Xenotransplantation

Deceased humans and living pigs as sources of kidneys for clinical transplantation—Can they be compared? 2021

Potential roles of mesenchymal stromal cells in islet allo- and xenotransplantation for type 1 diabetes mellitus 2021

The first clinical trial—Kidney or heart?.  28. 2021

Efficacy of ATG and Rituximab in capuchin monkeys (a New World monkey)–An in vitro study relevant to xenotransplantation.  27. 2020

Immunosuppressive and metabolic agents that influence allo- and xenograft survival by in vivo expansion of T regulatory cells.  27. 2020

Extracellular histones and xenotransplantation.  27. 2020

Fluid intake and output in baboons.  27. 2020

How the COVID-19 pandemic may impact public support for clinical xenotransplantation in the United States?.  27. 2020

The final obstacle to successful pre-clinical xenotransplantation?.  27. 2020

The human T-cell proliferative response to triple-knockout pig cells in mixed lymphocyte reaction.  27. 2020

What will be the cost of a genetically-engineered pig organ for clinical xenotransplantation?.  27. 2020

Meta-analysis of public perception toward xenotransplantation.  27. 2020

Clinical trials of xenotransplantation: The need for a worldwide registry.  27. 2020

Recommendations to the IRB review process in preparation of xenotransplantation clinical trials.  27. 2020

Growth hormone receptor knockout: Relevance to xenotransplantation 2020

Racial differences in attitudes to clinical pig organ Xenotransplantation 2020

The problem of the “4th xenoantigen” after pig organ transplantation in non-human primates may be overcome by expression of human “protective” proteins 2020

Decellularization methods for developing porcine corneal xenografts and future perspectives.  26. 2019

Downregulation of Gabarapl1 significantly attenuates antibody binding to porcine aortic endothelial cells.  26. 2019

Selective inhibition of cyclooxygenase-2 protects porcine aortic endothelial cells from human antibody-mediated complement-dependent cytotoxicity.  26. 2019

A potential role of TLR2 in xenograft rejection of porcine iliac endothelial cells: An in vitro study.  26. 2019

Circulating pig-specific DNA as a novel biomarker for monitoring xenograft rejection.  26. 2019

Justification of specific genetic modifications in pigs for clinical organ xenotransplantation.  26. 2019

The complex functioning of the complement system in xenotransplantation.  26. 2019

The “Baby Fae” baboon heart transplant—Potential cause of rejection.  26. 2019

A review of pig liver xenotransplantation: Current problems and recent progress.  26. 2019

Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation.  26. 2019

Cover Image, Volume 26, Issue 3.  26. 2019

Financial support for xenotransplantation research.  26. 2019

Life-supporting porcine cardiac xenotransplantation: The Munich study.  26. 2019

Potential pathological role of pro-inflammatory cytokines (IL-6, TNF-α, and IL-17) in xenotransplantation.  26. 2019

Chronic dialysis in patients with end-stage renal disease: Relevance to kidney xenotransplantation.  26. 2019

Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?.  26. 2019

Oscar Salvatierra, Jr, MD (1935-2019).  26:e12521. 2019

Will donor-derived neoplasia be problematic after clinical pig organ or cell xenotransplantation?.  26. 2019

Circulating miRNA or circulating DNA—Potential biomarkers for organ transplant rejection.  26. 2019

An approach to induction of tolerance to pig cardiac xenografts in neonates.  25. 2018

Porcine IL-6, IL-1β, and TNF-α regulate the expression of pro-inflammatory-related genes and tissue factor in human umbilical vein endothelial cells.  25. 2018

Donor-derived infections and infectious risk in xenotransplantation and allotransplantation.  25. 2018

20th Anniversary of IXA, 1998–2018.  25. 2018

Is sensitization to pig antigens detrimental to subsequent allotransplantation?.  25. 2018

Jewish, Christian and Muslim theological perspectives about xenotransplantation.  25. 2018

Cover Image, Volume 25, Issue 2.  25:e12397-e12397. 2018

The Sda and Cad glycan antigens and their glycosyltransferase, β1,4GalNAcT-II, in xenotransplantation.  25. 2018

The Natural Anti-Gal Antibody as Foe Turned Friend in MedicineUri GaliliPhD, Academic Press (an imprint of Elsevier), London, 2018. pp. 1-300. Price US$95.50..  25:e12364-e12364. 2018

