Janet Yother

Janet Yother
Professor of Microbiology

Professor (P), Microbiology , Academic Joint Departments 2002 -
Senior Scientist (C), Center for AIDS Research , School of Medicine 2007 -
Senior Scientist (C), Center for Biophysical Sciences and Engineering (CBSE) , School of Optometry 2008 -
Senior Scientist (C), Comprehensive Diabetes Center , School of Medicine 2013 -

Selected Publications

Academic Article

Year	Title	Altmetric
2017	Streptococcus pneumoniae capsular polysaccharide is linked to peptidoglycan via a direct glycosidic bond to β-D-N-acetylglucosamine 2017
2016	The effects of differences in pspA alleles and capsular types on the resistance of Streptococcus pneumoniae to killing by apolactoferrin 2016
2014	Streptococcus pneumoniae phosphotyrosine phosphatase CpsB and alterations in capsule production resulting from changes in oxygen availability 2014
2013	Biochemical activities of streptococcus pneumoniae serotype 2 capsular glycosyltransferases and significance of suppressor mutations affecting the initiating glycosyltransferase Cps2E 2013
2013	Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units 2013
2012	Genetic and biochemical characterizations of enzymes involved in Streptococcus pneumoniae serotype 2 capsule synthesis demonstrate that Cps2T (WchF) catalyzes the committed step by addition of β1-4 rhamnose, the second sugar residue in the repeat unit 2012
2012	Biochemical, genetic, and serological characterization of two capsule subtypes among Streptococcus pneumoniae serotype 20 strains: Discovery of a new pneumococcal serotype 2012
2011	Capsules of streptococcus pneumoniae and other bacteria: Paradigms for polysaccharide biosynthesis and regulation 2011
2009	A kinetic model for chain length modulation of Streptococcus pneumoniae cellubiuronan capsular polysaccharide by nucleotide sugar donor concentrations 2009
2009	Characterization of the lipid linkage region and chain length of the cellubiuronic acid capsule of Streptococcus pneumoniae 2009
2007	CcpA-dependent and -independent control of beta-galactosidase expression in Streptococcus pneumoniae occurs via regulation of an upstream phosphotransferase system-encoding operon 2007
2007	Mutations blocking side chain assembly, polymerization, or transport of a Wzy-dependent Streptococcus pneumoniae capsule are lethal in the absence of suppressor mutations and can affect polymer transfer to the cell wall 2007
2006	Control of capsular polysaccharide chain length by UDP-sugar substrate concentrations in Streptococcus pneumoniae 2006
2006	Role of the carbohydrate binding site of the Streptococcus pneumoniae capsular polysaccharide type 3 synthase in the transition from oligosaccharide to polysaccharide synthesis 2006
2005	CpsE from type 2 Streptococcus pneumoniae catalyzes the reversible addition of glucose-1-phosphate to a polyprenyl phosphate acceptor, initiating type 2 capsule repeat unit formation 2005
2005	Initiation and synthesis of the Streptococcus pneumoniae type 3 capsule on a phosphatidylglycerol membrane anchor 2005
2003	Positive correlation between tyrosine phosphorylation of CpsD and capsular polysaccharide production in Streptococcus pneumoniae 2003
2003	Genetic alteration of capsule type but not PspA type affects accessibility of surface-bound complement and surface antigens of Streptococcus pneumoniae 2003
2001	Expression of the Streptococcus pneumoniae Type 3 Synthase in Escherichia coli: Assembly of type 3 polysaccharide on a lipid primer 2001
2001	CpsB Is a Modulator of Capsule-associated Tyrosine Kinase Activity in Streptococcus pneumoniae 2001
2001	Requirement for capsule in colonization by Streptococcus pneumoniae 2001
2001	Essential role for cellular phosphoglucomutase in virulence of type 3 Streptococcus pneumoniae 2001
2000	Genetic relatedness within serotypes of penicillin-susceptible Streptococcus pneumoniae isolates 2000
2000	Biosynthesis of type 3 capsular polysaccharide in Streptococcus pneumoniae: Enzymatic chain release by an abortive translocation process 2000
2000	Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutase 2000
2000	Mechanism of type 3 capsular polysaccharide synthesis in Streptococcus pneumoniae 2000
1998	Generation and properties of a Streptococcus pneumoniae mutant which does not require choline or analogs for growth 1998
1998	Capsule genetics in Streptococcus pneumoniae and a possible role for transposition in the generation of the type 3 locus 1998
1997	Association of a partial H-rpt element with the type 3 capsule locus of Streptococcus pneumoniae [1] 1997
1995	Characterization of the cassette containing genes for type 3 capsular polysaccharide biosynthesis in streptococcus pneumoniae 1995
1995	Capsules and cassettes: genetic organization of the capsule locus of Streptococcus pneumoniae. 1995
1994	Effect of genetic switching of capsular type on virulence of Streptococcus pneumoniae 1994
1994	Genetic and molecular characterization of capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 3 1994
1994	Novel surface attachment mechanism of the Streptococcus pneumoniae protein PspA 1994
1992	Molecular localization of variable and conserved regions of pspA and identification of additional pspA homologous sequences in Streptococcus pneumoniae 1992
1992	Strong association between capsular type and virulence for mice among human isolates of Streptococcus pneumoniae 1992
1992	Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis 1992
1992	Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of the pspA gene 1992
1991	The salmonella typhlmurium locus mv/a regulates virulence in ity^s but not ity^r mice: Functional mv/a results in avirulence; mutant (nonfunctional) mv/a results in virulence 1991
1991	A 43-kilodalton pneumococcal surface protein, PspA: Isolation, protective abilities, and structural analysis of the amino-terminal sequence 1991
1991	Analysis of Streptococcus pneumoniae sequences cloned into Escherichia coli: Effect of promoter strength and transcription terminators 1991
1990	Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae 1990
1989	Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae 1989
1988	Role of pneumococcal surface protein A in the virulence of Streptococcus pneumoniae. 1988
1987	Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein a (PspA) 1987
1986	Plasmid-determined cytotoxicity in Yersinia pestis and Yersinia pseudotuberculosis 1986
1986	Temperature-controlled plasmid regulon associated with low calcium response in Yersinia pestis 1986
1986	Transformation of encapsulated Streptococcus pneumoniae 1986
1985	Isolation and characterization of Ca²⁺-blind mutants of Yersinia pestis 1985
1984	Genetic analysis of the low calcium response in Yersinia pestis Mu d1(Ap lac) insertion mutants 1984
1982	Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in mice 1982
1982	Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody 1982