Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Streptococcus pneumoniae capsular polysaccharide is linked to peptidoglycan via a direct glycosidic bond to β-D-N-acetylglucosamineProceedings of the National Academy of Sciences.  114:5695-5700. 2017
2016 The effects of differences in pspA alleles and capsular types on the resistance of Streptococcus pneumoniae to killing by apolactoferrinMicrobial Pathogenesis.  99:209-219. 2016
2014 Streptococcus pneumoniae phosphotyrosine phosphatase CpsB and alterations in capsule production resulting from changes in oxygen availabilityJournal of Bacteriology.  196:1992-2003. 2014
2013 Biochemical activities of streptococcus pneumoniae serotype 2 capsular glycosyltransferases and significance of suppressor mutations affecting the initiating glycosyltransferase Cps2EJournal of Bacteriology.  195:5469-5478. 2013
2013 Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating unitsJournal of Biological Chemistry.  288:21945-21954. 2013
2012 Genetic and biochemical characterizations of enzymes involved in Streptococcus pneumoniae serotype 2 capsule synthesis demonstrate that Cps2T (WchF) catalyzes the committed step by addition of β1-4 rhamnose, the second sugar residue in the repeat unitJournal of Bacteriology.  194:6479-6489. 2012
2012 Biochemical, genetic, and serological characterization of two capsule subtypes among Streptococcus pneumoniae serotype 20 strains: Discovery of a new pneumococcal serotypeJournal of Biological Chemistry.  287:27885-27894. 2012
2011 Capsules of streptococcus pneumoniae and other bacteria: Paradigms for polysaccharide biosynthesis and regulationAnnual Review of Microbiology.  65:563-581. 2011
2009 A kinetic model for chain length modulation of Streptococcus pneumoniae cellubiuronan capsular polysaccharide by nucleotide sugar donor concentrationsJournal of Biological Chemistry.  284:11836-11844. 2009
2009 Characterization of the lipid linkage region and chain length of the cellubiuronic acid capsule of Streptococcus pneumoniaeJournal of Biological Chemistry.  284:11826-11835. 2009
2007 CcpA-dependent and -independent control of beta-galactosidase expression in Streptococcus pneumoniae occurs via regulation of an upstream phosphotransferase system-encoding operonJournal of Bacteriology.  189:5183-5192. 2007
2007 Mutations blocking side chain assembly, polymerization, or transport of a Wzy-dependent Streptococcus pneumoniae capsule are lethal in the absence of suppressor mutations and can affect polymer transfer to the cell wallJournal of Bacteriology.  189:3369-3381. 2007
2006 Control of capsular polysaccharide chain length by UDP-sugar substrate concentrations in Streptococcus pneumoniaeMicrobiological sciences.  61:723-733. 2006
2006 Role of the carbohydrate binding site of the Streptococcus pneumoniae capsular polysaccharide type 3 synthase in the transition from oligosaccharide to polysaccharide synthesisJournal of Biological Chemistry.  281:6283-6289. 2006
2005 CpsE from type 2 Streptococcus pneumoniae catalyzes the reversible addition of glucose-1-phosphate to a polyprenyl phosphate acceptor, initiating type 2 capsule repeat unit formationJournal of Bacteriology.  187:7425-7433. 2005
2005 Initiation and synthesis of the Streptococcus pneumoniae type 3 capsule on a phosphatidylglycerol membrane anchorJournal of Bacteriology.  187:4470-4479. 2005
2003 Positive correlation between tyrosine phosphorylation of CpsD and capsular polysaccharide production in Streptococcus pneumoniaeJournal of Bacteriology.  185:6057-6066. 2003
2003 Genetic alteration of capsule type but not PspA type affects accessibility of surface-bound complement and surface antigens of Streptococcus pneumoniaeInfection and Immunity.  71:218-225. 2003
2001 Expression of the Streptococcus pneumoniae Type 3 Synthase in Escherichia coli: Assembly of type 3 polysaccharide on a lipid primerJournal of Biological Chemistry.  276:48831-48839. 2001
2001 CpsB Is a Modulator of Capsule-associated Tyrosine Kinase Activity in Streptococcus pneumoniaeJournal of Biological Chemistry.  276:47966-47974. 2001
2001 Requirement for capsule in colonization by Streptococcus pneumoniaeInfection and Immunity.  69:3755-3761. 2001
2001 Essential role for cellular phosphoglucomutase in virulence of type 3 Streptococcus pneumoniaeInfection and Immunity.  69:2309-2317. 2001