Low anti-pig antibody levels are key to the success of solid organ xenotransplantation: But is this sufficient?.  24. 2017

Miscellaneous.  24. 2017

David J. G. White, PhD, FRCPath.  24. 2017

Angiopoietin-1 and angiopoietin-2 protect porcine iliac endothelial cells from human antibody-mediated complement-dependent cytotoxicity through phosphatidylinositide 3-kinase/AKT pathway activation.  24. 2017

Financial aspects of organ procurement from deceased donors in the USA—Relevance to xenotransplantation.  24. 2017

The impact of serum incubation time on IgM/IgG binding to porcine aortic endothelial cells.  24. 2017

Early clinical xenotransplantation experiences—An interview with Thomas E. Starzl, MD, PhD.  24. 2017

Human IL-6, IL-17, IL-1β, and TNF-α differently regulate the expression of pro-inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells.  24. 2017

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts.  24. 2017

Therapeutic regulation of systemic inflammation in xenograft recipients.  24. 2017

Thomas E. Starzl, MD, PhD, 1926-2017.  24. 2017

Transplantation of hepatocytes from genetically engineered pigs into baboons.  24. 2017

Development of retrocorneal membrane following pig-to-monkey penetrating keratoplasty.  24. 2017

Initial study of α1,3-galactosyltransferase gene-knockout/CD46 pig full-thickness corneal xenografts in rhesus monkeys.  24. 2017

Klotho attenuated antibody-mediated porcine endothelial cell activation and injury.  24. 2017

Safe use of anti-CD154 monoclonal antibody in pig islet xenotransplantation in monkeys.  24. 2017

Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration?.  23:370-380. 2016

Psychosocial challenges of xenotransplantation: the need for a multidisciplinary, religious, and cultural dialogue.  23:335-337. 2016

Is successful orthotopic heart transplantation in the pig-to-non-human primate model required before proceeding to a clinical trial?.  23:328-329. 2016

Thyroid hormone: relevance to xenotransplantation.  23:293-299. 2016

Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs.  23:137-150. 2016

The pathobiology of pig-to-primate xenotransplantation: A historical review.  23:83-105. 2016

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 2b: Genetically modified source pigs.  23:32-37. 2016

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 4: Pre-clinical efficacy and complication data required to justify a clinical trial.  23:46-52. 2016

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Executive summary.  23:3-13. 2016

Transgenic expression of human CD46: Does it reduce the primate T-cell response to pig endothelial cells?.  22:487-489. 2015

Further evidence for sustained systemic inflammation in xenograft recipients (SIXR).  22:399-405. 2015

Experimental hepatocyte xenotransplantation - A comprehensive review of the literature.  22:239-248. 2015

Pig kidney graft survival in a baboon for 136 days: Longest life-supporting organ graft survival to date.  22:302-309. 2015

Characterization of the cellular infiltrate in bioprosthetic heart valves explanted from patients with structural valve deterioration.  22:406-407. 2015

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.  22:310-316. 2015

Expression of NeuGc on pig heart valves.  22:153-154. 2015

Glucose metabolism in pigs expressing human genes under an insulin promoter.  22:70-79. 2015

In vitro exposure of pig neonatal isletlike cell clusters to human blood.  22:317-324. 2015

Islet xenotransplantation: What is the optimal age of the islet-source pig?.  22:7-19. 2015

Pig-to-baboon heterotopic heart transplantation - Exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens.  22:211-220. 2015

Systemic inflammation in xenograft recipients precedes activation of coagulation.  22:32-47. 2015

Development of a consensus protocol to quantify primate anti-non-Gal xenoreactive antibodies using pig aortic endothelial cells.  21:555-566. 2014

Progress in pig-to-non-human primate transplantation models (1998-2013): A comprehensive review of the literature.  21:397-419. 2014

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation.  21:420-430. 2014

Tribute to Carl-Gustav Groth (1933-2014), first president of the International Xenotransplantation Association.  21:97-98. 2014

