Journal of Clinical Investigation

Journal

Publication Venue For

  • Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD.  131. 2021
  • Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection.  131. 2021
  • Erratum: Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2 (Journal of Clinical Investigation (2017) 127:8 (3075-3089) DOI: 10.1172/JCI89092).  130:6187. 2020
  • Erratum: Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2 (The Journal of clinical investigation PII: 142404).  130:5027. 2020
  • Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs.  130:214. 2020
  • An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup 2019
  • STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion.  128:1867-1872. 2018
  • Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance.  128. 2018
  • Epiregulin and EGFR interactions are involved in pain processing.  127:3353. 2017
  • Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2.  127:3075. 2017
  • NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.  126:3917-3928. 2016
  • PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model.  126:3053. 2016
  • Heterogeneity of leukemia-initiating capacity of chronic myelogenous leukemia stem cells.  126:975-991. 2016
  • Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells.  125:4077-4090. 2015
  • Rescuing the physician-scientist workforce: The time for action is now.  125. 2015
  • Exploiting metabolic and antioxidant pathways to maintain vision in blinding disease.  125:1390-1392. 2015
  • The genetics and immunobiology of IgA nephropathy.  124. 2014
  • SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome.  124:1512-1524. 2014
  • ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.  124:981-999. 2014
  • B cells mediate chronic allograft rejection independently of antibody production.  124:1052. 2014
  • Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal.  124:553-563. 2014
  • Fibrosis: Ultimate and proximate causes.  124:4673-4677. 2014
  • Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.  123:5319-5333. 2013
  • Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.  123:4786-4798. 2013
  • Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.  123. 2013
  • Proximal tubule h-ferritin mediates iron trafficking in acute kidney injury.  123:4423-4434. 2013
  • ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling.  123. 2013
  • Atrial natriuretic peptide is negatively regulated by microRNA-425.  123:3378-3382. 2013
  • MERTK receptor tyrosine kinase is a therapeutic target in melanoma.  123:2257-2267. 2013
  • Amelioration of arthritis through mobilization of peptide-specific CD8 + regulatory T cells.  123:1382-1389. 2013
  • Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis.  123. 2013
  • CXCR5+ T helper cells mediate protective immunity against tuberculosis.  123:712-726. 2013
  • Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction.  122:4218-4230. 2012
  • Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.  122:2807-2816. 2012
  • Mechanism and prevention of acute kidney injury from cast nephropathy in a rodent model.  122. 2012
  • Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis.  122:1907-1919. 2012
  • P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.  122. 2012
  • Erratum: Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy (Journal of Clinical Investigation (2011) 121, 10 (3991-4002) DOI: 10.1172/JCI45563).  122:778. 2012
  • Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy.  121:3991. 2011
  • Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8 - Mediated activation of TGF-β.  121:2863-2875. 2011
  • Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice.  121:2169-2180. 2011
  • The human visual cortex responds to gene therapy-mediated recovery of retinal function.  121. 2011
  • Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties.  120:4532-4545. 2010
  • Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis.  120. 2010
  • GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in mice.  120:2280-2291. 2010
  • A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates.  120:1125. 2010
  • Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity.  119:1668-1677. 2009
  • Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.  119. 2009
  • A nervous breakdown in the skin: Stress and the epidermal barrier.  117:3166-3169. 2007
  • LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems.  117:3383-3392. 2007
  • Synaptopodin regulates the actin-bundling activity of α-actinin in an isoform-specific manner.  115:1188-1198. 2005
  • The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling.  114:206-213. 2004
  • Do allelic variants of SLC6A14 predispose to obesity?.  1633-1636. 2003
  • Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load.  1244-1254. 2003
  • The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse..  111. 2003
  • Erratum: Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice (Journal of Clinical Investigation (2003) 111 (445-452)).  111:1259. 2003
  • Erratum: Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice (Journal of Clinical Investigation (2003) 111 (445-452)).  111:1259. 2003
  • The role of uncoupling protein 3 in human physiology.  111:438. 2003
  • Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.  111:445-452. 2003
  • Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior.  1895. 2003
  • The role of uncoupling protein 3 in human physiology.  111:438. 2003
  • Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.  109:533-540. 2002
  • Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.  109:533-540. 2002
  • Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival.  109:755-764. 2002
  • Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells..  1657-1665. 2001
  • A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function..  107:1137. 2001
  • The de-adhesive activity of matricellular proteins: Is intermediate cell adhesion an adaptive state?.  107:785-790. 2001
  • Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. 2000
  • Immune recognition of OxLDL in atherosclerosis 2000
  • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.  102:1515. 1998
  • Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirus.  102:1431-1443. 1998
  • Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease.  101:935. 1998
  • Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.  1107-1113. 1996
