PLoS Genetics

Journal

Publication Venue For

  • Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry.  15. 2019
  • Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression.  15. 2019
  • Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.  15. 2019
  • De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay.  14. 2018
  • Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus.  14. 2018
  • MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus.  13. 2017
  • The RhoJ-BAD signaling network: An Achilles’ heel for BRAF mutant melanomas.  13. 2017
  • Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African ancestry anthropometry genetics consortium.  13. 2017
  • GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.  13. 2017
  • Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.  12. 2016
  • Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology.  12. 2016
  • Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I.  12. 2016
  • Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.  12. 2016
  • De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects..  12:e1005963. 2016
  • A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4.  12. 2016
  • Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap..  11:e1005155. 2015
  • A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension.  11. 2015
  • Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.  11. 2015
  • Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).  11. 2015
  • Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.  11. 2015
  • Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.  11. 2015
  • Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes.  10. 2014
  • MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis.  10. 2014
  • ATRA-Induced Cellular Differentiation and CD38 Expression Inhibits Acquisition of BCR-ABL Mutations for CML Acquired Resistance.  10. 2014
  • Deletion of a Conserved cis-Element in the Ifng Locus Highlights the Role of Acute Histone Acetylation in Modulating Inducible Gene Transcription.  10. 2014
  • Glutamate Receptor Gene GRIN2A, Coffee, and Parkinson Disease.  10. 2014
  • Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity.  10. 2014
  • Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression.  9. 2013
  • VAPB/ALS8 MSP Ligands Regulate Striated Muscle Energy Metabolism Critical for Adult Survival in Caenorhabditis elegans.  9. 2013
  • Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci.  9. 2013
  • Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations.  9. 2013
  • A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors.  9. 2013
  • Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4.  9. 2013
  • Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis.  9. 2013
  • Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production.  9. 2013
  • A Heterogeneous Mixture of F-Series Prostaglandins Promotes Sperm Guidance in the Caenorhabditis elegans Reproductive Tract.  9. 2013
  • A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study.  9. 2013
  • Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart.  9:e1004024-e1004024. 2013
  • MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus.  9. 2013
  • Enrichment of HP1a on Drosophila Chromosome 4 Genes Creates an Alternate Chromatin Structure Critical for Regulation in this Heterochromatic Domain.  8. 2012
  • Genetic Modulation of Lipid Profiles following Lifestyle Modification or Metformin Treatment: The Diabetes Prevention Program.  8. 2012
  • Rates of Gyrase Supercoiling and Transcription Elongation Control Supercoil Density in a Bacterial Chromosome.  8. 2012
  • The chicken frizzle feather is due to an α-Keratin (KRT75) mutation that causes a defective rachis.  8. 2012
  • Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation.  8. 2012
  • Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis.  8. 2012
  • Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis.  8. 2012
  • Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context.  8. 2012
  • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals.  8. 2012
  • Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDgene database.  8. 2012
  • Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.  8. 2012
  • A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.  7. 2011
  • Hierarchical generalized linear models for multiple groups of rare and common variants: Jointly estimating group and Individual-Variant effects.  7. 2011
  • The NF1 gene contains hotspots for L1 endonuclease-dependent De Novo insertion.  7. 2011
  • Positional cloning of a type 2 diabetes quantitative trait locus; Tomosyn-2, a negative regulator of insulin secretion.  7. 2011
  • Analysis of dna methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation.  7. 2011
  • Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase i in drosophila oocytes.  7. 2011
  • Genome-wide gene-environment study identifies glutamate receptor gene grin2a as a parkinson's disease modifier gene via interaction with coffee.  7. 2011
  • Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections.  7. 2011
  • Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.  7. 2011
  • Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility..  7:e1002079. 2011
  • Beyond missing heritability: Prediction of complex traits.  7. 2011
  • The exocyst protein sec10 interacts with polycystin-2 and knockdown causes PKD-phenotypes.  7. 2011
  • Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production..  7:e1001323. 2011
  • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.  7. 2011
  • A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for crohn's disease and celiac disease.  7. 2011
  • CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-igf2 imprinting control region in prospermatogonia.  6. 2010
  • Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.  6:1-12. 2010
  • A microarray-based genetic screen for yeast chronological aging factors.  6. 2010
  • Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.  6:1-11. 2010
  • Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.  5. 2009
  • Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer.  5. 2009
  • The role of geography in human adaptation.  5. 2009
  • A genome-wide association study of pulmonary function measures in the framingham heart study.  5. 2009
  • An african ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in african americans.  5. 2009
  • Retraction: an African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans..  5. 2009
  • The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice.  5. 2009
  • Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development.  4:e1000259-e1000259. 2008
  • Evaluating statistical methods using plasmode data sets in the age of massive public databases: An illustration using false discovery rates.  4. 2008
  • The ets-related transcription factor GABP directs bidirectional transcription.  3:2247-2255. 2007
  • A Dinucleotide Deletion in CD24 Confers Protection against Autoimmune Diseases.  3:e49-e49. 2007
  • Identification of two independent risk factors for lupus within the MHC in United Kingdom families.  3:2109-2121. 2007
  • Regional admixture mapping and structured association testing: Conceptual unification and an extensible general linear model.  2:1254-1264. 2006
  • Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model..  2. 2006
  • Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice.  1:0205-0212. 2005
  • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function..  1. 2005
  • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.  1:0480-0488. 2005
  • Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants.  8:e1002707-e1002707.
  • International Standard Serial Number (issn)

  • 1553-7390
  • Electronic International Standard Serial Number (eissn)

  • 1553-7404