A milestone in xenotransplantation research.  21:13-15. 2014

Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?.  21:287-290. 2014

Bioprosthetic heart valves of the future.  21:1-10. 2014

Corneal blindness and xenotransplantation.  21:99-114. 2014

Plasma free triiodothyronine (fT3) levels in baboons undergoing pig organ transplantation: Relevance to early recovery of organ function.  21:582-583. 2014

Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition.  21:72-83. 2014

Role of P-selectin and P-selectin glycoprotein ligand-1 interaction in the induction of tissue factor expression on human platelets after incubation with porcine aortic endothelial cells.  21:16-24. 2014

The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options.  21:201-220. 2014

Minimal effect of bortezomib in reducing anti-pig antibodies in human leukocyte antigen-sensitized patients: A pilot study.  20:429-437. 2013

Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection.  20:292-307. 2013

Toward clinical islet xenotransplantation - Are revisions to the IXA guidelines warranted?.  20:68-74. 2013

Commentary: Limitations of the pig-to-non-human primate islet transplantation model.  20:2-4. 2013

Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species.  19:342-354. 2012

Anti-gal antibodies in α1,3-galactosyltransferase gene-knockout pigs.  19:305-310. 2012

Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation.  19:273-285. 2012

Human T-cell proliferation in response to thrombin-activated GTKO pig endothelial cells.  19:311-316. 2012

Costimulation blockade in pig artery patch xenotransplantation - A simple model to monitor the adaptive immune response in nonhuman primates.  19:221-232. 2012

Platelet aggregation in humans and nonhuman primates: Relevance to xenotransplantation.  19:233-243. 2012

Clinical lung xenotransplantation - What donor genetic modifications may be necessary?.  19:144-158. 2012

Porcine alanine transaminase after liver allo-and xenotransplantation.  19:52-55. 2012

The effect of Gal expression on pig cells on the human T-cell xenoresponse.  19:56-63. 2012

Thrombocytopenia after pig-to-baboon liver xenotransplantation: Where do platelets go?.  18:320-327. 2011

A record of international meetings on xenotransplantation 1988-2010.  18:229-231. 2011

Clinical pig liver xenotransplantation: How far do we have to go?.  18:158-167. 2011

Genetically-modified pig mesenchymal stromal cells: Xenoantigenicity and effect on human T-cell xenoresponses.  18:183-195. 2011

Multivisceral xenotransplantation-does it have a future?.  17:418-422. 2010

An in vitro model of pig liver xenotransplantation-pig complement is associated with reduced lysis of wild-type and genetically modified pig cells.  17:370-378. 2010

The immunology of corneal xenotransplantation: A review of the literature.  17:338-349. 2010

Outwitting evolution: Honorary Fellowship Lecture.  17:171-180. 2010

Insulin secretion and glucose metabolism in alpha 1,3-galactosyltransferase knock-out pigs compared to wild-type pigs.  17:131-139. 2010

Investigation of potential carbohydrate antigen targets for human and baboon antibodies.  17:197-206. 2010

The potential of genetically-modified pig mesenchymal stromal cells in xenotransplantation.  17:3-5. 2010

Monitoring of porcine and baboon cytomegalovirus infection in xenotransplantation.  16:535-536. 2009

Pandemic swine flu 2009: Invited commentary.  16:463-465. 2009

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig.  16:477-485. 2009

Current status of xenotransplantation and prospects for clinical application.  16:263-280. 2009

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Chapter 4: Pre-clinical efficacy and complication data required to justify a clinical trial.  16:229-238. 2009

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Executive summary.  16:196-202. 2009

Invited commentary.  16:58-60. 2009

Identification of αgal as the major target for human anti-pig antibodies.  16:47-49. 2009

Islet xenotransplantation: The pig-to-non-human primate model.  15:104-106. 2008

Erratum: Babesia as a complication of immunosuppression following pig-to-baboon heart transplantation (Xenotransplantation (2007) 14,2, (162-165) DOI: 10.1111/j.1399-3089.2007.00375.x).  14:374. 2007

Erratum: The potential of statins in xenotransplantation (Xenotransplantation (2007) 14,2, (100-103) DOI: 10.1111/j.1399-3089.2007.00389. x).  14:374. 2007

Rapid loss of intraportally transplanted islets: An overview of pathophysiology and preventive strategies.  14:288-297. 2007

Acute gastric dilatation after porcine islet transplantation in a cynomolgus monkey - Case history and review of the literature.  14:265-270. 2007

