Free Radical Biology and Medicine

Journal

Publication Venue For

  • Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents.  141:408-415. 2019
  • Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension.  134:343-349. 2019
  • The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetes.  125:81-89. 2018
  • Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart.  124:447-453. 2018
  • Rust never sleeps: The continuing story of the Iron Bolt.  124:353-357. 2018
  • An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clock.  119:75-84. 2018
  • Circadian regulation of renal function.  119:93-107. 2018
  • Introduction to special issue: Circadian regulation of metabolism, redox signaling and function in health and disease.  119:1-2. 2018
  • Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling.  108:918-928. 2017
  • Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.  102:217-228. 2017
  • TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity.  102:260-273. 2017
  • Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism.  100:94-107. 2016
  • Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension..  95:96-111. 2016
  • Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism.  91:143-153. 2016
  • Hydrogen Sulfide Alters M. Tuberculosis Bioenergetics and Promotes Tuberculosis Disease.  87:S141-S141. 2015
  • Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis.  86:47-56. 2015
  • Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage.  85:207-218. 2015
  • Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation.  85:83-94. 2015
  • Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence.  79:197-205. 2015
  • Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage.  81:22-29. 2015
  • Exposure to Cigarette Smoke Causes DNA Damage and Contributes to Drug Resistance in Mycobacterium Tuberculosis.  76:S166-S167. 2014
  • A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetes.  67:437-450. 2014
  • Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167..  67:255-264. 2014
  • Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics.  71:196-207. 2014
  • Mechanistic Insights into the Role of Hydrogen Sulfide in Mycobacterial Disease and Persistence.  65:S62-S62. 2013
  • Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688)).  58:45. 2013
  • Dietary patterns are associated with plasma F2-isoprostanes in an observational cohort study of adults.  57:201-209. 2013
  • Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo.  55:119-129. 2013
  • Temporal patterns of tyrosine nitration in embryo heart development.  55:101-108. 2013
  • Cellular metabolic and autophagic pathways: Traffic control by redox signaling.  63:207-221. 2013
  • Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons.  65:1215-1228. 2013
  • Mitochondrial genetics and obesity: Evolutionary adaptation and contemporary disease susceptibility.  65:1229-1237. 2013
  • Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products.  59:56-68. 2013
  • Vascular peroxidase 1 catalyzes the formation of hypohalous acids: Characterization of its substrate specificity and enzymatic properties.  53:1954-1959. 2012
  • Administration of nitrite after chlorine gas exposure prevents lung injury: Effect of administration modality.  53:1431-1439. 2012
  • Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model.  53:554-563. 2012
  • Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice.  52:2047-2056. 2012
  • Corrigendum to "Ozone exposure is a risk factor for Alzheimer's disease" [Free Radical Biology and Medicine (2011) 51 (S68)).  52:1334. 2012
  • Metabolic syndrome and mitochondrial dysfunction: Insights from preclinical studies with a mitochondrially targeted antioxidant.  52:838-840. 2012
  • Measuring reactive oxygen and nitrogen species with fluorescent probes: Challenges and limitations.  52:1-6. 2012
  • Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.  51:2007-2017. 2011
  • Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload.  51:1975-1984. 2011
  • Assessing bioenergetic function in response to oxidative stress by metabolic profiling.  51:1621-1635. 2011
  • Reactive Oxygen Species and the Macroalgal Wound Response.  51:S106-S107. 2011
  • Role of VPO1, a newly identified heme-containing peroxidase, in ox-LDL induced endothelial cell apoptosis.  51:1492-1500. 2011
  • Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling.  51:1271-1288. 2011
  • Vascular peroxidase-1 is rapidly secreted, circulates in plasma, and supports dityrosine cross-linking reactions.  51:1445-1453. 2011
  • Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy.  51:805-812. 2011
  • Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse.  51:406-416. 2011
