Science Translational Medicine

TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model.  14. 2022

PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease.  13. 2021

Undiagnosed sars-cov-2 seropositivity during the first 6 months of the covid-19 pandemic in the united states.  13. 2021

Depleting plasmacytoid dendritic cells reduces local type i interferon responses and disease activity in patients with cutaneous lupus.  13. 2021

Citrullinated vimentin mediates development and progression of lung fibrosis.  13. 2021

Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates.  13. 2021

Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption.  13. 2021

Metabolic vulnerabilities of intratumoral T cells and tumor cells.  12. 2020

Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans.  12. 2020

Down-regulation of Beclin1 promotes direct cardiac reprogramming.  12. 2020

Lymph nodes: The cradle for antitumor immunity.  12. 2020

Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine.  12. 2020

Sirt2: A master regulator of T cell metabolism?.  12. 2020

Less is more for adoptive immunotherapy?.  12. 2020

Erratum: Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells (Science Translation Medicine (2020) 12:536 (eaaw6003) DOI: 10.1126/scitranslmed.aaw6003).  12. 2020

Glutamine: A bad guy for antitumor immunity?.  12. 2020

Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells.  12. 2020

Trimming the “fatty” intratumoral T _regs for cancer immunotherapy.  12. 2020

A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees.  12. 2020

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade.  12. 2020

Antigenic competition in CD4⁺ T cell responses in a randomized, multicenter, double-blind clinical HIV vaccine trial.  11. 2019

Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies.  11. 2019

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model.  11. 2019

Depicting brighter possibilities for treating blindness.  11. 2019

Response to Comment on "An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness".  11. 2019

Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration.  10. 2018

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.  10. 2018

LRRK2 activation in idiopathic Parkinson's disease.  10. 2018

Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice.  10. 2018

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease.  10. 2018

Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.  9. 2017

Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.  9. 2017

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.  9. 2017

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.  9. 2017

Tumor-homing cytotoxic human induced neural stem cells for cancer therapy.  9. 2017

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells.  8. 2016

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.  8:350ra104. 2016

Distilling complexity to advance cardiac tissue engineering.  8. 2016

Plasticity of the human visual system after retinal gene therapy in patients with Leber's congenital amaurosis.  7. 2015

Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis.  7. 2015

Global implementation of genomic medicine: We are not alone.  7. 2015

SLC7A1 expression is associated with seizures, predicts poor survival in patients with malignant glioma.  7. 2015

How to know when physicians are ready for genomic medicine.  7. 2015

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.  7. 2015

Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans.  7:284ra59. 2015

Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.  7. 2015

Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance.  6. 2014

Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles.  6. 2014

Detection of circulating tumor DNA in early- and late-stage human malignancies.  6. 2014

Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses.  5. 2013

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.  5. 2013

Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis.  5. 2013

Genomics in clinical practice: Lessons from the front lines.  5. 2013

Seeing the light.  5. 2013

A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer.  4. 2012

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.  4. 2012

Gene therapy: AAV2 gene therapy readministration in three adults with congenital blindness.  4. 2012

Therapeutic ultrasound: Bubble, bubble, tumor in trouble.  4. 2012

Colon cancer screening: A less controversial colon cleanser?.  4. 2012

Rett syndrome: Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: Implication for therapy in Rett syndrome.  3. 2011

Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey.  3. 2011

Cirrhosis: A sound treatment.  3. 2011

Roaming cancers are cooked.  3. 2011

Ultrasound therapy: Bubbles and sound, what a blast!.  3. 2011

The Midas touch.  3. 2011

Johnny, Johnny, eating sugar?.  3. 2011

Connecting the dots for obsessive-compulsive disorder.  3. 2011

Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey.  3. 2011

Leave no stone unturned.  3. 2011

Drug delivery: "Captain, shields are down, we can't survive another hit".  3. 2011

Breast cancer imaging goes green.  3. 2011

The hunt for red October.  3. 2011

Therapeutic targeting of SPINK1-positive prostate cancer.  3. 2011

Stem cell therapy works (in mice models of emphysema)!.  3. 2011

Novel peptide to treat sepsis-induced acute lung injury.  3. 2011

Solving cystic fibrosis one swine at a time.  2. 2010

Breathe bitter, breathe easy!.  2. 2010

When too much oxygen is not too much.  2. 2010

Improving stem cell survival, one hurdle at a time.  2. 2010

Amnion epithelial cells: Cell therapy going green!.  2. 2010

Recommendations for biomarker identification and qualification in clinical proteomics.  2. 2010

Antibodies against TIM-1 for asthma therapy.  2. 2010

A stem cell factory in the making!.  2. 2010

Rtp801: Caught Redd handed.  2. 2010

A key role for caveolin.  2. 2010

Cracking the code of pseudomonas longevity: Unveiling the PAMPs!.  2. 2010

Emerging targets.  2. 2010

Methylation balancing act.  2. 2010

Rx: A little sunshine without sunscreen?.  2. 2010

Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness.  2. 2010

Some rozi for CF too!.  2. 2010

Metabolic signatures of exercise in human plasma.  2. 2010

New hope for premature newborns.  2. 2010