The pig-to-primate immune response: Relevance for xenotransplantation.  14:227-235. 2007

The potential of statins in xenotransplantation: Commentary.  14:100-103. 2007

Babesia as a complication of immunosuppression following pig-to-baboon heart transplantation.  14:162-165. 2007

Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies.  14:74-82. 2007

Rene Kuss's clinical experience with pig kidney transplantation in 1966 [4].  14:93. 2007

Extended coagulation profiles of healthy baboons and of baboons rejecting GT-KO pig heart grafts.  13:522-528. 2006

Measurement of anti-CD154 monoclonal antibody in primate sera by competitive inhibition ELISA.  13:566-570. 2006

Selected physiologic compatibilities and incompatibilities between human and porcine organ systems.  13:488-499. 2006

ABO-incompatible allotransplantation as a basis for clinical xenotransplantation.  13:390-399. 2006

Antibodies directed to pig non-Gal antigens in naïve and sensitized baboons.  13:400-407. 2006

Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans.  13:357-365. 2006

PERV methodology.  13:171. 2006

Buccal mucosal cell immunohistochemistry: A simple method of determining the ABH phenotype of baboons, monkeys, and pigs.  13:63-68. 2006

Journal requirements for manuscripts on clinical trials of xenotransplantation.  13:2. 2006

Letter from the Editors.  13:1. 2006

Localized myocardial infarction following pig-to-baboon heart transplantation.  12:489-491. 2005

Reducing Gal expression on the pig organ - A retrospective review.  12:278-285. 2005

Antibody- and complement-independent phagocytotic and cytolytic activities of human macrophages toward porcine cells.  12:181-188. 2005

Which patients first? Planning the first clinical trial of xenotransplantation: A case for cardiac bridging.  12:168-172. 2005

How strong is the T cell response in the pig-to-primate model?.  12:85-87. 2005

Draft reports for public comment from the US Secretary's Advisory Committee on Xenotransplantation..  12:255-257. 2005

Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus.  12:59-62. 2005

Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons.  11:416-425. 2004

Bone marrow transplantation from α1,3-galactosyltransferase gene-knockout pigs in baboons.  11:361-370. 2004

Initial experience with the human anti-human CD154 monoclonal antibody, ABI793, in pig-to-baboon xenotransplantation.  11:353-360. 2004

Letter to the editor [3].  11:380-381. 2004

Letter to the editor [4].  11:382. 2004

Pig spleen transplantation induces transient hematopoietic cell chimerism in baboons [2].  11:298-300. 2004

Transfusion of pig red blood cells into baboons [1].  11:295-297. 2004

Reduction of anti-Galα1,3Gal antibodies by infusion of types 2 and 6 gal trisaccharides conjugated to poly-L-lysine.  11:210-215. 2004

Xenotransplantation Manuscripts Now Published OnlineEarly.  11:109. 2004

Absence of humoral and cellular alloreactivity in baboons sensitized to pig antigens.  11:27-32. 2004

Galα1,3Gal expression on porcine pancreatic islets, testis, spleen, and thymus.  11:101-106. 2004

In vitro and in vivo investigation of a novel monoclonal antibody to plasma cells (W5 mAb).  11:78-90. 2004

Initial investigation of the potential of modified porcine erythrocytes for transfusion in primates.  11:18-26. 2004

Relative effects of GAL⁺ and GAL^low/- porcine hematopoietic cells on primate platelet aggregation and endothelial cell activation: Implications for the induction of mixed hematopoietic chimerism in the pig-to-primate model.  11:72-77. 2004

Statement on allogeneic and xenogeneic transplantation by Fifty-Seventh World Health Assembly, 22 May 2004..  11:390. 2004

Xenotransplantation: Letter from the Editors.  11:1. 2004

Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin-Galα1-3Gal conjugate.  10:606-614. 2003

An investigation of the effect of thalidomide on anti-gal antibody production in baboons.  10:470-474. 2003

Porcine red blood cells as a source of blood transfusion in humans.  10:384-386. 2003

Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons.  10:357-367. 2003

Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene.  10:374-379. 2003

6th Congress of the International Xenotransplantation Association.  10:7-9. 2003

An exploratory investigation of the effect of arsenic trioxide on anti-Gal antibody production in baboons.  10:80-87. 2003