  • Elevated levels of NO are localized to distal airways in asthma.  50:1679-1688. 2011
  • Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stress.  50:262-269. 2011
  • Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury.  49:1273-1282. 2010
  • ICAM-1 cytoplasmic tail regulates endothelial glutathione synthesis through a NOX4/PI3-kinase-dependent pathway.  49:1119-1128. 2010
  • Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels.  49:339-347. 2010
  • Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overload.  49:401-407. 2010
  • Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species.  48:905-914. 2010
  • Effects of T-state and R-state stabilization on Deoxyhemoglobin-nitrite Reactions and Stimulation of Nitric Oxide (NO) Signaling.  49:S111-S111. 2010
  • Oxidative stress and glutathione in TGF-β-mediated fibrogenesis.  48:1-15. 2010
  • Post–Cl2 Exposure Therapeutics Using Nitrite: Different Effects of IM vs. IP Administration.  49:S196-S196. 2010
  • Role of Hemoglobin Beta93Cys as an Antioxidant in the Vascular Compartment: Implications for Vascular Homeostasis During Endotoxemia.  49:S150-S150. 2010
  • The Effects of Red Blood Cell Storage Time on Nitric Oxide and Nitrite-dependent Signaling.  49:S30-S30. 2010
  • The Role of Reactive Oxygen Species in Antiherbivore Defense along the Western Antarctic Peninsula.  49:S98-S98. 2010
  • Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes.  47:1753-1761. 2009
  • Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.  47:917-923. 2009
  • Methods for the determination and quantification of the reactive thiol proteome.  47:675-683. 2009
  • Methods for imaging and detecting modification of proteins by reactive lipid species.  47:201-212. 2009
  • Ozone Induces Pulmonary Fibrosis via a TGF-beta Signaling Pathway.  47. 2009
  • Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE-/- mouse: Implications for a "multihit" hypothesis of fatty liver disease.  46:928-938. 2009
  • Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.  46:866-875. 2009
  • Supression of hemin-mediated oxidation of low-density lipoprotein and subsequent endothelial reactions by hydrogen sulfide (H2S).  46:616-623. 2009
  • Antioxidant Role of Hemoglobin Beta93 Cysteine in the Red Blood Cell and the Vascular Compartment.  47:S67-S68. 2009
  • Hypoxic Nitrite Reduction to Nitric Oxide Varies by Cell Type.  47:S33-S34. 2009
  • Mouse Strains with Differential Cardiovascular Disease Susceptibilities Have Significantly Different Measures of Mitochondrial Function and Damage.  47:S57-S58. 2009
  • Sodium Nitrite Administration Mitigates Lung Injury After Chlorine Gas Exposure in Rats.  47:S103-S103. 2009
  • Identification and characterization of VPO1, a new animal heme-containing peroxidase.  45:1682-1694. 2008
  • Redox modulation inhibits CD8 T cell effector function.  45:1477-1486. 2008
  • Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases.  44:1259-1272. 2008
  • Activation of Endothelial Nitric Oxide Synthase and Heme Oxygenase 1 Expression in Vasculature by Nitro-Fatty Acids.  45:S32-S32. 2008
  • Direct Measurement of Bioenergetic Stress in Cardiomyocytes Exposed to Hydrogen Peroxide and Protection by O-Glcnac.  45:S143-S143. 2008
  • Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis.  43:1279-1288. 2007
  • Action of reactive oxygen species on colonic mucus secretions.  43:800-808. 2007
  • Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion.  42:1571-1578. 2007
  • Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis.  42:720-729. 2007
  • Deoxyhemoglobin possesses dual functions as NO scavenger and a nitrite dependent NO generator: Insights from oxygen controlled vessel bioassays.  43:S167-S167. 2007
  • ICAM-1 cytoplasmic tail regulates endothelial cell redox status through an NADPH oxidase pathway.  43:S78-S78. 2007
  • Nitrite transport in erythrocytes: Evidence for oxygen-dependent modulation of export.  43:S172-S173. 2007
  • Purinergic signaling and kinase activation for survival in pulmonary oxidative stress and disease.  41:29-40. 2006
  • γ-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells.  40:1281-1292. 2006
  • Endothelial Akt activation by hyperoxia: Role in cell survival.  40:1108-1118. 2006
  • Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells.  40:952-959. 2006
  • Upregulation of immunoproteasomes by nitric oxide: Potential antioxidative mechanism in endothelial cells.  40:1034-1044. 2006
  • A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress.  40:459-468. 2006
  • Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia.  40:348-358. 2006
  • Chlorination modulates anti-inflammatory effects of isoflavones via PPAR gamma: Insights into the structure-activity relationships.  41:S20-S20. 2006
