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Return of Individual Research Results: A Guide for Biomedical Researchers Utilizing Human Biospecimens.
Mouse Models of Heart Failure with Preserved or Reduced Ejection Fraction.
Thrombin-Induced Decidual Colony-Stimulating Factor-2 Promotes Abruption-Related Preterm Birth by Weakening Fetal Membranes.
Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of Nephronophthisis.
Role of Apolipoprotein L1 in Human Parietal Epithelial Cell Transition.
Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer.
A Shared Pattern of β-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis.
γδ T Cells Contribute to Injury in the Developing Brain.
Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease.
Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.
BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea–Induced Gliomagenesis.
Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.
Genomic and Epigenomic Alterations in Cancer.
Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis.
Generation of Novel Thyroid Cancer Stem-Like Cell Clones Effects of Resveratrol and Valproic Acid.
Inhibition of transforming growth factor-β activation diminishes tumor progression and osteolytic bone disease in mouse models of multiple myeloma.
Coming into Focus: Computational pathology as the new big data microscope.
Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.
Insights into environmental factors impacting celiac disease microbiota modulation of disease pathogenesis.
Pathogenesis of necrotizing enterocolitis: Modeling the innate immune response.
CREB-Induced inflammation is important for malignant mesothelioma growth.
Exosomes: A novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions.
Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in ptch+/- mice.
Long interspersed element-1 protein expression is a hallmark of many human cancers.
Matrix biology of idiopathic pulmonary fibrosis: A workshop report of the national heart, lung, and blood institute.
The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression.
CNS inflammation and bone marrow neuropathy in type 1 diabetes.
Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): Role of the host immune response in pathogenesis.
Generation of a dual-functioning antitumor immune response in the peritoneal cavity.
FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.
Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury.
Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.
Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis.
Nuclear kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells.
Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes.
Myotubularin-deficient myoblasts display increased apoptosis, delayed proliferation, and poor cell engraftment.
The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma.
Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling.
Clinical and biological significance of KISS1 expression in prostate cancer.
Participation of miR-200 in pulmonary fibrosis.
Pivotal role of apoptosis signal-regulating kinase 1 in monoclonal free light chain-mediated apoptosis.
The dark side of publishing: Promoting ethics in AJP 2003 to 2008.
Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression.
Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis.
Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.
A human-mouse chimeric model of obliterative bronchiolitis after lung transplantation.
Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy.
CD14 signaling reciprocally controls collagen deposition and turnover to regulate the development of lyme arthritis.
Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis.
Peptide-directed highly selective targeting of pulmonary arterial hypertension.
The development of cutaneous neurofibromas.
γδ T cells attenuate bleomycin-induced fibrosis through the production of CXCL10.
Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells.
Epithelial NF-κB Enhances Transmucosal Fluid Movement by Altering Tight Junction Protein Composition after T Cell Activation.
Heme oxygenase-1 expression in murine dendritic cell subpopulations: Effect on CD8+ dendritic cell differentiation in vivo.
Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin.
TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomes.
The calreticulin-binding sequence of thrombospondin 1 regulates collagen expression and organization during tissue remodeling.
The Fibrotic Phenotype Induced by IGFBP-5 Is Regulated by MAPK Activation and Egr-1-Dependent and -Independent Mechanisms.
Activation of the wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models.
COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting.
Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation.
Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2.
Latent transforming growth factor-β-binding protein-4 regulates transforming growth factor-β1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.
Renal gene and protein expression signatures for prediction of kidney disease progression.
Suppression of activation and costimulatory signaling in splenic CD4 + T cells after trauma-hemorrhage reduces t-cell function: A mechanism of post-traumatic immune suppression.
Age-related changes in bone morphology are accelerated in group VIA Phospholipase A2 (iPLA2β)-null mice.
BRMS1 suppresses breast cancer experimental metastasis to multiple organs by inhibiting several steps of the metastatic process.
Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (FcγRI)-dependent.
In the blink of an eye....
Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.
Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide pro-gly-pro.
Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.
Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from α1,3-galactosyltransferase gene-knockout pigs in baboons.
A thrombospondin-1 antagonist of transforming growth factor-β activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II.
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-δ knockout mice.
G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage.
Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease.
Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes.
The myofibroblast: One function, multiple origins.
p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitis.
Activation of mitogen-activated protein kinases by lysophosphatidylcholine- induced mitochondrial reactive oxygen species generation in endothelial cells.
Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice.
Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3′-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein.
Introducing biological perspectives.
JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-α.
Kupffer cells and their mediators: The culprits in producing distant organ damage after trauma-hemorrhage.
Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis.
The metabolic syndrome: A high-risk state for cancer?.
SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells..
Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endothelium.
CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury.
Cathepsin deficiency as a model for neuronal ceroid lipofuscinoses.
Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts.
Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis.
Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis.
Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury.
Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy.
P-selectin can support both Th1 and Th2 lymphocyte rolling in the intestinal microvasculature.
SCFβ-TrCP1 controls Smad4 protein stability in pancreatic cancer cells.
Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma.
C5a-Induced Gene Expression in Human Umbilical Vein Endothelial Cells.
CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis.
Evolutionary change and The American Journal of Pathology.
