Positions

Overview

  • As an immunologist by training, my ongoing research focuses on immunogenetic factors in several infectious diseases, especially HIV/AIDS.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Immunogenetic determinants of heterosexual HIV-1 transmission: key findings and lessons from two distinct African cohortsGenes and Immunity.  22:65-74. 2021
    2021 Cohort Profile: IAVI's HIV epidemiology and early infection cohort studies in Africa to support vaccine discoveryInternational Journal of Epidemiology.  50:29-30. 2021
    2020 Rates and Correlates of Incident Type 2 Diabetes Mellitus Among Persons Living With HIV-1 InfectionFrontiers in Endocrinology.  11. 2020
    2020 Identifying the immune interactions underlying HLA class I disease associationseLife.  9. 2020
    2019 Control of the HIV-1 Load Varies by Viral Subtype in a Large Cohort of African Adults with Incident HIV-1 InfectionJournal of Infectious Diseases.  220:432-441. 2019
    2019 HLA-DQB1*06 is a risk marker for chlamydia reinfection in African American womenGenes and Immunity.  20:69-73. 2019
    2018 Immunogenetic factors in early immune control of human immunodeficiency virus type 1 (HIV-1) infection: Evaluation of HLA class I amino acid variants in two African populationsHuman Immunology.  79:166-171. 2018
    2018 Herpes Zoster in Persons Living with HIV-1 Infection: Viremia and Immunological Defects Are Strong Risk Factors in the Era of Combination Antiretroviral Therapy.Frontiers in Public Health.  6:70. 2018
    2016 Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progressionJournal of Experimental Medicine.  213:2049-2063. 2016
    2016 Enhanced allogeneic cellular responses to mismatched HLA-B antigens results in more efficient killing of HIV infected cells 2016
    2016 Dynamics and correlates of CD8 T-cell counts in Africans with primary human immunodeficiency virus type 1 infectionJournal of Virology.  90:10423-10430. 2016
    2015 Immunogenetic influences on acquisition of HIV-1 infection: Consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2)Genes and Immunity.  16:213-220. 2015
    2015 CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: Findings from an African cohort with prospective dataFrontiers in Microbiology.  6. 2015
    2015 Imputation of class I and II HLA loci using high-density SNPs from ImmunoChip and their associations with Kawasaki disease in family-based study 2015
    2014 Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactionsHuman Genetics.  133:1187-1197. 2014
    2014 Host genetics and immune control of HIV-1 infection: Fine mapping for the extended human MHC region in an African cohortGenes and Immunity.  15:275-281. 2014
    2013 Genetic associations with 25-hydroxyvitamin D deficiency in HIV-1-infected youth: Fine-mapping for the GC/DBP gene that encodes the vitamin D-binding proteinFrontiers in Genetics.  4. 2013
    2013 Dimorphic HLA-B signal peptides differentially influence HLA-E- and natural killer cell-mediated cytolysis of HIV-1-infected target cellsClinical and Experimental Immunology.  174:414-423. 2013
    2013 Variants in interleukin family of cytokines genes influence clearance of high risk HPV in HIV-1 coinfected African-American adolescentsHuman Immunology.  74:1696-1700. 2013
    2013 HLA-B*57 versus HLA-B*81 in HIV-1 infection: Slow and steady wins the race?Journal of Virology.  87:4043-4051. 2013
    2013 Cumulative impact of host and viral factors on HIV-1 viral-load control during early infectionJournal of Virology.  87:708-715. 2013
    2012 Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescentsJournal of Reproductive Immunology.  96:84-89. 2012
    2012 Protocol for analyzing human leukocyte antigen variants and sexually transmitted infections: From genotyping to immunoassaysMethods in Molecular Biology.  903:359-380. 2012
    2012 Erratum: Genetic variations and heterosexual HIV-1 infection: Analysis of clustered genes encoding CC-motif chemokine ligands (Genes and Immunity (2012) 13 (202-205) DOI:10.1038/gene.2011.70)Genes and Immunity.  13:444. 2012
    2012 HLA-B signal peptide polymorphism influences the rate of HIV-1 acquisition but not viral loadJournal of Infectious Diseases.  205:1797-1805. 2012
    2012 Genetic variations and heterosexual HIV-1 infection: Analysis of clustered genes encoding CC-motif chemokine ligandsGenes and Immunity.  13:202-205. 2012
    2011 Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct phases of primary HIV-1 infection in sub-Saharan Africans with several viral subtypesJournal of Virology.  85:8894-8902. 2011
