American Journal of Pathology

Impaired Mitochondria Promote Aging-Associated Sebaceous Gland Dysfunction and Pathology.  192:1546-1558. 2022

Single-Nucleus Transcriptional Profiling of Chronic Kidney Disease after Cisplatin Nephrotoxicity.  192:613-628. 2022

Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis.  191:1227-1239. 2021

In Vivo Tumorigenesis, Osteolytic Sarcomas, and Tumorigenic Cell Lines from Transgenic Mice Expressing the Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Viral Oncogene.  191:335-352. 2021

Mouse Models of Heart Failure with Preserved or Reduced Ejection Fraction.  190:1596-1608. 2020

Return of Individual Research Results: A Guide for Biomedical Researchers Utilizing Human Biospecimens.  190:918-933. 2020

Selective Recruitment of Monocyte Subsets by Endothelial N-Glycans.  190:947-957. 2020

Thrombin-Induced Decidual Colony-Stimulating Factor-2 Promotes Abruption-Related Preterm Birth by Weakening Fetal Membranes.  190:388-399. 2020

Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of Nephronophthisis.  190:176-189. 2020

Role of Apolipoprotein L1 in Human Parietal Epithelial Cell Transition.  188:2508-2528. 2018

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer.  188:1478-1485. 2018

A Shared Pattern of β-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis.  188:853-862. 2018

γδ T Cells Contribute to Injury in the Developing Brain.  188:757-767. 2018

Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease.  188:84-94. 2018

Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.  187:1772-1786. 2017

Adipocyte-Lineage Cells Support Growth and Dissemination of Multiple Myeloma in Bone.  186:3054-3063. 2016

BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea–Induced Gliomagenesis.  186:2551-2554. 2016

Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.  186:2637-2649. 2016

Genomic and Epigenomic Alterations in Cancer.  186:1724-1735. 2016

Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis.  186:1712-1723. 2016

Generation of Novel Thyroid Cancer Stem-Like Cell Clones Effects of Resveratrol and Valproic Acid.  186:1662-1673. 2016

Biological processes discovered by high-throughput sequencing.  186:722-732. 2016

Inhibition of transforming growth factor-β activation diminishes tumor progression and osteolytic bone disease in mouse models of multiple myeloma.  186:678-690. 2016

Insights into environmental factors impacting celiac disease microbiota modulation of disease pathogenesis.  185:2864-2866. 2015

Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.  185:969-986. 2015

Coming into Focus: Computational pathology as the new big data microscope.  185:600-601. 2015

Pathogenesis of necrotizing enterocolitis: Modeling the innate immune response.  185:4-16. 2015

Exosomes: A novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions.  184:28-41. 2014

Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in ptch^+/- mice.  184:1529-1540. 2014

Long interspersed element-1 protein expression is a hallmark of many human cancers.  184:1280-1286. 2014

Matrix biology of idiopathic pulmonary fibrosis: A workshop report of the national heart, lung, and blood institute.  184:1643-1651. 2014

The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression.  184:2342-2354. 2014

CNS inflammation and bone marrow neuropathy in type 1 diabetes.  183:1608-1620. 2013

Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): Role of the host immune response in pathogenesis.  183:1258-1268. 2013

Generation of a dual-functioning antitumor immune response in the peritoneal cavity.  183:1318-1328. 2013

FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.  182:1572-1584. 2013

Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury.  182:1239-1247. 2013

Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.  182:1412-1424. 2013

Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis.  182:646-667. 2013

Nuclear kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells.  181:1836-1846. 2012

Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes.  181:1338-1347. 2012

Myotubularin-deficient myoblasts display increased apoptosis, delayed proliferation, and poor cell engraftment.  181:961-968. 2012

The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma.  180:2108-2119. 2012

Clinical and biological significance of KISS1 expression in prostate cancer.  180:1170-1178. 2012

Participation of miR-200 in pulmonary fibrosis.  180:484-493. 2012

Pivotal role of apoptosis signal-regulating kinase 1 in monoclonal free light chain-mediated apoptosis.  180:41-47. 2012