Heme oxygenase-1 modulates early inflammatory responses: Evidence from the heme oxygenase-1-deficient mouse.
Interaction of Nkx3.1 and p27kip1 in Prostate Tumor Initiation.
Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Faslpr mice from autoimmune disease.
Pathological Role of Large Intestinal IL-12p40 for the induction of Th2-Type Allergic Diarrhea.
Pericyte-Like Location of GFP-Tagged Melanoma Cells: Ex Vivo and in Vivo Studies of Extravascular Migratory Metastasis.
Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-β in response to fibrogenic stimuli.
Psoriasiform dermatitis susceptibility in Itgb2tm1Bay PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe disease.
Intimal exuberance: Veins in jeopardy.
Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy.
Association of Aortic Atherosclerosis with Cerebral β-Amyloidosis and Learning Deficits in a Mouse Model of Alzheimer's Disease.
Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression.
Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation.
Changes in differential gene expression because of warm ischemia time of radical prostatectomy specimens.
α-Methylacyl-CoA racemase: Expression levels of this novel cancer biomarker depend on tumor differentiation.
Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae).
Glomeruloid microvascular proliferation orchestrated by VPF/VEGF: A new world of angiogenesis research.
Mapping the binding domain of immunoglobulin light chains for Tamm-Horsfall protein.
Potential role of modifier genes influencing transforming growth factor-β1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia.
The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys.
Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction.
Glucose stimulation of transforming growth factor-β bioactivity in mesangial cells is mediated by thrombospondin-1.
Human nasopharyngeal-associated lymphoreticular tissues: Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils.
Activation of rat alveolar macrophage-derived latent transforming growth factor β-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36.
Apoptosis and tumorigenesis in human cholangiocarcinoma cells: Involvement of Fas/APO-1 (CD95) and calmodulin.
Post-transcriptional induction of p21cip1 protein in condylomata and dysplasias is inversely related to human papillomavirus activities.
Post-infarction left ventricular remodeling induces changes in creatine kinase mRNA and protein subunit levels in porcine myocardium.
Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant: A new model to study the liver lesion.
Vitronectin expression in differentiating neuroblastic tumors: Integrin αvβ5 mediates vitronectin-dependent adhesion of retinoic-acid- differentiated neuroblastoma cells.
Isolation and characterization of liver epithelial cell lines from wild- type and mutant TgN737Rpw mice.
Oval cell proliferation associated with the murine insertional mutation TgN737Rpw.
Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis.
Role of calmodulin in HIV-potentiated fas-mediated apoptosis.
Effects of mutation and growth rates on patterns of microsatellite instability.
Stage-specific expression of integrin αvβ3 in neuroblastic tumors.
Stearate inhibition of breast cancer cell proliferation: A mechanism involving epidermal growth factor receptor and G-proteins.
Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases.
Highly metastatic 13762NF rat mammary adenocarcinoma cell clones stimulate bone marrow by secretion of granulocyte-macrophage colony-stimulating factor/interleukin-3 activity.
Pathogenesis of glomerulosclerosis in light chain deposition disease: Role for transforming growth factor-β.
Up-regulation of urokinase and urokinase receptor genes in malignant astrocytoma.
Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB.
Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4.
Transgenic mice that develop pituitary tumors: A model for Cushing's disease.
Molecular features of hypothalamic plaques in Alzheimer's disease.
The rapid detection of clonal T-cell proliferations in patients with lymphoid disorders.
In vitro and in vivo growth and differentiation of clones of tracheal basal cells.
Induction of Ia antigen expression on murine islet parenchymal cells does not diminish islet allograft survival.
Cardiac matrix alterations induced by adriamycin.
Tumor necrosis factor enhances interferon-induced Ia antigen expression on murine islet parenchymal cells.
Transmural progression of morphologic changes during ischemic contracture and reperfusion in the normal and hypertrophied rat heart.
Morphologic and immunohistochemical observations in granulomatous glomerulonephritis.
Analysis of changes in rat prostate carcinoma following hormone deprivation.
The epithelial origin of a stromal cell population in adenocarcinoma of the rat prostate.
Serologic and pathologic studies of mice immunized with homologous fibronectin.
In vitro inhibition of human sarcoma cells invasive ability by bis(5-amidino-2-benzimidazolyl)methane: A novel esteroprotease inhibitor.
Detection of autoantibodies and glomerular injury in rabbits immunized with denatured human fibronectin monomer.
The heterogeneity of LDH isoenzyme patterns of human uterine sarcomas and cultured sarcoma cell lines.
Development of the adult respiratory distress syndrome: Progressive alteration of neutrophil chemotactic and secretory processes.
Phenytoin sensitivity of fibroblasts as the basis for susceptibility to gingival enlargement.
An ultrastructural study of alveolar permeability to cytochrome C in the rabbit lung. Effect of exposure to 100% oxygen at one atmosphere.
Morphologic and immunofluorescence studies of the effect of fibroblast growth factor on the culture of guinea pig glomerular cell strains.
The growth of primary glomerular cells as a confluent monolayer in a chemically defined serum-free medium. Specific requirements for prostaglandins and extracellular matrix molecules.
Growth and maintenance of glomerular cells under defined conditions.