  • Chronic administration of nitrite therapy protects blood flow in the murine hind limb ischemia induced angiogenesis model.  41:S51-S51. 2006
  • Is S-nitrosohemoglobin dependent valsodilatation under allosteric control? Insights from a hemoglobin beta C93A mouse model.  41:S50-S50. 2006
  • Nitrite uptake by erythrocytes: Insights into mechanism and regulation.  41:S55-S55. 2006
  • Redox modulation of innate immune-derived pro-inflammatory third signals prevents diabetogenesis.  41:S76-S76. 2006
  • Sildenafil enhances ischemia-induced angiogenesis independent of nitric oxide.  41:S48-S48. 2006
  • The cytoplasmic tail of ICAM-1 regulates endothelial glutathione synthesis.  41:S72-S72. 2006
  • Evidence of cardiovascular protection by moderate alcohol: Role of nitric oxide.  39:540-548. 2005
  • HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells.  39:355-364. 2005
  • Lung epithelial cells release ATP during ozone exposure: Signaling for cell survival.  39:213-226. 2005
  • Antioxidant up-regulation and increased nuclear DNA protection play key roles in adaptation to oxidative stress in epithelial cells.  38:1382-1391. 2005
  • Mitochondrial dysfunction in cardiovascular disease.  38:1278-1295. 2005
  • Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process.  38:1361-1371. 2005
  • Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells.  38:1002-1013. 2005
  • Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal.  38:547-556. 2005
  • 4-Hydroxynonenal increases γ-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways.  38:463-471. 2005
  • Nitroxia: The pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway.  38:297-306. 2005
  • Mitochondrial proteomics in free radical research.  38:175-188. 2005
  • Dietary modulation of vascular N-glycosylation: Mechanistic implications for anti-inflammatory effects of polyphenols.  39:S31-S31. 2005
  • Mass spectrometric methods for the determination of flavonoids in biological samples.  37:1324-1350. 2004
  • Human glutamate cysteine ligase gene regulation through the electrophile response element.  37:1152-1159. 2004
  • The powerhouse takes control of the cell; The role of mitochondria in signal transduction.  37:753-754. 2004
  • Introduction to serial reviews on 4-hydroxy-2-nonenal as a signaling molecule.  37:594-596. 2004
  • Weight loss and race modulate nitric oxide metabolism in overweight women.  37:695-702. 2004
  • The biochemistry of nitric oxide, nitrite, and hemoglobin: Role in blood flow regulation.  36:707-717. 2004
  • The biochemistry of nitric oxide, nitrite, and hemoglobin: Role in blood flow regulation.  36:707-717. 2004
  • Physiologic, pathologic and therapeutic implications for hemoglobin interactions with nitric oxide.  36:399-401. 2004
  • Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: Implication for their use in targeting oxidation-reduction reactions in innate immunity.  36:233-247. 2004
  • Mechanistic re-examination of the reaction between nitrite and hemoglobin.  37:S82-S82. 2004
  • Nitrite activation of sGC in blood.  37:S84-S84. 2004
  • Proteomic analysis of skeletal muscle mitochondria reveal decreases in complex I and IV of the electron transport chain.  37:S27-S27. 2004
  • Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties.  35:1417-1430. 2003
  • MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells.  35:978-993. 2003
  • Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells.  35:662-675. 2003
  • The differential modification of mitochondrial proteins by nitroxyl and nitric oxide.  35:S97-S97. 2003
  • Inhibition of human surfactant protein A function by oxidation intermediates of nitrite.  33:1703-1713. 2002
  • Mitochondria, nitric oxide, and cardiovascular dysfunction.  33:1465-1474. 2002
  • Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration.  33:1243-1249. 2002
  • 4-Hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells.  33:974-987. 2002
  • Spatial mapping of pulmonary and vascular nitrotyrosine reveals the pivotal role of myeloperoxidase as a catalyst for tyrosine nitration in inflammatory diseases.  33:1010-1019. 2002
  • Mitochondria: Regulators of signal transduction by reactive oxygen and nitrogen species.  33:755-764. 2002
  • Erratum: AP-1 activation through endogenous H2O2 generation by alveolar macrophages (Free Radical Biology and Medicine (2002) 32 (1304-1313) PII: S0891584902008407).  33:725. 2002
  • AP-1 activation through endogenous H2O2 generation by alveolar macrophages.  32:1304-1313. 2002
  • Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin.  32:1220-1228. 2002
  • Hypothesis: The mitochondrial NO· signaling pathway, and the transduction of nitrosative to oxidative cell signals: An alternative function for cytochrome c oxidase.  32:370-374. 2002