The dark side of publishing: Promoting ethics in AJP 2003 to 2008.  181:730-732. 2012

Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression.  180:390-398. 2012

Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis.  179:2751-2765. 2011

Proteoglycan 4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells.  179:2431-2442. 2011

Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.  179:1719-1732. 2011

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.  179:1608-1615. 2011

A human-mouse chimeric model of obliterative bronchiolitis after lung transplantation.  179:745-753. 2011

Author's reply.  178:1404-1405. 2011

Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy.  178:2573-2586. 2011

CD14 signaling reciprocally controls collagen deposition and turnover to regulate the development of lyme arthritis.  178:724-734. 2011

Peptide-directed highly selective targeting of pulmonary arterial hypertension.  178:2489-2495. 2011

The development of cutaneous neurofibromas.  178:500-505. 2011

Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells.  176:2490-2499. 2010

Epithelial NF-κB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation.  176:158-167. 2010

Heme oxygenase-1 expression in murine dendritic cell subpopulations: Effect on CD8⁺ dendritic cell differentiation in vivo.  176:2831-2839. 2010

Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin.  176:2039-2050. 2010

Loss of negative feedback control of nuclear factor-κB2 activity in lymphocytes leads to fatal lung inflammation.  176:2646-2657. 2010

TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomes.  177:1606-1610. 2010

The calreticulin-binding sequence of thrombospondin 1 regulates collagen expression and organization during tissue remodeling.  177:1710-1724. 2010

The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms..  175:605-615. 2009

Activation of the wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models.  175:2676-2685. 2009

COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting.  174:1415-1425. 2009

Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation.  175:422-429. 2009

Latent transforming growth factor-β-binding protein-4 regulates transforming growth factor-β1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.  174:21-33. 2009

MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development.  175:856-866. 2009

Renal gene and protein expression signatures for prediction of kidney disease progression.  174:2073-2085. 2009

Suppression of activation and costimulatory signaling in splenic CD4 ⁺ T cells after trauma-hemorrhage reduces t-cell function: A mechanism of post-traumatic immune suppression.  175:1504-1514. 2009

Age-related changes in bone morphology are accelerated in group VIA Phospholipase A2 (iPLA2β)-null mice.  172:868-881. 2008

BRMS1 suppresses breast cancer experimental metastasis to multiple organs by inhibiting several steps of the metastatic process.  172:809-817. 2008

Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (FcγRI)-dependent.  172:22-30. 2008

In the blink of an eye....  172:1443-1444. 2008

Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.  172:893-904. 2008

Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide pro-gly-pro.  173:144-153. 2008

Suppression by CD4⁺CD25⁺ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.  173:154-160. 2008

A thrombospondin-1 antagonist of transforming growth factor-β activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II.  171:777-789. 2007

Bmi-1 is essential for the tumorigenicity of neuroblastoma cells.  170:1370-1378. 2007

Focal adhesion kinase controls ph-dependent epidermal barrier homeostasis by regulating actin-directed Na⁺/H⁺ exchanger 1 plasma membrane localization.  170:2055-2067. 2007

G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage.  170:1210-1218. 2007

Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease.  170:1064-1076. 2007

Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes.  171:415-427. 2007

Activation of mitogen-activated protein kinases by lysophosphatidylcholine- induced mitochondrial reactive oxygen species generation in endothelial cells.  168:1737-1748. 2006

Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice.  168:1425-1434. 2006

Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3′-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein.  169:1833-1842. 2006

Introducing biological perspectives.  169:337. 2006

JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-α.  169:889-902. 2006

Kupffer cells and their mediators: The culprits in producing distant organ damage after trauma-hemorrhage.  169:784-794. 2006

Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis.  169:1999-2013. 2006

The metabolic syndrome: A high-risk state for cancer?.  169:1505-1522. 2006

Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endothelium.  167:1661-1675. 2005

