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Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis
Sex-specific aging in animals: Perspective and future directions
Rhesus monkeys as a translational model for late-onset Alzheimer's disease
Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration
Physiological and metabolic characteristics of novel double-mutant female mice with targeted disruption of both growth hormone-releasing hormone and growth hormone receptor
mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial
Neuronal-specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age-related cognitive decline.
Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice
Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan.
Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease
Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health
Pathophysiology of heart failure and frailty: a common inflammatory origin?
Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan.
Long-lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high-fat diet on metabolic function and energy expenditure
Regional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction
Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice
Do altered energy metabolism or spontaneous locomotion 'mediate' decelerated senescence?
Genetic variants modify the effect of age on APOE methylation in the genetics of lipid lowering drugs and diet network study
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK
A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys
Modulation of methuselah expression targeted to Drosophila insulin-producing cells extends life and enhances oxidative stress resistance
The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia
Comparative biology of mammalian telomeres: Hypotheses on ancestral states and the roles of telomeres in longevity determination
Attenuation of liver insoluble protein carbonyls: Indicator of a longevity determinant?
Recent advances in vertebrate aging research 2009
Calorie restriction effects on silencing and recombination at the yeast rDNA
Effects of myostatin deletion in aging mice
Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging
Advances in vertebrate aging research 2007
Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
Vertebrate aging research 2006
Does caloric restriction extend life in wild mice?
Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size
Is aging programmed?
Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts
Rebuttal to Bredesen: 'The non-existent aging program: How does it work?'
Innate immunity in aging: Impact on macrophage function
Are mice calorically restricted in nature?
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