    2011 The role of HLA-DR-DQ haplotypes in variable antibody responses to Anthrax Vaccine AdsorbedGenes and Immunity.  12:457-465. 2011
    2011 The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African AmericansHuman Immunology.  72:312-318. 2011
    2011 Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersJournal of Virology.  85:2316-2324. 2011
    2011 Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couplesJournal of Infectious Diseases.  203:487-495. 2011
    2010 Human leukocyte antigen class I supertypes and HIV-1 control in African AmericansJournal of Virology.  84:2610-2617. 2010
    2010 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcriptionJournal of Experimental Medicine.  207:51-59. 2010
    2009 Predictors of suboptimal virologic response to highly active antiretroviral therapy among human immunodeficiency virus-infected adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) ProjectJAMA Pediatrics.  163:1100-1105. 2009
    2009 Gene copy number: Learning to count past twoNature Medicine.  15:1127-1129. 2009
    2009 The major histocompatibility complex conserved extended haplotype 8.1 in aids-related non-hodgkin lymphoma 2009
    2009 Clear and independent associations of several HLA-DRB1 alleles with diVerential antibody responses to hepatitis B vaccination in youthHuman Genetics.  126:685-696. 2009
    2009 Evolution of HLA-B 5703 hiv-1 escape mutations in HLA-B 5703-positive individuals and their transmission recipientsJournal of Experimental Medicine.  206:909-921. 2009
    2009 Adaptation of HIV-1 to human leukocyte antigen class INature.  458:641-645. 2009
    2008 Human leukocyte antigen class I genotypes in relation to heterosexual HIV type 1 transmission within discordant couplesJournal of Immunology.  181:2626-2635. 2008
    2008 Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipientsJournal of Experimental Medicine.  205:1009-1017. 2008
    2007 Haplotype inference for present-absent genotype data using previously identified haplotypes and haplotype patternsBioinformatics.  23:2399-2406. 2007
    2007 Interleukin-10 gene (IL10) polymorphisms and human papillomavirus clearance among immunosuppressed adolescentsCancer Epidemiology, Biomarkers and Prevention.  16:1626-1632. 2007
    2007 CCL3L1 and CCL4L1: Variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infectionGenes and Immunity.  8:224-231. 2007
    2006 Conserved extended haplotypes of the major histocompatibility complex: Further characterizationGenes and Immunity.  7:450-467. 2006
    2006 Human leukocyte antigen B58 supertype and human immunodeficiency virus type 1 infection in native AfricansJournal of Virology.  80:6056-6060. 2006
    2006 Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adultsClinical and Experimental Immunology.  144:117-124. 2006
    2005 Association between human leukocyte antigen class II alleles and genotype of Borrelia burgdorferi in patients with early Lyme diseaseJournal of Infectious Diseases.  192:2020-2026. 2005
    2005 Interleukin (IL)-2 and IL-12 responses to Chlamydia trachomatis infection in adolescentsClinical and Experimental Immunology.  142:548-554. 2005
    2005 A case-control study to examine HLA haplotype associations in patients with posttreatment chronic lyme diseaseJournal of Infectious Diseases.  192:1010-1013. 2005
    2005 Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiformeCancer Epidemiology, Biomarkers and Prevention.  14:2040-2044. 2005
    2005 HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcomaJournal of Medical Virology.  76:302-310. 2005
    2005 Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescentsJournal of Infectious Diseases.  191:1084-1092. 2005
    2005 Influence of host genetic variation on susceptibility to HIV type 1 infectionJournal of Infectious Diseases.  191. 2005
    2004 Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescentsJournal of Infectious Diseases.  190:1723-1729. 2004
    2004 HLA-DRB1 and -DQB1 alleles and haplotypes in Zambian couples and their associations with heterosexual transmission of HIV type 1Journal of Infectious Diseases.  189:1696-1704. 2004
    2004 Cytokine and Chemokine Gene Polymorphisms among Ethnically Diverse North Americans with HIV-1 Infection 2004
    2004 HLA and Cytokine Gene Polymorphisms Are independently Associated with Responses to Hepatitis B VaccinationHepatology.  39:978-988. 2004
    2003 Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white menJournal of Infectious Diseases.  188:856-863. 2003
    2003 Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities 2003