Cathepsin deficiency as a model for neuronal ceroid lipofuscinoses.  167:1473-1476. 2005

Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts.  167:705-719. 2005

Creutzfeldt-Jakob disease (CJD) with a mutation at codon 148 of prion protein gene: Relationship with sporadic CJD.  167:1729-1738. 2005

Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis.  167:365-379. 2005

Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy.  167:1621-1630. 2005

P-selectin can support both Th1 and Th2 lymphocyte rolling in the intestinal microvasculature.  167:1647-1660. 2005

Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma.  165:1151-1161. 2004

C5a-Induced Gene Expression in Human Umbilical Vein Endothelial Cells.  164:849-859. 2004

CD4⁺CD45RB^Hi interleukin-4 defective T cells elicit antral gastritis and duodenitis.  165:1257-1268. 2004

Evolutionary change and The American Journal of Pathology.  165:1055-1056. 2004

Heme oxygenase-1 modulates early inflammatory responses: Evidence from the heme oxygenase-1-deficient mouse.  165:1045-1053. 2004

Interaction of Nkx3.1 and p27^kip1 in Prostate Tumor Initiation.  164:1607-1614. 2004

Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas^lpr mice from autoimmune disease.  165:609-616. 2004

Pathological Role of Large Intestinal IL-12p40 for the induction of Th2-Type Allergic Diarrhea.  164:1327-1335. 2004

Pericyte-Like Location of GFP-Tagged Melanoma Cells: Ex Vivo and in Vivo Studies of Extravascular Migratory Metastasis.  164:1191-1198. 2004

Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-β in response to fibrogenic stimuli.  165:659-669. 2004

Psoriasiform dermatitis susceptibility in Itgb2^tm1Bay PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe disease.  163:197-202. 2003

Intimal exuberance: Veins in jeopardy.  162:1759-1761. 2003

Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy.  162:413-425. 2003

Association of Aortic Atherosclerosis with Cerebral β-Amyloidosis and Learning Deficits in a Mouse Model of Alzheimer's Disease.  163:2155-2164. 2003

Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression.  162:19-27. 2003

Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation.  161:2169-2178. 2002

Changes in differential gene expression because of warm ischemia time of radical prostatectomy specimens.  161:1743-1748. 2002

Expression of geminin as a marker of cell proliferation in normal tissues and malignancies.  161:267-273. 2002

α-Methylacyl-CoA racemase: Expression levels of this novel cancer biomarker depend on tumor differentiation.  161:841-848. 2002

Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae).  158:333-341. 2001

Glomeruloid microvascular proliferation orchestrated by VPF/VEGF: A new world of angiogenesis research.  158:789-796. 2001

Mapping the binding domain of immunoglobulin light chains for Tamm-Horsfall protein.  158:1859-1866. 2001

Potential role of modifier genes influencing transforming growth factor-β1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia.  158:2011-2020. 2001

The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys.  159:1735-1742. 2001

Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction.  159:639-650. 2001

Glucose stimulation of transforming growth factor-β bioactivity in mesangial cells is mediated by thrombospondin-1.  157:1353-1363. 2000

Human nasopharyngeal-associated lymphoreticular tissues: Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils.  157:2023-2035. 2000

Activation of rat alveolar macrophage-derived latent transforming growth factor β-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36.  155:841-851. 1999

Apoptosis and tumorigenesis in human cholangiocarcinoma cells: Involvement of Fas/APO-1 (CD95) and calmodulin.  155:193-203. 1999

Post-transcriptional induction of p21cip1 protein in condylomata and dysplasias is inversely related to human papillomavirus activities.  152:1015-1024. 1998

Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice.  152:391-398. 1998

Post-infarction left ventricular remodeling induces changes in creatine kinase mRNA and protein subunit levels in porcine myocardium.  151:257-264. 1997

Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant: A new model to study the liver lesion.  150:2231-2241. 1997

Isolation and characterization of liver epithelial cell lines from wild- type and mutant TgN737Rpw mice.  150:1189-1197. 1997

