Science

Haplotype-resolved diverse human genomes and integrated analysis of structural variation.  372. 2021

Improve traffic death statistics in China.  362:650. 2018

Comment on "the plateau of human mortality: Demography of longevity pioneers".  361. 2018

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells.  361. 2018

Erratum: The Report “Translocation of a gut pathobiont drives autoimmunity in mice and humans”(Science (2018)360:6388 (eaat9922)DOI: 10.1126/science.aar7201).  360. 2018

Translocation of a gut pathobiont drives autoimmunity in mice and humans.  359:1156-1161. 2018

Extremely efficient internal exciton dissociation through edge states in layered 2D perovskites.  355:1288-1292. 2017

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.  354. 2016

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.  354. 2016

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.  353. 2016

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.  353. 2016

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.  353. 2016

Full speed ahead to the City on the Hill.  352:887-887. 2016

Mitochondrial-nuclear DNA mismatch matters.  349:1449-1450. 2015

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.  348:1160-1163. 2015

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.  348:1031-1035. 2015

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.  347:1436-1441. 2015

Time-restricted feeding attenuates age-related cardiac decline in Drosophila.  347:1265-1269. 2015

China's balancing act.  346:1194. 2014

Selection bias at the heterosexual HIV-1 transmission bottleneck.  345. 2014

Constitutive  -Opioid Receptor Activity Leads to Long-Term Endogenous Analgesia and Dependence.  341:1394-1399. 2013

NextGen speaks [3].  340:28-29. 2013

Transmission studies resume for avian flu.  339:520-521. 2013

Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids.  339:335-339. 2013

Path to treat rett syndrome.  342:318-320. 2013

Putting health science into health education.  341:128. 2013

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.  342:971-976. 2013

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-Synuclein toxicity in neurons.  342:979-983. 2013

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent.  338:1465-1469. 2012

Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses.  337:1553-1556. 2012

Pause on avian flu transmission research.  335:400-401. 2012

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.  334:1241-1245. 2011

Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior.  333:1642-1646. 2011

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.  333:765-769. 2011

Evidence for Network Evolution in an Arabidopsis Interactome Map.  333:601-607. 2011

Independently evolved virulence effectors converge onto hubs in a plant immune system network.  333:596-601. 2011

Retraction (Science).  333:404. 2011

The ecoresponsive genome of Daphnia pulex.  331:555-561. 2011

Identification of functional elements and regulatory circuits by Drosophila modENCODE.  330:1787-1797. 2010

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.  330:1551-1557. 2010

Perspective: Residency 101 for Physician-Scientists 2010

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.  330:90-94. 2010

Studies support probable long-term safety of MRI.  329:512-513. 2010

Tumor immune evasion.  328:697-698. 2010

Cryo-EM model of the bullet-shaped vesicular stomatitis virus.  327:689-693. 2010

Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a pitxl enhancer.  327:302-305. 2010

Induced chromosomal proximity and gene fusions in prostate cancer.  326:1230. 2009

Comment on "the Arabiclopsis circadian clock incorporates a cADPR-based feedback loop".  326. 2009

Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice.  325:484-487. 2009

Caloric restriction delays disease onset and mortality in rhesus monkeys.  325:201-204. 2009

A vital role for Interleukin-21 in the control of a chronic viral infection.  324:1572-1576. 2009

Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1.  324:1289-1293. 2009

Human induced pluripotent stem cells free of vector and transgene sequences.  324:797-801. 2009

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.  323:1718-1722. 2009

Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy..  323:124-127. 2009

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.  322:1695-1699. 2008

The widespread threat of calcium decline in fresh waters.  322:1374-1377. 2008

Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation.  321:1350-1353. 2008

Plant immunity requires conformational charges of NPR1 via S-nitrosylation and thioredoxins.  321:952-956. 2008

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.  320:674-677. 2008

Worldwide human relationships inferred from genome-wide patterns of variation.  319:1100-1104. 2008

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.  318:1920-1923. 2007

Comment on "Emergence of novel color vision in mice engineered to express a human cone photopigment".  318. 2007