An investigation of the specificity of induced anti-pig antibodies in baboons.  10:88-93. 2003

Neurotoxicity of leflunomide in baboons [2].  10:187-188. 2003

Promotion of xenogeneic hematopoietic chimerism in rodents by mononuclear phagocyte depletion.  9:402-409. 2002

Differential expression of Galα1,3Gal epitopes on fetal and adult porcine hematopoietic cells.  9:297-300. 2002

Anti-Galα1-3Gal IgM and IgG antibody levels in sera of humans and old world non-human primates.  9:148-154. 2002

Modulation of the in vivo primate anti-Gal response through administration of anti-idiotypic antibodies.  9:106-114. 2002

Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade.  9:3-13. 2002

Xenotransplantation: Letter from the editor.  8:223. 2001

Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: Depletion of CD20- and CD22-positive B cells does not result in significantly decreased production of anti-αGal antibody.  8:157-171. 2001

Xenotransplantation: Letter from the editor.  8:81. 2001

Report: International Xenotransplantation Association.  8:2. 2001

Xenotransplantation: Editorial.  8:1. 2001

"Literature update 1999, part 3"..  8:80. 2001

Letter to Editor.  8:80. 2001

Inhibition of platelet aggregation in baboons: Therapeutic implications for xenotransplantation.  7:247-257. 2000

Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti-Gal antibody: Experience with 320 aphereses in baboons.  7:181-185. 2000

An approach to the control of disease transmission in pig-to-human xenotransplantation.  7:143-155. 2000

Venular thrombosis is the key event in the pathogenesis of antibody- mediated cardiac rejection.  7:31-41. 2000

Disordered regulation of coagulation and platelet activation in xenotransplantation.  7:166-176. 2000

Pig xenogeneic antigen modification with green coffee bean α- galactosidase.  6:238-248. 1999

Different responses of human anti-HLA and anti-αgal antibody to long- term intravenous immunoglobulin therapy.  6:181-186. 1999

The problem of anti-pig antibodies in pig-to-primate xenografting: Current and novel methods of depletion and/or suppression of production of anti-pig antibodies.  6:157-168. 1999

Major carbohydrate epitopes in tissues of domestic and African wild animals of potential interest for xenotransplantation research.  6:79-89. 1999

Effect of pig-specific cytokines on mobilization of hematopoietic progenitor cells in pigs and on pig bone marrow engraftment in baboons.  6:17-27. 1999

Intravenous synthetic αgal saccharides delay hyperacute rejection following pig-to-baboon heart transplantation.  6:36-42. 1999

Lack of variation in αgal expression on lymphocytes in miniature swine of different genotypes.  6:43-51. 1999

Comparative histopathology of hepatic allografts and xenografts in the nonhuman primate.  5:197-206. 1998

Depletion of anti-Galα1-3Gal antibody in baboons by specific α-Gal immunoaffinity columns.  5:122-131. 1998

Pharmacologic immunosuppressive therapy and extracorporeal immunoadsorption in the suppression of anti-αGal antibody in the baboon.  5:274-283. 1998

Xenoantigens and xenoantibodies.  5:6-17. 1998

Legal implications of xenotransplantation.  4:132-139. 1997

Ethical aspects of xenotransplantation of current importance.  3:264-274. 1996

Investigation of the anti-complement agents, FUT-175 and K76COOH, in discordant xenotransplantation.  3:237-245. 1996

Manipulation of the anti-αGal antibody-αGal epitope system in experimental discordant xenotransplantation.  3:102-111. 1996

Ratites (ostrich, emu) as potential heart donors for humans: Immunologic, anatomic, and physiologic considerations.  3:252-259. 1996

Detection, immunoabsorption, and inhibition of cytotoxic activity of anti‐αGal antibodies using newly developed substances with synthetic Gal α1–3Gal disaccharide epitopes.  2:98-106. 1995

Inhibition of human anti‐αGal IgG by oligosaccharides derived from porcine stomach mucin.  2:279-288. 1995

Screening of baboons as potential liver donors for humans.  2:244-252. 1995

Variability of anti‐αGal antibodies in human serum and their relation to serum cytotoxicity against pig cells.  1:58-65. 1994