Lymphocytes from orally tolerized mice display enhanced susceptibility to death by apoptosis when cultured in the absence of antigen in vitro.  149:1971-1979. 1996

Oval cell proliferation associated with the murine insertional mutation TgN737Rpw.  149:1919-1930. 1996

Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis.  149:1553-1564. 1996

Role of calmodulin in HIV-potentiated fas-mediated apoptosis.  149:903-910. 1996

Effects of mutation and growth rates on patterns of microsatellite instability.  148:1757-1761. 1996

Stage-specific expression of integrin αvβ3 in neuroblastic tumors.  148:1423-1434. 1996

Stearate inhibition of breast cancer cell proliferation: A mechanism involving epidermal growth factor receptor and G-proteins.  148:987-995. 1996

Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases.  148:331-339. 1996

Highly metastatic 13762NF rat mammary adenocarcinoma cell clones stimulate bone marrow by secretion of granulocyte-macrophage colony-stimulating factor/interleukin-3 activity.  147:1668-1681. 1995

Pathogenesis of glomerulosclerosis in light chain deposition disease: Role for transforming growth factor-β.  147:375-385. 1995

Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB.  145:1399-1410. 1994

Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4.  142:1239-1250. 1993

Transgenic mice that develop pituitary tumors: A model for Cushing's disease.  140:1071-1080. 1992

Molecular features of hypothalamic plaques in Alzheimer's disease.  139:681-691. 1991

In vitro and in vivo growth and differentiation of clones of tracheal basal cells.  134:539-549. 1989

Induction of Ia antigen expression on murine islet parenchymal cells does not diminish islet allograft survival.  134:237-242. 1989

Cardiac matrix alterations induced by adriamycin.  133:298-305. 1988

Tumor necrosis factor enhances interferon-induced Ia antigen expression on murine islet parenchymal cells.  130:427-430. 1988

Transmural progression of morphologic changes during ischemic contracture and reperfusion in the normal and hypertrophied rat heart.  129:152-167. 1987

Morphologic and immunohistochemical observations in granulomatous glomerulonephritis.  126:581-591. 1987

Analysis of changes in rat prostate carcinoma following hormone deprivation.  128:566-572. 1987

The epithelial origin of a stromal cell population in adenocarcinoma of the rat prostate.  128:555-565. 1987

Serologic and pathologic studies of mice immunized with homologous fibronectin.  125:182-190. 1986

In vitro inhibition of human sarcoma cells invasive ability by bis(5-amidino-2-benzimidazolyl)methane: A novel esteroprotease inhibitor.  123:46-56. 1986

Detection of autoantibodies and glomerular injury in rabbits immunized with denatured human fibronectin monomer.  117:1-11. 1984

Heterogeneity and subcompartmentalization in the distribution of eosinophils in human colonic carcinomas.  116:207-213. 1984

The heterogeneity of LDH isoenzyme patterns of human uterine sarcomas and cultured sarcoma cell lines.  116:85-93. 1984

Development of the adult respiratory distress syndrome: Progressive alteration of neutrophil chemotactic and secretory processes.  116:427-435. 1984

Phenytoin sensitivity of fibroblasts as the basis for susceptibility to gingival enlargement.  112:218-223. 1983

An ultrastructural study of alveolar permeability to cytochrome C in the rabbit lung. Effect of exposure to 100% oxygen at one atmosphere.  102:1-9. 1981

Morphologic and immunofluorescence studies of the effect of fibroblast growth factor on the culture of guinea pig glomerular cell strains.  103:129-136. 1981

The growth of primary glomerular cells as a confluent monolayer in a chemically defined serum-free medium. Specific requirements for prostaglandins and extracellular matrix molecules.  104:181-188. 1981

Growth and maintenance of glomerular cells under defined conditions.  101:195-203. 1980

Separation of cells with histochemically demonstrable acid phosphatase activity from suspensions of human prostatic cells in an isokinetic gradient of Ficoll in tissue culture medium.  80:79-90. 1975