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.  318:71-76. 2007

Problems with genome-wide association studies [2].  316:1840-1841. 2007

Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity.  316:1916-1919. 2007

Genome-wide mapping of in vivo protein-DNA interactions.  316:1497-1502. 2007

Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model.  316:750-754. 2007

A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission.  315:655-659. 2007

A plea for justice for jailed medical workers [4].  314:924-925. 2006

100 Years and counting: Prospects for defeating Alzheimer's disease.  314:781-784. 2006

Genome sequence diversity and clues to the evolution of variola (smallpox) virus.  313:807-812. 2006

Structure of the vesicular stomatitis virus nucleoprotein-RNA complex.  313:357-360. 2006

α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.  313:324-328. 2006

Response [2].  311:1552. 2006

Response [4].  311:1241-1242. 2006

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.  310:644-648. 2005

Epidemiology: Transmission of equine influenza virus to dogs.  310:482-485. 2005

Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome.  310:317-320. 2005

Characterization of the reconstructed 1918 Spanish influenza pandemic virus.  310:77-80. 2005

Widespread parallel evolution in sticklebacks by repeated fixation of ectodysplasin alleles.  307:1928-1933. 2005

Retraction [1].  307:206. 2005

Femtomolar sensitivity of a NO sensor from Clostridium botulinum.  306:1550-1553. 2004

The ENCODE (ENCyclopedia of DNA Elements) Project.  306:636-640. 2004

Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.  304:1940-1944. 2004

Regulation of Fasted Blood Glucose by Resistin.  303:1195-1198. 2004

The Structure of a Mycobacterial Outer-Membrane Channel.  303:1189-1192. 2004

T-bet or Not T-bet.  302:993-994. 2003

Human chromosome 7: DNA sequence and biology.  300:767-772. 2003

Role of Histone H3 Lysine 27 Methylation in X Inactivation.  300:131-135. 2003

Obesity and the environment: Where do we go from here?.  299:853-855. 2003

Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing.  298:1039-1043. 2002

Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes.  297:1301-1310. 2002

Requirement for hippocampal CA3 NMDA receptors in associative memory recall.  297:211-218. 2002

Myeloperoxidase, a leukocyte-derived vascular NO oxidase.  296:2391-2394. 2002

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.  296:2238-2243. 2002

Functional neuroanatomical differences between adults and school-age children in the processing of single words.  296:1476-1479. 2002

Science policy: The NIH budget in the "Postdoubling" era.  296:1401-1402. 2002

Divided by cytochrome oxidase: A map of the projections from V1 to V2 in macaques.  295:1734-1737. 2002

SIVcpz in wild chimpanzees.  295:465. 2002

Distinct effects of T-bet in Th1 lineage commitment and IFN-γ production in CD4 and CD8 T cells.  295:338-342. 2002

Dietary fat: At the heart of the matter [3] (multiple letter).  293:801-804. 2001

Dietary fat: at the heart of the matter..  293:801-804. 2001

Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor.  293:853-857. 2001

Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.  293:702-705. 2001

A high-resolution radiation hybrid map of the human genome draft sequence.  291:1298-1302. 2001

Cell Biology: Principles for the buffering of genetic variation.  291:1001-1004. 2001

Canine detectives: The nose knows - Or does it? [1].  290:1093. 2000

Limits to our knowledge [1].  287:1399. 2000

The role of CCR7 in T(H)1 and T(H)2 cell localization and delivery of B cell help in vivo.  286:2159-2162. 1999

Requirement for B cell linker protein (BLNK) in B cell development.  286:1949-1954. 1999

CFTR chloride channel regulation by an interdomain interaction.  286:544-548. 1999

X-ray crystallographic structure of the Norwalk virus capsid.  286:287-290. 1999

Erratum: Large animals in the fast lane (Sciences (July 9) (199)).  285:665. 1999

Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health..  285:666-667. 1999

Proposed changes for NIH's center for scientific review.  285:666-667. 1999

Large animals in the fast lane [1].  285:199. 1999

Erratum: (Science (April 23, 1999) (548-549)).  284:1623. 1999

Efficient persistence of extrachromosomal KSHV DNA mediated by latency- associated nuclear antigen.  284:641-644. 1999

A physical map of 30,000 human genes.  282:744-746. 1998

Distance modulation of neural activity in the visual cortex.  281:552-555. 1998

Environmental contributions to the obesity epidemic.  280:1371-1374. 1998

Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.  279:393-396. 1998

Transcription regulation by initiating NTP concentration: rRNA synthesis in bacteria.  278:2092-2097. 1997

