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Correction: Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation (Oncogene, (2020), 39, 9, (1846-1859), 10.1038/s41388-019-1104-z).
Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation.
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Correction: EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway (Oncogene, (2020), 39, 5, (1041-1048), 10.1038/s41388-019-1036-7).
EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway.
Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progression
Oncolytic herpes simplex virus immunotherapy for brain tumors: current pitfalls and emerging strategies to overcome therapeutic resistance.
MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer.
Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy.
Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.
JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity.
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.
Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.
Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.
KLF6 depletion promotes NF-κB signaling in glioblastoma.
LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism.
MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.
SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans.
Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1.
Runx1 contributes to neurofibromatosis type 1 neurofibroma formation.
The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models.
Erratum: Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation (Oncogene (2015) 34 (3881) DOI:10.1038/onc.2015.204).
Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.
Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation.
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids..
ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin.
Phosphodiesterase 10A: A novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.
ASC deficiency suppresses proliferation and prevents medulloblastoma incidence..
PTEN functions as a melanoma tumor suppressor by promoting host immune response.
Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signaling.
MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma.
Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer.
Soluble E-cadherin: A critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling.
ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis.
Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation.
Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation.
PI3K regulation of the SKP-2/p27 axis through mTORC2.
TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells.
SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells.
MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.
A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40kDa vasculostatin from tumor suppressor BAI1.
Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs.
Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair.
DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.
Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.
Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer..
A mouse model of heterogeneous, c-MYC-initiated prostate cancer with loss of Pten and p53.
The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma.
MiR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT.
NF-κB addiction and its role in cancer: One size does not fit all.
Prognostic significance of BRMS1 expression in human melanoma and its role in tumor angiogenesis.
The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.
Increased cell migration and plasticity in Nrf2-deficient cancer cell lines.
The prolyl isomerase Pin1 regulates the NF-B signaling pathway and interleukin-8 expression in glioblastoma.
Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma.
Repression of E-cadherin by the polycomb group protein EZH2 in cancer.
Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver.
Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells.
Regulation of normal cell cycle progression by flavin-containing oxidases.
Erratum: HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells (Oncogene (2006) 25, (1721-1732) DOI: 10.1038/sj.onc.1209199).
Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents.
Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases.
A novel antioxidant 3-O-Caffeoyl-1-methylquinic acid enhances ultraviolet A-mediated apoptosis in immortalized HaCaT keratinocytes via Sp1-dependent transcriptional activation of p21WAF1/Cip1.
Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity.
Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy.
Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-κB activation in normal human bronchial epithelial cells.
Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells.
Proteomic identification of the wt-p53-regulated tumor cell secretome.
Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death.
HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells.
Unique aspects of mda-7/IL-24 antitumor bystander activity: Establishing a role for secretion of MDA-7/IL-24 protein by normal cells.
Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors.
Expression of DLK1 in hematopoietic cells results in inhibition of differentiation and proliferation.
Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor.
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.
Induction of KLF4 in basal keratinocytes blocks the proliferation- differentiation switch and initiates squamous epithelial dysplasia.
Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21CIP1 levels in androgen-independent human prostate cancer cells.
Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice.
Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin.
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression.
Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappaB and induction of apoptosis.
Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes.
Regulation of apoptosis proteins in cancer cells by ubiquitin.
A novel time-course cDNA microarray analysis method identifies genes associated with the development of cisplatin resistance.
Peroxisome proliferator-activated receptor-γ activation inhibits tumor progression in non-small-cell lung cancer.
Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice.
Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells.
Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1.
Ras oncogene directs expression of a differentially sialylated, functionally altered β1 integrin.
p73 can suppress the proliferation of cells that express mutant p53.
Characterization of p73 functional domains necessary for transactivation and growth suppression.
A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy.
Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway.
Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate.
Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.
Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells.
Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells..
The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells.
The leukemia-associated transcription repressor aml1/mds1/evi1 requires ctbp to induce abnormal growth and differentiation of murine hematopoietic cells.
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.
Pathological splice mutations outside the invariant AG/GT splice sites of BRCA1 exon 5 increase alternative transcript levels in the 5′ end of the BRCA1 gene.
The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis.
TGF-β1 up-regulates paxillin protein expression in malignant astrocytoma cells: Requirement for a fibronectin substrate.
HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLα and hMLH1-hEXO1 complexes.
Quantitative real-time PCR does not show selective targeting of p14ARF but concomitant inactivation of both p16INK4A and p14ARF in 105 human primary gliomas.
Transcriptional regulation of the human osteopontin promoter: Functional analysis and DNA-protein interactions.
The Src/Csk regulatory circuit arose early in metazoan evolution.
p53 gene mutation and ink4a-arf-deletion appear to be two mutually exclusive events in human glioblastoma.
The p44(S10) locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma.
Increased protein kinase Cδ in mammary tumor cells: Relationship to transformation and metastatic progression.
Mitochondrial DNA determines the cellular response to cancer therapeutic agents.
Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes.
Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.
Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice.
Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma.
Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene.
Post-transcriptional induction of p21cip1 protein by human papillomavirus E7 inhibits unscheduled DNA synthesis reactivated in differentiated keratinocytes.
Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.
Genetic instability leads to loss of both p53 alleles in a human glioblastoma.
New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26.
Novel BRCA1 mutations and more frequent intron-20 alteration found among 236 women from Western Poland.
The role of p27(Kip1) in gamma interferon-mediated growth arrest of mammary epithelial cells and related defects in mammary carcinoma cells.
The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene.
ts BCR-ABL kinase activation confers increased resistance to genotoxic damage via cell cycle block.
Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: Activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q.
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells.
Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity.
Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity.
Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection.
Evidence for tau expression in cells of monocyte lineage and its in vitro phosphorylation by v-fms kinase.
In vitro and in vivo growth control of transformed lymphoid cells expressing plasma membrane galactosyltransferase.