2000 Genetic relatedness within serotypes of penicillin-susceptible Streptococcus pneumoniae isolatesJournal of Clinical Microbiology.  38:4548-4553. 2000
2000 Biosynthesis of type 3 capsular polysaccharide in Streptococcus pneumoniae: Enzymatic chain release by an abortive translocation processJournal of Biological Chemistry.  275:25972-25978. 2000
2000 Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutaseJournal of Bacteriology.  182:1854-1863. 2000
2000 Mechanism of type 3 capsular polysaccharide synthesis in Streptococcus pneumoniaeJournal of Biological Chemistry.  275:3907-3914. 2000
1998 Generation and properties of a Streptococcus pneumoniae mutant which does not require choline or analogs for growthJournal of Bacteriology.  180:2093-2101. 1998
1998 Capsule genetics in Streptococcus pneumoniae and a possible role for transposition in the generation of the type 3 locusMicrobial Drug Resistance.  4:11-23. 1998
1997 Association of a partial H-rpt element with the type 3 capsule locus of Streptococcus pneumoniae [1]Microbiological sciences.  25:201-203. 1997
1995 Characterization of the cassette containing genes for type 3 capsular polysaccharide biosynthesis in streptococcus pneumoniaeJournal of Experimental Medicine.  181:973-983. 1995
1995 Capsules and cassettes: genetic organization of the capsule locus of Streptococcus pneumoniae.Developments in Biological Standardization.  85:261-265. 1995
1994 Effect of genetic switching of capsular type on virulence of Streptococcus pneumoniaeInfection and Immunity.  62:1813-1819. 1994
1994 Genetic and molecular characterization of capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 3Microbiological sciences.  12:959-972. 1994
1994 Novel surface attachment mechanism of the Streptococcus pneumoniae protein PspAJournal of Bacteriology.  176:2976-2985. 1994
1992 Molecular localization of variable and conserved regions of pspA and identification of additional pspA homologous sequences in Streptococcus pneumoniaeMicrobial Pathogenesis.  13:261-269. 1992
1992 Strong association between capsular type and virulence for mice among human isolates of Streptococcus pneumoniaeInfection and Immunity.  60:111-116. 1992
1992 Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysisJournal of Bacteriology.  174:601-609. 1992
1992 Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of the pspA geneJournal of Bacteriology.  174:610-618. 1992
1991 The salmonella typhlmurium locus mv/a regulates virulence in itys but not ityr mice: Functional mv/a results in avirulence; mutant (nonfunctional) mv/a results in virulenceJournal of Experimental Medicine.  174:1073-1083. 1991
1991 A 43-kilodalton pneumococcal surface protein, PspA: Isolation, protective abilities, and structural analysis of the amino-terminal sequenceInfection and Immunity.  59:1285-1289. 1991
1991 Analysis of Streptococcus pneumoniae sequences cloned into Escherichia coli: Effect of promoter strength and transcription terminatorsJournal of Bacteriology.  173:5105-5109. 1991
1990 Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniaeInfection and Immunity.  58:3293-3299. 1990
1989 Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniaeInfection and Immunity.  57:2037-2042. 1989
1988 Role of pneumococcal surface protein A in the virulence of Streptococcus pneumoniae.Reviews of infectious diseases.  10 Suppl 2. 1988
1987 Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein a (PspA)Journal of Experimental Medicine.  165:381-394. 1987
1986 Plasmid-determined cytotoxicity in Yersinia pestis and Yersinia pseudotuberculosisInfection and Immunity.  51:788-794. 1986
1986 Temperature-controlled plasmid regulon associated with low calcium response in Yersinia pestisJournal of Bacteriology.  165:443-447. 1986
1986 Transformation of encapsulated Streptococcus pneumoniaeJournal of Bacteriology.  168:1463-1465. 1986
1985 Isolation and characterization of Ca2+-blind mutants of Yersinia pestisJournal of Bacteriology.  164:704-711. 1985
1984 Genetic analysis of the low calcium response in Yersinia pestis Mu d1(Ap lac) insertion mutantsJournal of Bacteriology.  160:842-848. 1984
1982 Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in miceJournal of Immunology.  128:2374-2376. 1982
1982 Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibodyInfection and Immunity.  36:184-188. 1982