Knockout-transgenic mouse model of sickle cell disease.  278:873-876. 1997

Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling.  275:841-844. 1997

Human homolog of patched, a candidate gene for the basal cell nevus syndrome.  272:1668-1671. 1996

Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).  271:1731-1734. 1996

Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers.  271:1289-1291. 1996

A gene map of the human genome.  274:540-546. 1996

Programmed cell death [3].  274:20-21. 1996

Earth's curying capacity [3].  270:898. 1995

Earth's carrying capacity..  270:898-899. 1995

Response..  267:1667. 1995

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.  269:242-244. 1995

Increased cortical representation of the fingers of the left hand in string players.  270:305-307. 1995

The body temperature of Tyrannosaurus rex [7].  267:1667. 1995

Assessing mapping progress in the human genome project.  265:2031-2032. 1994

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin.  264:703-707. 1994

Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule.  263:1759-1762. 1994

Protein configurations [4].  265:1510. 1994

Protein configurations [6].  265:1511. 1994

Seaborgium: Name not yet approved by ACS [7].  265:303. 1994

Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.  262:1056-1059. 1993

High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.  259:1749-1754. 1993

Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45.  260:544-546. 1993

Response [2].  260:1705-1706. 1993

The pluses of subtraction.  259:942-943. 1993

Erratum: Centriole duplication in lysates of Spisula solidissima oocytes (Science (219-221)).  256:1746. 1992

The time course of glutamate in the synaptic cleft..  258:1498-1501. 1992

Centriole duplication in lysates of Spisula solidissima oocytes.  256:219-221. 1992

Forensic DNA typing [2].  255:1050. 1992

Regulation of plasma membrane recycling by CFTR.  256:530-532. 1992

Specialized role for a murine class I-b MHC molecule in prokaryotic host defenses.  257:678-679. 1992

Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization..  251:1481-1485. 1991

Chloride conductance expressed by ΔF508 and other mutant CFTRs in xenopus oocytes.  254:1797-1799. 1991

Concurrent processing and complexity of temporally encoded neuronal messages in visual perception.  253:675-677. 1991

Experimental therapy of human glioma by means of a genetically engineered virus mutant.  252:854-856. 1991

Massive cortical reorganization after sensory deafferentation in adult macaques.  252:1857-1860. 1991

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.  254:432-437. 1991

Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45.  252:1839-1842. 1991

Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45..  252. 1991

Regulation of phagocytosis and [Ca²⁺]i flux by distinct regions of an Fc receptor.  254:1785-1788. 1991

Mapping of herpes simplex virus-1 neurovirulence to γ134.5, a gene nonessential for growth in culture.  250:1262-1266. 1990

Human sickle hemoglobin in transgenic mice.  247:566-568. 1990

Identification of mutations in the COL4A5 collagen gene in Alport syndrome.  248:1224-1227. 1990

Radiation hybrid mapping: A somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes.  250:245-250. 1990

Structural mutations of the T cell receptor ζ chain and its role in T cell activation.  249:174-177. 1990

Unusual topogenic sequence directs prion protein biogenesis.  248:226-229. 1990

Activation-driven programmed cell death and T cell receptor ζη expression.  246:1162-1165. 1989

Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.  244:1184-1186. 1989

Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor.  244:1163-1165. 1989

Class II MHC molecules are specific receptors for Staphylococcus enterotoxin A.  244:817-820. 1989

Murine MHC polymorphism and T cell specificities.  244:572-575. 1989

Persistence of abnormal chloride conductance regulation in transformed cystic fibrosis epithelia.  244:1472-1475. 1989

Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus.  245:60-63. 1989

Structure and specificity of a class II MHC alloreactive γδ T cell receptor heterodimer.  245:746-749. 1989

Synthesis of functional human hemoglobin in transgenic mice.  245:971-973. 1989

The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias.  246:379-382. 1989

Inhibition of self-binding antibodies (autobodies) by a V H-derived peptide.  240:1034-1036. 1988

Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets.  242:1702-1705. 1988

West African HIV-2-related human retrovirus with attenuated cytopathicity.  240:1525-1529. 1988

Response: virus-induced increases in plasma corticosterone..  238:1424-1425. 1987