  • Associations of weight loss and race with plasma NO3-/NO2-and 3-nitrotyrosine.  33:S366-S366. 2002
  • Contribution of mitochondria to oxidative stress associated with alcoholic liver disease.  32:11-16. 2002
  • ICAM-1 modulates GCLC expression and GSH localization within endothelial cells.  33:S345-S345. 2002
  • Induction of glutamate-cysteine ligase by oxidized lipids is mediated through antioxidant responsive element (ARE).  33:S354-S355. 2002
  • Nitric oxide and cellular respiration at low oxygen tension: A study on bovine aortic endothelial cells..  33:S400-S400. 2002
  • Antioxidant mechanisms of isoflavones in lipid systems: Paradoxical effects of peroxyl radical scavenging.  31:1570-1581. 2001
  • Mitochondrial tyrosine nitration precedes chronic allograft nephropathy.  31:1603-1608. 2001
  • Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxide.  31:688-696. 2001
  • Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells.  31:256-265. 2001
  • Acidic fibroblast growth factor (FGF-1) signaling inhibits peroxynitrite-induced cell death during pancreatic tumorigenesis.  30:957-966. 2001
  • A metalloporphyrin-based superoxide dismutase mimetic inhibits type I diabetes.  31:S50-S50. 2001
  • Anti-inflammatory effects of soy-isoflavones: Inhibition of leukocyte-endothelial interactions.  31:S35-S35. 2001
  • Biphasic effects of cyclopentenone prostaglandins on glutathione induction and apoptosis in endothelial cells: insights into the cell signaling pathways initiated by oxidized phospholipids.  31:S57-S57. 2001
  • Cytoprotection mediated by oxidized lipids in endothelial cells.  31:S88-S88. 2001
  • Effect of inhibition of mitochondrial protein synthesis on nitric oxide dependent apoptosis.  31:S106-S106. 2001
  • Glutathione nitroso-sulfoxide: a potential reaction product of glutathione and peroxynitrite.  31:S76-S76. 2001
  • Mitochondrial sensitivity to nitric oxide is dependent on respiratory state.  31:S73-S73. 2001
  • Non-heme iron enhances the induction of glutamate-cysteine ligase and heme oxygenase-1 by nitric oxide in human endothelial cells.  31:S70-S70. 2001
  • Regulation of endothelial cell redox status by ICAM-1: Identification of a novel pathway governing endothelial cell reactivity.  31:S47-S47. 2001
  • The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion.  29:1043-1050. 2000
  • Cell signaling by reactive nitrogen and oxygen species in atherosclerosis.  28:1780-1794. 2000
  • Biochemical aspects of the reaction of hemoglobin and NO: Implications for Hb-based blood substitutes.  28:1518-1525. 2000
  • Therapeutic applications of reactive oxygen and nitrogen species in human disease.  28:1449-1450. 2000
  • Peroxynitrite irreversibly decreases diastolic and systolic function in cardiac muscle.  27:1386-1392. 1999
  • Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III.  27:891-900. 1999
  • Effects of pyrrolidine dithiocarbamate on endothelial cells: Protection against oxidative stress.  26:1138-1145. 1999
  • Positive correlation between mammalian life span and cellular resistance to stress.  26:495-500. 1999
  • A critical appraisal of hydrogen peroxide and superoxide as signaling molecules using the JNK/SAPK map kinase pathway.  27:S64-S64. 1999
  • Is endothelium relaxing factor nitric oxide or an S-nitrosothiol? Insights from scavenging by hemoglobin.  27:S83-S83. 1999
  • Shear stress simulates cJUN N-terminal kinase (JNK) by activation of PI-3-kinase (PI3K), Akt and endothelial NO synthase (eNOS)..  27:S62-S62. 1999
  • Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media.  24:1107-1112. 1998
  • Endothelial injury from a circulating mediator following rat liver ischemia.  24:427-434. 1998
  • A novel cellular mechanism for the antioxidant effects of the NF kappa B inhibitor pyrrolidine dithiocarbamate..  25:S15-S15. 1998
  • S-nitrosation of hemoglobin: Effects on O-2 delivery and antioxidant properties.  25:S17-S17. 1998
  • Nitric oxide regulation of superoxide-dependent lung injury: Oxidant- protective actions of endogenously produced and exogenously administered nitric oxide.  21:43-52. 1996
  • Oxidation of human low-density lipoprotein by soybean 15-lipoxygenase in combination with copper (II) or met-myoglobin.  20:525-532. 1996
  • Xanthine oxidase activity in the circulation of rats following hemorrhagic shock.  15:407-414. 1993
  • A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues.  6:607-615. 1989
  • Oxidant inhibition of epithelial active sodium transport.  6:557-564. 1989
  • International Standard Serial Number (issn)

  • 0891-5849
  • Electronic International Standard Serial Number (eissn)

  • 1873-4596