Science University School of Medicine General Surgery, Residency
  • Oregon Health & Science University School of Medicine Colorectal Surgery, Postdoctoral Fellowship
  • Doctor of Medicine, University of Alabama at Birmingham 2004
  • Doctor of Philosophy in Physiology, University of Alabama at Birmingham 2002
  • Master of Sciences or Mathematics in Medical Basic Sciences/Other, University of Alabama at Birmingham 2000

    • Full Name

  • Karin Hardiman