Absence of duplication of chromosome 21 genes in familial and sporadic alzheimer's disease.  238:664-666. 1987

Availability of human tissues for research in cancer [4].  237:10-11. 1987

Distribution of cones in human and monkey retina: Individual variability and radial asymmetry.  236:579-582. 1987

Early restriction of the human antibody repertoire.  238:791-793. 1987

Germline organization of the murine T cell receptor β-chain genes.  238:545-548. 1987

Immunological self, nonself discrimination.  235:865-870. 1987

The genetic defect causing familial Alzheimer's disease maps on chromosome 21.  235:885-890. 1987

Transposition of gram-positive transposon Tn916 in acholeplasma laidlawii and mycoplasma pulmonis.  235:1392-1394. 1987

Virus-induced increases in plasma corticosterone [9].  238:1424-1425. 1987

Conformations of signal peptides induced by lipids suggest initial steps in protein export.  233:206-208. 1986

Crystal structures at megabar pressures determined by use of the Cornell synchrotron source.  231:1136-1138. 1986

Fine structure genetic analysis of a β-globin promoter.  232:613-618. 1986

A general method for saturation mutagenesis of cloned DNA fragments.  229:242-247. 1985

Atriopeptin-immunoreactive neurons in the brain: Presence in cardiovascular regulatory areas.  227:1047-1049. 1985

Corticotropin-releasing activity of monokines.  230:1035-1037. 1985

Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes.  230:1242-1246. 1985

Developmentally controlled expression of immunoglobulin VH genes.  227:1597-1601. 1985

Solitary grazers.  228:1485. 1985

Autoimmunity and increased c-myb transcription.  226:1087-1089. 1984

Nucleotide sequences of the human and mouse atrial natriuretic factor genes.  226:1206-1209. 1984

The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone.  225:324-326. 1984

Cell-to-cell transfer of interferon-induced antiproliferative activity.  221:953-955. 1983

A specific and enduring improvement in visual motion discrimination.  218:697-698. 1982

Cytoplasmic calcium in the mediation of macula densa tubulo-glomerular feedback responses.  215:670-673. 1982

Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells.  217:157-158. 1982

Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid adrenal axis.  218:1311-1312. 1982

A novel illusion of bars made from triangles.  212:1172-1175. 1981

Foot-length asymmetry, sex, and handedness.  212:1417-1419. 1981

Human aging and spatial vision.  209:1255-1256. 1980

Immunoglobulin gene rearrangement in immature B cells.  209:1366-1369. 1980

Hybrid ape offspring of a mating of gibbon and siamang.  205:308-310. 1979

Intraretinal distribution of cone pigments in certain teleost fishes.  204:523-526. 1979

Loss of Y-cells in the lateral geniculate nucleus of monocularly deprived tree shrews.  197:784-786. 1977

Mental set alters visibility of moving targets.  198:60-62. 1977

Trichromatic vision in the cat.  198:753-755. 1977

Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity.  192:1238-1240. 1976

Tunneling in ligand binding to heme proteins.  192:1002-1004. 1976

Isolated brain microvessels: A purified, metabolically active preparation from bovine cerebral cortex.  185:953-955. 1974

Behavioral development after forelimb deafferentation on day of birth in monkeys with and without blinding.  181:959-960. 1973

Prism adaptation: Control of intermanual transfer by distribution of practice.  180:755-757. 1973

Serological identification of an Ir-region product.  181:167-168. 1973

Somatic evoked response recording: An adequate test of deafferentation?.  181:187-188. 1973

A Fluorescent modification of adenosine triphosphate with activity in enzyme systems: 1,N⁶-ethenoadenosine triphosphate.  175:646-647. 1972

Fluorescent modification of adenosine 3′,5′-monophosphate: Spectroscopic properties and activity in enzyme systems.  177:279-280. 1972

Summated cortical evoked response testing in the deafferented primate.  178:1113-1115. 1972

Immunoglobulin M and secretory immunoglobulin A: Presence of a common polypeptide chain different from light chains.  171:1163-1165. 1971

Dermo-optical perception..  152:1109. 1966

Dermo-optical perception..  152:1109. 1966

Deafferentation in monkeys: Effect on conditioned grasp response.  151:593-594. 1966

Effect of deafferentation on a conditioned avoidance response.  128:842-843. 1958