Chapter

Year Title Altmetric
1999 Common themes in the genetics of streptococcal capsular polysaccharides.  161-184. 1999

Teaching Activities

  • GBSC742 - Student Theme Meeting Course (Fall Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Spring Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Fall Term 2018) 2018
  • GBS759 - Dev Pres Skills for Micro Res (Spring Term 2018) 2018
  • GBS759 - Dev Pres Skills for Micro Res (Fall Term 2017) 2017
  • GBS759 - Dev Pres Skills for Micro Res (Spring Term 2017) 2017
  • GBS759 - Dev Pres Skills for Micro Res (Fall Term 2016) 2016
  • GBS759 - Dev Pres Skills for Micro Res (Spring Term 2016) 2016
  • MIC772 - Bact Pathogenesis Journal Club (Spring Term 2016) 2016
  • GBS759 - Dev Pres Skills for Micro Res (Fall Term 2015) 2015
  • MIC772 - Bact Pathogenesis Journal Club (Fall Term 2015) 2015
  • GBS747 - Special Topics (Summer Term 2015) 2015
  • GBS759 - Dev Pres Skills for Micro Res (Spring Term 2015) 2015
  • MIC772 - Bact Pathogenesis Journal Club (Spring Term 2015) 2015
  • GBS748 - Special Topics (Fall Term 2014) 2014
  • GBS759 - Dev Pres Skills for Micro Res (Fall Term 2014) 2014
  • MIC772 - Bact Pathogenesis Journal Club (Fall Term 2014) 2014
  • GBS759 - Dev Pres Skills for Micro Res (Spring Term 2014) 2014
  • MIC772 - Bact Pathogenesis Journal Club (Spring Term 2014) 2014
  • GBS759 - Dev Pres Skills for Micro Res (Fall Term 2013) 2013
  • MIC772 - Bact Pathogenesis Journal Club (Fall Term 2013) 2013
  • GBS759 - Dev Pres Skills for Micro Res (Spring Term 2013) 2013
  • MIC772 - Bact Pathogenesis Journal Club (Spring Term 2013) 2013
  • OBHS112 - Fundamentals Dent/Optometry II (Fall Term 2012) 2012
  • GBS759 - Dev Pres Skills for Micro Res (Fall Term 2012) 2012
  • MIC772 - Bact Pathogenesis Journal Club (Fall Term 2012) 2012
  • GBS759 - Dev Pres Skills for Micro Res (Spring Term 2012) 2012
  • MIC772 - Bact Pathogenesis Journal Club (Spring Term 2012) 2012
  • OBHS121 - Fundamentals of Dent and Opt 2 (Fall Term 2011) 2011
  • MIC772 - Bact Pathogenesis Journal Club (Fall Term 2011) 2011
  • MIC772 - Bact Pathogenesis Journal Club (Spring Term 2011) 2011
  • MIC772 - Bact Pathogenesis Journal Club (Fall Term 2010) 2010
  • CMB741 - CMB IV Bacterial Gene & Physio (Spring Term 2010) 2010
  • CMB741 - BACTERIAL GENETICS & PHYSIOLOGY (Spring Term 2010) 2010
  • OBHS121 - Fundamentals of Dent and Opt 2 (Fall Term 2009) 2009
  • CMB741 - CMB IV Bacterial Gene & Physio (Spring Term 2009) 2009
  • CMB741 - CMB IV Bacterial Gene & Physio (Spring Term 2008) 2008
  • Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, University of Alabama at Birmingham 1985
  • Bachelor of Science or Mathematics in Biology, University of Alabama at Birmingham 1980
  • Full Name

  • Janet Yother