  • The expression of TNFα by human muscle: Relationship to insulin resistance.  97:1111-1116. 1996
  • Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle: Implications for glucose toxicity.  96:2792. 1995
  • Somatic mutation and CDR3 lengths of immunoglobulin κ light chains expressed in patients with rheumatoid arthritis and in normal individuals.  96:831. 1995
  • Targeted tumor killing via an intracellular antibody against erbB-2.  96:2980-2989. 1995
  • Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding.  94:228. 1994
  • Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization.  93. 1994
  • Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro.  93. 1994
  • Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.  94:2407. 1994
  • An idiotypic marker associated with a germ-line encoded κ light chain variable region that predominates the vaccine-induced human antibody response to the Haemophilus influenzae b polysaccharide.  88:1811-1818. 1991
  • Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis.  88:248-252. 1991
  • Preferential expression of human FcγRIII(PMN) (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins.  87:58-67. 1991
  • Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism.  87:894-900. 1991
  • Abnormal cardiac function in the streptozotocin-diabetic rat: Changes in active and passive properties of the left ventricle.  86:481-488. 1990
  • Mechanisms of intranephronal proteinaceous cast formation by low molecular weight proteins.  85:570. 1990
  • A novel mechanism for the generation of superoxide anions in hematoporphyrin derivative-mediated cutaneous photosensitization. Activation of the xanthine oxidase pathway.  83:1137-1143. 1989
  • In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzees.  84:962-970. 1989
  • Prostaglandin E2 selectively increases interferon gamma receptor expression on human CD8+ lymphocytes.  83. 1989
  • Protective immunity in bancroftian filariasis. Selective recognition of a 43-kD larval stage antigen by infection-free individuals in an endemic area.  83:14-22. 1989
  • Tolerance induced by physiological levels of secreted proteins in transgenic mice expressing human insulin.  84:1550. 1989
  • Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus.  81:1528. 1988
  • Defective antigen presentation and novel structural properties of DR1 from an HLA haplotype associated with 21-hydroxylase deficiency.  998-1008. 1987
  • Age-related normalization of the browning rate of collagen in diabetic subjects without retinopathy.  832-835. 1986
  • Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathies.  77. 1986
  • Electrogenic sodium/bicarbonate cotransport in rabbit renal cortical basolateral membrane vesicles 1986
  • Human complement protein D catabolism by the rat kidney.  77:1299. 1986
  • Proliferative signals for suppressor T cells. Helper cells stimulated with pokeweed mitogen in vitro produce a suppressor cell growth factor.  214-220. 1986
  • Expression of complement proteins C2 and factor B in transfected L cells.  76. 1985
  • Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes.  76:22-30. 1985
  • Suppression of in vitro monoclonal human rheumatoid factor synthesis by antiidiotypic antibody. Target cells and molecular requirements.  72. 1983
  • A novel polymorphism of FcγRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.  100.
  • A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C.  92:710.
  • Angiotensin II stimulates proliferation of normal early erythroid progenitors.  100:2310-2314.
  • Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors
  • Bacterial flagellin is a dominant antigen in Crohn disease.  1296-1306.
  • Bioactive extracellular matrix fragments in lung health and disease.  126:3176-3184.
  • Blinded by the light: A nonhuman primate model of achromatopsia.  513-515.
  • CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis.  1332-1341.
  • Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1.  124:3455-3468.
  • Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation.  1021-1029.
  • Cytomegalovirus induction of tumor necrosis factor-α by human monocytes and mucosal macrophages.  90.
  • Defective expression of p561ck in an infant with severe combined immunodeficiency.  102:421-429.
  • Deficiency of the autologous mixed lymphocyte reaction in patients with primary biliary cirrhosis.  66:1305-1310.
  • Epithelial P2X purinergic receptor channel expression and function.  875-884.
  • Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance.  101:2377-2386.
  • FGF23 induces left ventricular hypertrophy.  121:4393.
  • Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity.  115:66-75.
  • Hyperthermia induces expression of transforming growth factor-βs in rat cardiac cells in vitro and in vivo.  92:404-410.
  • Intravenous IgG: Supertherapy for superantigens?.  91:378.
  • Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury.  126.
  • Localization of a single binding site for immunoglobulin light chains on human Tamm-Horsfall glycoprotein.  99:732-736.
  • Major histocompatibility complex class III genes and susceptibility to immunoglobulin a deficiency and common variable immunodeficiency.  89:1914.
  • Mouse and primate lifespan is correlated with immunoproteasome expression
  • Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent.  128:2626.
  • Overcoming therapeutic resistance in glioblastoma: The way forward.  127:415-426.
  • Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury.  121:4409-4419.
  • Pathobiology of cast nephropathy from human Bence Jones proteins.  89:630-639.
  • Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.  1621-1629.
  • Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody.  92:1221-1228.
  • Replication, establishment of latency, and induced reactivation of herpes simplex virus γ1 34.5 deletion mutants in rodent models.  91:2837.
  • Role of the renal sympathetic nerves in the development and maintenance of hypertension in the spontaneously hypertensive rat.  66:971.
  • Role of transforming growth factor-β in maintenance of function of cultured neonatal cardiac myocytes. Autocrine action and reversal of damaging effects of interleukin-1.  90:2056-2062.
  • International Standard Serial Number (issn)

  • 0021-9738
  • Electronic International Standard Serial Number (eissn)

  • 1558-8238