    2003 The complexity of HLA class II (DRB1, DQB1, DM) associations with disseminated Mycobacterium avium complex infection among HIV-1-seropositive whites 2003
    2003 Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infectionJournal of Infectious Diseases.  187:1264-1271. 2003
    2002 C-C chemokine receptor 2 and C-C chemokine receptor 5 genotypes in patients treated for chronic hepatitis C virus infectionImmunologic Research.  26:167-175. 2002
    2002 Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1Journal of Virology.  76:8276-8284. 2002
    2002 Distribution of chemokine receptor ccr2 and ccr5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progressionJournal of Virology.  76:662-672. 2002
    2001 Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccinesJournal of Virology.  75:8681-8689. 2001
    2001 Novel alleles at the lymphotoxin alpha (LTĪ±) locus mark extended HLA haplotypes in native AfricansHuman Immunology.  62:269-278. 2001
    2001 TAP1 polymorphisms in several human ethnic groups: Characteristics, evolution, and genotyping strategiesHuman Immunology.  62:256-268. 2001
    2001 Genotyping TAP2 variants in North American Caucasians, Brazilians, and AfricansGenes and Immunity.  2:32-40. 2001
    2001 Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infectionHepatology.  33:708-712. 2001
    2001 Is protection in HIV infection due to Bw4 or not to Bw4?Lancet Infectious Diseases.  1:221-222. 2001
    2000 Characteristics of HLA class I and class II polymorphisms in Rwandan womenExperimental and Clinical Immunogenetics.  17:185-189. 2000
    2000 Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infectionGenes and Immunity.  1:386-390. 2000
    1999 Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual menJournal of Infectious Diseases.  180:299-309. 1999
    1999 Identification of bloodmeals in haematophagous Diptera by cytochrome B heteroduplex analysisMedical and Veterinary Entomology.  13:282-287. 1999
    1999 Biased TCR repertoire in infiltrating lesional T cells in human bancroftian filariasisJournal of Immunology.  162:1756-1764. 1999
    1999 Allelic variants of human beta-chemokine receptor 5 (CCR5) promoter: Evolutionary relationships and predictable associations with HIV-1 disease progressionGenes and Immunity.  1:20-27. 1999
    1998 Genetic variation in North American black flies in the subgenus Psilopelmia (Simulium: Diptera: Simuliidae)Canadian Journal of Zoology.  76:205-211. 1998
    1997 Onchocerca volvulus: Comparison of field collection methods for the preservation of parasite and vector samples for PCR analysisBulletin of the World Health Organization.  75:443-447. 1997
    1996 Genotyping North American black flies by means of mitochondrial ribosomal RNA sequencesCanadian Journal of Zoology.  74:39-46. 1996
    1996 Intra-specific heterogeneity of the rDNA internal transcribed spacer in the Simulium damnosum (Diptera: Simuliidae) complexMolecular Biology and Evolution.  13:244-252. 1996
    1996 Molecular phylogeny and typing of blackflies (Diptera: Simuliidae) that serve as vectors of human or bovine onchocerciasisMedical and Veterinary Entomology.  10:228-234. 1996
    1995 Phenotypes of Heligmosomoides polygyrus selected to survive protective immunity in Quackenbush miceJournal of Parasitology.  81:900-904. 1995
    1995 Antigens in phenotypes of Heligmosomoides polygyrus raised selectively from different strains of miceInternational Journal for Parasitology.  25:847-852. 1995
    1995 Discriminating PCR artifacts using directed heteroduplex analysis (DHDA) 1995
    1995 Mitochondrial alleles of Simulium damnosum sensu lato infected with Onchocerca volvulusInternational Journal for Parasitology.  25:1251-1254. 1995
    1995 Optimizing probe selection in directed heteroduplex analysis using HDProbe 1.1 1995
    1995 The Simulium damnosum species complex: phylogenetic analysis and molecular identification based upon mitochondrially encoded gene sequencesInsect Molecular Biology.  4:79-88. 1995

    Chapter

    Year Title Altmetric
    2008 Susceptibility to Human Infectious Diseases, Genetics of. 2008
    2004 The Role of Host Genetic Variation in HIV Infection and its Manifestations.  285-302. 2004

    Research Overview

  • Aging
    HIV/AIDS
    Immunogenetics
    Immunologic Health
  • Teaching Overview

  • Guest lecturer for CLS518 (MSc in Clinical Laboratory Science: Immunology)
  • Education And Training

  • Doctor of Philosophy Level Degree in Parasitology, The University of Queensland 1993
  • Doctor of Veterinary Medicine, Beijing University of Agriculture 1986
  • Full Name

  • Jianming Tang